Despina Fotiou, Foteini Theodorakakou, Sotiria Spiliopoulou, Maria Gavriatopoulou, Magdalini Migkou, Nikolaos Kanellias, Evangelos Eleutherakis-Papaiakovou, Panagiotis Malandrakis, Ioanna Dialoupi, Maria Roussou, Ioannis Ntanasis-Stathopoulos, Evangelos Terpos, Meletios A Dimopoulos, Efstathios Kastritis
Haemostatic abnormalities and deregulated coagulation are common complications in AL amyloidosis. The relevant risks of thromboembolic and haemorrhagic events have not been thoroughly evaluated. To describe clinically significant thrombotic/haemorrhagic events in 450 consecutive patients with AL amyloidosis. Venous thromboembolic events (VTEs) were reported in 6% and arterial embolic events (AEEs) in 5% of patients, respectively, during a 55-month median follow-up. Lower albumin, lower eGFR, higher BM infiltration, soft tissue involvement, IMiD-based therapy and prior thrombosis were associated with VTE risk...
February 6, 2024: British Journal of Haematology