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Daniela Iannazzo, Alessandro Pistone, Consuelo Celesti, Claudia Triolo, Salvatore Patané, Salvatore V Giofré, Roberto Romeo, Ida Ziccarelli, Raffaella Mancuso, Bartolo Gabriele, Giuseppa Visalli, Alessio Facciolà, Angela Di Pietro
Graphene quantum dots (GQD), the new generation members of graphene-family, have shown promising applications in anticancer therapy. In this study, we report the synthesis of a fluorescent and biocompatible nanovector, based on GQD, for the targeted delivery of an anticancer drug with benzofuran structure (BFG) and bearing the targeting ligand riboflavin (RF, vitamin B2). The highly water-dispersible nanoparticles, synthesized from multi-walled carbon nanotubes (MWCNT) by prolonged acidic treatment, were linked covalently to the drug by means of a cleavable PEG linker while the targeting ligand RF was conjugated to the GQD by π⁻π interaction using a pyrene linker...
February 18, 2019: Nanomaterials
Łukasz Janus, Marek Piątkowski, Julia Radwan-Pragłowska, Dariusz Bogdał, Dalibor Matysek
Rapid development in medicine and pharmacy has created a need for novel biomaterials with advanced properties such as photoluminescence, biocompability and long-term stability. The following research deals with the preparation of novel types of N -doped chitosan-based carbon quantum dots. Nanomaterials were obtained with simultaneous nitrogen-doping using biocompatible amino acids according to Green Chemistry principles. For the carbon quantum dots synthesis chitosan was used as a raw material known for its biocompability...
February 16, 2019: Nanomaterials
Jianjun Du, Ning Xu, Jiangli Fan, Wen Sun, Xiaojun Peng
Carbon dots (CDs), a kind of carbon material discovered accidentally, exhibit unexpected advantages in fluorescence imaging/sensing such as photostability, biocompatibility, and low toxicity. For emerging theranostics, an interdiscipline created by integrating therapy and diagnostics, CDs are good candidates when they are combined with targeted chemo/gene/photodynamic/photothermal therapeutic moieties. Here, the development of CDs in nanomedicine is reviewed from their use as original imaging agents and/or drug carriers to multifunctional theranostic systems...
February 18, 2019: Small
Furkan Ayaz, Melis Özge Alaş, Melike Oğuz, Rükan Genç
In this manuscript, we aimed to report the synthesis of aluminum (Al) incorporated carbon nanodots (CD) and their activities on the immune cells. A green synthesis method involving the in situ doping of the nanodot was conducted. Synthesized nanodots immunomodulatory and immunostimulatory activities were tested in vitro on the macrophages. The produced carbon dots were water-soluble, fluorescent and monodispersed, with an average diameter of around 10-20 nm. After Al-doping, their surface properties, stability, crystallinity, as well as their fluorescent and optical properties were evaluated...
February 18, 2019: Molecular Biology Reports
Ningqiang Gong, Xiaowei Ma, Xiaoxia Ye, Qunfang Zhou, Xiaoai Chen, Xiaoli Tan, Shengkun Yao, Shuaidong Huo, Tingbin Zhang, Shizhu Chen, Xucong Teng, Xixue Hu, Jie Yu, Yaling Gan, Huaidong Jiang, Jinghong Li, Xing-Jie Liang
Mitochondrial redox homeostasis, the balance between reactive oxygen species and antioxidants such as glutathione, plays critical roles in many biological processes, including biosynthesis and apoptosis, and thus is a potential target for cancer treatment. Here, we report a mitochondrial oxidative stress amplifier, MitoCAT-g, which consists of carbon-dot-supported atomically dispersed gold (CAT-g) with further surface modifications of triphenylphosphine and cinnamaldehyde. We find that the MitoCAT-g particles specifically target mitochondria and deplete mitochondrial glutathione with atomic economy, thus amplifying the reactive oxygen species damage caused by cinnamaldehyde and finally leading to apoptosis in cancer cells...
February 18, 2019: Nature Nanotechnology
Maryam Jodeyri, Mohammad Haghighi, Maryam Shabani
In this study, the plasmon silver/bulk graphitic carbon nitride-clinoptilolite (denoted as: Ag/BCN-CLT) nanophotocatalysts synthesized using sono-photoreduction dispersion of Ag over C3 N4 nanophotocatalyst with various contents of acid-treated clinoptilolite (10, 20, 40 wt%) that was employed in the tetracycline degradation, as the model antibiotic pollutant, using simulated solar-light radiation. X-ray diffraction, field emission scanning electron microscopy, Energy-dispersive X-ray spectroscopy-Dot mapping, Brunauer-Emmett-Teller and Barrett-Joyner-Halenda, particle size distribution, and Ultraviolet-Visible diffuse reflectance spectroscopy analyses results showed a high quality of synthesis of nanophotocatalysts and good dispersion of particles on the surface of nanophotocatalyst...
January 30, 2019: Ultrasonics Sonochemistry
Shaohui Zheng, Nana Yu, Cuiping Han, Ting Xie, Binru Dou, Ying Kong, Fengmei Zuo, Meilin Shi, Kai Xu
Gadolinium doped carbon dots (Gd-CDs) were prepared as a dual-modal imaging agent for enhanced MR imaging and cell fluorescence imaging. The Gd-CDs were synthesized via one-step solvent free technique with Gd-DTPA and l-arginine as the Gd and carbon sources with a quantum yield of 57.78%. The Gd-CDs exhibited good crystal structure, excellent aqueous dispersity, high colloidal stability, intense fluorescence and low cytotoxicity. The bio-TEM images revealed that the Gd-CDs could be easily internalized by cancer cells and escape from the endosomes...
February 15, 2019: Biochemical and Biophysical Research Communications
Wei Yang, Bing Wei, Zheng Yang, Liangquan Sheng
Due to the traditional therapies of cancer inducing huge pains to patients, the non-invasive photo-guided therapies are attracting massive attentions of researchers. Herein, the intelligent-designed carbon-dots/hemin nanoplatforms (HCDs NPs) were developed, owning high-authority photo-therapy for cancer. The fluorescence resonance energy transfer (FRET) effect enhanced the photo-thermal ability of HCDs NPs, endowing the synthesized nanoplatforms with photo-dynamic property simultaneously. Therefore, the obtained HCDs NPs could achieve synergetic photo-thermal and photo-dynamic therapies for cancer...
February 1, 2019: Journal of Inorganic Biochemistry
Shaomei Xu, Songtian Che, Pinyi Ma, Fangmei Zhang, Longbin Xu, Xin Liu, Xinghua Wang, Daqian Song, Ying Sun
Typically, sialic acids (SA) with a nine-carbon backbone are found at the glycan chain termini on the cell membranes, which play crucial roles in various physiological and pathological processes. The expression level of SA in the blood serum has been reported to correlate with various disease states among cancer. In this study, a novel approach for preparing fluorescent boronic-acid-modified carbon dots (C-dots) for the detection of SA was developed. The functionalized C-dots were synthesized by a facile, one-step hydrothermal method using 3-pyridineboronic acid as the sole carbon source...
May 15, 2019: Talanta
Cengceng Zhang, Hui Zhang, Yuanyuan Yu, Shu Wu, Fang Chen
A kind of nitrogen doped carbon dots (NCDs) with excellent stable luminescence performance was prepared by pyrolysis using ethanolamine as precursor. By simply mixing solution of NCDs and calcein-Eu3+ , a ratio fluorometric probe with carbon dots as "internal reference" and calcein-Eu3+ as recognition group was constructed for ATP detection. The fluorescence of the calcein can be selectively quenched by Eu3+ , and can be restored when ATP was added because Eu3+ ions exhibit higher affinity to the oxygen-donor atoms originated from phosphates than that from carboxylate groups...
May 15, 2019: Talanta
Wenxiao Gai, Die Ling Zhao, Tai-Shung Chung
We have incorporated Na+ -functionalized carbon quantum dots (Na-CQDs) into the polyamide layer via interfacial polymerization reaction and developed novel thin film nanocomposite (TFN) hollow fiber membranes for brackish water desalination. Comparing with the conventional thin film composite (TFC) membranes, the TFN membranes comprising Na-CQDs have a larger effective surface area, thinner polyamide layer and more hydrophilic oxygen-containing groups in the polyamide layer. Besides, the interstitial space among the polyamide chains becomes larger due to the presence of Na-CQDs...
February 4, 2019: Water Research
Zhenyuan Ji, Na Li, Yifei Zhang, Minghua Xie, Xiaoping Shen, Lizhi Chen, Keqiang Xu, Guoxing Zhu
Owing to their unique electronic properties and capability to host diverse functional groups on the surface, carbon dots (CDs) have attracted increasing attention in energy storage field. Herein, ultrathin nitrogen-doped carbon dots (NCDs) decorated nickel hydroxide (Ni(OH)2 ) nanosheets were fabricated by a facile hydrothermal approach, where NCDs play an important role as a structure-directing agent in tuning the size and thickness of the Ni(OH)2 . With the merits of the battery-type faradaic behavior of Ni(OH)2 and high electronic properties of NCDs, the achieved Ni(OH)2 /NCDs ultrathin nanosheets show a specific capacitance of about 1711...
February 11, 2019: Journal of Colloid and Interface Science
Kristian E Dalle, Julien Warnan, Jane J Leung, Bertrand Reuillard, Isabell S Karmel, Erwin Reisner
The synthesis of renewable fuels from abundant water or the greenhouse gas CO2 is a major step toward creating sustainable and scalable energy storage technologies. In the last few decades, much attention has focused on the development of nonprecious metal-based catalysts and, in more recent years, their integration in solid-state support materials and devices that operate in water. This review surveys the literature on 3d metal-based molecular catalysts and focuses on their immobilization on heterogeneous solid-state supports for electro-, photo-, and photoelectrocatalytic synthesis of fuels in aqueous media...
February 15, 2019: Chemical Reviews
Yu-Juan Chen, Zhao-En Liu, Qian Yang, Chun-Feng Wang, Ke-Lei Zhuo
A facile one-pot hydrothermal method for fabricating nitrogen-doped carbon dots (N-CDs) was developed by using citric acid as a carbon source and guanidine carbonate as a nitrogen and carbon source. X-ray diffraction, X-ray photoelectron spectroscopy, and Fourier transform infrared spectra indicated that the N-CDs were rich in elemental nitrogen. They had excellent stability in the presence of various salt concentrations and under UV irradiation. The N-CDs exhibited high quantum yields (52%), as well as down-conversion and up-conversion photoluminescence...
July 1, 2019: Journal of Nanoscience and Nanotechnology
Weicong Kuang, Qing Zhong, Xiaoli Ye, Yayuan Yan, Yunhua Yang, Jingxian Zhang, Langhuan Huang, Shaozao Tan, Qingshan Shi
Due to secondary pollution from bactericidal substances, the importance of eliminating microbial contamination has become a controversial topic. Three antibacterial nanorod materials of carbon quantum dots-zinc oxide (1/3CQDs-ZnO, CQDs-ZnO, and 2CQDs-ZnO), in which ZnO nanorods are surrounded by carbon quantum dots (CQDs), were successful prepared via in-situ sol-gel chemistry. Antibacterial nanorods of CQDs-ZnO had strong antibacterial activity under visible light irradiation, and a concentration of 0.1 mg/L was able to kill more than 96% of bacteria...
July 1, 2019: Journal of Nanoscience and Nanotechnology
Zhiqiang Ji, Enkeleda Dervishi, Stephen K Doorn, Milan Sykora
Electronic structure of a series of bottom-up synthesized GQDs smaller than 2 nm was investigated by ensemble level spectro-electrochemistry, yielding insights not available previously from ensemble studies. The results show that for the strongly confined GQDs the dependence of the band gap on the GQD size deviates from the prediction of the standard Dirac fermion model, but agrees well with the models explicitly accounting for the electron-electron interactions. The HOMO/LUMO energy levels are found to be distributed nearly symmetrically around the 0V value vs...
February 14, 2019: Journal of Physical Chemistry Letters
D Bharathi, R Hari Krishna, B Siddlingeshwar, Darshan Devang Divakar, Abdulaziz Abdullah Alkheraif
In spite copper oxide being one of the essential micronutrient, copper oxide in its nano size is found to be toxic in nature; this instigates for the detection of copper oxides in trace levels. In the present study, we demonstrate simple cost effective detection method for CuO/Cu2 O using carbon quantum dots (CQD) by fluorescence quenching technique. CuO/Cu2 O nanoparticles are synthesised by mere variation of fuel ratio by solution combustion technique. The resulting oxides are characterized by various analytical and spectroscopic techniques...
February 4, 2019: Journal of Hazardous Materials
Jianying Wang, Yuhua Zhu, Lei Wang
Carbon dots (CDs), a new class of fluorescent carbon nanoparticles (less than 10 nm in size), have been widely applied in various fields, including sensors, bioimaging, catalysis, light-emitting devices (LEDs), and photoelectronic devices, owing to their unique properties such as low toxicity, bio-compatibility, high photostability, easy surface modification, and up-conversion fluorescence, over the past decades. Recently, multiple-color-emissive CDs, especially red-emissive CDs (RCDs), have drawn much attention owing to their unique advantages, like the ability to penetrate the animal bodies without the disturbance of strong tissue autofluorescence, multiple-color fluorescence displaying or sensing, and the capacity to be one essential component to obtain white LED (WLED)...
February 14, 2019: Chemical Record: An Official Publication of the Chemical Society of Japan ... [et Al.]
Jiyang Li, Bolun Wang, Hongyue Zhang, Jihong Yu
As a new class of luminescent nanomaterials, carbon dots (CDs) have aroused significant interest because of their fascinating photoluminescence properties and potential applications in biological, optoelectronic, and energy-related fields. Strikingly, embedding CDs in host matrices endow them with intriguing luminescent properties, in particular, room temperature phosphorescence and thermally activated delayed fluorescence, due to the confinement effect of the host matrix and the H-bonding interactions between CDs and the matrix...
February 13, 2019: Small
Xinjing Wei, Li Li, Jinlong Liu, Lidong Yu, Hongbin Li, Feng Cheng, Xiaotong Yi, Jinmei He, Bingsheng Li
Fluorescent carbon dots (CDs) have been synthesized by a calcination method using natural gynostemma as precursor, without any toxic ingredients or surface passivation chemicals. The obtained CDs have a narrow size distribution and the average particle diameter is about 2.5 nm. The CDs exhibit good water dispersibility and emits intense blue fluorescence under 360 nm UV light in an aqueous solution, which can be stable in different conditions. The biotoxicity of CDs on the embryonic development of zebrafish are evaluated, the hatch rate and the survival rate of embryos are around 90%, the malformation rate is less than 10%...
February 13, 2019: ACS Applied Materials & Interfaces
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