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pancreatitis guideline

Yoshiyasu Kato, Suguru Yamada, Mitsuru Tashiro, Fuminori Sonohara, Hideki Takami, Masamichi Hayashi, Mitsuro Kanda, Daisuke Kobayashi, Chie Tanaka, Goro Nakayama, Masahiko Koike, Michitaka Fujiwara, Yasuhiro Kodera
BACKGROUND: This study aimed to evaluate novel resectability criteria for pancreatic ductal adenocarcinoma (PDAC) proposed by the International Association of Pancreatology (IAP) by comparing them with the National Comprehensive Cancer Network (NCCN) guidelines. METHODS: 369 patients who underwent upfront surgery for PDAC were retrospectively analyzed. Overall survival (OS) of each group as defined by either of the guidelines were compared and preoperative prognostic factors for OS were identified...
February 14, 2019: HPB: the Official Journal of the International Hepato Pancreato Biliary Association
Yexiong Li, Qinfu Feng, Jing Jin, Susheng Shi, Zhihui Zhang, Xu Che, Jianwei Zhang, Yingtai Chen, Xiuhong Wu, Rufu Chen, Shengping Li, Jing Wang, Guang Li, Fei Li, Menghua Dai, Lei Zheng, Chengfeng Wang
Pancreatic cancer (PC), one of the most lethal malignancies, accounts for 8% to 10% of digestive system cancers, and the incidence is increasing. Surgery, chemotherapy, and radiotherapy have been the main treatment methods but are not very effective. However, only 20% of patients have the opportunity to undergo surgical operation. Approximately 30-40% of patients present with locally advanced, unresectable pancreatic cancer because of invasion of mesenteric vessels or adjacent organs. The first patient with unresectable pancreatic cancer was treated with Intraoperative radiotherapy (IORT) in 1959[ 1 ] ...
February 13, 2019: Cancer Letters
Reto M Kaderli, Marko Spanjol, Attila Kollár, Lukas Bütikofer, Viktoria Gloy, Rebecca A Dumont, Christian A Seiler, Emanuel R Christ, Piotr Radojewski, Matthias Briel, Martin A Walter
Importance: Multiple therapies are currently available for patients with neuroendocrine tumors (NETs), yet many therapies have not been compared head-to-head within randomized clinical trials (RCTs). Objective: To assess the relative safety and efficacy of therapies for NETs. Data Sources: PubMed, Embase, the Cochrane Central Register of Controlled Trials, trial registries, meeting abstracts, and reference lists from January 1, 1947, to March 2, 2018, were searched...
February 14, 2019: JAMA Oncology
M Strijker, J W Chen, T H Mungroop, N B Jamieson, C H van Eijck, E W Steyerberg, J W Wilmink, B Groot Koerkamp, H W van Laarhoven, M G Besselink
BACKGROUND: As more therapeutic options for pancreatic cancer are becoming available, there is a need to improve outcome prediction to support shared decision-making. A systematic evaluation of prediction models in resectable pancreatic cancer is lacking. METHODS: This systematic review followed the CHARMS and PRISMA guidelines. PubMed, Embase and Cochrane Library databases were searched up to 11 October 2017. Studies reporting development or validation of models predicting survival in resectable pancreatic cancer were included...
February 13, 2019: British Journal of Surgery
Laura Pavel, Gheorghe Gh Bălan, Alexandra Nicorescu, Georgiana Emmanuela Gîlcă-Blanariu, Cătălin Sfarti, Ștefan Chiriac, Smaranda Diaconescu, Vasile Liviu Drug, Gheorghe Bălan, Gabriela Ștefănescu
BACKGROUND: Despite significant technical and training improvements, the incidence of post-endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis (PEP) has not significantly dropped. Although many studies have evaluated the efficacy of various agents, e.g . nonsteroidal anti-inflammatory drugs, octreotide, antioxidants, administered via various dosages, routes (oral, intrarectal or parenteral), and schedules (before or after the procedure), the results have been conflicting...
February 6, 2019: World Journal of Clinical Cases
Masaki Morimoto, Soichiro Honjo, Teruhisa Sakamoto, Takuki Yagyu, Ei Uchinaka, Masataka Amisaki, Joji Watanabe, Manabu Yamamoto, Yoji Fukumoto, Naruo Tokuyasu, Keigo Ashida, Hiroaki Saito, Yoshiyuki Fujiwara
OBJECTIVES: It is widely accepted that postoperative pancreatic fistula (POPF) accompanied by bacterial infection results in a worse outcome than POPF alone. However, few studies evaluating predictive indicators of POPF have focused on bacterial infection. METHODS: A consecutive 100 patients who underwent pancreaticoduodenectomy at our institute for periampullary disease were enrolled. POPF was assessed according to the International Study Group of Pancreatic Fistula consensus guidelines; grades B and C were defined as clinically relevant POPF (CR-POPF)...
January 29, 2019: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
Anjala Tess, Steven D Freedman, Tara Kent, Howard Libman
Acute pancreatitis, a common cause of hospitalization in the United States, is often the result of biliary tract disease. In 2016, the American Gastroenterological Association released a guideline that addresses the practical considerations in managing acute pancreatitis within the first 72 hours after the patient presents. The guideline specifically recommends goal-directed hydration therapy, early enteral feeding, judicious use of endoscopic retrograde cholangiopancreatography (ERCP), and gallbladder surgery during the index admission for patients with mild pancreatitis...
February 5, 2019: Annals of Internal Medicine
Shahad Alsadik, Siraj Yusuf, Adil Al-Nahhas
BACKGROUND: The incidence of pancreatic neuroendocrine tumours (pNETs) has increased considerably in the last few decades. The characteristic features of this tumour and the development of new investigative and therapeutic methods had a great impact on its management. OBJECTIVE: The aim of this review is to investigate the outcome of Peptide Receptor Radionuclide Therapy (PRRT) in treatment of pancreatic neuroendocrine tumours. METHODS: A comprehensive literature search strategy was used based on two databases (SCOPUS, and PubMed)...
February 1, 2019: Current Radiopharmaceuticals
Courtney J Pokrzywa, Daniel E Abbott, Kristina A Matkowskyj, Sean M Ronnekleiv-Kelly, Emily R Winslow, Sharon M Weber, Alexander V Fisher
BACKGROUND: While pancreatic ductal adenocarcinoma is the most common form of pancreatic cancer, many other histologic forms of pancreatic cancer are also recognized. These histologic variants portray unique characteristics in terms of patient demographics, tumor behavior, survival, and responsiveness to treatments. MATERIALS AND METHODS: Patients who underwent surgical resection of the pancreas for non-metastatic, invasive pancreatic cancer between 2004 and 2014 were selected from the National Cancer Data Base and categorized by histologic variant according to WHO classification guidelines...
January 31, 2019: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
Serin Cooper Maidlow, Michael Ardagh, Rosie Callender, Oliver Thomas
AIM: Hospital HealthPathways is an online database of local clinical guidelines produced by a dedicated team for use within Canterbury District Health Board (CDHB) hospitals. A 'Practice Point'-a bullet point making explicit a recommendation within the body of a clinical guideline-was added to the guideline for acute pancreatitis, instructing users to avoid serial measurements of serum amylase levels. The aim was to explore whether the addition of this Practice Point affected compliance with the amylase measurement recommendations...
February 1, 2019: New Zealand Medical Journal
Ewa Grudzińska, Joanna Pilch-Kowalczyk, Katarzyna Kuśnierz
RATIONALE: Pancreaticopleural and pancreaticomediastinal fistulas are rare complications of pancreatitis. They are often misdiagnosed and there are no strict guidelines of treatment. In this study, we present a brief report of a combined pancreaticopleural and pancreaticomediastinal fistula extending to the cervical region, causing dysphagia and cervical swelling as initial symptoms. PATIENT CONCERNS: A 36-year-old female with history of alcohol abuse and pancreatitis presented progressing dysphagia and mild dyspnea on admission...
February 2019: Medicine (Baltimore)
Luís Lopes, Jorge Canena
Background/Aims: Recently the European Society of Gastrointestinal Endoscopy delivered guidelines on the prevention of post-endoscopic retrograde cholangiopancreatography pancreatitis (PEP) and on the papillary cannulation and sphincterotomy techniques at endoscopic retrograde cholangiopancreatography (ERCP). There are no data concerning current practices in Portugal. The aim of this study was to capture practice patterns of Portuguese pancreaticobiliary endoscopists with special interest in the prevention of PEP and cannulation techniques...
December 2018: GE Portuguese journal of gastroenterology
Ricardo Rio-Tinto, Jacques Devière
No abstract text is available yet for this article.
December 2018: GE Portuguese Journal of Gastroenterology
Marco Del Chiaro, Ross Beckman, Zeeshan Ateeb, Nicola Orsini, Neda Rezaee, Lindsey Manos, Roberto Valente, Chunhui Yuan, Ding Ding, Georgios A Margonis, Lingdi Yin, John L Cameron, Martin A Makary, Richard A Burkhart, Matthew J Weiss, Jin He, Urban Arnelo, Jun Yu, Christopher L Wolfgang
MINI: This retrospective analysis of 901 patients who underwent pancreatic resection for IPMN shows significant risk of malignancy associated with main duct dilatation greater than 5 mm. While previous studies and guidelines have focused on a 10 mm cutoff for criteria for resection, we provide evidence that lower levels of dilatation may warrant consideration for surgery as well. OBJECTIVE: The purpose of this study is to determine preoperative factors that are predictive of malignancy in patients undergoing pancreatic resection for intraductal papillary mucinous neoplasms (IPMN)...
January 18, 2019: Annals of Surgery
Dimitri Declercq, Svenya Van Meerhaeghe, Sophie Marchand, Eva Van Braeckel, Sabine van Daele, Frans De Baets, Stephanie Van Biervliet
BACKGROUND: Nutritional therapy is one of the cornerstones in cystic fibrosis (CF) therapy. There is a strong association between nutritional status and pulmonary function and thus longevity. Therefore nutritional therapy should be continuously adapted to preserve or improve the nutritional status. This narrative review was written to reconsider nutritional therapy in CF based on the latest evidence available since the publication of the ESPEN - ESPGHAN - ECFS guidelines on nutrition care for infants, children and adults with CF...
February 2019: Clinical Nutrition ESPEN
J Jokelainen, S Ismail, L Kylänpää, M Udd, H Mustonen, O Lindström, R Pöyhiä
BACKGROUND AND AIMS: Several studies and guidelines are questioning routine preoperative laboratory tests in surgical and endoscopic procedures. Their effect in endoscopic retrograde cholangiopancreatography is not currently known. This study was carried out to evaluate the risk of adverse effects in endoscopic retrograde cholangiopancreatography and their association with preoperative lab tests. MATERIALS AND METHODS: A single-center, prospective observational study on all 956 patients undergoing 1196 endoscopic retrograde cholangiopancreatographies in the Endoscopy Unit of Helsinki University Central Hospital from 1 March 2012 to 28 February 2013...
January 17, 2019: Scandinavian Journal of Surgery: SJS
Armelle deLaforcade, Lenore Bacek, Marie-Claude Blais, Robert Goggs, Alex Lynch, Elizabeth Rozanski
OBJECTIVES: Thrombosis is a well-recognized phenomenon in dogs and cats with a significant impact on morbidity and mortality. Despite growing awareness of thrombosis and increased use of antithrombotic therapy, there is little information in the veterinary literature to guide the use of anticoagulant and antiplatelet medications. The goal of Domain 1 was to explore the association between disease and thrombosis in a number of conditions identified as potential risk factors in the current veterinary literature, to provide the basis for prescribing recommendations...
January 2019: Journal of Veterinary Emergency and Critical Care
Jean-Marc Dumonceau, Myriam Delhaye, Andrea Tringali, Marianna Arvanitakis, Andres Sanchez-Yague, Thierry Vaysse, Guruprasad P Aithal, Andrea Anderloni, Marco Bruno, Paolo Cantú, Jacques Devière, Juan Enrique Domínguez-Muñoz, Selma Lekkerkerker, Jan-Werner Poley, Mohan Ramchandani, Nageshwar Reddy, Jeanin E van Hooft
ESGE suggests endoscopic therapy and/or extracorporeal shockwave lithotripsy (ESWL) as the first-line therapy for painful uncomplicated chronic pancreatitis (CP) with an obstructed main pancreatic duct (MPD) in the head/body of the pancreas. The clinical response should be evaluated at 6 - 8 weeks; if it appears unsatisfactory, the patient's case should be discussed again in a multidisciplinary team and surgical options should be considered.Weak recommendation, low quality evidence.ESGE suggests, for the selection of patients for initial or continued endoscopic therapy and/or ESWL, taking into consideration predictive factors associated with a good long-term outcome...
January 17, 2019: Endoscopy
Hirokazu Saito, Takehiko Koga, Masafumi Sakaguchi, Yoshihiro Kadono, Kentaro Kamikawa, Atsushi Urata, Haruo Imamura, Shuji Tada, Tatsuyuki Kakuma, Ikuo Matsushita
BACKGROUND AND AIM: For asymptomatic common bile duct (CBD) stones, removal by endoscopic retrograde cholangiopancreatography (ERCP) is recommended in available guidelines. However, few studies have reported the risk of post-ERCP pancreatitis (PEP), which is the most common and serious ERCP-related complication for asymptomatic CBD stones. We performed a propensity-score-matching analysis to examine the risk of PEP in therapeutic ERCP for asymptomatic CBD stones. METHODS: Information from medical databases of three institutions in Japan was collected over 6 years to identify 1,113 patients with native papilla who underwent therapeutic ERCP for choledocholithiasis (excluding biliary pancreatitis)...
January 16, 2019: Journal of Gastroenterology and Hepatology
Hiroshi Kurahara, Hiroyuki Shinchi, Takao Ohtsuka, Yoshihiro Miyasaka, Taketo Matsunaga, Hirokazu Noshiro, Tomohiko Adachi, Susumu Eguchi, Naoya Imamura, Atsushi Nanashima, Kazuhiko Sakamoto, Hiroaki Nagano, Masayuki Ohta, Masafumi Inomata, Akira Chikamoto, Hideo Baba, Yusuke Watanabe, Kazuyoshi Nishihara, Masafumi Yasunaga, Koji Okuda, Shoji Natsugoe, Masafumi Nakamura
PURPOSE: Neoadjuvant therapy (NAT) is increasingly used to improve the prognosis of patients with borderline resectable pancreatic cancer (BRPC) albeit with little evidence of its advantage over upfront surgical resection. We analyzed the prognostic impact of NAT on patients with BRPC in a multicenter retrospective study. METHODS: Medical data of 165 consecutive patients who underwent treatment for BRPC between January 2010 and December 2014 were collected from ten institutions...
January 16, 2019: Langenbeck's Archives of Surgery
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