Zhipeng Ling, Junping Pan, Zhongfei Zhang, Guisi Chen, Jiayuan Geng, Qiang Lin, Tao Zhang, Shuqin Cao, Cheng Chen, Jinrong Lin, Hongyao Yuan, Weilong Ding, Fei Xiao, Xinke Xu, Fangcheng Li, Guocai Wang, Yubo Zhang, Junliang Li
Glioblastoma (GBM), one of the most malignant brain tumors in the world, has limited treatment options and a dismal survival rate. Effective and safe disease-modifying drugs for glioblastoma are urgently needed. Here, we identified a small molecule, Molephantin (EM-5), effectively penetrated the blood-brain barrier (BBB) and demonstrated notable antitumor effects against GBM with good safety profiles both in vitro and in vivo. Mechanistically, EM-5 not only inhibits the proliferation and invasion of GBM cells but also induces cell apoptosis through the reactive oxygen species (ROS)-mediated PI3K/Akt/mTOR pathway...
April 30, 2024: Cancer Letters