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urine reflux

Angela M Arlen, Christopher S Cooper
Vesicoureteral reflux, retrograde flow of urine from the bladder into the upper urinary tract, is one of the most common urological diagnoses in the pediatric population. Diagnosis and subsequent management of urinary reflux have become increasingly debated in the past decade, with divergent opinions over which patients should be evaluated for reflux, and when detected, which children should receive intervention. Although some argue that vesicoureteral reflux is a "phenotype" that often resolves without intervention, others contest that untreated reflux has the potential to cause irreversible renal damage over time...
February 14, 2019: International Journal of Urology: Official Journal of the Japanese Urological Association
K Ln Rao, Prema Menon, R Samujh, J K Mahajan, M Bawa, M A Malik, B R Mittal
OBJECTIVE: To report our experience with endoscopic management of vesicoureteral reflux (VUR) by injection of a tissue bulking substance - Dextranomer/ hyaluronic acid co-polymer at vesicoureteric junction. DESIGN: Retrospective analyses of case records. SETTING: Pediatric Surgery department in a tertiary care government Institute. PARTICIPANTS: 500 children (767 renal units) consecutively referred to the out-patient department with vesicoureteral reflux noted on micturating cysto-urethrogram (MCU) over a period of 13 years (2004-2016)...
December 15, 2018: Indian Pediatrics
José Antonio March-Villalba, Leopoldo Marzullo-Zucchet, David Hervás-Marín, Alba Polo Rodrigo, Agustín Serrano Durbá, Carlos Domínguez Hinarejos, Francisco Boronat Tormo, Francisco Boronat Tormo
OBJECTIVES: To determine the usefulnessof voiding diary (VD), uroflowmetry with electromyography(UF-EMG), bladder wall thickness (before micturition)(VWTUS) and residual urine (PVR) (ultrasound measure)in predicting the outcome of the first endoscopic treatment(1ENDT) of vesicoureteral reflux (VUR) in children> 3 years. METHODS: Cross-sectional ambispective study of 48children with vesicoureteral reflux. Those with previousendoscopic treatment, age or neurological abnormalities and a history of urethralor abdominal surgery were excluded...
January 2019: Archivos Españoles de Urología
Víctor García-Nieto, Victoria E García-Rodríguez, María Isabel Luis-Yanes, Margarita Monge, Pedro Arango-Sancho, Eduardo H Garin
Severe (grades IV and V) vesicoureteral reflux (VUR) is a risk factor for acute pyelonephritis, renal scars, and renal failure. This study evaluates albumin and N-acetylglucosaminidase (NAG) urinary excretion, and renal concentrating ability as screening tools to select patients for voiding cystourethrogram (VCUG). Children (111 M, 52 F) aged 10.97 ± 21.17 months (mean + SD), diagnosed with UTI, and who had undergone renal ultrasound and a VCUG, underwent a desmopressin test and had albumin/creatinine and NAG/creatinine urinary excretion measured...
January 31, 2019: European Journal of Pediatrics
Kashish Khanna, Sandeep Agarwala, Sameer Bakhshi, M Srinivas, Manisha Jana, K Devasenathipathy, Minu Bajpai, Veereshwar Bhatnagar
AIM: To assess the long-term urologic outcomes in follow-up of patients of sacrococcygeal teratoma (SCT) using urodynamic study (UDS) in addition to clinical and radiologic evaluation. METHODS: A prospective study of clinical, radiological and urodynamic evaluation in patients with SCT who underwent resection between January 2002-June 2015 and were followed up till January 2016 was conducted. RESULTS: Total 57 patients, 42 (73.7%) females and 15 (26...
December 29, 2018: Journal of Pediatric Surgery
Vittorio Magri, Matteo Boltri, Tommaso Cai, Roberto Colombo, Salvatore Cuzzocrea, Pieter De Visschere, Rosanna Giuberti, Clara Maria Granatieri, Maria Agnese Latino, Gaetano Larganà, Christian Leli, Giorgio Maierna, Valentina Marchese, Elisabetta Massa, Alberto Matteelli, Emanuele Montanari, Giuseppe Morgia, Kurt G Naber, Vaia Papadouli, Gianpaolo Perletti, Nektaria Rekleiti, Giorgio I Russo, Alessandra Sensini, Konstantinos Stamatiou, Alberto Trinchieri, Florian M E Wagenlehner
The modern clinical research on prostatitis started with the work of Stamey and coworkers who developed the basic principles we are still using. They established the segmented culture technique for localizing the infections in the males to the urethra, the bladder, or the prostate and to differentiate the main categories of prostatitis. Such categories with slight modifications are still used according to the NIH classification: acute bacterial prostatitis, chronic bacterial prostatitis, Chronic Pelvic Pain Syndrome (CPPS) and asymptomatic prostatitis...
January 18, 2019: Archivio Italiano di Urologia, Andrologia
Norihiro Murakami, Jun-Ichi Kawada, Azumi Watanabe, Toshinao Arakawa, Takamasa Kano, Takako Suzuki, Ryo Tanaka, Daiei Kojima, Yoshihiko Kawano, Shin Hoshino, Hideki Muramatsu, Yoshiyuki Takahashi, Yoshiaki Sato, Masashi Koyama, Jun Natsume
OBJECTIVE: Urinary tract infection (UTI), one of the most common bacterial infections occurring during infancy and early childhood, is frequently associated with vesicoureteral reflux (VUR). Although several guidelines recommend performing ultrasonography as a screening test, its utility is not adequate and appropriate screening tests are strongly desirable. In this study, we evaluate the use of magnetic resonance imaging (MRI) as a screening test for VUR in children with UTI. METHODS: We prospectively studied 108 patients with suspected UTI between April 2014 and March 2016...
2018: PloS One
Eoghan Dunne, Martin O'Halloran, Darren Craven, Prem Puri, Paul Frehill, Sarah Loughney, Emily Porter
OBJECTIVE: The purpose of this study is to detect vesicoureteral reflux (VUR) non-invasively using electrical impedance tomography (EIT). VUR is characterized by the backflow of urine from the bladder to the kidneys. METHODS: Using porcine models, small quantities of a solution mimicking the electrical properties of urine were infused into each ureter. EIT measurements were taken before, during and after the infusion using electrodes positioned around the abdomen...
December 14, 2018: IEEE Transactions on Bio-medical Engineering
Antonio Macedo, Sergio Leite Ottoni, Gilmar Garrone, Riberto Liguori, Sergio Cavalheiro, Antonio Moron, Marcela Leal Da Cruz
OBJECTIVES: To evaluate the first 100 cases of in utero myelomeningocoele (MMC) repair and urological outcomes in a prospective analysis aiming to define possible improvement in bladder function. PATIENTS AND METHODS: We used a protocol consisting of a detailed medical history, urinary tract ultrasonography, voiding cystourethrography, and urodynamic evaluation. Patients were categorised into four groups: normal, high risk (overactive bladder with a detrusor leak-point pressure >40 cm H2 O and high filling pressures also >40 cm H2 O), incontinent, and underactivity (underactive bladder with post-void residual urine), and patients were treated accordingly...
December 9, 2018: BJU International
Wei Zhang, Baohuan Cai, Xiaole Zhang, Jianhua Zhou, Liru Qiu, Huiming Yi
Vesicoureteral reflux (VUR) is one of the most common urinary tract anomalies in children. It has been reported that VUR may be associated with reflux nephropathy. Ultrasound contrast-enhanced voiding urosonography (CeVUS) has become a routine diagnostic method for VUR in a number of European countries; however, it is not widely used in China. The aim of the present study was to analyze the clinical application and evaluate the safety of CeVUS as a diagnostic tool for VUR in children in order to establish a standardized operating procedure for CeVUS in pediatric VUR in China...
December 2018: Experimental and Therapeutic Medicine
C Egrot, A Dinh, G Amarenco, L Bernard, G Birgand, F Bruyère, E Chartier-Kastler, M Cosson, X Deffieux, P Denys, M Etienne, B Fatton, X Fritel, X Gamé, C Lawrence, L Lenormand, D Lepelletier, J-C Lucet, E Marit Ducamp, C Pulcini, G Robain, E Senneville, M de Sèze, A Sotto, J-R Zahar, F Caron, J-F Hermieu
OBJECTIVE: The aim of this work was to issue clinical practice guidelines on antibiotic prophylaxis in urodynamics (urodynamic studies, UDS). MATERIALS AND METHODS: Clinical practice guidelines were provided using a formal consensus method. Guidelines proposals were drew up by a multidisciplinary experts group (pilot group = steering group), then rated by a panel of 12 experts (rating group) using a formal consensus method, and then peer reviewed by a reviewing/reading group of experts (different from the rating group)...
December 2018: Progrès en Urologie
Wenjing Li, Bo Hong, Qing Li, Zuojing Li, Kaishun Bi
ETHNOPHARMACOLOGICAL RELEVANCE: Rhizoma Curcumae and Rhizoma Sparganii (RCRS), a celebrated traditional Chinese medicine drug pair, has been used to treat hysteromyoma (HY). AIM OF THE STUDY: We aimed to identify the endogenous biomarkers of RCRS against HY. MATERIALS AND METHODS: HY rat model was established by injecting intramuscularly estradiol benzoate and progesterone injection from inner thigh in sequence. Body weight, uterus morphological indexes, immunohistochemistry (IHC) and hematoxylin and eosin (HE) staining experiments were used to evaluate the efficacy of RCRS (The rats were treated with RCRS extract, which was made by soxhlet reflux method...
November 23, 2018: Journal of Ethnopharmacology
Bernardo Pereira, Catarina Macedo, Sara Anacleto, Marina Gonçalves, Estêvão Lima, Emanuel Carvalho-Dias
INTRODUCTION: Vesicoureteral reflux (VUR) corresponds to the reflux of urine from the bladder into the upper urinary system. It can be a congenital or an acquired anomaly and although its incidence is high in children it is uncommon in the adult life. One of its presentations in the adult population is the presence of recurrent Pyelonephritis. CASE PRESENTATION: Here we report a case of an adult patient with repetitive uncomplicated pyelonephritis caused by VUR...
October 29, 2018: International Journal of Surgery Case Reports
Ahmed Tasnub Takaddus, Abhilash J Chandy
Numerical simulations of ureter peristalsis have been carried out in the past to understand both the flow field and ureter wall mechanics. The main objective of the current investigations is to have a better understanding of the urine transport due to the peristalsis in the ureter, thus making the information helpful for a better treatment and diagnosis of ureteral complications like urine reflux. In the current study, a numerical simulation is performed using a finite-element-based solver with a two-way fully coupled fluid structure interaction approach between the ureter wall and urine...
October 27, 2018: Computer Methods in Biomechanics and Biomedical Engineering
Lida Sharifi-Rad, Seyedeh-Sanam Ladi-Seyedian, Hossein Amirzargar, Abdol-Mohammad Kajbafzadeh
OBJECTIVE: To determine the different urine flow patterns and active pelvic floor electromyography (EMG) during voiding in children with vesicoureteral reflux (VUR) as well as presenting the prevalence of lower urinary tract symptoms in these patients. MATERIALS AND METHODS: We retrospectively reviewed the charts of children diagnosed with VUR after toilet training from Sep 2013 to Jan 2016. 225 anatomically and neurologically normal children were included. The reflux was diagnosed with voiding cystourethrography...
September 25, 2018: International Braz J Urol: Official Journal of the Brazilian Society of Urology
Imen Gorsane, Sana Barrah, Samia Barbouch, Hayet Kaaroud, Amel Harzallah, Taieb Ben Abdallah
INTRODUCTION: Acute pyelonephritis (APN) results from bacterial invasion of the renal parenchyma. The aim of this study was to investigate the epidemiological, clinico-biological, therapeutic and evolutionary APN and to identify the risk factors of this renal disease. METHODS: We conducted a retrospective and descriptive study, over a period of 37 years (1977-2014), including 43 patients with APN, hospitalized in our Department. RESULTS: There were 43 patients with mean age of 36...
January 2018: La Tunisie Médicale
Reem Alfattouh, Nedaa Aldairi, Nazish Masud, Asma Awadalla
The retrospective study was planned to assess the outcome of extensive investigations done for infants admitted with apparent life-threatening event (ALTE), and comprised chart review of 275 infants admitted to King Abdul-Aziz Medical City (KAMC), Riyadh, Saudi Arabia, between 2012 and 2015. The outcome of each investigation was compared in terms of whether the test was performed or not performed, and, if performed, whether the test report was normal or abnormal. Also, sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) was assessed for each test...
October 2018: JPMA. the Journal of the Pakistan Medical Association
Seyed Esmail Razavi, Mohammad Jouybar
Two common abnormalities in ureters include primary refluxing megaureter (PRM) and primary obstructed megaureter (POM). The aim of this study was to represent the numerical simulation of the urine flow at the end of the ureter with vesicoureteral reflux (VUR) and POM during peristalsis. Methodologically, the peristalsis in the ureter wall was created using Gaussian distribution. Fluid-structure interaction (FSI) was applied to simulate urine-elastic wall interactions; and governing equations were solved using the arbitrary Lagrangian-Eulerian method...
2018: Bio-medical Materials and Engineering
Aron Liaw, Gerald R Cunha, Joel Shen, Mei Cao, Ge Liu, Adriane Sinclair, Laurence Baskin
The urinary bladder collects urine from the kidneys and stores it until the appropriate moment for voiding. The trigone and ureterovesical junctions are key to bladder function, by allowing one-way passage of urine into the bladder without obstruction. Embryological development of these structures has been studied in multiple animal models as well as humans. In this report we review the existing literature on bladder development and cellular signalling with particular focus on bladder development in humans...
August 28, 2018: Differentiation; Research in Biological Diversity
G Lau, R Anderson, P Cartwright, M C Wallis, A Schaeffer, S Oottamasathien, B Snow
INTRODUCTION: Historically, patients with unilateral high-grade vesicoureteral reflux (VUR) and contralateral low-grade or resolved VUR have been treated with bilateral intravesical ureteral reimplantation, which requires postoperative admission. If the high-grade VUR side is treated alone, then the contralateral side is at risk of developing recurrent or worsening VUR. Bilateral subureteric injection of dextronomer/hyaluronic acid (DHA) is another option that can be performed as an outpatient therapy, but a single injection is less effective for high-grade VUR...
July 25, 2018: Journal of Pediatric Urology
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