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Fugal infection

Jun Zi Zhu, Hong Jian Zhu, Bi Da Gao, Qian Zhou, Jie Zhong
Sclerotium rolfsii , which causes southern blight in a wide variety of crops, is a devastating plant pathogen worldwide. Mycoviruses that induce hypovirulence in phytopathogenic fungi are potential biological control resources against fungal plant diseases. However, in S. rolfsii , mycoviruses are rarely reported. In a previous study, we found a hypovirulent strain carrying a diverse pattern of dsRNAs. Here, we utilized the RNA_Seq technique to detect viral sequences. Deep sequencing, RT-PCR and Sanger sequencing validation analyses revealed that this strain harbors various new viral species that show affinity to the distinctly established and proposed families Benyviridae, Endornaviridae , Fusariviridae, Hypoviridae , and Fusagraviridae...
2018: Frontiers in Plant Science
Mario Ro Barsottini, Bárbara A Pires, Maria L Vieira, José Gc Pereira, Paulo Cs Costa, Jaqueline Sanitá, Alessandro Coradini, Fellipe Mello, Cidnei Marschalk, Eder M Silva, Daniele Paschoal, Antonio Figueira, Fábio Hs Rodrigues, Artur T Cordeiro, Paulo Cml Miranda, Paulo Sl Oliveira, Maurício L Sforça, Marcelo F Carazzolle, Silvana A Rocco, Gonçalo Ag Pereira
BACKGROUND: Moniliophthora perniciosa (Stahel) Aime & Phillips-Mora is the causal agent of witches' broom disease (WBD) of cocoa (Theobroma cacao L.) and a threat to the chocolate industry. The membrane-bound enzyme alternative oxidase (AOX) is critical for M. perniciosa virulence and resistance to fungicides, which has also been observed in other phytopathogens. Notably AOX is an escape mechanism from strobilurins and other respiration inhibitors, making AOX a promising target for controlling WBD and other fungal diseases...
October 22, 2018: Pest Management Science
Ghadeer I Basunbul, Abdulelah M BinMahfooz, Khaled K El-Din Amin, Mosa M Altassan, Osama A Qutub, Sahar Mn Bukhary
AIM: The purpose of this in vitro study is to compare the bond strength to denture acrylics efficacy of miconazole gel against two denture adhesives with improved retentive properties (zinc-free PoliGrip cream and Snug denture soft cushion). MATERIALS AND METHODS: Eight heat-cured acrylic samples were prepared measuring 0.7 cm × 1.4 cm flat tested surface. The two well-adapted tested surfaces were matched and fixed to Universal Testing Machine clamp. Vertical separating load was applied at a rate of 1 mm/min to yield the maximum load before denture adhesive failure occurs...
August 1, 2018: Journal of Contemporary Dental Practice
C Quan, X Li, R-F Shi, X-Q Zhao, H Xu, B Wang, X-P Wang, W-G Hu, C Hua, J Zheng
CARD9 (caspase recruitment domain-containing protein 9) deficiency has been reported in individuals with recurrent and invasive fugal infections. We reported a patient first suffered from Trichosporon Asahii (T. asahii) affecting skin, and then Candida albicans (C. albicans) infections involving digestive tract and joint, along with elevated serum IgE. After stimulation with C. albicans, PBMCs of this patient produced less TNF-a, IFN-γ and IL-17 than health controls. Furthermore, serum IgE levels of this patient were positively correlated with the severity of fungal infection during the course of treatment...
August 16, 2018: British Journal of Dermatology
Sanjeev Sharma, Deepak Bajaj, Pritika Sharma
INTRODUCTION: Burn Wound Infection (BWI) is primarily caused by aerobic bacteria followed by fungi, anaerobes and viruses. There has been a worldwide decrease in incidence of bacterial infections in burns due to better patient care and availability of effective antibiotics. Consequently, the fungal burn wound infection has shown an increasing trend. AIM: The aim of study was to assess the frequency of fungal infections in thermal burn wounds with respect to age of wounds, total body surface involved, depth of burns and to assess common fungal pathogens...
September 2016: Journal of Clinical and Diagnostic Research: JCDR
Yuki Shinya, Satoru Miyawaki, Hirofumi Nakatomi, Atsushi Okano, Hideaki Imai, Masahiro Shin, Kazuya Sato, Takeyuki Tsuchida, Toshihiro Hayashi, Yasuo Terao, Satoe Numakura, Teppei Morikawa, Junji Shibahara, Shu Kikuta, Kenji Kondo, Keita Tatsuno, Harushi Mori, Akira Kunimatsu, Shoji Tsuji, Nobuhito Saito
Destructive infiltration of invasive fungal sinusitis can easily occur into the central nervous system (CNS). Cerebral aneurysms associated with fungal infection are highly vulnerable to rupture, and can frequently and rapidly take a serious clinical course. We experienced a patient who twice developed cerebral aneurysm followed by rupture due to invasive fugal sinusitis. This 77-year-old man was admitted for progressive bilateral visual disturbance, which was initially treated as idiopathic hypertrophic pachymeningitis...
2015: International Journal of Clinical and Experimental Pathology
Xueping Yue, Qing Li, Hongwei Wang, Yilin Sun, Aiping Wang, Qi Zhang, Cuiping Zhang
BACKGROUND: Trichophyton rubrum (T.rubrum) caused onychomycosis is the most common nail fungal disease. The common diagnostic methods are direct microscopic examination and fungal culture. In this study we used scanning electron microscopy (SEM) and transmission electron microscopy (TEM) to study the subungual ultrastructural changes in T. rubrum induced onychomycosis. METHODS: Six outpatients with onychomycosis were recruited and T.rubrum infection was confirmed by fungal culture...
2015: BMC Infectious Diseases
Abdul Karim, Yuanzhong Jiang, Li Guo, Zhengyi Ling, Shenglong Ye, Yanjiao Duan, Chaofeng Li, Keming Luo
Salicylic acid (SA) is a defense-related key signaling molecule involved in plant immunity. In this study, a subgroup IIa WRKY gene PtrWRKY40 was isolated from Populus trichocarpa, which displayed amino acid sequence similar to Arabidopsis AtWRKY40, AtWRKY18 and AtWRKY60. PtrWRKY40 transcripts accumulated significantly in response to SA, methyl jasmonate and hemibiotrophic fungus Dothiorella gregaria Sacc. Overexpression of PtrWRKY40 in transgenic poplar conferred higher susceptibility to D. gregaria infection...
October 2015: Tree Physiology
Yu'e Wu, Fangui Min, Jinchun Pan, Jing Wang, Wen Yuan, Yu Zhang, Ren Huang, Lixin Zhang
This study was to establish a systemic C. parapsilosis infection model in immunosuppressed ICR mice induced by cyclophosphamide and evaluate the antifungal efficiency of fluconazole. Three experiments were set to confirm the optimal infectious dose of C. parapsilosis, outcomes of infectious model, and antifungal efficiency of fluconazole in vivo, respectively. In the first experiment, comparisons of survival proportions between different infectious doses treated groups showed that the optimal inoculum for C...
2015: Veterinary Medicine International
H Teixeira, L Silva, J J F Magalhães, C Matias, J F F Magalhães, J M A Lyra, V Magalhães, N Lucena-Silva, H R L Melo, M B Jucá, C A A Brito
In febrile neutropenic onco-hematological patients, delayed microbiological diagnosis leads to an increase in morbidity and mortality. Identification of the microorganism changes antibiotic therapy in more than half of cases; however, in only 20-30 % of such cases pathogen isolation is achieved. This study evaluates the frequency of fungus infection and its etiology in onco-hematological patients with febrile neutropenia utilizing blood cultures and non-commercial multiplex polymerase chain reaction (MT-PCR) primers...
October 2014: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
Babak Sharifkashani, Maham Farshidpour, Atousa Droudinia, Majid Marjani, Zargham Ahmadi, Zahra Ansari, Mohsen Mirhosseini, Neda Behzadnia, Davood Mansouri, Payam Tabarsi
Cutaneous alternariosis infection occurs mainly in immunocompromised individuals. The incidence of alternariosis in a heart transplant recipient is infrequent. Coincidence of the aforementioned infection with additional fugal agents is rare. We describe a case of alternariosis with Trichosporon fungal infection in a patient who was successfully treated with combined antifungal therapy, modulation of immunosuppressive regimen, and blood glucose management. The patient had a good response to treatment, and has had an uneventful 1-year follow-up at the time of this writing...
October 2013: Experimental and Clinical Transplantation
Pitchamuthu Abirami, Muthiah Gomathinayagam, Rajaram Panneerselvam
OBJECTIVE: To study the antimicrobial activity of Enicostemma littorale (E. littorale) using different solvents. METHODS: Chloroform, methanol and acetone extracts of different parts of E. littorale (leaf, stem and root) were evaluated for antimicrobial activity using disc diffusion method against some gram-negative species such as Escherichia coli, Klebsiella pnemoniae, Pseudomonas aeruginosa, Salmonella typhi and gram-positive species Staphylococcus aureus, Bacillus cereus, Bacillus subtilis and two fugal species viz...
July 2012: Asian Pacific Journal of Tropical Medicine
Phillip Stafford, Rebecca Halperin, Joseph Bart Legutki, Dewey Mitchell Magee, John Galgiani, Stephen Albert Johnston
Identifying new, effective biomarkers for diseases is proving to be a challenging problem. We have proposed that antibodies may offer a solution to this problem. The physical features and abundance of antibodies make them ideal biomarkers. Additionally, antibodies are often elicited early in the ontogeny of different chronic and infectious diseases. We previously reported that antibodies from patients with infectious disease and separately those with Alzheimer's disease display a characteristic and reproducible "immunosignature" on a microarray of 10,000 random sequence peptides...
April 2012: Molecular & Cellular Proteomics: MCP
Xu Yang, Ke Lei
OBJECTIVE: To improve the cognition of fungal ball sinusitis (FB) for diagnosing and treatting it rightly, we retrospectively analyzed the hospitalization cases. METHOD: We analyzed 98 cases FB patients' first symptom, acoustic rhinometry, CT manifestation, operation fashion. RESULT: The first symptoms of FB include: 47.2% nosebleed, 38.8% snuffle, 28.6% headache and face-ache, 4.0% nasal peculiar smell, 2.0% excessive tear, 4.0% no symptom...
September 2011: Journal of Clinical Otorhinolaryngology, Head, and Neck Surgery
Jinsup Kim, Dae Sung Kim, Yong Seong Lee, Nak Gyeu Choi
PURPOSE: It is well known that fungi become predominant microorganisms in the urine of patients with long-term Foley catheters. This study was conducted to evaluate the lengths of time for fungi to cause urinary tract infection (UTI) and to identify predictors of fungal UTI in burn patients with long-term Foley catheters. MATERIALS AND METHODS: A total of 93 patients who did not have infection at the time of admission but later had fugal UTI were evaluated. Urinalysis, urine culture, and Foley catheter indwelling were done at admission...
September 2011: Korean Journal of Urology
Ming-yu Chen, Le-dong Sun, Jia Zhao, Kang Zeng
OBJECTIVE: To establish a rapid, sensitive and specific method based on multiplex fluorescent quantitative PCR for detection of deep infections with Candida albicans and Aspergillus flavus in patients with systemic lupus erythematosus (SLE). METHODS: Two pairs of primers and Taqman probes were designed according to the gene sequences of Candida albicans and Aspergillus flavus available in American Type Culture Collection. The positivity rate, sensitivity and specificity of the multiplex fluorescent quantitative PCR-based method for detecting the fungal infection was tested in 20 specimens from SLE patients with Candida albicans and Aspergillus flavus infections, 20 specimens from SLE patients with suspected deep fungal infections, and 20 microbial samples other than Candida albicans or Aspergillus flavus...
October 2009: Nan Fang Yi Ke da Xue Xue Bao, Journal of Southern Medical University
Hiroshi Egusa, Niroshani S Soysa, Arjuna N Ellepola, Hirofumi Yatani, Lakshman P Samaranayake
Oral candidosis (syn. Oral candidiasis; OC), is a collective term given to a group of oral mucosal disorders caused by the fugal pathogen belonging to the genus Candida. The association of OC with the human immunodeficiency virus (HIV) infection has been known since the advent of the acquired immune deficiency syndrome (AIDS) pandemic. OC is one of the earliest manifestations of HIV disease in high risk individuals not undergoing chemotherapy and is also a strong predictor of the subsequent risk of AIDS-related illness or death...
November 2008: Current HIV Research
Xin-yu Hong, Yu-Cheng Chou, Jorge A Lazareff
BACKGROUND: Infectious process can mimic cerebral tumors. We present the first report of a fugal infection in brainstem mimicking cerebral tumors in the literature. CASE DESCRIPTION: A 17-month-old boy presented with abnormal movements of his left arm and difficulty walking for 2 weeks. The MRI of the patient showed an enhancing partially cystic and partially solid mass in the right CP angle cistern, interpreting as CP tumor. On MRS, there was a decreased N-acetylaspartate/Creatine ratio and an elevated choline/Cr ratio...
July 2008: Surgical Neurology
P Manzoni, M Monstert, G Agriesti, C Priolo, P Galletto, D Farina
Candida spp is the 3rd most frequent cause of sepsis in preterm infants, with high attributable mortality and poor outcome. Neonatal fugal infections include bloodstream, urine, cerebrospinal and peritoneal infections. Preterm infants display specific, often unavoidable, risk factors for SFI, with fungal colonization being the most significant one. Prompt treatment does not prevent poor long-term neurodevelopmental outcomes. Thus, prevention is the milestone, and should mainly rely on the administration of targeted prophylactic fluconazole to high-risk infants, as recently demonstrated by a large Italian multicenter study...
October 2007: Journal of Chemotherapy
D El Euch, F Ben Ammar, M Ben Sassi, M Mokni, S Mezlini, H Abidi, A Ben Osman Dhahri
The object of our study is to release the epidemiological, clinical and mycological characteristics of superficial fugal infections. A retrospective study was carried out during three years (1996-1998). Direct microscopy was positive in 86% cases, the culture in 62% cases. Trichophyton rubrum accounts for 85% of the dermatophytic flora. The superficial fugal infections account for 15% of the reasons for consultation in our service. They would touch according to data's of literature 2 to 13% of the general population...
July 2006: La Tunisie Médicale
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