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Osayame A Ekhaguere, Michael A Padula, Erik A Jensen
OBJECTIVE:  The use of acid suppression therapies in newborns lacks efficacy and is associated with adverse effects. Point-of-care (POC) assessment of gastric aspirate pH may provide an objective, noninvasive measure of gastric acidity in tube fed infants. We conducted the present study to characterize the POC gastric pH levels in gastric tube fed infants before and after initiation of enteral omeprazole or ranitidine. STUDY DESIGN:  Retrospective cohort study of infants with gastric aspirate pH levels determined by POC pH strips...
February 19, 2019: American Journal of Perinatology
Ma Yanchun, Wang Yi, Wang Lu, Qian Yu, Yang Jian, Kong Pengzhou, Yan Ting, Li Hongyi, Wang Fang, Cheng Xiaolong, Cui Yongping
Triptolide, the component of traditional Chinese herb, has been used as an inflammatory medicine and reported to be anti-tumor for various cancers recently. However, the effect of triptolide on Esophageal Squamous Cell Cancer (ESCC) has not yet been elucidated. In the study, we found that triptolide significantly inhibited cell proliferation, invasion, migration and survivability of ESCC cells. Moreover, we observed that triptolide induced ESCC cell cycle arrest at the G1/S phase and apoptosis through cyclin D1-CDK4/6 regulation and caspases activation...
February 16, 2019: European Journal of Pharmacology
Huihui Wang, Xiaoguang Yan, Haijun Zhang, Xiaorong Zhan
BACKGROUND Circular RNAs are important regulators in human cancers, including thyroid carcinoma. The circ_0067934 RNA is reported to participate in hepatocellular carcinoma, esophageal squamous cell carcinoma, and lung cancer. Whether it regulates thyroid carcinoma remains unclear. The purpose of this study was to research potential mechanisms of circ_0067934 in thyroid tumors to provide potential new diagnostic and treatment targets. MATERIAL AND METHODS The expression level of circ_0067934 in thyroid tumors, adjacent tissues, and cell lines was measured by qRT-PCR...
February 19, 2019: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
Dustin R Allen, M U Huang, Nathan B Morris, Georgia K Chaseling, Elliot M Frohman, Ollie Jay, Scott L Davis
INTRODUCTION: Impairments in sudomotor function during passive whole-body heating have been reported in multiple sclerosis (MS), a demyelinating disease of the CNS that disrupts autonomic function. However, the capability of the thermoregulatory system to control body temperature during exercise has never been assessed in MS. Thus, the aim of the present study was to test the hypothesis that thermoregulatory function is impaired in MS patients compared with healthy controls (CON) exercising at similar rates of metabolic heat production...
March 2019: Medicine and Science in Sports and Exercise
Gary D Peksa, Joshua M DeMott, Giles W Slocum, Jaxson Burkins, Michael Gottlieb
BACKGROUND: Glucagon is frequently utilized for the relief of esophageal impactions. This systematic review and meta-analysis was performed to evaluate the efficacy and safety of glucagon for acute esophageal foreign body and food impactions. METHODS: PubMed, CINAHL, Latin American and Caribbean Health Sciences Literature (LILACS), Scopus, Cochrane Database of Systematic Reviews, and Cochrane Central Register of Controlled Trials were searched from inception to March 1, 2018...
February 18, 2019: Pharmacotherapy
Amneet Sandhu, Matthew M Zipse, Ryan T Borne, Ryan G Aleong, Christine Tompkins, Joseph Schuller, Michael Rosenberg, Paul D Varosy, Wendy S Tzou, Duy T Nguyen, William H Sauer
BACKGROUND: Despite improvement in catheter ablation for atrial fibrillation (AF), ability to recognize and prevent esophageal injury remains challenging. We hypothesized that esophageal course may impact esophageal heating, as measured through ablation, and thereby risk of injury. METHODS: We evaluated all patients undergoing first-time AF ablation with pre-procedural CT imaging from 2014-2016 at our institution focusing on esophageal position at the LA-PV junction...
February 19, 2019: Pacing and Clinical Electrophysiology: PACE
C Liu, X Tian, H-B Sun, Z-F Wang, L-F Jiang, Z-X Li
OBJECTIVE: The aim of this study was to explore the role of microRNA-601 (miR-601) in the proliferation and invasion of esophageal squamous cell carcinoma (ESCC) cells, thereby providing new thoughts for prognosis evaluation and targeted therapy of ESCC. PATIENTS AND METHODS: 23 pairs of ESCC tissue samples and adjacent normal tissues were collected, and the expression level of miR-601 was detected. Biological information analysis and Luciferase report gene assay were used to verify the potential target genes of miR-601...
February 2019: European Review for Medical and Pharmacological Sciences
Keita Nakanishi, Hiroyuki Daiko, Fumihiko Kato, Jun Kanamori, Hiroyasu Igaki, Yuji Tachimori, Kazuo Koyanagi
OBJECTIVE: There is no consensus concerning whether the residual stomach should be preserved after esophagectomy for thoracic esophageal cancer patients with previous distal or segmental gastrectomy. The purpose of this retrospective study was to assess the efficacy of preserving the residual stomach after esophagectomy in patients with previous gastrectomy. METHODS: Between 2000 and 2015, 45 consecutive thoracic esophageal cancer patients with previous distal or segmental gastrectomy underwent esophagectomy followed by colon reconstruction...
February 18, 2019: General Thoracic and Cardiovascular Surgery
Ponnie Robertlee Dolo, Yong Shao, Chao Li, Xiaocheng Zhu, Libin Yao, Hui Wang
BACKGROUND: Gastric bypass with a proximal gastric pouch (Roux-en-Y gastric bypass) induces early diabetes remission. The effect of gastric bypass with a distal gastric pouch remains unknown. OBJECTIVE: To observe the effect on glucose tolerance and diabetes remission of gastric bypass with a distal gastric pouch. METHOD: A type 2 diabetes (T2D) model was created in 44 Sprague-Dawley (SD) rats that randomly underwent Roux-en-Y gastric bypass (RYGB, n = 8); gastric bypass with duodenal-jejunal transit (GB-DJT, n = 8); distal-pouch gastric bypass with duodenal-jejunal transit (DPGB-DJT, n = 8); distal-pouch gastric bypass with duodenal-jejunal bypass (DPGB-DJB, n = 8); sham (n = 6); and Roux-en-Y gastric bypass with esophageal re-anastomosis (RYGB-Er, n = 6) surgery...
February 18, 2019: Obesity Surgery
Alberto Aiolfi, Stefania Tornese, Gianluca Bonitta, Emanuele Rausa, Giancarlo Micheletto, Davide Bona
INTRODUCTION: The development of achalasia after Roux-en-Y gastric bypass (RYGB) is rare. Heller myotomy (HM) is the gold standard treatment while peroral endoscopic myotomy (POEM) is an emerging technique with promising results. The aim of this narrative review was to summarize the current knowledge on the treatment of esophageal achalasia after RYGB. METHODS: PubMed, EMBASE, and Web of Science databases were consulted. All articles that described the management of achalasia after RYGB were included in this narrative review...
February 18, 2019: Obesity Surgery
Takuji Sato, Takeo Fujita, Hisashi Fujiwara, Hiroyuki Daiko
BACKGROUND: Minimally invasive esophagectomy is considered a beneficial approach to esophageal cancer, although a hiatal hernia occurs more frequently in this approach than in open esophagectomy with reconstruction via the mediastinal route. Development of an internal hernia to the retrosternal space is not a recognized complication of reconstruction via the retrosternal route after esophagectomy. We herein report three cases of the development of an internal hernia to the retrosternal space after minimally invasive esophagectomy...
February 18, 2019: Surgical Case Reports
Fumiaki Shiratori, Masaaki Ito, Satoshi Yajima, Takashi Suzuki, Yoko Oshima, Tatsuki Nanami, Kimihiko Funahashi, Hideaki Shimada
BACKGROUND: Studies investigating serum midkine (s-MK) concentrations have employed a polyclonal antibody enzyme-linked immunosorbent assay system (ELISA), because the targeted polyclonal antibody has low specificity. We used a newly developed monoclonal antibody ELISA to investigate the prognostic and diagnostic capabilities of s-MK in patients with esophageal squamous cell carcinoma. METHODS: Serum samples from 102 patients with esophageal squamous cell carcinoma were analyzed using a newly developed monoclonal antibody ELISA specifically developed to detect s-MK...
February 18, 2019: Esophagus: Official Journal of the Japan Esophageal Society
Einar A Hart, Sander De Bock, Matthieu De Beule, Arco J Teske, Steven A J Chamuleau, Michiel Voskuil, Adriaan O Kraaijeveld
No abstract text is available yet for this article.
February 19, 2019: EuroIntervention
Francisco Schlottmann, Fernando Herbella, Marco E Allaix, Marco G Patti
No abstract text is available yet for this article.
February 2019: Current Problems in Surgery
I-Ying Kuo, Yu-Lin Huang, Chien-Yu Lin, Chien-Hsun Lin, Wei-Lun Chang, Wu-Wei Lai, Yi-Ching Wang
BACKGROUND: Prognosis of esophageal squamous cell carcinoma (ESCC) patients is poor and the concurrent chemoradiation therapy (CCRT) provided to ESCC patients often failed due to resistance. Therefore, development of biomarkers for predicting CCRT response is immensely important. In this study, we evaluated the predicting value of SRY (sex determining region Y)-box 17 (SOX17) protein during CCRT and its dysregulation of transcriptional targets in CCRT resistance in ESCC. METHODS: Pyrosequencing methylation, RT-qPCR and immunohistochemistry assays were performed to examine the DNA methylation, mRNA expression and protein expression levels of SOX17 in endoscopic biopsy from a total of 70 ESCC patients received CCRT...
February 18, 2019: Journal of Biomedical Science
Celine Bourgier, Anne Auperin, Sofia Rivera, Pierre Boisselier, Benoit Petit, Philippe Lang, Nathalie Lassau, Patrice Taourel, Raphael Tetreau, David Azria, Jean Bourhis, Eric Deutsch, Marie-Catherine Vozenin
PURPOSE: The "xxx" phase II trial (NCTxxx) assessed the efficacy of pravastatin as anti-fibrotic agent in patients with established cutaneous and subcutaneous radiation-induced fibrosis (RIF) after head and neck squamous cell carcinoma (HNSCC) radiotherapy and/or radio-chemotherapy. METHODS AND MATERIALS: The main inclusion criteria were: patients with HNSCC in remission, with grade ≥2 cutaneous and subcutaneous neck RIF (NCI-CTCAE v4.0); no current treatment with statins or fibrates...
February 15, 2019: International Journal of Radiation Oncology, Biology, Physics
Ruhong Jiang, Eric Buch, Jean Gima, Gaurav A Upadhyay, Hemal M Nayak, Andrew D Beaser, Zaid Aziz, Kalyanam Shivkumar, Roderick Tung
BACKGROUND: Recurrences of atrial fibrillation (AF) after ablation have been attributed to conduction gaps and non-transmural ablation lesions OBJECTIVE: To assess the feasibility of adjunctive percutaneous mapping of the epicardial regions of the left atrium to characterize the transmural extent of substrate and ablation lesions. METHODS: Between 2014-2018, combined epi-endo mapping of AF was performed in 18 patients via inferior subxiphoid percutaneous approach (16 with previously failed ablations, and 2 patients with long-standing persistent AF) at 2 centers...
February 15, 2019: Heart Rhythm: the Official Journal of the Heart Rhythm Society
Roberto de Franchis
No abstract text is available yet for this article.
February 15, 2019: Gastroenterology
Alexandre Biasi Cavalcanti, Marcelo Britto Passos Amato, Ary Serpa-Neto
No abstract text is available yet for this article.
February 18, 2019: JAMA: the Journal of the American Medical Association
Jeremy R Beitler, Todd Sarge, Valerie M Banner-Goodspeed, Michelle N Gong, Deborah Cook, Victor Novack, Stephen H Loring, Daniel Talmor
Importance: Adjusting positive end-expiratory pressure (PEEP) to offset pleural pressure might attenuate lung injury and improve patient outcomes in acute respiratory distress syndrome (ARDS). Objective: To determine whether PEEP titration guided by esophageal pressure (PES), an estimate of pleural pressure, was more effective than empirical high PEEP-fraction of inspired oxygen (Fio2) in moderate to severe ARDS. Design, Setting, and Participants: Phase 2 randomized clinical trial conducted at 14 hospitals in North America...
February 18, 2019: JAMA: the Journal of the American Medical Association
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