keyword
https://read.qxmd.com/read/38534115/-proteus-mirabilis-urer-coordinates-cellular-functions-required-for-urease-activity
#1
JOURNAL ARTICLE
Madison J Fitzgerald, Melanie M Pearson, Harry L T Mobley
UNLABELLED: A hallmark of Proteus mirabilis infection of the urinary tract is the formation of stones. The ability to induce urinary stone formation requires urease, a nickel metalloenzyme that hydrolyzes urea. This reaction produces ammonia as a byproduct, which can serve as a nitrogen source and weak base that raises the local pH. The resulting alkalinity induces the precipitation of ions to form stones. Transcriptional regulator UreR activates expression of urease genes in a urea-dependent manner...
March 27, 2024: Journal of Bacteriology
https://read.qxmd.com/read/38532402/seroprevalence-and-risk-factors-of-toxoplasma-gondii-in-sheep-and-goats-of-north-west-province-south-africa
#2
JOURNAL ARTICLE
Mthokozisi Masombuka, Malekoba B N Mphuthi, Yusuf B Ngoshe, Gloria Mokolopi, Nomakorinte Gcebe
BACKGROUND: The protozoan parasite Toxoplasma gondii causes toxoplasmosis, one of the most prevalent parasitic zoonotic diseases with significant economic and public health implications worldwide. Infection with the parasite has a significant adverse effect on sheep and goat production and can frequently go undetected in the herd, resulting in abortions and weak or dead offspring. Although there are few studies on seroprevalence and risk factors associated with T. gondii infections in livestock in other provinces of South Africa, there is no data in the North West province...
March 26, 2024: BMC Veterinary Research
https://read.qxmd.com/read/38524515/significant-risk-factors-for-intensive-care-unit-acquired-weakness-a-processing-strategy-based-on-repeated-machine-learning
#3
JOURNAL ARTICLE
Ling Wang, Deng-Yan Long
BACKGROUND: Intensive care unit-acquired weakness (ICU-AW) is a common complication that significantly impacts the patient's recovery process, even leading to adverse outcomes. Currently, there is a lack of effective preventive measures. AIM: To identify significant risk factors for ICU-AW through iterative machine learning techniques and offer recommendations for its prevention and treatment. METHODS: Patients were categorized into ICU-AW and non-ICU-AW groups on the 14th day post-ICU admission...
March 6, 2024: World Journal of Clinical Cases
https://read.qxmd.com/read/38520815/vitamin-deficiencies-in-children-lessons-from-clinical-and-neuroimaging-findings
#4
JOURNAL ARTICLE
Gabrielle Dupuy, Charles-Joris Roux, Rémi Barrois, Apolline Imbard, Clément Pontoizeau, Marie Thérèse Dangles, Mélodie Aubart, Jean-Baptiste Arnoux, Diane Margoses, Anaïs Brassier, Clothilde Marbach, Claire-Marine Bérat, Eugénie Sarda, Cyril Gitiaux, Pascale de Lonlay, Nathalie Boddaert, Manuel Schiff, Isabelle Desguerre
BACKGROUND AND AIMS: Water-soluble vitamins play an essential coenzyme role in the nervous system. Acquired vitamin deficiencies are easily treatable, however, without treatment, they can lead to irreversible complications. This study aimed to provide clinical, laboratory parameters and neuroimaging data on vitamin deficiencies in an attempt to facilitate early diagnosis and prompt supplementation. METHODS: From July 1998 to July 2023, patients at Necker-Enfants-Malades Hospital presenting with acute neurological symptoms attributed to acquired vitamin deficiency were included...
February 26, 2024: European Journal of Paediatric Neurology: EJPN
https://read.qxmd.com/read/38519098/on-post-covid-19-intensive-care-unit-acquired-weakness-compromises-long-term-functional-status-schmidt-d-margarites-ag-alvarenga-lpkb-paesi-pm-friedman-g-sbruzzi-g-phys-ther-2023-103-pzad117-http-doi-org-10-1093-ptj-pzad117
#5
JOURNAL ARTICLE
https://read.qxmd.com/read/38497822/neuroimaging-findings-in-us-government-personnel-and-their-family-members-involved-in-anomalous-health-incidents
#6
JOURNAL ARTICLE
Carlo Pierpaoli, Amritha Nayak, Rakibul Hafiz, M Okan Irfanoglu, Gang Chen, Paul Taylor, Mark Hallett, Michael Hoa, Dzung Pham, Yi-Yu Chou, Anita D Moses, André J van der Merwe, Sara M Lippa, Carmen C Brewer, Chris K Zalewski, Cris Zampieri, L Christine Turtzo, Pashtun Shahim, Leighton Chan, Brian Moore, Lauren Stamps, Spencer Flynn, Julia Fontana, Swathi Tata, Jessica Lo, Mirella A Fernandez, Annie Lori-Joseph, Jesse Matsubara, Julie Goldberg, Thuy-Tien D Nguyen, Noa Sasson, Justine Lely, Bryan Smith, Kelly A King, Jennifer Chisholm, Julie Christensen, M Teresa Magone, Chantal Cousineau-Krieger, Louis M French, Simge Yonter, Sanaz Attaripour, Chen Lai
IMPORTANCE: US government personnel stationed internationally have reported anomalous health incidents (AHIs), with some individuals experiencing persistent debilitating symptoms. OBJECTIVE: To assess the potential presence of magnetic resonance imaging (MRI)-detectable brain lesions in participants with AHIs, with respect to a well-matched control group. DESIGN, SETTING, AND PARTICIPANTS: This exploratory study was conducted at the National Institutes of Health (NIH) Clinical Center and the NIH MRI Research Facility between June 2018 and November 2022...
March 18, 2024: JAMA
https://read.qxmd.com/read/38496542/developmental-hematopoietic-stem-cell-variation-explains-clonal-hematopoiesis-later-in-life
#7
Jesse Kreger, Jazlyn A Mooney, Darryl Shibata, Adam L MacLean
Clonal hematopoiesis becomes increasingly common with age, but its cause is enigmatic because driver mutations are often absent. Serial observations infer weak selection indicating variants are acquired much earlier in life with unexplained initial growth spurts. Here we use fluctuating CpG methylation as a lineage marker to track stem cell clonal dynamics of hematopoiesis. We show, via the shared prenatal circulation of monozygotic twins, that weak selection conferred by stem cell variation created before birth can reliably yield clonal hematopoiesis later in life...
March 5, 2024: bioRxiv
https://read.qxmd.com/read/38492041/a-clinico-anatomical-dissection-of-the-magnocellular-and-parvocellular-pathways-in-a-patient-with-the-riddoch-syndrome
#8
JOURNAL ARTICLE
Ahmad Beyh, Samuel E Rasche, Alexander Leff, Dominic Ffytche, Semir Zeki
The Riddoch syndrome is thought to be caused by damage to the primary visual cortex (V1), usually following a vascular event. This study shows that damage to the anatomical input to V1, i.e., the optic radiations, can result in selective visual deficits that mimic the Riddoch syndrome. The results also highlight the differential susceptibility of the magnocellular and parvocellular visual systems to injury. Overall, this study offers new insights that will improve our understanding of the impact of brain injury and neurosurgery on the visual pathways...
March 16, 2024: Brain Structure & Function
https://read.qxmd.com/read/38491135/correlation-between-the-spread-of-imp-producing-bacteria-and-the-promoter-strength-of-bla-imp-genes
#9
JOURNAL ARTICLE
Yuta Kikuchi, Mariko Yoshida, Asaomi Kuwae, Yukihiro Asami, Yuki Inahashi, Akio Abe
The first report of transmissible carbapenem resistance encoded by blaIMP-1 was discovered in Pseudomonas aeruginosa GN17203 in 1988, and blaIMP-1 has since been detected in other bacteria, including Enterobacterales. Currently, many variants of blaIMPs exist, and point mutations in the blaIMP promoter have been shown to alter promoter strength. For example, the promoter (Pc) of blaIMP-1 , first reported in P. aeruginosa GN17203, was a weak promoter (PcW) with low-level expression intensity. This study investigates whether point mutations in the promoter region have helped to create strong promoters under antimicrobial selection pressure...
March 15, 2024: Journal of Antibiotics
https://read.qxmd.com/read/38490489/hospital-acquired-bloodstream-infections-in-cancer-patients-current-knowledge-and-future-directions
#10
REVIEW
Aleece MacPhail, Claire Dendle, Monica Slavin, Zoe McQuilten
Cancer patients experience higher rates of preventable harm from hospital acquired bloodstream infection (haBSI) and central line associated bloodstream infections (CLABSI) than the general hospital population. Prevention of haBSI and CLABSI in cancer patients is an urgent priority and requires standardised surveillance and reporting efforts. The application of haBSI and CLABSI definitions, classification systems and surveillance strategies for cancer patients is complex and there is wide variation in clinical practice...
March 13, 2024: Journal of Hospital Infection
https://read.qxmd.com/read/38489862/does-inspiratory-muscle-training-improve-lung-function-and-quality-of-life-in-people-with-inclusion-body-myositis-a-pilot-study
#11
JOURNAL ARTICLE
Ethan Williams, Ian Cooper, Kelly Beer, Kathryn Hird, Vinicius Cavalheri, Kathryn Watson, Merrilee Needham
Inclusion Body Myositis is the most common acquired myositis in adults, predominantly weakening forearm flexor and knee extensor muscles. Subclinical respiratory muscle weakness has recently been recognised in people with Inclusion Body Myositis, increasing their risk of respiratory complications. Inspiratory muscle training, a technique which demonstrates efficacy and safety in improving respiratory function in people with neuromuscular disorders, has never been explored in those with Inclusion Body Myositis...
February 22, 2024: Neuromuscular Disorders: NMD
https://read.qxmd.com/read/38487223/precisely-modulating-the-chromatin-tracker-via-substituent-engineering-reporting-pathological-oxidative-stress-during-mitosis
#12
JOURNAL ARTICLE
Jinsong Li, Yingyong Ni, Junjun Wang, Yicai Zhu, Aidong Wang, Xiaojiao Zhu, Xianshun Sun, Sen Wang, Dandan Li, Hongping Zhou
An in-depth understanding of cancer-cell mitosis presents unprecedented advantages for solving metastasis and proliferation of tumors, which has aroused great interest in visualizing the behavior via a luminescence tool. We developed a fluorescent molecule CBTZ-yne based on substituent engineering to acquire befitting lipophilicity and electrophilicity for anchoring lipid droplets and the nucleus, in which the low polarity environment and nucleic acids triggered a "weak-strong" fluorescence and "short-long" fluorescence-lifetime response...
March 13, 2024: Chemical Science
https://read.qxmd.com/read/38484943/assessing-left-atrial-size-and-pump-function-in-ischemic-stroke-patients-is-cardiac-mri-superior-to-transthoracic-echocardiography
#13
JOURNAL ARTICLE
Maxwell Isaac, Senthil A Kumar, Gregory F Petroski, Alex Shinn, Ashir Mehra, Camilo R Gomez
OBJECTIVES: Current guidelines recommend transthoracic echocardiography (TTE) following an ischemic stroke as the primary technique to identify cardiac abnormalities associated with an increased risk of cerebral embolism. It is unclear whether cardiac magnetic resonance imaging (cMRI), a technique shown to provide increased imaging resolution, may also enhance the cardiac assessment of ischemic stroke patients. We compared cMRI with TTE in the evaluation of LA size and pump function in a cohort of 44 patients with ischemic stroke...
March 12, 2024: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://read.qxmd.com/read/38470598/scac-a-semi-supervised-learning-approach-for-cervical-abnormal-cell-detection
#14
JOURNAL ARTICLE
Zheng Zhang, Peng Yao, Mingxiao Chen, Liang Zeng, Pengfei Shao, Shuwei Shen, Ronald X Xu
Cervical abnormal cell detection plays a crucial role in the early screening of cervical cancer. In recent years, some deep learning-based methods have been proposed. However, these methods rely heavily on large amounts of annotated images, which are time-consuming and laborintensive to acquire, thus limiting the detection performance. In this paper, we present a novel Semi-supervised Cervical Abnormal Cell detector (SCAC), which effectively utilizes the abundant unlabeled data. We utilize Transformer as the backbone of SCAC to capture long-range dependencies to mimic the diagnostic process of pathologists...
March 12, 2024: IEEE Journal of Biomedical and Health Informatics
https://read.qxmd.com/read/38457541/cerebral-venous-thrombosis-presented-with-symmetrical-crescent-shaped-intracranial-hemorrhage-in-alcoholic-liver-disease-case-reports
#15
JOURNAL ARTICLE
Lingjia Xu, Guoping Fu
RATIONALE: Cerebral venous thrombosis (CVT) is a relatively uncommon but fatal disease. It can be caused by a variety of hereditary or acquired thrombotic diseases. Initial presentation with intracranial hemorrhage (ICH) in CVT is rare but can further complicate the therapeutic measures and prognosis. Cases of CVT presented with ICH in patients with alcoholic liver disease (ALD) have not been described in the literature, and it might be related with hemostatic abnormalities in ALD patients...
March 8, 2024: Medicine (Baltimore)
https://read.qxmd.com/read/38454357/emotional-coping-factors-and-personality-traits-that-influenced-alcohol-consumption-in-romanian-students-during-the-covid-19-pandemic-a-cross-sectional-study
#16
JOURNAL ARTICLE
Cornelia Rada, Cristina Faludi, Mihaela Lungu
BACKGROUND: During the COVID-19 pandemic, after 3 months from the installation of the state of emergency on the territory of Romania, data were collected from 677 students and master's students, to explore the problematic alcohol consumption (AC). METHODS: The evaluation was done with: Alcohol Use Disorders Identification Test, Depression, Anxiety and Stress Scales, Strategic Coping Approach Scale and The Freiburg Personality Inventory. The statistical methods used were linear regression with bootstrap procedure, Spearman's rank correlation, and the Mann-Whitney U test...
March 7, 2024: BMC Public Health
https://read.qxmd.com/read/38441257/age-related-differences-in-macromolecular-resonances-observed-in-ultra-short-te-steam-mr-spectra-at-7t
#17
JOURNAL ARTICLE
Guglielmo Genovese, Melissa Terpstra, Pavel Filip, Silvia Mangia, J Riley McCarten, Laura S Hemmy, Małgorzata Marjańska
PURPOSE: To understand how macromolecular content varies in the human brain with age in a large cohort of healthy subjects. METHODS: In-vivo 1 H-MR spectra were acquired using ultra-short TE STEAM at 7T in the posterior cingulate cortex. Macromolecular content was studied in 147 datasets from a cohort ranging in age from 19 to 89 y. Three fitting approaches were used to evaluate the macromolecular content: (1) a macromolecular resonances model developed for this study; (2) LCModel-simulated macromolecules; and (3) a combination of measured and LCModel-simulated macromolecules...
March 5, 2024: Magnetic Resonance in Medicine
https://read.qxmd.com/read/38439631/acquired-aquagenic-syringeal-keratoderma-following-covid-19-infection
#18
JOURNAL ARTICLE
Bryce W Polascik, Samantha P Karklins, Matthew C Johnson, Warren C Hammert, Amy J McMichael
Aquagenic syringeal keratoderma (ASK), rare in males, is characterized by the rapid onset of edematous palmar wrinkling with small white papules after brief contact with water or sweat. A 24-year-old atopic male presented with a 2-week subacute history of bilateral palmar edema with whitish-colored papules after exposure to water, 3 months after having had COVID-19 infection treated with a full course of ritonavir-boosted nirmatrelvir (PAXLOVIDTM ). He had received 3 COVID-19 vaccines (Pfizer, New York, NY) about 12 months prior...
March 4, 2024: Hand: Official Journal of the American Association for Hand Surgery
https://read.qxmd.com/read/38439076/protocol-for-a-parallel-cluster-randomized-trial-of-a-participatory-tailored-approach-to-reduce-overuse-of-antibiotics-at-hospital-discharge-the-road-home-trial
#19
JOURNAL ARTICLE
Julia E Szymczak, Lindsay A Petty, Tejal N Gandhi, Robert A Neetz, Adam Hersh, Angela P Presson, Peter K Lindenauer, Steven J Bernstein, Brandi M Muller, Andrea T White, Jennifer K Horowitz, Scott A Flanders, Justin D Smith, Valerie M Vaughn
BACKGROUND: Antibiotic overuse at hospital discharge is common, costly, and harmful. While discharge-specific antibiotic stewardship interventions are effective, they are resource-intensive and often infeasible for hospitals with resource constraints. This weakness impacts generalizability of stewardship interventions and has health equity implications as not all patients have access to the benefits of stewardship based on where they receive care. There may be different pathways to improve discharge antibiotic prescribing that vary widely in feasibility...
March 4, 2024: Implementation Science: IS
https://read.qxmd.com/read/38438485/effects-of-acute-phase-intensive-electrical-muscle-stimulation-in-covid-19-patients-requiring-invasive-mechanical-ventilation-an-observational-case-control-study
#20
JOURNAL ARTICLE
Yohei Tsuchikawa, Shinya Tanaka, Daisuke Kasugai, Riko Nakagawa, Miho Shimizu, Takayuki Inoue, Motoki Nagaya, Takafumi Nasu, Norihito Omote, Michiko Higashi, Takanori Yamamoto, Naruhiro Jingushi, Atsushi Numaguchi, Yoshihiro Nishida
We investigated the effects of acute-phase intensive electrical muscle stimulation (EMS) on physical function in COVID-19 patients with respiratory failure requiring invasive mechanical ventilation (IMV) in the intensive care unit (ICU). Consecutive COVID-19 patients requiring IMV admitted to a university hospital ICU between January and April 2022 (EMS therapy group) or between March and September 2021 (age-matched historical control group) were included in this retrospective observational case-control study...
March 4, 2024: Scientific Reports
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