keyword
Keywords Breast cancer, breast, immunol...

Breast cancer, breast, immunology, genetics,

https://read.qxmd.com/read/37552125/exploring-the-potential-of-humanin-as-a-biomarker-for-early-breast-cancer-detection-a-study-of-serum-levels-and-diagnostic-performance
#21
JOURNAL ARTICLE
Munevver Gizem Hekim, Sibel Ozcan, Mesut Yur, Nilgun Yildirim, Mete Ozcan
INTRODUCTION: Breast cancer (BC) is a leading cause of cancer death in women worldwide, and early detection is crucial for effective treatment. Mitochondrial dysfunction has been linked to cancer development and progression. Humanin, a mitochondrial-derived peptide, has been shown to have cytoprotective effects and may be involved in breast cancer development. In this study, we aimed to investigate the potential of humanin as a biomarker for breast cancer. METHODS: We recruited 45 female patients diagnosed with primary invasive ductal breast cancer and 45 healthy volunteers...
August 8, 2023: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://read.qxmd.com/read/37484811/integrated-analysis-of-fkbp1a-slc3a2-axis-in-everolimus-inducing-ferroptosis-of-breast-cancer-and-anti-proliferation-of-t-lymphocyte
#22
JOURNAL ARTICLE
Zihan Chen, Rongxue Li, Min Fang, Ying Wang, Aihong Bi, Lixian Yang, Tao Song, Yucheng Li, Qiang Li, Baihua Lin, Yongshi Jia, Shi Fu, Shuiqiao Fu, Hanchu Xiong
Background : Solute Carrier Family 3 Member 2 (SLC3A2) is a member of the solute carrier family that plays pivotal roles in regulation of intracellular calcium levels and transports L-type amino acids. However, there are insufficient scientific researches on the prognostic and immunological roles of SLC3A2 in breast cancer (BC) and whether everolimus regulates novel SLC3A2 related molecular mechanism in the immuno-oncology context of the tumor microenvironment (TME), therefore, we see a necessity to conduct the current in silico and biological experimental study...
2023: International Journal of Medical Sciences
https://read.qxmd.com/read/37403656/from-premalignant-biology-to-precision-interception-connecting-the-dots-with-a-curated-collection-of-invited-articles
#23
JOURNAL ARTICLE
Karen Colbert Maresso, Anirban Maitra, Ernest T Hawk, Eduardo Vilar
Nearly all cancers have identifiable histologically defined precursors known as precancers. These precancers offer a window of opportunity to intercept the neoplastic process to prevent its development into invasive cancer. However, lack of knowledge regarding the evolution of precancers and the microenvironmental pressures shaping them precludes efforts to intercept them. Technological developments over the past decade have facilitated the study of precancers at a previously unattainable resolution. Calls for a national PreCancer Atlas effort incorporating these technologies were heeded in 2018, with the launch of the Human Tumor Atlas Network (HTAN) as part of the Beau Biden National Cancer Moonshot...
July 5, 2023: Cancer Prevention Research
https://read.qxmd.com/read/37388742/ferroptosis-related-gene-hic1-in-the-prediction-of-the-prognosis-and-immunotherapeutic-efficacy-with-immunological-activity
#24
JOURNAL ARTICLE
Yanlin Wu, Zhengjun Lin, Xianzhe Tang, Zhongyi Tong, Yuqiao Ji, Yingting Xu, Ziting Zhou, Jing Yang, Zhihong Li, Tang Liu
BACKGROUND: Hypermethylated in Cancer 1 (HIC1) was originally confirmed as a tumor suppressor and has been found to be hypermethylated in human cancers. Although growing evidence has supported the critical roles of HIC1 in cancer initiation and development, its roles in tumor immune microenvironment and immunotherapy are still unclear, and no comprehensive pan-cancer analysis of HIC1 has been conducted. METHODS: HIC1 expression in pan-cancer, and differential HIC1 expression between tumor and normal samples were investigated...
2023: Frontiers in Immunology
https://read.qxmd.com/read/37368077/using-patient-derived-tumor-organoids-from-common-epithelial-cancers-to-analyze-personalized-t-cell-responses-to-neoantigens
#25
JOURNAL ARTICLE
Anup Y Parikh, Robert Masi, Billel Gasmi, Ken-Ichi Hanada, Maria Parkhurst, Jared Gartner, Sivasish Sindiri, Todd Prickett, Paul Robbins, Nikolaos Zacharakis, Mike Beshiri, Kathleen Kelly, Steven A Rosenberg, James C Yang
Adoptive cell transfer of tumor-infiltrating lymphocytes (TIL) can mediate durable complete responses in some patients with common epithelial cancers but does so infrequently. A better understanding of T-cell responses to neoantigens and tumor-related immune evasion mechanisms requires having the autologous tumor as a reagent. We investigated the ability of patient-derived tumor organoids (PDTO) to fulfill this need and evaluated their utility as a tool for selecting T-cells for adoptive cell therapy. PDTO established from metastases from patients with colorectal, breast, pancreatic, bile duct, esophageal, lung, and kidney cancers underwent whole exomic sequencing (WES), to define mutations...
June 27, 2023: Cancer Immunology, Immunotherapy: CII
https://read.qxmd.com/read/37312170/a-pan-cancer-analysis-of-the-oncogenic-and-immunological-roles-of-apolipoprotein-f-apof-in-human-cancer
#26
JOURNAL ARTICLE
Xu Shi, Dechao Feng, Dengxiong Li, Ping Han, Lu Yang, Wuran Wei
BACKGROUND: Apolipoprotein F (APOF) has been less studied in cancers. Thus, we aimed to perform a pan-cancer analysis of the oncogenic and immunological effects of APOF on human cancer. METHODS: A standardized TCGA pan-cancer dataset was downloaded. Differential expression, clinical prognosis, genetic mutations, immune infiltration, epigenetic modifications, tumor stemness and heterogeneity were analyzed. We conducted all analyses through software R (version 3.6...
June 14, 2023: European Journal of Medical Research
https://read.qxmd.com/read/37283769/genetically-predicted-vitamin-c-levels-significantly-affect-patient-survival-and-immunotypes-in-multiple-cancer-types
#27
JOURNAL ARTICLE
Jing Yuan, Yu-Hong Zhang, Xin Hua, Hui-Qi Hong, Wei Shi, Kun-Xiang Liu, Ze-Xian Liu, Peng Huang
BACKGROUND: Recent observational studies and meta-analyses have shown that vitamin C reduces cancer incidence and mortality, but the underlying mechanisms remain unclear. We conducted a comprehensive pan-cancer analysis and biological validation in clinical samples and animal tumor xenografts to understand its prognostic value and association with immune characteristics in various cancers. METHODS: We used the Cancer Genome Atlas gene expression data involving 5769 patients and 20 cancer types...
2023: Frontiers in Immunology
https://read.qxmd.com/read/37275857/comprehensive-analysis-of-33-human-cancers-reveals-clinical-implications-and-immunotherapeutic-value-of-the-solute-carrier-family-35-member-a2
#28
JOURNAL ARTICLE
Shengshan Xu, Xiguang Chen, Jianxiong Fang, Hongyu Chu, Shuo Fang, Leli Zeng, Hansu Ma, Tianzhi Zhang, Yu Chen, Tao Wang, Xin Zhang, Tao Shen, Youbin Zheng, Dongming Xu, Zhuming Lu, Yihang Pan, Yuchen Liu
BACKGROUND: Solute carrier family 35 member A2 (SLC35A2), which belongs to the SLC35 solute carrier family of human nucleoside sugar transporters, has shown regulatory roles in various tumors and neoplasms. However, the function of SLC35A2 across human cancers remains to be systematically assessed. Insights into the prediction ability of SLC35A2 in clinical practice and immunotherapy response remains limited. MATERIALS AND METHODS: We obtained the gene expression and protein levels of SLC35A2 in a variety of tumors from Molecular Taxonomy of Breast Cancer International Consortium, The Cancer Genome Atlas, Gene Expression Omnibus, Chinese Glioma Genome Atlas, and Human Protein Atlas databases...
2023: Frontiers in Immunology
https://read.qxmd.com/read/37256255/targeted-tlr9-agonist-elicits-effective-antitumor-immunity-against-spontaneously-arising-breast-tumors
#29
JOURNAL ARTICLE
Caitlyn L Miller, Idit Sagiv-Barfi, Patrick Neuhöfer, Debra K Czerwinski, Carolyn R Bertozzi, Jennifer R Cochran, Ronald Levy
Spontaneous tumors that arise in genetically engineered mice recapitulate the natural tumor microenvironment and tumor-immune coevolution observed in human cancers, providing a more physiologically relevant preclinical model relative to implanted tumors. Similar to many cancer patients, oncogene-driven spontaneous tumors are often resistant to immunotherapy, and thus novel agents that can effectively promote antitumor immunity against these aggressive cancers show considerable promise for clinical translation, and their mechanistic assessment can broaden our understanding of tumor immunology...
May 31, 2023: Journal of Immunology
https://read.qxmd.com/read/37256142/conversion-of-primary-liver-cancer-after-targeted-therapy-for-liver-cancer-combined-with-afp-targeted-car-t-cell-therapy-a-case-report
#30
Yun Wang, Yan Zhao, Miaoling Li, Huilian Hou, Zhijie Jian, Weizhi Li, Peijie Li, Fuquan Ma, Mengying Liu, Haibo Liu, Hui Xue
Primary liver cancer (PLC) that originates in the liver is a malignant tumor with the worst prognosis. Hepatocellular carcinoma (HCC) is the most common type of PLC. Most PLC cases are diagnosed at advanced stages mainly due to their insidious onset and rapid progression. Patients with PLC undergo surgical intervention or localized treatment, but their survival is often affected by its high relapse rate. Medical treatment is the primary option for patients with liver cancer, especially with advanced extrahepatic metastases...
2023: Frontiers in Immunology
https://read.qxmd.com/read/37248547/lncrna-wac-as1-expression-in-human-tumors-correlates-with-immune-infiltration-and-affects-prognosis
#31
JOURNAL ARTICLE
Yanyang Wang, Haiyan Gong, Yue Cao
BACKGROUND: WAC-antisense RNA1 (WAC-AS1) is a newly identified long non-coding RNA (lncRNA) implicated in the prognosis and development of a few types of tumors. However, the correlations of WAC-AS1 with immune infiltration and patient prognosis in pan-cancer remain unclear. In the present study, we aimed to investigate the prognostic value and immunological functions of WAC-AS1 across 33 different types of cancers. METHODS: To investigate the potential oncogenic roles of WAC-AS1, bioinformatics analyses were performed using the Cancer Genome Atlas (TCGA) and Genotype Tissue-Expression (GTEx) datasets...
May 30, 2023: Hereditas
https://read.qxmd.com/read/37122728/investigating-the-role-of-fads-family-members-in-breast-cancer-based-on-bioinformatic-analysis-and-experimental-validation
#32
JOURNAL ARTICLE
Tingting Zhao, Pingping Gao, Yanling Li, Hao Tian, Dandan Ma, Na Sun, Ceshi Chen, Yi Zhang, Xiaowei Qi
Breast cancer (BC) is the most common malignant tumor in women worldwide. Emerging evidence indicates the significance of fatty acid metabolism in BC. Fatty acid desaturase (FADS) is closely associated with cancer occurrence and development. Here, bioinformatic analysis and experimental validation were applied to investigate the potential functions of FADS in BC. Several public databases, including TCGA, GEO, HPA, Kaplan-Meier plotter, STRING, DAVID, cBioPortal, TIMER, TRRUST, and LinkedOmics were used to determine mRNA/protein expression levels, prognostic significance, functional enrichment, genetic alterations, association with tumor-infiltrating immune cells, and related transcription factors and kinases...
2023: Frontiers in Immunology
https://read.qxmd.com/read/37107558/inverse-comorbidity-between-down-syndrome-and-solid-tumors-insights-from-in-silico-analyses-of-down-syndrome-critical-region-genes
#33
JOURNAL ARTICLE
Kwadwo Fosu, Jude Tetteh Quarshie, Kwabena Amofa Nketia Sarpong, Anastasia Rosebud Aikins
An inverse comorbidity has been observed between Down syndrome (DS) and solid tumors such as breast and lung cancers, and it is posited that the overexpression of genes within the Down Syndrome Critical Region (DSCR) of human chromosome 21 may account for this phenomenon. By analyzing publicly available DS mouse model transcriptomics data, we aimed to identify DSCR genes that may protect against human breast and lung cancers. Gene expression analyses with GEPIA2 and UALCAN showed that DSCR genes ETS2 and RCAN1 are significantly downregulated in breast and lung cancers, and their expression levels are higher in triple-negative compared to luminal and HER2-positive breast cancers...
March 26, 2023: Genes
https://read.qxmd.com/read/37091063/engineered-human-pluripotent-stem-cell-derived-natural-killer-cells-with-pd-l1-responsive-immunological-memory-for-enhanced-immunotherapeutic-efficacy
#34
JOURNAL ARTICLE
Yun Chang, Gyuhyung Jin, Weichuan Luo, Qian Luo, Juhyung Jung, Sydney N Hummel, Sandra Torregrosa-Allen, Bennett D Elzey, Philip S Low, Xiaojun Lance Lian, Xiaoping Bao
Adoptive chimeric antigen receptor (CAR)-engineered natural killer (NK) cells have shown promise in treating various cancers. However, limited immunological memory and access to sufficient numbers of allogenic donor cells have hindered their broader preclinical and clinical applications. Here, we first assess eight different CAR constructs that use an anti-PD-L1 nanobody and/or universal anti-fluorescein (FITC) single-chain variable fragment (scFv) to enhance antigen-specific proliferation and anti-tumor cytotoxicity of NK-92 cells against heterogenous solid tumors...
September 2023: Bioactive Materials
https://read.qxmd.com/read/37035750/gelsolin-a-comprehensive-pan-cancer-analysis-of-potential-prognosis-diagnostic-and-immune-biomarkers
#35
JOURNAL ARTICLE
Yiyang Wang, Xiaojuan Bi, Zhiwen Luo, Haiyan Wang, Dilimulati Ismtula, Chenming Guo
Introduction: Gelsolin (GSN), a calcium-regulated actin-binding protein, is out of balance in various cancers. It can mediate cytoskeletal remodeling and regulate epithelial-mesenchymal conversion (EMT), but the studies on GSN function in pan-cancer are limited. Methods: We studied the transcription level, prognostic impact, diagnostic value, genetic, epigenetic modification, methylation level and immune significance of GSN in pan-cancer to fully comprehend the function of GSN in various malignancies based on multiple databases like The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO)...
2023: Frontiers in Genetics
https://read.qxmd.com/read/37031396/impacts-of-retn-genetic-polymorphism-on-breast-cancer-development-in-beni-suef-females-egypt
#36
JOURNAL ARTICLE
Hanan M Farhan, Khadiga Abougabal, Mamdoh E Ramadan, Tarek Darwish, Nourhan A Eldeiry, Shaimaa A Abdelkareem
Breast cancer is the most common cancer among females with increasing incidence and death rates. Resistin is pro-inflammatory molecule which shares in diverse cellular signaling pathways. This study aimed to evaluate resistin and RETN rs3219175 gene polymorphism and their relevance to diagnostic susceptibility, prognostic value, and genetic risk among Egyptian female patients with breast cancer. Eighty female patients with breast cancer were recruited from the Oncology Department, Faculty of Medicine, Beni-Suef University...
April 2023: Egyptian Journal of Immunology
https://read.qxmd.com/read/37014514/ido-blockade-negatively-regulates-the-ctla-4-signaling-in-breast-cancer-cells
#37
JOURNAL ARTICLE
Parviz Azimnasab-Sorkhabi, Maryam Soltani-Asl, TĂșlio Teruo Yoshinaga, Cristina de Oliveira Massoco, Jose Roberto Kfoury Junior
Cancer is classified into metabolic and/or genetic disorders; notably, the tryptophan catabolism pathway is vital in different cancer types. Here, we focused on the interaction and molecular connection between the cytotoxic T lymphocyte-associated antigen-4 (CTLA-4) receptor and indoleamine-2,3-dioxygenase (IDO) enzyme. To test the impact of the selected immunotherapies on breast cancer cell migration and cell survival, we used in vitro assays. Also, we test the impact of anti-CTLA-4 antibody on the IDO-positive cells...
April 4, 2023: Immunologic Research
https://read.qxmd.com/read/37014493/breast-cancer-prognosis-and-immunological-characteristics-are-predicted-using-the-m6a-m5c-m1a-m7g-related-long-noncoding-rna-signature
#38
JOURNAL ARTICLE
Lina Zhang, Chengyu Liu, Xiaochong Zhang, Changjing Wang, Dengxiang Liu
According to statistics, breast cancer (BC) has replaced lung cancer as the most common cancer in the world. Therefore, specific detection markers and therapeutic targets need to be explored as a way to improve the survival rate of BC patients. We first identified m6A/m5C/m1A/m7G-related long noncoding RNAs (MRlncRNAs) and developed a model of 16 MRlncRNAs. Kaplan-Meier survival analysis was applied to assess the prognostic power of the model, while univariate Cox analysis and multivariate Cox analysis were used to assess the prognostic value of the constructed model...
April 4, 2023: Functional & Integrative Genomics
https://read.qxmd.com/read/36960071/the-prognostic-significance-of-human-ovarian-aging-related-signature-in-breast-cancer-after-surgery-a-multicohort-study
#39
JOURNAL ARTICLE
Xin Hua, Qi-Wei Zhu, Yi-Nuan Zhang, Lu Cao, Meng-Di Wang, Yun-Sheng Gao, Jia-Yi Chen
BACKGROUND: Recent studies have shown that ovarian aging is strongly associated with the risk of breast cancer, however, its prognostic impact on breast cancer is not yet fully understood. In this study, we performed a multicohort genetic analysis to explore its prognostic value and biological features in breast cancer. METHODS: The gene expression and clinicopathological data of 3366 patients from the The Cancer Genome Atlas (TCGA) cohort, the Molecular Taxonomy of Breast Cancer International Consortium (METABRIC) cohort and the GSE86166 cohort were analyzed...
2023: Frontiers in Immunology
https://read.qxmd.com/read/36941680/increasing-incidence-rate-of-breast-cancer-in-cystic-fibrosis-relationship-between-pathogenesis-oncogenesis-and-prediction-of-the-treatment-effect-in-the-context-of-worse-clinical-outcome-and-prognosis-of-cystic-fibrosis-due-to-estrogens
#40
REVIEW
Nela Stastna, Kristian Brat, Lukas Homola, Audun Os, Dagmar Brancikova
Cystic fibrosis (CF) is the most common genetic disease in the Caucasion population. Thanks to the CFTR modulators therapy, life expectancy will significantly improve. New therapeutic challenges can be expected, including diseases associated with ageing and higher incidence of cancer, as evidenced by recent epidemiological studies. The increasing incidence of tumors includes also breast cancer. The risk of breast cancer is higher in CF patients compared to the general population. Sex hormones, especially estrogens, also affect on the pathophysiology and immunology of the CF...
March 20, 2023: Orphanet Journal of Rare Diseases
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