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Protein status

Mahdieh Abbasalizad Farhangi
Current study was aimed to evaluate the relationship between emotional eating and night eating syndrome (NES) with sleep quality among adolescents in Tabriz-Iran. The current study was conducted among eighty adolescent boys aged 12-16 years old from Tabriz-Iran. Night eating syndrome and Emotional eating were measured by validated specific questionnaires. Pittsburgh Sleep Quality Index questionnaire (PSQI) was used for assessment of sleep quality. Emotional and very emotional eaters had significantly higher protein and fat intake...
March 16, 2019: Community Mental Health Journal
Gilberto Pires da Rosa, Francisca Costa, Joana Guimarães, Fernando Friões
We report the case of a 50-year-old caucasian man presenting with lumbar pain, bilateral ataxia, central facial palsy, ophthalmoparesis and urinary retention. Cerebral MRI hinted a hyperintensity of the medulla oblongata and cervical medulla suggestive of myelitis. Cerebrospinal fluid displayed lymphocytic pleocytosis and elevated protein concentration. Without the possibility to rule out an infectious or inflammatory aetiology, antibiotics and corticosteroids were started. Nevertheless, neurological status deteriorated with loss of muscle strength and left eye amaurosis...
March 16, 2019: BMJ Case Reports
Jie Shen, Daphne Hernandez, Lorna Haughton McNeill, Wong-Ho Chow, Hua Zhao
C-Reactive protein (CRP) is a well-known inflammatory marker, and elevated CRP levels has been reported to be associated with the risk of various cancers. To date, no study has investigated the association between elevated CRP and incidents of cancer among Mexican Americans. In the current prospective cohort study, we measured pre-diagnostic CRP levels in serum samples and evaluated their relationships with demographic characteristics and health behaviors associated with cancer risk among 2753 Mexican Americans selected from the Mano-A-Mano Mexican American Cohort Study...
March 14, 2019: Cancer Epidemiology
Irfan Ullah Khan, Justice Kipkoir Rono, Bai Qing Zhang, Xue Song Liu, Meng Qi Wang, Lei Lei Wang, Xue Chun Wu, Xi Chen, Hong Wei Cao, Zhi Min Yang
HPP (heavy metal associated plant protein) and HIPP (heavy metal associated isoprenylated plant protein) are a group of metal-binding metallochaperones playing crucial roles in metal homeostasis and detoxification. Up to now, only few of them have been functionally identified in plants. Here, we identified 54 HPP and HIPP genes in rice genome. Analysis of the transcriptome datasets of the rice genome exposed to cadmium (Cd) revealed 17 HPP/HIPP genes differentially expressed, with 11 being upregulated (>2 fold change, p < 0...
March 14, 2019: Ecotoxicology and Environmental Safety
Tsuyoshi Inoue, Hiroshi Maekawa, Reiko Inagi
Organelle damage can cause various kidney diseases. In particular, organelle stress such as decreased proteostatic activity in the endoplasmic reticulum (ER) and altered energy metabolism in mitochondria contribute to glomerular and tubulointerstitial damage, resulting in the progression and development of kidney diseases. The ER regulates protein quality control via the unfolded protein response (UPR) pathway. Pathogenic ER stress leads to dysregulation of this pathway, and a maladaptive UPR is highly deleterious to renal cell function, and thereby has been implicated in the pathophysiology of various kidney diseases...
March 4, 2019: Kidney International
Katharina May, Kerstin Brügemann, Sven König, Christina Strube
Infections with the liver fluke Fasciola hepatica may result in considerable economic losses in the dairy livestock industry worldwide. Infections have been associated with detrimental impacts on milk production and milk quality as well as reduced fertility. However, most related data rely on examinations on herd level and the rather few studies on individual cow level are based solely on antibodies as measure for F. hepatica infections. This entails the risk of including false-positives as anti-F. hepatica antibodies persist for months even if the infection is cleared...
March 2019: Veterinary Parasitology
Anurag Bhargava, Madhavi Bhargava, Tripti Pande, Raghuram Rao, Malik Parmar
Undernutrition is the most prevalent comorbidity in patients with tuberculosis (TB) in India. Undernutrition is often severe and results in higher risk of death, drug toxicity during treatment, poor functional status at end of treatment and a higher risk of relapse after successful treatment. A World Health Organization guideline has recommended nutritional assessment, counseling, and care as integral parts of TB care. The Revised National Tuberculosis Control Programme has recognized undernutrition as a significant comorbidity, released a guidance document for improving nutritional care and support, and launched a scheme for direct bank transfer of monthly cash benefit to TB patients...
January 2019: Indian Journal of Tuberculosis
V E Baksheeva, O S Gancharova, V V Tiulina, E N Iomdina, A A Zamyatnin, P P Philippov, E Yu Zernii, I I Senin
Visual system is at high risk of iatrogenic damage. Laser ocular surgery, the use of powerful illumination devices in diagnostics and surgical treatment of eye diseases, as well as long surgeries under general anesthesia provoke the development of chronic degenerative changes in eye tissues, primarily in the cornea and the retina. Despite the existence of approaches for prevention and treatment of these complications, the efficacy of these approaches is often limited. Here, we review the mechanisms of iatrogenic damage to eye tissues at the cellular and biochemical levels...
December 2018: Biochemistry. Biokhimii︠a︡
Panagiota Economopoulou, Vassiliki Kotoula, Georgia-Angeliki Koliou, Kyriaki Papadopoulou, Christos Christodoulou, George Pentheroudakis, Georgios Lazaridis, Petroula Arapantoni-Dadioti, Angelos Koutras, Dimitris Bafaloukos, Pavlos Papakostas, Helen Patsea, Kitty Pavlakis, Dimitrios Pectasides, Athanasios Kotsakis, Evangelia Razis, Gerasimos Aravantinos, Epaminondas Samantas, Konstantine T Kalogeras, Theofanis Economopoulos, Amanta Psyrri, George Fountzilas
BACKGROUND: Src, CDKN1B, and JAK2 play a crucial role in the coordination of cell signaling pathways. In the present study, we aim to investigate the prognostic significance of these biomarkers in HER2-positive metastatic breast cancer (MBC) patients treated with trastuzumab (T). METHODS: Formalin-fixed paraffin-embedded tumor tissue samples from 197 patients with HER2-positive MBC treated with T were retrospectively collected. All tissue samples were centrally assessed for ER, PgR, Ki67, HER2, and PTEN protein expression; EGFR gene amplification; PI3KCA mutational status; and tumor-infiltrating lympocytes density...
March 13, 2019: Translational Oncology
Spencer Dean, Ching-Shuen Wang, Kihoon Nam, Christina L Maruyama, Bryan G Trump, Olga J Baker
OBJECTIVES: SS is characterized by chronic inflammation of the salivary glands leading to loss of secretory function, thereby suggesting specialized pro-resolving mediators targeting inflammation to be a viable option for treating SS. Previous studies demonstrated that aspirin-triggered resolvin D1 (AT-RvD1) prevents chronic inflammation and enhances saliva secretion in a SS-like mouse model when applied before disease onset. However, this therapy cannot be used in SS patients given that diagnosis occurs post-disease onset and no reliable screening methods exist...
March 15, 2019: Rheumatology
Zhi Huang, Yajun Lian, Yuan Chen, Shuang Li, Haifeng Zhang, Nanchang Xie, Yake Zheng, Shouyi Wu, Yuhan Wang, Wenchao Cheng, Qiaoman Zhang, Chengze Wang, Yinping Shi, Na Xie
Botulinum neurotoxins (BoNTs) block the release of a series of neurotransmitters, which are pivotal for neuron action. Intrahippocampal administration of BoNTs inhibits glutamate release, protects neurons against cell death, and attenuates epileptic seizures. Compared with intrahippocampal administration, intranasal delivery is less invasive and more practical for chronic drug administration. To assess whether intranasal administration is feasible, we examined the role of botulinum neurotoxin A (BoNT/A) in hippocampal neuronal injury after status epilepticus (SE) induced by pilocarpine...
March 14, 2019: Neurochemical Research
Sergey V Shabelnikov, Danila E Bobkov, Natalia S Sharlaimova, Olga A Petukhova
Echinoderms, possessing outstanding regenerative capabilities, provide a unique model system for the study of response to injury. However, there is little known about the proteomic composition of coelomic fluid, an important biofluid circulating throughout the animal's body and reflecting the overall biological status of the organism. In this study, we used LC-MALDI tandem mass spectrometry to characterize the proteome of the cell-free coelomic fluid of starfish Asterias rubens and to follow the changes occurring in response to puncture wound and blood loss...
March 15, 2019: Journal of Experimental Biology
Yingxue Yang, Esther Lenherr, Roland Gromes, Shanshan Wang, Markus Wirtz, Rüdiger Hell, Tanja Peskan-Berghöfer, Klaus Scheffzek, Thomas Rausch
Plant ɣ-glutamylcysteine ligase (GCL), catalyzing the first and tightly regulated step of glutathione biosynthesis, is redox-activated via formation of an intramolecular disulfide bond. In vitro , redox-activation of recombinant GCL protein causes formation of homo-dimers. Here we have investigated whether dimerization occurs in vivo and if so whether it contributes to redox-activation. FPLC analysis indicated that recombinant redox-activated WT AtGCL dissociates into monomers at concentrations below 10-6 M, i...
March 15, 2019: Biochemical Journal
Amanda R Vest, Michael Chan, Anita Deswal, Michael M Givertz, Carolyn Lekavich, Terry Lennie, Sheldon E Litwin, Lauren Parsly, Jo Ellen Rodgers, Michael W Rich, P Christian Schulze, Aaron Slader, Akshay Desai
Dietary guidance for patients with heart failure (HF) has traditionally focused on sodium and fluid intake restriction, but dietary quality is frequently poor in patients with HF and may contribute to morbidity and mortality. Restrictive dietary counselling can lead to inadequate intake of macronutrients and micronutrients by patients with HF, with the potential for deficiencies of calcium, magnesium, zinc, iron, thiamine, vitamins D, E, K, and folate. Although inadequate intake and low plasma levels of micronutrients have been associated with adverse clinical outcomes, evidence supporting therapeutic repletion is limited...
March 12, 2019: Journal of Cardiac Failure
Ali M Omari, Leen S Omari, Hazar H Dagash, Waleed M Sweileh, Nehal Natour, Sa'ed H Zyoud
BACKGROUND: Protein-energy wasting (PEW) is a relatively prevalent problem among adult haemodialysis patients (HDP). PEW is an important determinant of morbidity and mortality in HDP, therefore it is essential for dietitians to accurately assess malnutrition (MN) in these patients. HDP appear to be more susceptible to developing MN; however, this is not well documented. Therefore this study aimed to assess the nutritional status among HDP and to establish the factors associated with MN in these patients...
March 15, 2019: BMC Nephrology
Ha-Na Kim, Sang-Wook Song
Obesity is a risk factor for many health issues, as are metabolic abnormalities. However, few studies have addressed the associations between obesity/metabolic risk phenotypes and dietary macronutrient intakes (carbohydrate, protein, and fat). Therefore, this study examined the associations between macronutrient intakes and obesity/metabolic risk phenotypes in a Korean population. We used data from the Korean National Health and Nutrition Examination Survey, a cross-sectional survey of Korean civilians, conducted in 2014 and 2016, and data on a total of 7374 participants were analyzed...
March 14, 2019: Nutrients
Mengxing Ouyang, Dino Di Carlo
We demonstrate a swarm biosensing platform that detects analyte based on the change in plasmonic signal from thousands of single nanoparticles sensors, leading to increased quantitative accuracy. Following dark field microscopy, we perform computational image registration and analyses to compile the hue change from thousands of single gold nanoparticles acting as individual quantitative biosensors. This platform demonstrated a limit of detection of 10 pM with a dynamic range of at least 4 orders of magnitude in buffer solution, and the successful detection of c-reactive protein (CRP) in serum compatible with 3-tier clinical cutoffs within a 10-fold difference without the need for a blocking step...
March 4, 2019: Biosensors & Bioelectronics
Silvia Lai, Maurizio Muscaritoli, Paola Andreozzi, Alessandro Sgreccia, Sabrina De Leo, Sandro Mazzaferro, Anna Paola Mitterhofer, Marzia Pasquali, Paolo Protopapa, Alessandra Spagnoli, Maria Ida Amabile, Alessio Molfino
OBJECTIVE: Chronic kidney disease (CKD) is a condition with high cardiovascular mortality associated with emerging risk factors, including sarcopenia. Several mechanisms can affect muscle mass, such as vitamin D deficiency, low protein intake, physical inactivity, metabolic acidosis, and inflammation leading to a worsening of cardiovascular outcomes and cognitive function. We aimed to evaluate the prevalence of sarcopenia in CKD patients on conservative and replacement therapy and the associations between sarcopenia and markers of atherosclerosis, endothelial dysfunction, psychological and cognitive function...
December 11, 2018: Nutrition
Meghan E Ahern, Elizabeth M Bafaro, Ann Cowan, Robert E Dempski
The human (h) zinc transporter ZIP4 is expressed on the plasma membrane and functions to increase cytosolic zinc levels. Mutations in hZIP4 cause the disease Acrodermatitis Enteropathica (AE). Dysfunction in the regulation of hZIP4 has also been indicated in solid tissue cancers, including pancreatic and prostate cancer. Although structural studies of the extracellular domain and computational modeling of the membrane domain suggest hZIP4 exists as a dimer, the oligomerization status of hZIP4 in the plasma membrane of mammalian cells has not been directly quantified in vivo...
March 15, 2019: Biochemistry
Ahmareen Baten, Masoom Desai, Miguel Melo-Bicchi, Camilo Gutierrez
OBJECTIVE: Herpes simplex virus encephalitis (HSE) is the most common cause of sporadic fatal encephalitis worldwide and remains a devastating disease despite antiviral therapy. EEG can be an important tool in the diagnosis of HSE, and we propose that it can be used to monitor the progression of the disease in patients with treatment refractory HSE. METHODS: This is a case report of a patient with HSE who was monitored on continuous EEG (CEEG) throughout course of her disease...
March 15, 2019: Clinical EEG and Neuroscience: Official Journal of the EEG and Clinical Neuroscience Society (ENCS)
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