Vebjørn J Melum, Cristina Sáenz de Miera, Fredrik A F Markussen, Fernando Cázarez-Márquez, Catherine Jaeger, Simen R Sandve, Valérie Simonneaux, David G Hazlerigg, Shona H Wood
In mammals, maternal photoperiodic programming (MPP) provides a means whereby juvenile development can be matched to forthcoming seasonal environmental conditions.1 , 2 , 3 , 4 This phenomenon is driven by in utero effects of maternal melatonin5 , 6 , 7 on the production of thyrotropin (TSH) in the fetal pars tuberalis (PT) and consequent TSH receptor-mediated effects on tanycytes lining the 3rd ventricle of the mediobasal hypothalamus (MBH).8 , 9 , 10 Here we use LASER capture microdissection and transcriptomic profiling to show that TSH-dependent MPP controls the attributes of the ependymal region of the MBH in juvenile animals...
January 9, 2024: Current Biology: CB