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https://read.qxmd.com/read/30771942/analytical-aspects-of-smart-phone-fluorometric-measurements
#1
Mateusz Granica, Łukasz Tymecki
Facing the problem of a growing number of analyses, the need for using simple equipment appears. Smartphone-based optical detection is one of the most widely applied ideas nowadays. A personal device such as a smartphone equipped with a camera is affordable even in the source-limited places. After a simple modification, providing the light source of both defined properties and orientation, a smartphone may become an efficient analytical device. In this work we present a uniform methodology of such a modification, offering a complete hand-held device for fluorometric measurements...
May 15, 2019: Talanta
https://read.qxmd.com/read/30768617/baseline-high-sensitivity-c-reactive-protein-predicts-the-risk-of-incident-ankylosing-spondylitis-results-of-a-community-based-prospective-study
#2
Jinmei Su, Liufu Cui, Wenhao Yang, Huijing Shi, Cheng Jin, Rong Shu, Hongfen Li, Xiaofeng Zeng, Shouling Wu, Xiang Gao
BACKGROUND: A hospitalized-based cohort study suggested that elevated C-reactive protein (CRP) levels are associated with radiographic sacroiliitis progression in ankylosing spondylitis (AS) patients. However, data from community-based populations are limited. OBJECTIVE: We sought to determine the association between elevated CRP levels and AS diagnosis in a prospective community-based study of 129,681 Chinese adults over a follow-up period of 8 years. METHODS: We measured the plasma CRP concentration at baseline and every 2 years thereafter with the high-sensitivity (hs)-CRP test...
2019: PloS One
https://read.qxmd.com/read/30767736/3d-printing-in-personalized-drug-delivery
#3
Afsana, Vineet Jain, Nafis Haider, Keerti Jain
BACKGROUND: Personalized medicines are becoming more popular as they enables the use of patient's genomics and hence help in better drug design with fewer side effects. In fact several doses can be combined into one dosage form which suits the patient's demography. 3 Dimensional (3D) printing technology for personalized medicine is a modern day treatment method based on genomics of patient. METHODS: 3D printing technology uses digitally controlled devices for formulating API and excipients in a layer by layer pattern for developing a suitable personalized drug delivery system as per the need of patient...
February 15, 2019: Current Pharmaceutical Design
https://read.qxmd.com/read/30766752/five-cpg-based-prognostic-signature-for-predicting-survival-in-hepatocellular-carcinoma-patients
#4
Feng Fang, Xiaoqing Wang, Tianqiang Song
Objective: Hepatocellular carcinoma (HCC) is a common malignancy associated with high morbidity and mortality rates worldwide. Early diagnosis plays an important role in the improvement of HCC prognosis. Methods: In this study, we conducted a comprehensive analysis of HCC DNA methylation and gene expression datasets in The Cancer Genome Atlas (TCGA), to identify a prognostic signature for HCC diagnosis and survival prediction. First, we identified differential methylation CpG (dmCpG) sites in HCC samples and compared them with those in adjacent normal liver tissues; this was followed by univariate analysis and Sure Independence Screening (SIS) in the training set...
November 2018: Cancer Biology & Medicine
https://read.qxmd.com/read/30765979/collaborative-tele-neuropsychiatry-consultation-services-for-patients-in-central-prisons
#5
Preethi Pansari Agarwal, Narayana Manjunatha, Guru S Gowda, M N Girish Kumar, Neelaveni Shanthaveeranna, Channaveerachari Naveen Kumar, Suresh Bada Math
Background: Tele-medicine helps to provide clinical care comparable to in-person treatment in various clinical settings. It is a novel system of healthcare delivery in both low-resource settings and sites where adequate medical care continues to pose greatest challenge like in prison's in India and worldwide. Aim: To study the sociodemographic and clinical profile of patients from Central Prisons, having received collaborative Tele-Neuropsychiatric Care. Methodology: Psychiatry, neurology, and neurosurgery specialists provided tele-neuropsychiatry consultation through Specialist-Doctor-Patient model as part of the state-run program for the two central prisons from July 1, 2014, to June 30, 2016...
January 2019: Journal of Neurosciences in Rural Practice
https://read.qxmd.com/read/30765939/the-changing-face-of-hepatocellular-carcinoma-forecasting-prevalence-of-nonalcoholic-steatohepatitis-and-hepatitis-c-cirrhosis
#6
Osmanuddin Ahmed, Lisa Liu, Antony Gayed, Amanjit Baadh, Mikin Patel, Jordan Tasse, Ulku Turba, Bulent Arslan
Background/objectives: The purpose of this research is to analyze the past and forecast the future prevalence of Hepatitis C Virus (HCV) and Nonalcoholic Steatohepatitis (NASH) and their respective contribution to Hepatocellular Carcinoma (HCC) incidence in the setting of novel anti-viral agents and rising obesity rates in the United States. Methods: Existing data of HCV and NASH prevalence in the United States utilizing the National Health and Nutrition Examination Survey (NHANES) and Organ Procurement and Transplantation Network (OPTN) was collected and analyzed to project future prevalence trends...
January 2019: Journal of Clinical and Experimental Hepatology
https://read.qxmd.com/read/30764663/sleep-related-practices-behaviors-and-sleep-related-difficulties-in-deployed-active-duty-service-members-performing-security-duties
#7
Panagiotis Matsangas, Nita Lewis Shattuck, Arlene Saitzyk
OBJECTIVE: To assess sleep-related difficulties (e.g., trouble staying asleep, oversleeping, falling asleep while on duty, disturbing dreams, sleep paralysis) and behavioral patterns of active-duty service members (ADSMs) performing security duties. PARTICIPANTS: The participants were 1,169 ADSMs (20-44 years of age). METHODS: ADSMs completed an online survey (67.3% response rate) with items assessing demographics, the occupational environment, sleep-related attributes, habits, or difficulties, factors affecting sleep, aids and techniques used to improve sleep, and the use of sleep-related products...
February 15, 2019: Behavioral Sleep Medicine
https://read.qxmd.com/read/30763149/excessive-drinking-and-drug-use-during-college-prospective-associations-with-graduate-school-plans-and-attendance
#8
Amelia M Arria, Hannah K Allen, Kimberly M Caldeira, Kathryn B Vincent, Kevin E O'Grady
OBJECTIVE: This study examines the prospective relationship between substance use during college and two outcomes: having definite plans to attend graduate school; and, among individuals with plans, enrolling in graduate school upon college graduation. PARTICIPANTS: n = 980 were originally enrolled as first-time, first-year college students in an ongoing longitudinal study (August 2004 to present). METHODS: Measures from personal interviews included demographics, GPA, alcohol use, alcohol abuse/dependence, and other drug use during college...
February 14, 2019: Journal of American College Health: J of ACH
https://read.qxmd.com/read/30760752/assessment-of-incidence-and-various-demographic-risk-factors-of-traumatic-humeral-shaft-fractures-in-china
#9
Chenni Ji, Jia Li, Yanbin Zhu, Song Liu, Lei Fu, Wei Chen, Yingze Zhang
As a sub-study of the China National Fracture Study, this study aimed to better determine the incidence and risk factors of humeral shaft fracture in mainland China. We obtained all the data on humeral shaft fracture from the China National Fracture Study reported in 2017. Trained research teams personally interviewed all qualifying household members using a standardised questionnaire. A total of 512,187 (259649 boys and men, 252538 girls and women) questionnaires were collected and analysed from 112 neighbourhood communities and 223 administrative villages using stratified random sampling and the probability proportional to size method...
February 13, 2019: Scientific Reports
https://read.qxmd.com/read/30760250/a-stepped-wedge-cluster-randomised-trial-of-a-cognitive-remediation-intervention-in-alcohol-and-other-drug-aod-residential-treatment-services
#10
Jamie Berry, Isabella Jacomb, Jo Lunn, Antoinette Sedwell, Anthony Shakeshaft, Peter J Kelly, Pooria Sarrami, Megan James, Skye Russell, Talia Nardo, Daniel Barker, Jennifer Holmes
BACKGROUND: Executive functioning impairment is common in substance use disorder and is a major risk factor for poor treatment outcomes, including treatment drop-out and relapse. Cognitive remediation interventions seek to improve executive functioning and offer a promising approach to increase the efficacy of alcohol and other drug (AOD) treatments and improve long-term therapeutic outcomes. This protocol describes a study funded by the NSW Agency for Clinical Innovation that assesses the effectiveness of delivering a six-week group-based intervention of cognitive remediation in an ecologically valid sample of people attending residential AOD treatment services...
February 13, 2019: BMC Psychiatry
https://read.qxmd.com/read/30759125/alcohol-and-breast-cancer-risk-middle-aged-women-s-logic-and-recommendations-for-reducing-consumption-in-australia
#11
Samantha B Meyer, Kristen Foley, Ian Olver, Paul R Ward, Darlene McNaughton, Lillian Mwanri, Emma R Miller
BACKGROUND: We aimed to understand the factors shaping alcohol consumption patterns in middle-aged women (45-64), and to identify participant-driven population- and policy-level strategies that may be used to addresses alcohol consumption and reduce breast cancer risk. METHODS: Semi-structured interviews (n = 35) were conducted with 'middle-aged' women conversant in English and living in South Australia with no history of breast cancer diagnosis. Data were deductively coded using a co-developed framework including variables relevant to our study objectives...
2019: PloS One
https://read.qxmd.com/read/30758921/psychiatric-disorders-and-crime-in-the-us-population-results-from-the-national-epidemiologic-survey-on-alcohol-and-related-conditions-wave-iii
#12
Kelly E Moore, Lindsay M S Oberleitner, Howard V Zonana, Alec W Buchanan, Brian P Pittman, Terril L Verplaetse, Gustavo A Angarita, Walter Roberts, Sherry A McKee
OBJECTIVE: Current knowledge regarding the intersection of psychiatric disorders and crime in the United States is limited to psychiatric, forensic, and youth samples. This study presents nationally representative data on the relationship of DSM-5 psychiatric disorders, comorbid substance and mental health disorders, and multimorbidity (number of disorders) with criminal behavior and justice involvement among non-institutionalized US adults. METHODS: Data were drawn from the National Epidemiologic Survey on Alcohol and Related Conditions Wave III (NESARC-III; 2012-2013; N = 36,309)...
February 12, 2019: Journal of Clinical Psychiatry
https://read.qxmd.com/read/30756422/psychiatric-and-medical-correlates-of-dsm-5-eating-disorders-in-a-nationally-representative-sample-of-adults-in-the-united-states
#13
Tomoko Udo, Carlos M Grilo
OBJECTIVE: To examine psychiatric and somatic correlates of DSM-5 eating disorders (EDs)-anorexia nervosa (AN), bulimia nervosa (BN), and binge-eating disorder (BED)-in a nationally representative sample of adults in the United States. METHOD: A national sample of 36,309 adult participants in the national epidemiologic survey on alcohol and related conditions III (NESARC-III) completed structured diagnostic interviews (AUDADIS-5) to determine psychiatric disorders, including EDs, and reported 12-month diagnosis of chronic somatic conditions...
January 2019: International Journal of Eating Disorders
https://read.qxmd.com/read/30753102/modeling-the-distinct-negative-reinforcement-mechanisms-associated-with-alcohol-misuse-and-unhealthy-snacking
#14
Danielle L Reaves, Paul Christiansen, Emma J Boyland, Jason C G Halford, Clare H Llewellyn, Charlotte A Hardman
BACKGROUND: Negative personality characteristics have been implicated in promoting overconsumption of both alcohol and food. Furthermore, positive motivations (enhancement) and negative motivations (coping) may mediate the association between personality and alcohol or food (over)consumption. OBJECTIVES: This study hypothesized that i.) drinking to cope and ii.) eating to cope would mediate the association between hopelessness/anxiety sensitivity and hazardous drinking/unhealthy snacking, respectively, and iii...
February 12, 2019: Substance Use & Misuse
https://read.qxmd.com/read/30748025/the-new-orleans-alcohol-use-in-hiv-noah-study-launching-a-translational-investigation-of-the-interaction-of-alcohol-use-with-biological-and-socioenvironmental-risk-factors-for-multi-morbidity-in-people-living-with-hiv
#15
David A Welsh, Tekeda Ferguson, Katherine P Theall, Liz Simon, Angela Amedee, Robert W Siggins, Steve Nelson, Meghan Brashear, Donald Mercante, Patricia E Molina
BACKGROUND: Alcohol use disorders (AUDs) are highly prevalent in persons living with HIV (PLWH) and are associated with increased HIV risk behaviors, suboptimal treatment adherence, potential interaction with medication pharmacodynamics, and greater risk for disease progression. Preclinical studies show that chronic binge alcohol administration accelerates disease progression and aggravates pathogenesis in the simian immunodeficiency virus (SIV)-infected rhesus macaque model despite viral suppression by antiretroviral therapy...
February 12, 2019: Alcoholism, Clinical and Experimental Research
https://read.qxmd.com/read/30744600/-do-as-we-say-not-as-we-do-the-lifestyle-behaviours-of-hospital-doctors-working-in-ireland-a-national-cross-sectional-study
#16
Anthony O' Keeffe, Blánaid Hayes, Lucia Prihodova
BACKGROUND: This study was conducted to assess the lifestyle behaviours of a national sample of hospital doctors working in Ireland. We also sought to compare the prevalence of these behaviours in doctors to the general Irish population. METHODS: This was a national cross-sectional study of a randomised sample of hospital doctors working in Irish publicly funded hospitals and residential institutions. The final cohort consisted of 1749 doctors (response rate of 55%)...
February 11, 2019: BMC Public Health
https://read.qxmd.com/read/30744131/3d-printing-for-bio-synthetic-biliary-stents
#17
Christen J Boyer, Moheb Boktor, Hrishikesh Samant, Luke A White, Yuping Wang, David H Ballard, Robert C Huebert, Jennifer E Woerner, Ghali E Ghali, Jonathan S Alexander
Three-dimensional (3D) printing is an additive manufacturing method that holds great potential in a variety of future patient-specific medical technologies. This project validated a novel crosslinked polyvinyl alcohol (XL-PVA) 3D printed stent infused with collagen, human placental mesenchymal stem cells (PMSCs), and cholangiocytes. The biofabrication method in the present study examined 3D printing and collagen injection molding for rapid prototyping of customized living biliary stents with clinical applications in the setting of malignant and benign bile duct obstructions...
February 9, 2019: Bioengineering
https://read.qxmd.com/read/30743006/association-between-severe-serum-alanine-aminotransferase-flares-and-hepatitis-b-e-antigen-seroconversion-and-hbv-dna-decrease-in-untreated-patients-with-chronic-hbv-infection
#18
Mayur Brahmania, Manuel Lombardero, Bettina E Hansen, Norah A Terrault, Anna S Lok, Robert P Perrillo, Steven H Belle, Adrian M Di Bisceglie, Jordan J Feld, William M Lee, Michael W Fried, Harry L A Janssen
BACKGROUND & AIMS: The incidence and outcomes of alanine aminotransferase (ALT) flares during the natural history of chronic HBV infection has not been determined in a large, racially heterogeneous groups of patients in North America. METHODS: We collected data from the Hepatitis B Research Network-an observational cohort study of untreated adults with chronic HBV infection enrolled at 21 sites in the United States and Canada. Clinical and laboratory data were collected from 1587 participants (49...
February 8, 2019: Clinical Gastroenterology and Hepatology
https://read.qxmd.com/read/30740750/dsm-5-alcohol-use-disorder-severity-as-a-function-of-sexual-orientation-discrimination-a-national-study
#19
Sean Esteban McCabe, Tonda L Hughes, Brady T West, Phil Veliz, Carol J Boyd
BACKGROUND: Sexual minorities are more likely than their heterosexual counterparts to develop alcohol use disorder (AUD), and understanding the underlying reasons for this heightened risk is a public health priority. This study examined relationships between sexual orientation discrimination and DSM-5 AUD severity. METHODS: The 2012 to 2013 National Epidemiologic Survey on Alcohol and Related Conditions III conducted in-person interviews with a nationally representative sample of U...
February 11, 2019: Alcoholism, Clinical and Experimental Research
https://read.qxmd.com/read/30739595/basic-computer-skills-and-computer-preferences-of-inner-city-hospitalized-medical-patients-implications-for-web-based-alcohol-screening-and-brief-intervention
#20
Lisa Berger, Katelyn Blair, Carol Hein
Health care delivery is being transformed by the use of computer technology, and integrated physical health with mental and behavioral health care are national priorities. This study examined the basic computer skills and computer preferences of inner-city hospitalized medical patients in a design study of a web-based alcohol screening and brief intervention program prototype. Participants were 26 patients observed going through the program prototype using both a laptop computer and mouse, and an iPad. The majority of patients were able to do all the basic laptop and basic iPad skills to complete the program prototype, including older patients (aged 50 years or older) and patients with a high school degree or less...
February 9, 2019: Social Work in Health Care
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