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sniffin sticks

Robert Pellegrino, Pengfei Han, Nicole Reither, Thomas Hummel
OBJECTIVE/HYPOTHESIS: A common, lasting condition from traumatic brain injury is impairment to smell. In patients with olfactory impairment, recent meta-analyses have demonstrated that olfactory training consistently improves higher-order functions, such as odor identification. The focus of this work was to assess effects of olfactory training (OT) in posttraumatic olfactory loss patients through several metrics including psychophysical, olfactory bulb (OB) volume, and functional magnetic resonance imaging...
March 8, 2019: Laryngoscope
Carla Masala, C Käehling, F Fall, T Hummel
PURPOSE: Few studies have investigated the correlation between chemosensory function (trigeminal and olfactory) and nasal volume in humans, even though nasal anatomy is crucial for the sense of smell. Aim of this study was to evaluate these correlations in normosmic subjects. METHODS: Two hundred and fifty-six healthy volunteers (age range 19-69 years) participated. Olfactory function was investigated for (the rose-like) phenylethyl alcohol odor threshold and odor identification (OI) using the Sniffin' Sticks test, while nasal structure was evaluated by acoustic rhinometry (AR); trigeminal sensitivity was assessed in terms of detection "thresholds" for the odorless carbon dioxide (CO2 )...
March 6, 2019: European Archives of Oto-rhino-laryngology
Piotr Sorokowski, Maciej Karwowski, Michał Misiak, Michalina Konstancja Marczak, Martyna Dziekan, Thomas Hummel, Agnieszka Sorokowska
Although the view that women's olfactory abilities outperform men's is taken for granted, some studies involving large samples suggested that male and female olfactory abilities are actually similar. To address this discrepancy, we conducted a meta-analysis of existing studies on olfaction, targeting possible sex differences. The analyzed sample comprised n = 8 848 (5 065 women and 3 783 men) for olfactory threshold (as measured with the Sniffin Sticks Test; SST), n = 8 067 (4 496 women and 3 571 men) for discrimination (SST), n = 13 670 (7 501 women and 6 169 men) for identification (SST), and a total sample of n = 7 154 (3 866 women and 3 288 men) for works using University of Pennsylvania Smell Identification Test (UPSIT)...
2019: Frontiers in Psychology
Kyujin Han, Jiyeon Lee, Bo Yoon Choi, Hamin Jeong, Jae Hoon Cho, Jin Kook Kim
Objectives.: Past several studies have proven that caffeine facilitates attentional enhancement by acting as an adenosine antagonist once it is absorbed by the body, resulting in improved psycho-behavioral function. Modern clinical olfactory function tests are usually assessed by psychophysical tests but due to a paucity of data, the influence of enhanced attention by caffeine on olfactory function still remains unclear. The objective of this study was to compare results of cognitive function (attention) and olfactory function before and after caffeine administration in order to analyze effects of caffeine on olfactory function in normosmic subjects...
March 1, 2019: Clinical and Experimental Otorhinolaryngology
Yi-Qi Lin, Shi-Shuang Cui, Juan-Juan Du, Gen Li, Yi-Xi He, Ping-Chen Zhang, Yang Fu, Pei Huang, Chao Gao, Bin-Yin Li, Sheng-Di Chen
Background: Hyposmia is one of the most important clinical markers of Parkinson's disease (PD) with a prevalence ranging from 50 to 96% of PD patients. A significant association was found between hyposmia and cognitive impairment of PD. However, there were no reports of event-related potentials (ERP) performance in PD patients with and without hyposmia for cognitive functions assessment. Purpose: The aim of our study was to compare ERP performance and its association with cognitive domains between PD with and without hyposmia...
2019: Frontiers in Aging Neuroscience
Alessandro Tonacci, Sara Calderoni, Lucia Billeci, Sandra Maestro, Pamela Fantozzi, Federica Ciuccoli, Maria Aurora Morales, Antonio Narzisi, Filippo Muratori
The correct functioning of the chemosensory pathway is pivotal for the attitude towards feeding. In some neuropsychiatric disorders, abnormalities of the sensory processing dramatically affect feeding behavior; however, evidences for an olfactory involvement in Anorexia Nervosa (AN) are still controversial. We administered a complete olfactory testing battery, the Sniffin' Sticks Extended Test, to a cohort of 19 girls with Restrictive Anorexia Nervosa (AN-R) and 19 healthy controls. A battery of questionnaires aiming to evaluate eating attitude, psychopathologic disorders and autistic traits was also administered...
February 11, 2019: Psychiatry Research
Fabrizia Caminiti, Rosella Ciurleo, Simona De Salvo, Francesco Galletti, Placido Bramanti, Silvia Marino
Hydrocephalus is one of the lesser known causes of central olfactory loss. The pathogenesis of hydrocephalus involves the olfactory bulbs or tracts, and more rarely, other frontotemporal cortical regions. We describe a case of olfactory dysfunction in a macrocephalic 63-year-old female patient with arrested hydrocephalus. Her olfactory function was assessed by using the Sniffin' Sticks test, olfactory event-related potentials (OERPs), and 3-Tesla magnetic resonance imaging (MRI). An OERP examination suggested partial impairment of the central olfactory pathways and central parietal regions where OERP amplitude is maximal...
February 8, 2019: Journal of International Medical Research
Guo Feng, Yuan Zhuang, Fangshu Yao, Yuting Ye, Qiannong Wan, Wen Zhou
Smell identification ability reflects the functional integrity of the human olfactory system. Its deficit is a prodromal marker for Parkinson's disease and is also implicated in Alzheimer's disease and other neurological and psychiatric disorders. Considering the impact of cultural factors on odor identifiability, we have developed a smell identification test specifically for the Chinese population (CSIT), which includes 40 odor items that are familiar to this population, presented in a multiple-choice format...
January 30, 2019: Chemical Senses
Xin-Yi Wang, Ying-Ying Han, Gang Li, Bei Zhang
BACKGROUND: The aim was to investigate the autonomic dysfunction between Parkinson's disease (PD) patients with olfactory dysfunction and PD patients without olfactory dysfunction in southern Chinese population. METHODS: Fifty-six PD patients with olfactory dysfunction and 44 patients without olfactory dysfunction were included. All patients were evaluated by Sniffin' sticks (SS-16), scales for outcomes in Parkinson's disease-autonomic questionnaire, Hamilton anxiety rating scale and Hamilton depression rating scale RESULTS: The score of subpart of gastrointestinal symptoms and subpart of urinary symptoms were different in two groups (gastrointestinal symptoms: p value: 0...
February 2, 2019: BMC Neurology
Philipp Hendrix, Gerrit Fischer, Alan-Christopher Linnebach, Julian B Krug, Stefan Linsler, Christoph J Griessenauer, Joachim Oertel
OBJECTIVE: Olfactory dysfunction represents a main symptom in olfactory groove meningiomas (OGM). Besides this, olfactory function has been sparsely investigated in patients suffering from supratentorial meningiomas. Here, the authors explore pre- and postoperative variables associated with olfactory dysfunction in supratentorial meningioma patients. METHODS: This is a retrospective study on supratentorial meningioma patients who underwent meningioma resection between January 2015 and January 2016...
January 31, 2019: Clinical Anatomy
Giuseppe Riva, Pierfrancesco Franco, Erica Provenzano, Francesca Arcadipane, Claudia Bartoli, Paolo Lava, Umberto Ricardi, Giancarlo Pecorari
BACKGROUND: Oral mucositis is a well-known adverse event of radiotherapy (RT) for head and neck cancer (HNC). Its nasal counterpart, the radiation-induced rhinitis, is poorly studied and considered in clinical practice. OBJECTIVE: The aim of this observational study was to evaluate acute cytological and olfactory alterations during RT and their correlation with RT doses. METHODS: Ten patients who underwent RT for HNC, excluding tumors of the nasal cavities, were evaluated with nasal scraping for cytological examination, Sniffin' Sticks test for olfactory assessment, and Nasal Obstruction Symptom Evaluation scale...
January 11, 2019: American Journal of Rhinology & Allergy
Boris R Haxel
OBJECTIVE: Investigation of the postoperative olfactory function after sinus surgery for chronic rhinosinusitis (CRS) with and without polyps in a review. DATA SOURCES: PubMed. REVIEW METHODS: A comprehensive literature search was conducted through June 2018 using relevant keywords. The titles/abstracts were reviewed to identify studies evaluating the sense of smell in CRS-patients pre- and postoperatively by either using the whole or parts of the University of Pennsylvania Smell Identification Test or the Sniffin' Sticks test...
January 8, 2019: Laryngoscope
Qiujin Yu, Peng Guo, Danning Li, Lijun Zuo, Tenghong Lian, Shuyang Yu, Yang Hu, Li Liu, Zhao Jin, Ruidan Wang, Yingshan Piao, Lixia Li, Xiaomin Wang, Wei Zhang
Our study aimed to analyse the olfactory dysfunction (OD) evaluations between self-report, the Hyposmia Rating Scale (HRS) and the Sniffin' Sticks test, and the relationship between OD and clinical features of AD. Sixty patients with AD dementia, 37 patients with mild cognitive impairment (MCI) due to AD and 30 healthy controls were consecutively recruited. Olfactory function was evaluated by self-report, HRS and Sniffin' Sticks test. Patients were divided into AD with OD (AD-OD) and AD with no OD (AD-NOD) groups based on the results of the Sniffin' Sticks test...
December 2018: Aging and Disease
A Oleszkiewicz, V A Schriever, I Croy, A Hähner, Thomas Hummel
PURPOSE: To provide up-to-date and detailed normative data based on a large-scale sample, increasing diagnostic validity by reference to narrow age groups as previous normative values were based upon smaller sample sizes-especially in the group of older subjects. METHOD: Data were obtained from 9139 healthy subjects (4928 females aged 5-96 years and 4211 males aged 5-91 years). The standard "Sniffin' Sticks" test was applied, comprising threshold (T), discrimination (D) and identification (I) subtests, and yielding a TDI sum score...
December 15, 2018: European Archives of Oto-rhino-laryngology
Massimiliano Garzaro, Giancarlo Pecorari, Giuseppe Riva, Valentina Pennacchietti, Paolo Pacca, Luca Raimondo, Eleonora Tron, Alessandro Ducati, Francesco Zenga
OBJECTIVES: Endoscopic transnasal transsphenoidal surgery has become the standard procedure for the majority of skull base diseases, including sellar, parasellar, and clival pathologies. The aim of this study was the objective evaluation of nasal airflow resistances and olfactory function in 3-dimensional (3D) endoscopic transnasal transsphenoidal surgery. METHODS: One hundred patients who underwent 3D transnasal endoscopic surgery for sellar, parasellar, and clival diseases were enrolled...
December 10, 2018: Annals of Otology, Rhinology, and Laryngology
Gerold Besser, Leandra Jobs, David Tianxiang Liu, Christian A Mueller, Bertold Renner
OBJECTIVES: Neurodegenerative diseases can alter odor memory in addition to inducing quantitative impairment, and olfactory memory can be tested using the validated olfactory memory test with encapsulated odors (Odor Discrimination Memory Test [ODMT]). The aim of this study was to investigate the new Sniffin' Sticks ODMT (SSODMT), which is comparable with the ODMT. METHODS: The SSODMT was administered to 48 subjects (30 women, 18 men; mean age, 34.6 ± 16.3 years)...
December 7, 2018: Annals of Otology, Rhinology, and Laryngology
Marlene Richter Jensen, Elisabeth Arndal, Christian Von Buchwald
The aim of this review is to evaluate current guidelines for diagnosis, treatment and follow-up of patients with chronic rhinosinusitis. We discuss: 1) diagnostic criteria, 2) the use of supplementary tools like visual analogue scale, Sino-Nasal Outcome Test and Sniffin' Sticks, 3) the use of tests like allergy, serum IgE and biopsy and 4) comorbidity in relation to the unified airways concept. Furthermore, we evaluate: 1) initial treatment with topical steroids and nasal irrigation, 2) additional treatment options including surgery, systemic steroids and antibiotics and 3) treatment risks...
November 19, 2018: Ugeskrift for Laeger
Luzia Jaeger Hintze, Gary Goldfield, Ryan Seguin, Aleck Damphousse, Alexandre Riopel, Éric Doucet
BACKGROUND: Evidence of metabolic adaptations following weight loss is available in the literature. However, the impact of different degrees of caloric restriction on a comprehensive panel including energy expenditure (EE) and intake (EI), appetite, palatability and olfactory performance remains to be investigated. Accordingly, the purpose of the study was to investigate the changes in resting energy expenditure (REE), appetite, olfaction, palatability and EI in women who were engaged in either a slow (-500 kcal/day, 20-week) or in a rapid (-1000 kcal/ day, 10 weeks) weight loss program...
November 26, 2018: Physiology & Behavior
Gabriel Bsteh, Klaus Berek, Harald Hegen, Barbara Teuchner, Michael Auer, Sebastian Wurth, Franziska Di Pauli, Florian Deisenhammer, Thomas Berger
BACKGROUND: Peripapillary retinal nerve fiber layer (pRNFL) thickness and olfactory function are both emerging biomarkers in multiple sclerosis (MS). Impairment of odor identification and discrimination is an irreversible feature of more advanced MS suggested to be associated with neurodegeneration, while olfactory threshold is a transient feature of early, active MS possibly associated with short-term inflammatory disease activity. OBJECTIVE: The aim of this study was to validate the association of olfactory (dys)function and parameters of MS disease course in a large cohort of MS patients and to correlate olfactory function with pRNFL thickness as a surrogate biomarker of neurodegeneration...
November 22, 2018: Multiple Sclerosis: Clinical and Laboratory Research
Andreas Hinz, Tobias Luck, Steffi G Riedel-Heller, Philipp Y Herzberg, Claudia Rolffs, Kerstin Wirkner, Christoph Engel
PURPOSE: The Sniffin' Sticks Screening 12 test is a test of olfactory performance based on pen-like odor dispensing devices. The aims of this study were to analyze the performance of this test in a general population sample and to explore associations between olfactory dysfunction and quality of life. METHODS: A large community sample (n = 7267) completed the Sniffin' Sticks Screening 12 test and several questionnaires measuring quality of life, anxiety, dispositional optimism, social support, and satisfaction with life...
November 20, 2018: European Archives of Oto-rhino-laryngology
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