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conducting wound dressing

Faranak Alinejad, Mahnoush Momeni, Mohammad Javad Fatemi, Mostafa Dahmardehei, Soheila Naderi, Mohammad Reza Akhoondinasab, Masoume Zayedly, Omid Mahboubi, Hossein Rahbar
Background and Objectives: This study was conducted to compare the effect of acticoat and agcoat dressing (2 types of silver nano-crystalline dressings) in the treatment of burn wounds. Infection is one of the most important causes of death in patients with major burn. Despite using different prevention methods, including prophylaxis antibiotics with broad-spectrum antibiotics, no method has been found to prevent this dangerous complication for burn patients. Topical silver sulfadiazine is one of the best topical antibiotics in infection control of burn wounds, and other forms of AG dressings are also useful...
December 2018: Iranian Journal of Microbiology
Joshua P Totty, Louise H Hitchman, Paris L Cai, Amy E Harwood, Tom Wallace, Dan Carradice, George E Smith, Ian C Chetter
A surgical site infection (SSI) may occur in up to 30% of procedures and results in significant morbidity and mortality. We aimed to assess the feasibility of conducting a randomised controlled trial (RCT) examining the use of dialkylcarbamoylchloride (DACC)-impregnated dressings, which bind bacteria at the wound bed, in the prevention of SSI in primarily closed incisional wounds. This pilot RCT recruited patients undergoing clean or clean-contaminated vascular surgery. Participants were randomised intraoperatively on a 1:1 basis to either a DACC-coated dressing or a control dressing...
March 14, 2019: International Wound Journal
Christian Bianchi, William Tettelbach, Niki Istwan, Brandon Hubbs, Kimberly Kot, Stan Harris, Donald Fetterolf
Statistical interpretation of data collected in a randomised controlled trial (RCT) is conducted on the intention-to-treat (ITT) and/or the per-protocol (PP) study populations. ITT analysis is a comparison of treatment groups including all patients as originally allocated after randomisation regardless if treatment was initiated or completed. PP analysis is a comparison of treatment groups including only those patients who completed the treatment as originally allocated, although it is often criticised because of its potential to instil bias...
March 12, 2019: International Wound Journal
Yuhui Lu, Yanan Wang, Jieyu Zhang, Xuefeng Hu, Zeyu Yang, Yi Guo, Yunbing Wang
Electrical stimulation (ES) via electrodes is promising for treating chronic wounds, but this electrode-based strategy is unable to stimulate the whole wound area and the therapeutic outcome may be compromised. In this study, a conductive poly(2-hydroxyethyl methacrylate) (polyHEMA)/polypyrrole (PPY) hydrogel was developed herein, and 3-sulfopropyl methacrylate was covalently incorporated in the hydrogel's network to in-situ dope the PPY and maintain the hydrogel's conductivity in the weak alkaline physiological environment...
March 9, 2019: Acta Biomaterialia
Sheila A Connery, Jerome Yankowitz, Linda Odibo, Olivia Raitano, Dusan Nikolic-Dorschel, Judette Marie Louis
BACKGROUND: Surgical site infections are associated with significant healthcare cost and burden. Silver impregnated dressings have been associated with a decrease in surgical site infections in select populations but it is unknown if the benefit can be observed after cesarean deliveries. OBJECTIVE: We sought to evaluate the impact of silver nylon dressings in reducing superficial surgical site infections after cesarean delivery. STUDY DESIGN: A blinded randomized clinical trial of women undergoing scheduled or unscheduled cesarean delivery at a single site was conducted...
March 5, 2019: American Journal of Obstetrics and Gynecology
Marek Konop, Ewa Kłodzińska, Joanna Borowiec, Anna Katarzyna Laskowska, Jonna Czuwara, Piotr Konieczka, Bartłomiej Cieślik, Emilia Waraksa, Lidia Rudnicka
The recent emergence of nanotechnology has provided a new therapeutic modality in case of silver nanoparticles. Dressings containing silver form the basis for the treatment of burns and wounds, either acute or chronic ones. The aim of the study was to examine silver release from the different wound dressings: commercially available (Atrauman Ag, Aquacel Ag) and experimental (FKDP-AgNPs) using micellar electrokinetic chromatography (MEKC). In order to characterize prepared keratin based wound dressing before and after its modification with AgNPs, a compositional analysis was conducted using energy dispersive X-ray (EDX) spectroscopy...
March 8, 2019: Electrophoresis
Sumarno Adi Subrata, Rutja Phuphaibul, Nirobol Kanogsunthornrat, Apinya Siripitayakunkit
BACKGROUND AND AIMS: Diabetic foot ulcer is recognized as the consequence of peripheral neuropathy and peripheral arterial disease amid individuals with diabetes. As is well known, this situation still remains a crucial problem in nursing practice. Available studies describing an algorithm of inter-related nursing interventions concerned with diabetic foot ulcers are limited. Therefore, this integrative review was aimed to present evidence-based practice for overcoming the complications of diabetic foot ulcer as well as preventing lower extremity amputation...
March 7, 2019: Current Diabetes Reviews
Louis Kamus, Marie Rameau, Christine Theoret
BACKGROUND: Wounds are among the most common medical conditions affecting horses and have a major economic impact on the horse industry. Wound healing in horses is distinct to that documented in other species, and often results in delayed healing and extensive scarring, with compromised functional and aesthetic outcomes. To date, there is no conventional method objectively proven to accelerate healing or to successfully prevent complications associated with second intention healing. Several effects of Negative Pressure Wound Therapy (NPWT) may be particularly useful to the management of wounds in horses...
March 6, 2019: BMC Veterinary Research
Amy J Zhang, Rachel M Nygaard, Frederick W Endorf, Sara A Hylwa
BACKGROUND: Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are severe mucocutaneous disorders. To date, relatively few studies have looked at institutional approaches to treatment of SJS/TEN, particularly with a focus on wound care. METHODS: A retrospective review was conducted on patients admitted to the Hennepin County Medical Center from 2007 to 2017 with a final diagnosis of SJS or TEN. Data were obtained for demographics, causative drug, hospital course, supportive care, medical management, complications, and disposition...
March 1, 2019: International Journal of Dermatology
Christopher N Matthews, Antonia F Chen, Tanine Daryoush, Richard H Rothman, Mitchell G Maltenfort, William J Hozack
BACKGROUND: Compression bandages often are used after TKA to reduce swelling. However, the degree to which they are helpful has not been well characterized. QUESTIONS/PURPOSES: The purpose of this study was to determine whether use of a compression bandage after TKA was associated with (1) less leg swelling (our primary endpoint); or (2) secondary study endpoints, including improved ROM of flexion and extension, lower visual analog scale (VAS) pain scores for worst pain and pain during physical therapy just before surgery, postoperative day (POD) 1, POD 2, and POD 28, or fewer wound complications within 90 days of surgery...
January 2019: Clinical Orthopaedics and related Research
Yongping Liang, Xin Zhao, Tianli Hu, Baojun Chen, Zhanhai Yin, Peter X Ma, Baolin Guo
Developing injectable nanocomposite conductive hydrogel dressings with multifunctions including adhesiveness, antibacterial, and radical scavenging ability and good mechanical property to enhance full-thickness skin wound regeneration is highly desirable in clinical application. Herein, a series of adhesive hemostatic antioxidant conductive photothermal antibacterial hydrogels based on hyaluronic acid-graft-dopamine and reduced graphene oxide (rGO) using a H2 O2 /HPR (horseradish peroxidase) system are prepared for wound dressing...
February 20, 2019: Small
Zurab Kakabadze, David Chakhunashvili, Ketevan Gogilashvili, Ketevan Ediberidze, Konstantine Chakhunashvili, Konstantine Kalandarishvili, Lia Karalashvili
OBJECTIVES: In this study, our aim was to create a bioactive wound dressing that combined decellularized and lyophilized human amniotic membrane and freeze-dried rat bone marrow stem cells for the treatment of nonhealing wounds. MATERIALS AND METHODS: For the decellularized human amniotic membrane, sodium dodecyl sulfate and 1% Triton X-100 were used. The mononuclear fraction of bone marrow stem cells was isolated by density gradient centrifugation using Ficoll Paque Plus (GE Healthcare Bio-Sciences, Pittsburgh, PA, USA)...
January 2019: Experimental and Clinical Transplantation
Yan Yang, Nan Zheng, Yanjun Zhou, Weiguang Shan, Jie Shen
Fibrous films have attracted considerable attention in the field of drug delivery and wound dressings owing to their porous structure and highly aligned fiber orientation. However, current fabrication methods such as electrospinning have certain limitations, including high voltage requirement and conductivity dependency. This has greatly hindered the product development and applications of fibrous films. The objective of the present study was to develop a high throughput and solventless fiber fabrication method via centrifugal melt spinning (CMS) technology...
February 12, 2019: International Journal of Pharmaceutics
Joshua P Totty, Amy E Harwood, Paris L Cai, Louise H Hitchman, George E Smith, Ian C Chetter
Background: Surgical site infection in vascular surgery has a reported incidence of up to 19%. A novel method of reducing this rate of infection is dressings coated with dialkylcarbamoylchloride (DACC), a hydrophobic wound contact layer that binds bacteria and removes them from the wound bed. Early research has suggested that DACC-coated wound dressings are effective in reducing surgical site infection when applied to wounds healing by primary intention post-operatively, therefore this trial aims to assess the feasibility of producing high-quality evidence assessing this theory...
2019: Pilot and Feasibility Studies
Woan Sean Tan, Palanisamy Arulselvan, Shiow-Fern Ng, Che Norma Mat Taib, Murni Nazira Sarian, Sharida Fakurazi
BACKGROUND: Impaired wound healing is a debilitating complication of diabetes that leads to significant morbidity, particularly foot ulcers. The risk of developing diabetic foot ulcers for diabetic patients is 15% over their lifetime and approximately 85% of limb amputations is caused by non-healing ulcers. Unhealed, gangrenous wounds destroy the structural integrity of the skin, which acts as a protective barrier that prevents the invasion of external noxious agents into the body. Vicenin-2 (VCN-2) has been reported to contain prospective anti-oxidant and anti-inflammatory properties that enhance cell proliferation and migration...
January 17, 2019: BMC Complementary and Alternative Medicine
Elizabeth Foy White-Chu, Tri Le, Renee Cordrey
OBJECTIVE: To determine the feasibility of a piloted wound care curriculum within a busy internal medicine (IM) curriculum. METHODS: This prospective pilot study was conducted with 89 IM residents at an academic teaching hospital. The residents were provided a 90-minute workshop in chronic wound care. They anonymously completed a clinical vignette to target practice behavior prior to the workshop. The workshop was mixture of didactic and hands-on practice of sharp debridement and wound dressing selection...
February 2019: Advances in Skin & Wound Care
Maleea D Holbert, Bronwyn R Griffin, Steven M McPhail, Robert S Ware, Kelly Foster, Demi C Bertoni, Roy M Kimble
BACKGROUND: Burns are a painful and traumatic experience, particularly in children. Reduced pain and anxiety positively influences re-epithelialisation rates in paediatric burn patients, however current literature fails to fully explain the effects of pain and anxiety and their links with wound healing. This study will determine if Burnaid® hydrogel dressing is an effective treatment for reducing pain in the acute period of a burn injury. It is hypothesised that a reduction in pain will then improve re-epithelialisation time in comparison to plastic wrap, which is standard practice at our institution - a metropolitan tertiary paediatric hospital located in Brisbane, Australia...
January 6, 2019: Trials
Linda L Benskin
Objective: Wound management recommendations usually group dressings by base substrate material or reimbursement codes, even when functional differences are vast ( e.g ., honey-containing alginates, super-absorbent hydrogels). Polymeric membrane dressings (PMDs) diverge dramatically from conventional foam dressings in functional attributes, indications, and patient results, providing an opportunity to demonstrate the evidence for categorizing dressings based upon functional differences. Approach: A search of ALL published literature describing the use of PMDs, with no date or language limits, was conducted...
December 1, 2018: Advances in Wound Care
Devinder Singh, Virginia Lobach, Tripp Holton
BACKGROUND: Recently published studies have demonstrated clinical effectiveness of closed-incision negative-pressure therapy (ciNPT) in many fields of surgery including vascular, cardiac, colorectal, orthopedic, and reconstructive surgery. A review of current literature was conducted to determine whether the application of negative-pressure therapy to closed incisions post aesthetic procedures was beneficial. METHODS: The PubMed/MEDLINE databases were searched for preclinical and clinical studies published through June 2018...
January 2019: Plastic and Reconstructive Surgery
Itxaso Garcia-Orue, Garazi Gainza, Patricia Garcia-Garcia, Francisco Borja Gutierrez, Jose Javier Aguirre, Rosa Maria Hernandez, Araceli Delgado, Manoli Igartua
Electrospun nanofibrous dressings present suitable characteristics to be used in wound healing, such as high porosity and high surface area-to-volume ratio. In this study, a wound dressing based on PLGA and Aloe vera containing lipid nanoparticles (NLCs) was developed. NLCs were added in order to add a lipid component that could avoid the adhesion of the dressing to the wound and improve its handling. Membranes with and without NLCs were composed of uniform fibers of about 1 µm in diameter. Their porosity was above 80 % and their thickness was about 160 µm...
December 12, 2018: International Journal of Pharmaceutics
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