keyword
https://read.qxmd.com/read/36838531/potential-treatment-of-dermatophyte-trichophyton-rubrum-in-rat-model-using-topical-green-biosynthesized-silver-nanoparticles-with-achillea-santolina-extract
#1
JOURNAL ARTICLE
Basem M Abdallah, Peramaiyan Rajendran, Enas M Ali
Trichophyton rubrum is the most common dermatophyte, and can cause cutaneous infections in humans and animals (dermatophytosis). In this study, we investigated the anti-dermatophytic potential of green synthesized silver nanoparticles using Achillea santolina extract (AS-AgNPs) in an in vitro and in vivo rat model of dermal T. rubrum dermatophytosis (TRD). The green synthesis of AS-AgNPs was performed using A. santolina extract and characterized by UV-VIS spectroscopy, zeta potential, imaging (transmission electron microscopy (TEM), X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR) and Energy dispersive X-ray analysis (EDX)...
February 5, 2023: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://read.qxmd.com/read/36830104/evaluation-of-an-antifungal-stewardship-initiative-targeting-micafungin-at-an-academic-medical-center
#2
JOURNAL ARTICLE
J Myles Keck, David A Cretella, Kayla R Stover, Jamie L Wagner, Katie E Barber, Tulip A Jhaveri, Prakhar Vijayvargiya, Zerelda Esquer Garrigos, Mary Joyce B Wingler
Delays in the treatment of proven invasive fungal disease have been shown to be harmful. However, empiric treatment for all patients at risk of infection has not demonstrated benefit. This study evaluates the effects of a micafungin stewardship initiative on the duration of therapy and clinical outcomes at the University of Mississippi Medical Center in Jackson, Mississippi. This single-center quasi-experiment evaluated patients who received micafungin. Adult inpatients who received at least one treatment dose of micafungin in the pre-intervention (1 October 2020 to 30 September 2021) or post-intervention (1 October 2021 to 30 April 2022) groups were included...
January 17, 2023: Antibiotics
https://read.qxmd.com/read/36548213/a-strategy-of-on-demand-immune-activation-for-antifungal-treatment-using-near-infrared-responsive-conjugated-polymer-nanoparticles
#3
JOURNAL ARTICLE
Zijuan Wang, Shuyi Qu, Dong Gao, Qi Shao, Chenyao Nie, Chengfen Xing
Pathogenic fungal infection is a major clinical threat because pathogenic fungi have developed resistant mechanisms to evade the innate immune response, especially interactions with macrophages. Herein, a strategy to activate immune responses of macrophages to fungi based on near-infrared (NIR) responsive conjugated polymer nanoparticles (CPNs-M) is reported for antifungal immunotherapy. Under NIR light irradiation, CPNs-M exposes β-glucan on the surface of fungal conidia by photothermal damage and drug released from CPNs-M...
December 22, 2022: Nano Letters
https://read.qxmd.com/read/36061876/vaccines-against-candidiasis-status-challenges-and-emerging-opportunity
#4
REVIEW
Satya Ranjan Sahu, Swagata Bose, Manish Singh, Premlata Kumari, Abinash Dutta, Bhabasha Gyanadeep Utkalaja, Shraddheya Kumar Patel, Narottam Acharya
Candidiasis is a mycosis caused by opportunistic Candida species. The occurrence of fungal infections has considerably increased in the last few years primarily due to an increase in the number of immune-suppressed individuals. Alarming bloodstream infections due to Candida sp. are associated with a higher rate of morbidity and mortality, and are emerged as major healthcare concerns worldwide. Currently, chemotherapy is the sole available option for combating fungal diseases. Moreover, the emergence of resistance to these limited available anti-fungal drugs has further accentuated the concern and highlighted the need for early detection of fungal infections, identification of novel antifungal drug targets, and development of effective therapeutics and prophylactics...
2022: Frontiers in Cellular and Infection Microbiology
https://read.qxmd.com/read/35533833/covid-19-associated-mucormycosis-an-opportunistic-fungal-infection-a-case-series-and-review
#5
REVIEW
Asma Al Balushi, Ahmed Al Ajmi, Qais Al Sinani, Varna Menon, Zainab Al Berieki, Asma Al Shezawi, Saleh Al Azri, Azza Al Rashdi, Amina Al Jardani, Thuwaiba Al Baluki, Salem Al Ghaithi, Ali Al Reesi, Ahmed Talib Al-Za'abi, Mohammed Abdullah Al' Balushi, Talib Al Maqbali
BACKGROUND: A surge in COVID-19-associated mucormycosis cases has been observed during the second wave of COVID-19 in summer of 2021. Most cases were reported from India. The Delta variant (B.1.617.2) was the most common variant circulating at that time. Mucormycosis is an opportunistic angioinvasive fungal infection with high morbidity and mortality. METHODS: We present 10 cases of COVID-19-associated rhino-orbital and rhino-orbital-cerebral mucormycosis managed in a secondary hospital in Oman...
August 2022: International Journal of Infectious Diseases: IJID
https://read.qxmd.com/read/34489988/-brassica-napus-mediator-subunit16-induces-bnmed25-and-bnwrky33-activated-defense-signaling-to-confer-sclerotinia-sclerotiorum-resistance
#6
JOURNAL ARTICLE
Huizhen Hu, Yiwei Tang, Jian Wu, Feizhi Chen, Yidan Yang, Xuancheng Pan, Xiang Dong, Xianda Jin, Sheng Liu, Xuezhu Du
The plant mediator is a highly conserved protein complex that interacts with transcription factors (TFs) and RNA polymerase II (RNAP II) to relay regulatory information during transcription. Plant immune response is one of the biological processes that is orchestrated by this regulatory mechanism. Brassica napu s, an important oil crop, is severely attacked by a devastating disease Sclerotinia stem rot. Here, we explored broad-spectrum disease resistant roles of B. napus mediator subunit 16 (BnMED16) and its host defense mechanism against fugal pathogen Sclerotinia sclerotiorum ...
2021: Frontiers in Plant Science
https://read.qxmd.com/read/31316570/efficacy-of-two-stage-treatment-of-onychomycosis-using-a-long-pulsed-nd-yag-1064-nm-laser
#7
JOURNAL ARTICLE
Shan Zhong, Guan-Ting Lin, Jun-Ying Zhao
OBJECTIVES: Onychomycosis is a fungal infection of the nail bed, nail matrix, and nail plate. Lasers have recently been studied as future clinical options for onychomycosis. We sought to evaluate the efficacy of the long-pulsed Nd:YAG 1064-nm laser on onychomycosis using a two-stage treatment. METHODS: A total of 100 affected nails (88 toenails and 12 fingernails from 22 patients) were treated using a long-pulsed Nd:YAG 1064-nm laser. The self-controlled treatment schedule included the first stage (1 session per week for 8 weeks) and the second stage (1 session every 4 weeks for 16 weeks)...
2019: Evidence-based Complementary and Alternative Medicine: ECAM
https://read.qxmd.com/read/30542362/diverse-novel-mycoviruses-from-the-virome-of-a-hypovirulent-sclerotium-rolfsii-strain
#8
JOURNAL ARTICLE
Jun Zi Zhu, Hong Jian Zhu, Bi Da Gao, Qian Zhou, Jie Zhong
Sclerotium rolfsii , which causes southern blight in a wide variety of crops, is a devastating plant pathogen worldwide. Mycoviruses that induce hypovirulence in phytopathogenic fungi are potential biological control resources against fungal plant diseases. However, in S. rolfsii , mycoviruses are rarely reported. In a previous study, we found a hypovirulent strain carrying a diverse pattern of dsRNAs. Here, we utilized the RNA_Seq technique to detect viral sequences. Deep sequencing, RT-PCR and Sanger sequencing validation analyses revealed that this strain harbors various new viral species that show affinity to the distinctly established and proposed families Benyviridae, Endornaviridae , Fusariviridae, Hypoviridae , and Fusagraviridae...
2018: Frontiers in Plant Science
https://read.qxmd.com/read/30350447/synthesis-and-testing-of-novel-alternative-oxidase-aox-inhibitors-with-antifungal-activity-against-moniliophthora-perniciosa-stahel-the-causal-agent-of-witches-broom-disease-of-cocoa-and-other-phytopathogens
#9
JOURNAL ARTICLE
Mario Ro Barsottini, Bárbara A Pires, Maria L Vieira, José Gc Pereira, Paulo Cs Costa, Jaqueline Sanitá, Alessandro Coradini, Fellipe Mello, Cidnei Marschalk, Eder M Silva, Daniele Paschoal, Antonio Figueira, Fábio Hs Rodrigues, Artur T Cordeiro, Paulo Cml Miranda, Paulo Sl Oliveira, Maurício L Sforça, Marcelo F Carazzolle, Silvana A Rocco, Gonçalo Ag Pereira
BACKGROUND: Moniliophthora perniciosa (Stahel) Aime & Phillips-Mora is the causal agent of witches' broom disease (WBD) of cocoa (Theobroma cacao L.) and a threat to the chocolate industry. The membrane-bound enzyme alternative oxidase (AOX) is critical for M. perniciosa virulence and resistance to fungicides, which has also been observed in other phytopathogens. Notably AOX is an escape mechanism from strobilurins and other respiration inhibitors, making AOX a promising target for controlling WBD and other fungal diseases...
October 22, 2018: Pest Management Science
https://read.qxmd.com/read/30150494/effects-of-using-antifungal-gel-on-retentive-bond-strength-of-two-forms-of-denture-adhesives-an-in-vitro-study
#10
COMPARATIVE STUDY
Ghadeer I Basunbul, Abdulelah M BinMahfooz, Khaled K El-Din Amin, Mosa M Altassan, Osama A Qutub, Sahar Mn Bukhary
AIM: The purpose of this in vitro study is to compare the bond strength to denture acrylics efficacy of miconazole gel against two denture adhesives with improved retentive properties (zinc-free PoliGrip cream and Snug denture soft cushion). MATERIALS AND METHODS: Eight heat-cured acrylic samples were prepared measuring 0.7 cm × 1.4 cm flat tested surface. The two well-adapted tested surfaces were matched and fixed to Universal Testing Machine clamp. Vertical separating load was applied at a rate of 1 mm/min to yield the maximum load before denture adhesive failure occurs...
August 1, 2018: Journal of Contemporary Dental Practice
https://read.qxmd.com/read/30117151/recurrent-fungal-infections-in-a-chinese-patient-with-card9-deficiency-and-a-review-of-48-cases
#11
JOURNAL ARTICLE
C Quan, X Li, R-F Shi, X-Q Zhao, H Xu, B Wang, X-P Wang, W-G Hu, H Cao, J Zheng
Deficiency of CARD9 (caspase recruitment domain-containing protein 9) has been reported in individuals with recurrent and invasive fungal infections. We report on a patient who first had Trichosporon asahii affecting the skin then Candida albicans infections involving the digestive tract and knee joint, along with elevated serum IgE. After stimulation with C. albicans, peripheral blood mononuclear cells of this patient produced less tumour necrosis factor-α, interferon-γ and interleukin-17 than those of healthy controls...
May 2019: British Journal of Dermatology
https://read.qxmd.com/read/27790507/fungal-infection-in-thermal-burns-a-prospective-study-in-a-tertiary-care-centre
#12
JOURNAL ARTICLE
Sanjeev Sharma, Deepak Bajaj, Pritika Sharma
INTRODUCTION: Burn Wound Infection (BWI) is primarily caused by aerobic bacteria followed by fungi, anaerobes and viruses. There has been a worldwide decrease in incidence of bacterial infections in burns due to better patient care and availability of effective antibiotics. Consequently, the fungal burn wound infection has shown an increasing trend. AIM: The aim of study was to assess the frequency of fungal infections in thermal burn wounds with respect to age of wounds, total body surface involved, depth of burns and to assess common fungal pathogens...
September 2016: Journal of Clinical and Diagnostic Research: JCDR
https://read.qxmd.com/read/26722566/recurrent-cerebral-aneurysm-formation-and-rupture-within-a-short-period-due-to-invasive-aspergillosis-of-the-nasal-sinus-pathological-analysis-of-the-catastrophic-clinical-course
#13
JOURNAL ARTICLE
Yuki Shinya, Satoru Miyawaki, Hirofumi Nakatomi, Atsushi Okano, Hideaki Imai, Masahiro Shin, Kazuya Sato, Takeyuki Tsuchida, Toshihiro Hayashi, Yasuo Terao, Satoe Numakura, Teppei Morikawa, Junji Shibahara, Shu Kikuta, Kenji Kondo, Keita Tatsuno, Harushi Mori, Akira Kunimatsu, Shoji Tsuji, Nobuhito Saito
Destructive infiltration of invasive fungal sinusitis can easily occur into the central nervous system (CNS). Cerebral aneurysms associated with fungal infection are highly vulnerable to rupture, and can frequently and rapidly take a serious clinical course. We experienced a patient who twice developed cerebral aneurysm followed by rupture due to invasive fugal sinusitis. This 77-year-old man was admitted for progressive bilateral visual disturbance, which was initially treated as idiopathic hypertrophic pachymeningitis...
2015: International Journal of Clinical and Experimental Pathology
https://read.qxmd.com/read/26578095/an-ultrastructural-study-of-trichophyton-rubrum-induced-onychomycosis
#14
JOURNAL ARTICLE
Xueping Yue, Qing Li, Hongwei Wang, Yilin Sun, Aiping Wang, Qi Zhang, Cuiping Zhang
BACKGROUND: Trichophyton rubrum (T.rubrum) caused onychomycosis is the most common nail fungal disease. The common diagnostic methods are direct microscopic examination and fungal culture. In this study we used scanning electron microscopy (SEM) and transmission electron microscopy (TEM) to study the subungual ultrastructural changes in T. rubrum induced onychomycosis. METHODS: Six outpatients with onychomycosis were recruited and T.rubrum infection was confirmed by fungal culture...
November 17, 2015: BMC Infectious Diseases
https://read.qxmd.com/read/26423133/isolation-and-characterization-of-a-subgroup-iia-wrky-transcription-factor-ptrwrky40-from-populus-trichocarpa
#15
JOURNAL ARTICLE
Abdul Karim, Yuanzhong Jiang, Li Guo, Zhengyi Ling, Shenglong Ye, Yanjiao Duan, Chaofeng Li, Keming Luo
Salicylic acid (SA) is a defense-related key signaling molecule involved in plant immunity. In this study, a subgroup IIa WRKY gene PtrWRKY40 was isolated from Populus trichocarpa, which displayed amino acid sequence similar to Arabidopsis AtWRKY40, AtWRKY18 and AtWRKY60. PtrWRKY40 transcripts accumulated significantly in response to SA, methyl jasmonate and hemibiotrophic fungus Dothiorella gregaria Sacc. Overexpression of PtrWRKY40 in transgenic poplar conferred higher susceptibility to D. gregaria infection...
October 2015: Tree Physiology
https://read.qxmd.com/read/26240775/systemic-candida-parapsilosis-infection-model-in-immunosuppressed-icr-mice-and-assessing-the-antifungal-efficiency-of-fluconazole
#16
JOURNAL ARTICLE
Yu'e Wu, Fangui Min, Jinchun Pan, Jing Wang, Wen Yuan, Yu Zhang, Ren Huang, Lixin Zhang
This study was to establish a systemic C. parapsilosis infection model in immunosuppressed ICR mice induced by cyclophosphamide and evaluate the antifungal efficiency of fluconazole. Three experiments were set to confirm the optimal infectious dose of C. parapsilosis, outcomes of infectious model, and antifungal efficiency of fluconazole in vivo, respectively. In the first experiment, comparisons of survival proportions between different infectious doses treated groups showed that the optimal inoculum for C...
2015: Veterinary Medicine International
https://read.qxmd.com/read/24897963/evaluation-of-multiplex-pcr-in-first-episodes-of-febrile-neutropenia-as-a-tool-to-improve-early-yeast-diagnosis-in-leukemic-preleukemic-patients
#17
JOURNAL ARTICLE
H Teixeira, L Silva, J J F Magalhães, C Matias, J F F Magalhães, J M A Lyra, V Magalhães, N Lucena-Silva, H R L Melo, M B Jucá, C A A Brito
In febrile neutropenic onco-hematological patients, delayed microbiological diagnosis leads to an increase in morbidity and mortality. Identification of the microorganism changes antibiotic therapy in more than half of cases; however, in only 20-30 % of such cases pathogen isolation is achieved. This study evaluates the frequency of fungus infection and its etiology in onco-hematological patients with febrile neutropenia utilizing blood cultures and non-commercial multiplex polymerase chain reaction (MT-PCR) primers...
October 2014: Supportive Care in Cancer
https://read.qxmd.com/read/23530868/cutaneous-alternariosis-with-trichosporon-infection-in-a-heart-transplant-recipient-a-case-report
#18
JOURNAL ARTICLE
Babak Sharifkashani, Maham Farshidpour, Atousa Droudinia, Majid Marjani, Zargham Ahmadi, Zahra Ansari, Mohsen Mirhosseini, Neda Behzadnia, Davood Mansouri, Payam Tabarsi
Cutaneous alternariosis infection occurs mainly in immunocompromised individuals. The incidence of alternariosis in a heart transplant recipient is infrequent. Coincidence of the aforementioned infection with additional fugal agents is rare. We describe a case of alternariosis with Trichosporon fungal infection in a patient who was successfully treated with combined antifungal therapy, modulation of immunosuppressive regimen, and blood glucose management. The patient had a good response to treatment, and has had an uneventful 1-year follow-up at the time of this writing...
October 2013: Experimental and Clinical Transplantation
https://read.qxmd.com/read/22647818/preliminary-study-on-the-antimicrobial-activity-of-enicostemma-littorale-using-different-solvents
#19
JOURNAL ARTICLE
Pitchamuthu Abirami, Muthiah Gomathinayagam, Rajaram Panneerselvam
OBJECTIVE: To study the antimicrobial activity of Enicostemma littorale (E. littorale) using different solvents. METHODS: Chloroform, methanol and acetone extracts of different parts of E. littorale (leaf, stem and root) were evaluated for antimicrobial activity using disc diffusion method against some gram-negative species such as Escherichia coli, Klebsiella pnemoniae, Pseudomonas aeruginosa, Salmonella typhi and gram-positive species Staphylococcus aureus, Bacillus cereus, Bacillus subtilis and two fugal species viz...
July 2012: Asian Pacific Journal of Tropical Medicine
https://read.qxmd.com/read/22261726/physical-characterization-of-the-immunosignaturing-effect
#20
JOURNAL ARTICLE
Phillip Stafford, Rebecca Halperin, Joseph Bart Legutki, Dewey Mitchell Magee, John Galgiani, Stephen Albert Johnston
Identifying new, effective biomarkers for diseases is proving to be a challenging problem. We have proposed that antibodies may offer a solution to this problem. The physical features and abundance of antibodies make them ideal biomarkers. Additionally, antibodies are often elicited early in the ontogeny of different chronic and infectious diseases. We previously reported that antibodies from patients with infectious disease and separately those with Alzheimer's disease display a characteristic and reproducible "immunosignature" on a microarray of 10,000 random sequence peptides...
April 2012: Molecular & Cellular Proteomics: MCP
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