Read by QxMD icon Read

Reverse triggering

William Wheat, Lyndah Chow, Jonathan Coy, Elena Contreras, Michael Lappin, Steven Dow
BACKGROUND: Nonspecific induction of local innate immune responses by mucosally administered immunotherapy is a new approach to protection from upper respiratory tract infections. Therefore, a new liposome-toll-like receptor complex (LTC) immune stimulant was developed and investigated for its ability to activate innate immune responses in cats, both in vitro and in vivo, as part of an initial evaluation of LTC for use as an immunotherapeutic agent in cats. OBJECTIVES: We hypothesized that LTC could activate innate immune responses in cats after topical application to nasal and oropharyngeal mucosal surfaces...
February 15, 2019: Journal of Veterinary Internal Medicine
Panteleimon Pantelidis, Michail Sideris, Margus Viigimaa, Konstantinos Avranas, Pavlos Deligkaris, Ioanna Zografou, Dragan Lovic
BACKGROUND: Aldosterone, through its actions on Mineralcorticosteroid Receptors (MR), controls fluid and electrolyte balance, but also exerts various direct deleterious actions on the vasculature. A number of aldosterone antagonists have been manufactured to reverse these effects. OBJECTIVE: A comprehensive review of the underlying mechanisms of the actions of aldosterone and its antagonists in cardiovascular disease. METHOD: The relevant studies indexed in PubMed, Scopus and Google Scholar databases, published from 2003 to May 2018 were identified and reported...
February 14, 2019: Current Pharmaceutical Design
Zhenzhen Du, Xingjia Chen, Wei Hu, ChengHao Chuang, Shuai Xie, Ajuan Hu, Wensheng Yan, Xianghua Kong, Xiaojun Wu, Hengxing Ji, Li-Jun Wan
Due to their high theoretical energy density and low cost, lithium-sulphur (Li-S) batteries are promising next-generation energy storage devices. The electrochemical performance of Li-S batteries largely depends on the efficient reversible conversion of Li polysulphides to Li2 S in discharge, and to elemental S during charging. Here, we report on our discovery that monodisperse cobalt atoms embedded in nitrogen-doped graphene (Co-N/G) can trigger the surface-mediated reaction of Li polysulphides. Using a combination of operando X-ray absorption spectroscopy and first-principles calculation, we reveal that the Co-N-C coordination centre serves as a bifunctional electrocatalyst to facilitate both the formation and the decomposition of Li2 S in discharge and charge processes, respectively...
February 14, 2019: Journal of the American Chemical Society
Nasser Abdulatif Al-Shabib, Javed Masood Khan, Ajamaluddin Malik, Priyankar Sen, Mohammad A Alsenaidy, Fohad Mabood Husain, Abdulrahman M Alsenaidy, Rizwan Hasan Khan, Hani Choudhry, Mazin A Zamzami, Mohmmad Imran Khan, Syed Ali Shahzad
β-lactoglobulin (BLG) is a well characterized milk protein and a model for folding and aggregation studies. Rutin is a quercetin based-flavanoid and a famous dietary supplement. It is a potential protector from coronary heart disease, cancers, and inflammatory bowel disease. In this study, amyloid fibrillation is reported in BLG at pH 2.0 and temperature 358 K. It is inhibited to some extent by rutin with a rate of 99.3 h-1  M-1 . Amyloid fibrillation started taking place after 10 h of incubation and completed near 40 h at a rate of 16...
February 5, 2019: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
Vanessa P Nguyen, Loganathan Palanikumar, Stephen J Kennel, Daiane S Alves, Yujie Ye, Jonathan S Wall, Mazin Magzoub, Francisco N Barrera
pH-responsive peptides are promising therapeutic molecules that can specifically target the plasma membrane in the acidified extracellular medium that bathes cells in tumors. We designed the acidity-triggered rational membrane (ATRAM) peptide to have a pH-responsive membrane interaction. At physiological pH, ATRAM binds to the membrane surface in a largely unstructured conformation, while in acidic conditions it inserts into lipid bilayers forming a transmembrane helix. However, the molecular mechanism ATRAM uses to target and insert into tumor cells remains poorly understood...
February 11, 2019: Journal of Controlled Release: Official Journal of the Controlled Release Society
Atsuhiro Osuka, Daiki Shimizu, Yuki Ide, Takahisa Ikeue
A bis(NiII-porphyrinyl)aminyl radical with meso-C6F5 groups was prepared as a spin-delocalized stable aminyl radical with a doublet spin state. Upon addition of pyridine, both NiII centers became hexacoordinated by accepting two axial pyridines, which triggered a spin state change of the NiII centers from diamagnetic (S = 0) to paramagnetic (S = 1). The resulting high-spin NiII centers interact with the aminyl radical ferromagnetically to give rise to an overall sextet state (S = 5/2). Importantly, this coordination-induced spin-state switching can be conducted in a reversible manner, in that washing of the high-spin radical with aqueous hydrochloric acid regenerates the original doublet radical in good yield...
February 13, 2019: Angewandte Chemie
Yinghui Liu, Xiaowen Huang, Hongfang Liu, Liyan Xi, Chester R Cooper
Fonsecaea monophora has been the predominant pathogen of chromoblastomycosis in Southern China, but its pathogenic mechanism remains unclear. New models are needed to study this infection. In the current study, we examined the role of melanin on the pathogenicity of F. monophora in Galleria mellonella model using melanin and albino strain. Interestingly, the albino mutant strain displayed higher pathogenicity compared to the melanin stain and restoration of melanin of albino mutant could reverse the pathogenicity...
February 13, 2019: Medical Mycology: Official Publication of the International Society for Human and Animal Mycology
Sara Vilas-Boas, Ana Corte-Real
Posterior reversible encephalopathy syndrome (PRES) is a rare syndrome that presents with neurological manifestations, often associated with arterial hypertension. Magnetic resonance imaging (MRI) shows bilateral white matter oedema in the posterior vascular territories. Immunosuppression, (pre) eclampsia and autoimmune diseases can be implicated. A 27-year-old woman, with mixed connective tissue disease under azathioprine, was admitted in the emergency room in status epilepticus and with severe hypertension...
2019: European Journal of Case Reports in Internal Medicine
Hong-Chun Xiang, Li-Xue Lin, Xue-Fei Hu, He Zhu, Hong-Ping Li, Ru-Yue Zhang, Liang Hu, Wen-Tao Liu, Yi-Lin Zhao, Yang Shu, Hui-Lin Pan, Man Li
BACKGROUND: Chronic pain is a major clinical problem with limited treatment options. Previous studies have demonstrated that activation of adenosine monophosphate-activated protein kinase (AMPK) can attenuate neuropathic pain. Inflammation/immune response at the site of complete Freund's adjuvant (CFA) injection is known to be a critical trigger of the pathological changes that produce inflammatory pain. However, whether activation of AMPK produces an analgesic effect through inhibiting the proinflammatory cytokines, including interleukin-1β (IL-1β), in inflammatory pain remains unknown...
February 12, 2019: Journal of Neuroinflammation
Carolyn M Mitchell, Jonathan J Hirst, Murray D Mitchell, Henry G Murray, Tamas Zakar
Inflammatory genes are expressed increasingly in the fetal membranes at late gestation triggering birth. Here we have examined whether epigenetic histone modifications contribute to the upregulation of proinflammatory genes in the amnion in late pregnancy and at labour. Amnion samples were collected from early pregnancy, at term in the absence of labour and after spontaneous birth. The expression of the labour-associated proinflammatory genes PTGS2, BMP2 and NAMPT was determined by reverse transcription-coupled quantitative real-time PCR (qRT-PCR)...
February 12, 2019: Molecular Human Reproduction
Michael J Gray
Production of inorganic polyphosphate (polyP) by bacteria is triggered by a variety of different stress conditions. PolyP is required for stress survival and virulence in diverse pathogenic microbes. Previous studies have hypothesized a model for regulation of polyP synthesis in which production of the stringent response second messenger (p)ppGpp directly stimulates polyP accumulation. In this work, I have now shown that this model is incorrect, and (p)ppGpp is not required for polyP synthesis in Escherichia coli However, stringent mutations of RNA polymerase that frequently arise spontaneously in strains defective in (p)ppGpp synthesis and null mutations of the stringent response-associated transcription factor DksA both strongly inhibit polyP accumulation...
February 11, 2019: Journal of Bacteriology
Soha Talih, Rola Salman, Rachel El-Hage, Ebrahim Karam, Nareg Karaoghlanian, Ahmad El-Hellani, Najat Saliba, Alan Shihadeh
INTRODUCTION: JUUL is an electronic cigarette (ECIG) with a compact form factor. It is prefilled with a liquid that is advertised to contain a high concentration of nicotine salt. JUUL commands 50% of the US ECIG market share, and its wide popularity with underage users has triggered unprecedented actions by the US FDA. Apart from its nicotine salt-containing liquid and compact form, a salient advertised design feature is a control circuit that limits the heating coil temperature, presumably reducing unwanted toxicants...
February 11, 2019: Tobacco Control
Hongjuan Li, Weixiao Yan, Xiaomin Suo, Haotong Peng, Xinjian Yang, Zhenhua Li, Jinchao Zhang, Dandan Liu
Many efforts have focused on the cancer stem cell (CSC) targeting nano delivery system, however, the anticancer therapy efficacy is relative low due to the highly drug-resistance and drug efflux. Nucleus-targeted drug delivery is a promising strategy for reverse the drug resistance and drug efflux of CSCs, but in vivo nucleus-targeted drug delivery has been challenging. Herein, we designed a mesoporous silica nanoparticle (MSN)-based nucleus-targeted system, which could directly target the CSCs and further enter the nucleus by the surface modification of anti-CD133 and thermal-triggered exposure of TAT peptides under an alternating magnetic field (AMF)...
February 6, 2019: Biomaterials
Li Hu, Shutian Zhang, Haoyu Wen, Tianfeng Liu, Jian Cai, Dongshu Du, Danian Zhu, Fuxue Chen, Chunmei Xia
Accumulating evidence suggests that neuroinflammation and oxidative stress in cardiovascular center contribute to the pathological processes underlying hypertension. Microglia activation triggers the inflammation and oxidative stress. Melatonin is a documented potent anti-inflammatory regent and antioxidant, the underlying roles of melatonin in regulating microglia activation via mitochondria remain unclear. In present study, we investigated the protective role of melatonin in decreasing M1 phenotype switching via attenuating mitochondrial oxidative damage in dependence on uncoupling protein 2 (UCP2) pathway in microglia...
2019: PloS One
Jason Gandhi, Anthony C Antonelli, Adil Afridi, Sohrab Vatsia, Gunjan Joshi, Victor Romanov, Ian V J Murray, Sardar Ali Khan
Protein folding is a complex, multisystem process characterized by heavy molecular and cellular footprints. Chaperone machinery enables proper protein folding and stable conformation. Other pathways concomitant with the protein folding process include transcription, translation, post-translational modifications, degradation through the ubiquitin-proteasome system, and autophagy. As such, the folding process can go awry in several different ways. The pathogenic basis behind most neurodegenerative diseases is that the disruption of protein homeostasis (i...
February 12, 2019: Reviews in the Neurosciences
Ningning Ma, Fei Li, Siyuan Li, Shengnan Chu, Lili Han, Shengda Liu, Tengfei Yan, Ruizhen Tian, Quan Luo, Junqiu Liu
A photoresponsive hydrolase model was constructed through the spatial organization of histidine/arginine-containing peptide supra-amphiphiles that are held together by cucurbit[8]uril (CB[8]) methylviologen (MV) azobenzene (Azo) ternary complexation and subsequently self-assemble into highly uniform giant vesicles. The reversible morphological transition of the vesicular structures to non-assembled peptide fragments was triggered by azobenzene photoisomerization. This enables the assembly/disassembly of its enzyme-like active site to cause a dramatic change in hydrolytic activity...
February 11, 2019: Nanoscale
Jun-Yu Li, Zhi-Qiang Luo
Lung cancer is one of the most common cancers and has been the most common cause of cancer deaths for several decades. Recently, lung cancer-associated lncRNA 1 (LCAL1) has been identified to be overexpressed in lung cancer tissues, while inhibiting LCAL1 expression has shown potential to inhibiting lung cancer growth. However, the molecular mechanism between LCAL1 and lung cancer cell survival remains poorly understood. In the present study, we provided the first evidence that LCAL1 may support lung cancer survival via inhibiting the activity of AMP-activated protein kinase (AMPK)...
February 11, 2019: Molecular and Cellular Biochemistry
Tengfei Yan, Feihu Yang, Shuaiwei Qi, Xiaotong Fan, Shengda Liu, Ningning Ma, Quan Luo, Zeyuan Dong, Junqiu Liu
Herein, we demonstrate a supramolecular nanochannel formed by intermolecular π stacking of pyridine-pyridazine helical oligomers, wherein alkali ions could be easily recognized and transported. Importantly, this nanochannel also revealed reversible collection and triggered-release behaviors via modulating the folded and unfolded states of helical pyridine-pyridazine oligomers.
February 11, 2019: Chemical Communications: Chem Comm
Yiyue Xu, Chun So, Hon-Ming Lam, Ming-Chiu Fung, Suk-Ying Tsang
Cancer recurrence has long been studied by oncologists while the underlying mechanisms remain unclear. Recently, we and others found that a phenomenon named apoptosis reversal leads to increased tumorigenicity in various cell models under different stimuli. Previous studies have been focused on tracking this process in vitro and in vivo; however, the isolation of real reversed cells has yet to be achieved, which limits our understanding on the consequences of apoptosis reversal. Here, we take advantage of a Caspase-3/7 Green Detection dye to label cells with activated caspases after apoptotic induction...
January 26, 2019: Journal of Visualized Experiments: JoVE
Bo Peng, Rong He, Qihua Xu, Yifei Yang, Qin Hu, Hongping Hou, Xinmin Liu, Jianrong Li
Metastasis is the primary cause of cancer recurrence and cancer related mortality in triple-negative breast cancer (TNBC). EGFR overexpression is in 50-75% TNBC and EGFR-mediated signaling has potential as an attractive therapeutic target in some specific subtypes of breast cancer due to its significant association with tumor metastasis and poor prognosis. Therefore, identification of promising therapeutic strategies targeting EGFR with higher specificity toward cancer metastasis is urgently needed. 20(S)-protopanaxadiol (PPD), one of the major active metabolites from Panax ginseng, has been widely reported to possess pleiotropic anticancer activities in various cancers...
February 5, 2019: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"