keyword
https://read.qxmd.com/read/38532618/extended-period-of-ventilation-before-delayed-cord-clamping-augments-left-to-right-shunting-and-decreases-systemic-perfusion-at-birth-in-preterm-lambs
#1
JOURNAL ARTICLE
Joseph J Smolich, Kelly R Kenna, Jonathan P Mynard
Previous studies have suggested that an extended period of ventilation before delayed cord clamping (DCC) augments birth-related rises in pulmonary arterial (PA) blood flow. However, it is unknown whether this greater rise in PA flow is accompanied by increases in left ventricular (LV) output and systemic arterial perfusion or whether it reflects enhanced left-to-right shunting across the ductus arteriosus and/or foramen ovale (FO), with decreased systemic arterial perfusion. Using an established preterm lamb birth transition model, this study compared the effect of a short (∼40 s, n = 11), moderate (∼2 min, n = 11) or extended (∼5 min, n = 12) period of initial mechanical lung ventilation before DCC on flow probe-derived perinatal changes in PA flow, LV output, total systemic arterial blood flow, ductal shunting and FO shunting...
March 26, 2024: Journal of Physiology
https://read.qxmd.com/read/38522482/effect-of-prophylactic-use-of-cefazolin-in-caesarean-section-on-postoperative-infection-a-meta-analysis
#2
JOURNAL ARTICLE
Xiangyang Lv, Xiaoshuang Ren, Jiqun Xu, Haicui Wu
Caesarean section rate is increasing and postoperative wound infection is a major health-threatening complication after caesarean section (CS). The aim of this study was to evaluate the efficacy of Cefazolin at different time for post-caesarean delivery. The aim of this study was to compare the use of Cefazolin at different times on infections after CS. The time of antibiotic use in CS can be divided into two groups: before skin incision (SI) and after cord clamping (CC). In this study, 268 relevant articles were found in the database, and finally, 10 articles were analysed...
April 2024: International Wound Journal
https://read.qxmd.com/read/38509614/multicentre-randomised-controlled-trial-of-physiological-based-cord-clamping-versus-immediate-cord-clamping-in-infants-with-a-congenital-diaphragmatic-hernia-pinc-statistical-analysis-plan
#3
RANDOMIZED CONTROLLED TRIAL
Emily J J Horn-Oudshoorn, Marijn J Vermeulen, Ronny Knol, Rebekka Bout-Rebel, Arjan B Te Pas, Stuart B Hooper, Suzan C M Cochius-den Otter, Rene M H Wijnen, Kelly J Crossley, Neysan Rafat, Thomas Schaible, Willem P de Boode, Anne Debeer, Berndt Urlesberger, Calum T Roberts, Florian Kipfmueller, Irma Capolupo, Carmen M Burgos, Bettina E Hansen, Irwin K M Reiss, Philip L J DeKoninck
BACKGROUND: Infants born with congenital diaphragmatic hernia (CDH) are at high risk of respiratory insufficiency and pulmonary hypertension. Routine practice includes immediate clamping of the umbilical cord and endotracheal intubation. Experimental animal studies suggest that clamping the umbilical cord guided by physiological changes and after the lungs have been aerated, named physiological-based cord clamping (PBCC), could enhance the fetal-to-neonatal transition in CDH. We describe the statistical analysis plan for the clinical trial evaluating the effects of PBCC versus immediate cord clamping on pulmonary hypertension in infants with CDH (PinC trial)...
March 20, 2024: Trials
https://read.qxmd.com/read/38490468/curcumin-analogue-nl04-inhibits-spinal-cord-central-sensitization-in-rats-with-bone-cancer-pain-by-inhibiting-nlrp3-inflammasome-activation-and-reducing-il-1%C3%AE-production
#4
JOURNAL ARTICLE
Liping Chen, Bohan Hua, Qiuli He, Zixin Han, Yahui Wang, Yujing Chen, Huadong Ni, Zefeng Zhu, Longsheng Xu, Ming Yao, Chaobo Ni
The management and therapy of bone cancer pain (BCP) remain formidable clinical challenges. Curcumin and its analogues have been shown to have anti-inflammatory and analgesic properties. In the present study, we investigated the efficacy of curcumin analogue NL04 (NL04) in modulating inflammation in spinal dorsal horn (SDH), thereby exploring its potential to reduce central sensitization of BCP in a rat model. Differing doses of NL04 and curcumin were administered intrathecally either once (on day 12 of BCP) or over seven consecutive days (from day 6-12 of BCP)...
March 13, 2024: European Journal of Pharmacology
https://read.qxmd.com/read/38469570/omega-conotoxin-mviia-reduces-neuropathic-pain-after-spinal-cord-injury-by-inhibiting-n-type-voltage-dependent-calcium-channels-on-spinal-dorsal-horn
#5
JOURNAL ARTICLE
Nobuko Ohashi, Daisuke Uta, Masayuki Ohashi, Rintaro Hoshino, Hiroshi Baba
Spinal cord injury (SCI) leads to the development of neuropathic pain. Although a multitude of pathological processes contribute to SCI-induced pain, excessive intracellular calcium accumulation and voltage-gated calcium-channel upregulation play critical roles in SCI-induced pain. However, the role of calcium-channel blockers in SCI-induced pain is unknown. Omega-conotoxin MVIIA (MVIIA) is a calcium-channel blocker that selectively inhibits N-type voltage-dependent calcium channels and demonstrates neuroprotective effects...
2024: Frontiers in Neuroscience
https://read.qxmd.com/read/38462248/third-stage-of-labor-evidence-based-practice-for-prevention-of-adverse-maternal-and-neonatal-outcomes
#6
REVIEW
Alyssa R Hersh, Guillermo Carroli, G Justus Hofmeyr, Bharti Garg, Metin Gülmezoglu, Pisake Lumbiganon, Bremen De Mucio, Sarah Saleem, Mario Philip R Festin, Suneeta Mittal, Jorge Andres Rubio-Romero, Tsungai Chipato, Catalina Valencia, Jorge E Tolosa
The third stage of labor is defined as the time period between delivery of the fetus through delivery of the placenta. During a normal third stage, uterine contractions lead to separation and expulsion of the placenta from the uterus. Postpartum hemorrhage is a relatively common complication of the third stage of labor. Strategies have been studied to mitigate the risk of postpartum hemorrhage, leading to the widespread implementation of active management of the third stage of labor. Initially, active management of the third stage of labor consisted of a bundle of interventions including administration of a uterotonic agent, early cord clamping, controlled cord traction, and external uterine massage...
March 2024: American Journal of Obstetrics and Gynecology
https://read.qxmd.com/read/38452434/effect-of-placental-transfusion-on-long-term-neurodevelopmental-outcomes-in-premature-infants-a-systematic-review-and-meta-analysis-of-randomized-controlled-trials
#7
JOURNAL ARTICLE
Zi-Ming Wang, Jia-Yu Zhou, Wan Tang, Ying-Ying Jiang, Rui Wang, Lai-Shuan Wang
BACKGROUND: The pathophysiology and the potential risks of placental transfusion (PT) differ substantially in preterm infants, necessitating specific studies in this population. This study aimed to evaluate the safety and efficacy of PT in preterm infants from the perspective of long-term neurodevelopmental outcomes. METHODS: We conducted a systematic literature search using placental transfusion, preterm infant, and its synonyms as search terms. Cochrane Central Register of Controlled Trials, Medline, and Embase were searched until March 07, 2023...
February 1, 2024: Pediatric Neurology
https://read.qxmd.com/read/38452223/microrna-let-7b-enhances-spinal-cord-nociceptive-synaptic-transmission-and-induces-acute-and-persistent-pain-through-neuronal-and-microglial-signaling
#8
JOURNAL ARTICLE
Ouyang Chen, Changyu Jiang, Temugin Berta, Bethany Powell Gray, Kenta Furutani, Bruce A Sullenger, Ru-Rong Ji
Secreted microRNAs (miRNAs) have been detected in various body fluids including the cerebrospinal fluid, yet their direct role in regulating synaptic transmission remains uncertain. We found that intrathecal injection of low dose of let-7b (1 μg) induced short-term (<24 hours) mechanical allodynia and heat hyperalgesia, a response that is compromised in Tlr7-/- or Trpa1-/- mice. Ex vivo and in vivo calcium imaging in GCaMP6-report mice revealed increased calcium signal in spinal cord afferent terminals and doral root ganglion/dorsal root ganglia neurons following spinal perfusion and intraplantar injection of let-7b...
March 6, 2024: Pain
https://read.qxmd.com/read/38445130/impact-of-the-timing-of-umbilical-cord-clamping-on-maternal-and-neonatal-outcomes-in-saudi-arabia
#9
JOURNAL ARTICLE
Bayan Sonbol, Abeer Orabi, Hend Al Najjar
INTRODUCTION: The optimal time for umbilical cord clamping after delivery has been under debate for several decades. This study aimed to assess the time-dependent effects of umbilical cord clamping on maternal and neonatal outcomes. METHODS: An observational correlational design was used to recruit 161 pregnant women conveniently. Outcomes were observed and recorded using a structured checklist developed by the authors. Pregnant females aged ≥18 years, with uncomplicated delivery, and who were willing to participate were recruited...
February 2024: Curēus
https://read.qxmd.com/read/38439024/physiological-based-cord-clamping-in-very-preterm-infants-the-aeration-breathing-clamping-3-abc3-trial-statistical-analysis-plan-for-a-multicenter-randomized-controlled-trial
#10
RANDOMIZED CONTROLLED TRIAL
Sten P Willemsen, Ronny Knol, Emma Brouwer, Thomas van den Akker, Philip L J DeKoninck, Enrico Lopriore, Wes Onland, Willem P de Boode, Anton H van Kaam, Debbie H Nuytemans, Irwin K M Reiss, G Jeroen Hutten, Sandra A Prins, Estelle E M Mulder, Christian V Hulzebos, Sam J van Sambeeck, Mayke E van der Putten, Inge A Zonnenberg, Arjan B Te Pas, Marijn J Vermeulen
BACKGROUND: Mortality, cerebral injury, and necrotizing enterocolitis (NEC) are common complications of very preterm birth. An important risk factor for these complications is hemodynamic instability. Pre-clinical studies suggest that the timing of umbilical cord clamping affects hemodynamic stability during transition. Standard care is time-based cord clamping (TBCC), with clamping irrespective of lung aeration. It is unknown whether delaying cord clamping until lung aeration and ventilation have been established (physiological-based cord clamping, PBCC) is more beneficial...
March 4, 2024: Trials
https://read.qxmd.com/read/38429570/caffeine-pharmacokinetics-following-umbilical-vein-injection-during-delayed-cord-clamping-in-preterm-lambs
#11
JOURNAL ARTICLE
Lida Zeinali, Evan Giusto, Heather Knych, Amy Lesneski, Houssam Joudi, Morgan Hardie, Deepika Sankaran, Satyan Lakshminrusimha, Payam Vali
BACKGROUND: Spontaneous breathing during and after delayed cord clamping (DCC) stabilizes cardiopulmonary transition at birth. Caffeine stimulates breathing and decreases apnea in premature newborns. We evaluated the pharmacokinetics and physiological effects of early caffeine administration-direct injection into the umbilical vein (UV) during DCC or administered through a UV catheter (UVC) after delivery. METHODS: Eighteen extremely premature lambs (125-127d, term gestation 145d) were exteriorized and instrumented...
March 1, 2024: Pediatric Research
https://read.qxmd.com/read/38423465/veno-arterial-extracorporeal-membrane-oxygenation-ecmo-va-as-part-of-a-multimodal-approach-for-the-protection-of-spinal-cord-ischemia-in-surgical-repair-of-a-thoracoabdominal-aneurysm
#12
F E Fernández-Suárez, J M López-González, C M Fernández-Vallina, V Cueva-Carril, B M Jiménez Gómez, J García-Menéndez
Spinal cord ischaemia leading to paraplegia or paraparesis is one of the most devastating complications of aortic surgery. The risk of ischaemia is particularly high in repairs involving both the thoracic and abdominal segments, because in these cases blood flow to the spinal arteries can be interrupted. Multimodal protocols have now been developed to reduce the incidence of this complication, and include measures such as cerebrospinal fluid (CSF) drainage, avoidance of hypotension and anaemia, systemic hypothermia, neuromonitoring, maintaining distal perfusion during proximal clamping of the aorta, and reimplantation of intercostal or lumbar arteries, whenever feasible...
February 27, 2024: Revista española de anestesiología y reanimación
https://read.qxmd.com/read/38418142/involvement-of-notch1-mediated-microglia-activation-in-neuromodulation-of-chronic-prostatitis-related-pain
#13
JOURNAL ARTICLE
Heng Zhang, Ruifen Gu, Jisheng Luo, Chuanhua Zhong, Jinhong Pan
BACKGROUND/AIM: This study aimed to investigate the role of NOTCH receptor 1 (NOTCH1)-mediated activation of microglia in the L5-S2 spinal dorsal horn in chronic prostatitis pain. MATERIALS AND METHODS: Rats were divided into chronic prostatitis (CP) group and control group. Complete Freund's adjuvant was injected into the prostate, and prostate pathology and pain-related behavior were monitored to assess the successful establishment of the CP-related pain model...
2024: In Vivo
https://read.qxmd.com/read/38417349/deferred-cord-clamping-to-improve-neonatal-blood-values-a-systematic-review-and-meta-analysis
#14
JOURNAL ARTICLE
Charifa Zemouri, Eveline Mestdagh, Mieke Stiers, Kimberly Torfs, Yvonne Kuipers
BACKGROUND: Practices related to umbilical cord clamping at birth should be evidence-based. Deferred cord clamping, compared to immediate cord clamping, shows benefits for preterm neonates but this may also apply to healthy term neonates. Different blood sampling techniques are used to measure effect of deferred and immediate cord clamping. OBJECTIVE: To assess the statistical and effect size differences between blood biomarkers from umbilical cord and capillary blood samples of healthy term neonates following either immediate or deferred cord clamping...
February 9, 2024: International Journal of Nursing Studies
https://read.qxmd.com/read/38401787/process-and-outcome-measures-for-moderate-and-late-preterm-infants-in-tertiary-canadian-neonatal-intensive-care-units
#15
JOURNAL ARTICLE
Ayman Abou Mehrem, Jennifer Toye, Marc Beltempo, Khalid Aziz, Victoria Bizgu, Jonathan Wong, Nalini Singhal, Prakesh S Shah
OBJECTIVE: To describe the prevalence of and between-center variations in care practices and clinical outcomes of moderate and late preterm infants (MLPI) admitted to tertiary Canadian neonatal intensive care units (NICUs). STUDY DESIGN: A retrospective cohort study including infants born at 320/7 through 366/7 weeks' gestation and admitted to 25 NICUs participating in the Canadian Neonatal Network between 2015 and 2020. Patient characteristics, process measures represented by care practices, and outcome measures represented by clinical in-hospital and discharge outcomes were reported by gestational age weeks...
February 22, 2024: Journal of Pediatrics
https://read.qxmd.com/read/38345477/excitatory-action-of-low-frequency-depolarizing-gaba-glycine-synaptic-inputs-is-prevalent-in-prenatal-spinal-sod1-g93a-motoneurons
#16
JOURNAL ARTICLE
Hongmei Zhu, Urvashi Dalvi, William Cazenave, Daniel Cattaert, Pascal Branchereau
Amyotrophic lateral sclerosis (ALS) is a fatal adult-onset neurodegenerative disease characterized by progressive motor neuron degeneration and muscle paralysis. Recent evidence suggests the dysfunction of inhibitory signalling in ALS motor neurons. We have shown that embryonic day (E)17.5 spinal motoneurons (MNs) of the SOD1G93A mouse model of ALS exhibit an altered chloride homeostasis. At this prenatal stage, inhibition of spinal motoneurons (MNs) is mediated by depolarizing GABAergic/glycinergic postsynaptic potentials (dGPSPs)...
February 12, 2024: Journal of Physiology
https://read.qxmd.com/read/38340499/thrombospondin-4-a-mediator-and-candidate-indicator-of-pain
#17
JOURNAL ARTICLE
Yanqiong Wu, Min Yang, Xueqin Xu, Yan Gao, Xiaohui Li, Yang Li, Shanchun Su, Xianqiao Xie, Zeyong Yang, Changbin Ke
Pain is the most common symptom for which patients seek medical attention. Existing treatments for pain control are largely ineffective due to the lack of an accurate way to objectively measure pain intensity and a poor understanding of the etiology of pain. Thrombospondin 4(TSP4), a member of the thrombospondin gene family, is expressed in neurons and astrocytes and induces pain by interacting with the calcium channel alpha-2-delta-1 subunit (Cavα2δ1). In the present study we show that TSP4 expression level correlates positively with pain intensity, suggesting that TSP4 could be a novel candidate of pain indicator...
February 6, 2024: European Journal of Cell Biology
https://read.qxmd.com/read/38337526/impact-of-intercostal-artery-reinsertion-on-neurological-outcome-after-thoracoabdominal-aortic-replacement-a-25-year-single-center-experience
#18
JOURNAL ARTICLE
Florian Helms, Reza Poyanmehr, Heike Krüger, Bastian Schmack, Alexander Weymann, Aron-Frederik Popov, Arjang Ruhparwar, Andreas Martens, Ruslan Natanov
BACKGROUND: Intercostal artery reinsertion (ICAR) during thoracoabdominal aortic replacement remains controversial. While some groups recommend the reinsertion of as many arteries as possible, others consider the sacrifice of multiple intercostals practicable. This study investigates the impact of intercostal artery reinsertion or sacrifice on neurological outcomes and long-term survival after thoracoabdominal aortic repair. METHODS: A total of 349 consecutive patients undergoing thoracoabdominal aortic replacement at our institution between 1996 and 2021 were analyzed in a retrospective single-center study...
January 31, 2024: Journal of Clinical Medicine
https://read.qxmd.com/read/38293717/physiological-based-cord-clamping-stabilised-cardiorespiratory-parameters-in-very-low-birth-weight-infants
#19
JOURNAL ARTICLE
Nina Hoeller, Christina Helene Wolfsberger, Ernst Prethaler, Bernhard Schwaberger, Gerhard Pichler, Berndt Urlesberger
AIM: We investigated the influence of physiological-based cord clamping (PBCC) on cardiorespiratory stability in very low birth weight (VLBW) infants during the first 72 h of life. METHODS: This retrospective study comprised VLBW infants born at <32 + 0 weeks of gestation and admitted to the neonatal intensive care unit of the Medical University of Graz, Austria, from December 2014 to April 2021. VLBW infants delivered with PBCC were matched by gestational age and birth weight to delayed cord clamping controls...
January 31, 2024: Acta Paediatrica
https://read.qxmd.com/read/38286453/-mechanism-of-shikonin-on-spinal-cord-injury-in-rats-based-on-tnfr-ripk1-pathway
#20
JOURNAL ARTICLE
Ji-Sheng Shi, Ji-Ze Qina, Jin-Guang Wang, Bin Lin, Tong-Tao Pang
OBJECTIVE: To explore the effect of shikonin on the recovery of nerve function after acute spinal cord injury(SCI) in rats. METHODS: 96 male Sprague-Dawley(SD)rats were divided into 4 groups randomly:sham operation group (Group A), sham operation+shikonin group (Group B), SCI+ DMSO(Group C), SCI+shikonin group (Group D).The acute SCI model of rats was made by clamp method in groups C and D . After subdural catheterization, no drug was given in group A. rats in groups B and D were injected with 100 mg·kg-1 of shikonin through catheter 30 min after modeling, and rats in group C were given with the same amount of DMSO, once a day until the time point of collection tissue...
January 25, 2024: Zhongguo Gu Shang, China Journal of Orthopaedics and Traumatology
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