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https://read.qxmd.com/read/30767098/hyperglycaemia-cause-vascular-inflammation-through-advanced-glycation-end-products-early-growth-response-1-axis-in-gestational-diabetes-mellitus
#1
Barathi Rajaraman, Nirupama Ramadas, Sundar Krishnasamy, Vidya Ravi, Atima Pathak, C S Devasena, Krishnan Swaminathan, Arunkumar Ganeshprasad, Ashok Ayyappa Kuppuswamy, Srinivasan Vedantham
Hyperglycaemia during pregnancy is the main reason for developing diabetes mediated vascular complications. Advanced glycation end products (AGEs) are formed due to non-enzymatic glycation of proteins, lipids and nucleic acids during hyperglycaemia. It has the potential to damage vasculature by modifying the substrate or by means of AGEs and receptor of AGE (RAGE) interaction. It has been linked with the pathogenesis of various vascular diseases including coronary heart disease, atherosclerosis, restenosis etc...
February 14, 2019: Molecular and Cellular Biochemistry
https://read.qxmd.com/read/30669879/impact-of-socioeconomic-inequalities-on-quality-of-life-in-oral-submucous-fibrosis-patients
#2
Shailesh M Gondivkar, Rahul R Bhowate, Amol R Gadbail, Rima S Gondivkar, Sachin C Sarode
AIM: The purpose of this study was to analyze the impact of socioeconomic characteristics on oral health-related quality of life (OHRQoL) in patients with oral submucous fibrosis (OSF). METHODS:  A total of 300 OSF patients' quality of life (QoL) data were obtained using OHRQoL-OSF and global self ratings of oral health and overall wellbeing. The socioeconomic status (SES) of participants was analyzed by using modified Kuppuswamy scale. RESULTS: OSF patients with lower SES had worse OHRQoL as compared with those with middle and upper SES (p < 0...
January 23, 2019: Future Oncology
https://read.qxmd.com/read/30613514/a-study-on-awareness-and-utilization-of-mission-indradhanush-in-an-urban-slum-of-bhubaneswar
#3
Ipsa Mohapatra, Amit Kumar, Krishna Mishra
Background: India records 5 lakh child-deaths annually due to vaccine preventable diseases. As a strategic endeavor, the Ministry of Health and Family Welfare, Government of India, launched Mission Indradhanush in December 2014 to achieve more than 90% full immunization coverage by the year 2020. Objectives: To assess the awareness of the respondents about Mission Indradhanush, to assess their attitude and practices regarding childhood immunization, and to determine the association between knowledge and practice with selected variables...
November 2018: Journal of Family Medicine and Primary Care
https://read.qxmd.com/read/30581265/extended-spectrum-beta-lactamase-producing-community-acquired-urinary-tract-infections-in-children-chart-review-of-risk-factors
#4
Sundaram Balasubramanian, Dhanalakshmi Kuppuswamy, Swathi Padmanabhan, Vaishnavi Chandramohan, Sumanth Amperayani
Background: Community acquired urinary tract infections (CA-UTI) caused by extended spectrum beta lactamase (ESBL) producing organisms is on the rise throughout the world. There are known risk factors such as age <1 year, children on uroprophylaxis, recurrent UTI, recent antibiotic usage etc which can predict the occurrence of these ESBL producers. Objectives: To correlate known risk factors with occurrence of ESBL UTI and antibiotic susceptibility of uropathogens isolated...
October 2018: Journal of Global Infectious Diseases
https://read.qxmd.com/read/30576317/suppression-of-angiotensin-ii-induced-pathological-changes-in-heart-and-kidney-by-the-caveolin-1-scaffolding-domain-peptide
#5
Panneerselvam Chinnakkannu, Charles Reese, John Antony Gaspar, Saraswathi Panneerselvam, Dorea Pleasant-Jenkins, Rupak Mukherjee, Catalin Baicu, Elena Tourkina, Stanley Hoffman, Dhandapani Kuppuswamy
Dysregulation of the renin-angiotensin system leads to systemic hypertension and maladaptive fibrosis in various organs. We showed recently that myocardial fibrosis and the loss of cardiac function in mice with transverse aortic constriction (TAC) could be averted by treatment with the caveolin-1 scaffolding domain (CSD) peptide. Here, we used angiotensin II (AngII) infusion (2.1 mg/kg/day for 2 wk) in mice as a second model to confirm and extend our observations on the beneficial effects of CSD on heart and kidney disease...
2018: PloS One
https://read.qxmd.com/read/30398972/prevalence-of-traumatic-injuries-to-the-anterior-teeth-among-3-17-year-old-school-children-of-indore-and-correlating-it-with-kuppuswamy-ses-occlusal-relationship-and-ascertaining-percentage-of-those-seeking-the-treatment
#6
Vishal Khandelwal, Ullal Anand Nayak, Prathibha Anand Nayak, Nupur Ninawe
Background Orofacial trauma is one of the most prevailing oral health problems among the children. This study aimed to assess the prevalence and distribution of traumatic injuries and to correlate the causes, specific age groups, socio-economic status, occlusal relationship and ascertain the percentage of those seeking the treatment among school children in Indore (Madhya Pradesh, India). Materials and methods Five thousand school going children aged between 3 and 17 years belonging to different zones of Indore were randomly selected and divided into three age groups, Group I - 3-5 years; Group II - 6-11 years and Group III - 12-17 years...
November 6, 2018: International Journal of Adolescent Medicine and Health
https://read.qxmd.com/read/30374769/extracellular-urease-from-arthrobacter-creatinolyticus-mtcc-5604-scale-up-purification-and-its-cytotoxic-effect-thereof
#7
Ramesh Rajendran, Ajitha Pandi, Aparna Ramchary, Hemalatha Thiagarajan, Jithendra Panneerselvam, Ayyadurai Niraikulam, Gowthaman Marichetti Kuppuswami, Kamini Numbi Ramudu
Urease is a potent metalloenzyme with diverse applications. This paper describes the scale up and purification of an extracellular urease from Arthrobacter creatinolyticus MTCC 5604. The urease production was scaled-up in 3.7 L and 20 L fermentor. A maximum activity of 27 and 27.8 U/mL and a productivity of 0.90 and 0.99 U/mL/h were obtained at 30 h and 28 h in 3.7 and 20 L fermentor, respectively. Urease was purified to homogeneity with 49.85-fold purification by gel filtration and anion exchange chromatography with a yield of 36% and a specific activity of 1044...
October 29, 2018: Molecular Biology Reports
https://read.qxmd.com/read/30314008/inventorizing-the-modern-benthic-foraminiferal-assemblage-from-marginal-marine-environments-across-the-north-west-coast-of-bay-of-bengal
#8
Areen Sen, Ratul Saha, Kuppuswamy Sivakumar, Punyasloke Bhadury
Modern benthic foraminiferal assemblages are instrumental in providing information regarding changes in relative sea level as well as prevailing environmental conditions in marine environments. Marginal marine environments are coastal environments that are in most cases characterized by high influx of terrestrially originated nutrients. Inventorizing of modern benthic foraminiferal assemblages from such habitats can act as biotic indicators of water quality variations along with any changes in relative sea level...
June 27, 2018: Zootaxa
https://read.qxmd.com/read/29752166/circulating-matrix-modulators-mmp-9-and-timp-1-and-their-association-with-severity-of-diabetic-retinopathy
#9
Kuppuswami Jayashree, Md Yasir, Gandhipuram Periyasamy Senthilkumar, K Ramesh Babu, Vadivelan Mehalingam, Palani Selvam Mohanraj
AIMS: Diabetic Retinopathy (DR) is the leading cause of vision loss in the working age population. Matrix metalloproteinase-9 (MMP-9) and tissue inhibitor of metalloproteinase-1 (TIMP-1), are molecules involved in extracellular tissue matrix remodelling. They are implicated in the loss of retinal tissue integrity, a major cause of DR, that leads to retinal tissue degradation and apoptosis. This study is therefore, conducted to compare the serum levels of MMP-9 and TIMP-1 in T2DM patients without and with retinopathy, and to evaluate their association with the severity of DR...
November 2018: Diabetes & Metabolic Syndrome
https://read.qxmd.com/read/29708752/probing-fe-v-bonding-in-a-c-3-symmetric-heterobimetallic-complex
#10
Samuel M Greer, Johannes McKay, Kathryn M Gramigna, Christine M Thomas, Sebastian A Stoian, Stephen Hill
Direct metal-metal bonding of two distinct first-row transition metals remains relatively unexplored compared to their second- and third-row heterobimetallic counterparts. Herein, a recently reported Fe-V triply bonded species, [V( i PrNPPh2 )3 FeI] (1; Kuppuswamy, S.; Powers, T. M.; Krogman, J. P.; Bezpalko, M. W.; Foxman, B. M.; Thomas, C. M. Vanadium-iron complexes featuring metal-metal multiple bonds. Chem. Sci. 2013, 4, 3557-3565), is investigated using high-frequency electron paramagnetic resonance, field- and temperature-dependent 57 Fe nuclear gamma resonance (Mössbauer) spectroscopy, and high-field electron-electron double resonance detected nuclear magnetic resonance...
May 21, 2018: Inorganic Chemistry
https://read.qxmd.com/read/29589895/graphene-oxide-a-tool-for-the-preparation-of-chemically-crosslinking-free-alginate-chitosan-collagen-scaffolds-for-bone-tissue-engineering
#11
Elayaraja Kolanthai, Pugazhendhi Abinaya Sindu, Deepak Kumar Khajuria, Sarath Chandra Veerla, Dhandapani Kuppuswamy, Luiz Henrique Catalani, D Roy Mahapatra
Developing a biodegradable scaffold remains a major challenge in bone tissue engineering. This study was aimed at developing novel alginate-chitosan-collagen (SA-CS-Col)-based composite scaffolds consisting of graphene oxide (GO) to enrich porous structures, elicited by the freeze-drying technique. To characterize porosity, water absorption, and compressive modulus, GO scaffolds (SA-CS-Col-GO) were prepared with and without Ca2+ -mediated crosslinking (chemical crosslinking) and analyzed using Raman, Fourier transform infrared (FTIR), X-ray diffraction (XRD), and scanning electron microscopy techniques...
April 18, 2018: ACS Applied Materials & Interfaces
https://read.qxmd.com/read/29540500/puf-8-facilitates-homologous-chromosome-pairing-by-promoting-proteasome-activity-during-meiotic-entry-in-c-elegans
#12
Ganga Anil Kumar, Kuppuswamy Subramaniam
Pairing of homologous chromosomes is essential for genetic recombination during gametogenesis. In many organisms, chromosome ends are attached to cytoplasmic dynein, and dynein-driven chromosomal movements facilitate the pairing process. Factors that promote or control the cytoskeletal tethering of chromosomes are largely unknown. Here, we show that the conserved RNA-binding protein PUF-8 facilitates the tethering and pairing processes in the C. elegans germline by promoting proteasome activity. We have isolated a hypomorphic allele of pas-1 , which encodes a proteasome core subunit, and find that the homologous chromosomes fail to pair in the puf-8; pas-1 double mutant due to failure of chromosome tethering...
March 29, 2018: Development
https://read.qxmd.com/read/29533607/redox-active-metallodithiolene-groups-separated-by-insulating-tetraphosphinobenzene-spacers
#13
Kuppuswamy Arumugam, Malathy Selvachandran, Antony Obanda, Mohamed C Shaw, Perumalreddy Chandrasekaran, Sonya L Caston Good, Joel T Mague, Stephen Sproules, James P Donahue
Compounds of the type [(S2 C2 R2 )M(μ-tpbz)M(S2 C2 R2 )] (R = CN, Me, Ph, p-anisyl; M = Ni, Pd, Pt; tpbz = 1,2,4,5-tetrakis(diphenylphosphino)benzene) have been prepared by transmetalation with [(S2 C2 R2 )SnR'2 ] reagents, by direct displacement of dithiolene ligand from [M(S2 C2 R2 )2 ] with 0.5 equiv of tpbz, or by salt metathesis using Na2 [S2 C2 (CN)2 ] in conjunction with X2 M(μ-tpbz)MX2 (X = halide). X-ray crystallography reveals a range of topologies (undulating, chair, bowed) for the (S2 C2 )M(P2 C6 P2 )M(S2 C2 ) core...
April 2, 2018: Inorganic Chemistry
https://read.qxmd.com/read/29434512/dynamics-of-lumps-and-dark-dark-solitons-in-the-multi-component-long-wave-short-wave-resonance-interaction-system
#14
Jiguang Rao, Kuppuswamy Porsezian, Jingsong He, Thambithurai Kanna
General semi-rational solutions of an integrable multi-component (2+1)-dimensional long-wave-short-wave resonance interaction system comprising multiple short waves and a single long wave are obtained by employing the bilinear method. These solutions describe the interactions between various types of solutions, including line rogue waves, lumps, breathers and dark solitons. We only focus on the dynamical behaviours of the interactions between lumps and dark solitons in this paper. Our detailed study reveals two different types of excitation phenomena: fusion and fission...
January 2018: Proceedings. Mathematical, Physical, and Engineering Sciences
https://read.qxmd.com/read/29378272/fabrication-and-characterization-of-dual-acting-oleyl-chitosan-functionalised-iron-oxide-gold-hybrid-nanoparticles-for-mri-and-ct-imaging
#15
Thiagarajan Hemalatha, Periyathambi Prabu, Dharmalingam Nandagopal Gunadharini, Marichetti Kuppuswami Gowthaman
Bionanocomposites fabricated using metal nanoparticles serve a wide range of biomedical applications viz., site targeted drug delivery, imaging etc. Theranostics emerge as an important field of science, which focuses on the use of single entity for both disease diagnosis and treatment. The present work aimed at designing a multifunctional nanocomposite comprising of iron/gold hybrid nanoparticles, coated with oleyl chitosan and conjugated with methotrexate. The HR-TEM images revealed the spherical nature of the composite, while it's nontoxic and biocompatible property was proved by the MTT assay in NIH 3T3 cells and hemolysis assay...
June 2018: International Journal of Biological Macromolecules
https://read.qxmd.com/read/29368109/-quality-of-life-of-parents-of-children-suffering-from-pediatric-malignancies-in-a-low-income-setting
#16
Vibha Sanjay Bafna, Tanvi Ajay Bafna, Abhilasha Sampagar, Sunita Raman Rupavataram
OBJECTIVES: To evaluate the impact of pediatric malignancies on quality of life (QOL) and psychological status of parents and to correlate it with well-matched controls and socioeconomic status. METHODS: A prospective comparative cross-sectional study was conducted. Seventy parents of children diagnosed with pediatric malignancies within the last three months were enrolled in the study group (SG) and 50 matched parents of healthy children as the control group (CG)...
September 2018: Indian Journal of Pediatrics
https://read.qxmd.com/read/29336389/a-randomized-controlled-trial-comparing-the-myocardial-protective-effects-of-isoflurane-with-propofol-in-patients-undergoing-elective-coronary-artery-bypass-surgery-on-cardiopulmonary-bypass-assessed-by-changes-in-n-terminal-brain-natriuretic-peptide
#17
RANDOMIZED CONTROLLED TRIAL
Balaji Kuppuswamy, Kirubakaran Davis, Raj Sahajanandan, Manickam Ponniah
OBJECTIVE: The objective of the study is to compare the myocardial protective effects of isoflurane with propofol in patients undergoing elective coronary artery bypass surgery on cardiopulmonary bypass (CPB), the cardio protection been assessed by changes in N-terminal brain natriuretic peptide (NT proBNP). Methodology and Design: This study is designed as a participant blinded, prospective randomized clinical trial. SETTING: Christian Medical College Hospital, Vellore, India...
January 2018: Annals of Cardiac Anaesthesia
https://read.qxmd.com/read/29283118/optical-coherence-tomography-a-guide-to-interpretation-of-common-macular-diseases
#18
REVIEW
Muna Bhende, Sharan Shetty, Mohana Kuppuswamy Parthasarathy, S Ramya
Optical coherence tomography is a quick, non invasive and reproducible imaging tool for macular lesions and has become an essential part of retina practice. This review address the common protocols for imaging the macula, basics of image interpretation, features of common macular disorders with clues to differentiate mimickers and an introduction to choroidal imaging . It includes case examples and also a practical algorithm for interpretation.
January 2018: Indian Journal of Ophthalmology
https://read.qxmd.com/read/29251494/fe-5-mo-cluster-with-iron-carbide-and-molybdenum-carbide-bonding-motifs-structure-and-selective-alkyne-reductions
#19
Chris Joseph, Subramaniam Kuppuswamy, Vincent M Lynch, Michael J Rose
Herein we report the synthesis, X-ray structure, and characterization of the title pentairon (molybdo)carbido cluster. The reaction of the pentairon (μ5 -carbido) dianion [Fe5 (μ6 -C)(μ2 -CO)2 (CO)12 ]2- (1) with [Mo(CO)3 (chpt)] (chpt = cycloheptatriene) forms the heterohexanuclear cluster [K(benzo-18-crown-6)]2 [Fe5 Mo(μ6 -C)(μ2 -CO)3 (CO)14 ] (2). The dianion exhibits a Fe5 Mo(μ6 -C) core structure supported by three bridging (νCO = 1788 cm-1 ) and terminal (νCO = 1943 cm-1 ) CO ligands. Cluster 2 provides the selective reduction of diphenylacetylene to cis-diphenylethylene via a spectroscopically observed cluster-hydride intermediate (1 H NMR: δ -26)...
January 2, 2018: Inorganic Chemistry
https://read.qxmd.com/read/29227900/exposures-to-fine-particulate-matter-pm-2-5-and-birthweight-in-a-rural-urban-mother-child-cohort-in-tamil-nadu-india
#20
Kalpana Balakrishnan, Santu Ghosh, Gurusamy Thangavel, Sankar Sambandam, Krishnendu Mukhopadhyay, Naveen Puttaswamy, Arulselvan Sadasivam, Padmavathi Ramaswamy, Priscilla Johnson, Rajarajeswari Kuppuswamy, Durairaj Natesan, Uma Maheshwari, Amudha Natarajan, Gayathri Rajendran, Rengaraj Ramasami, Sathish Madhav, Saraswathy Manivannan, Srinivasan Nargunanadan, Srinivasan Natarajan, Sudhakar Saidam, Moumita Chakraborty, Lingeswari Balakrishnan, Vijayalakshmi Thanasekaraan
BACKGROUND: Exposure to PM2.5 (fine particulate matter <less than 2.5µm in aerodynamic diameter) related to ambient and household air pollution has been associated with low birthweight. Few of these studies, however, have been conducted in high exposure settings that are commonly encountered in low and middle income countries (LMICs). OBJECTIVES: We examined whether PM2.5 exposures during pregnancy were associated with birthweight in an integrated rural-urban, mother-child cohort in the state of Tamil Nadu, India...
February 2018: Environmental Research
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