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Médéa Locquet, Tom Willems, Clément Specque, Charlotte Beaudart, Olivier Bruyère, Julien Van Beveren, Nadia Dardenne, Jean-Yves Reginster, Jean-François Kaux
STUDY DESIGN: This consisted of a translation and validation study. BACKGROUND: Acute hamstring injury is a frequent muscle strain in sports that require high explosive strength, impulsion or running phases. Therefore, the Functional Assessment Scale for Hamstring Injury questionnaire was developed to assess pain, physical activity level and ability to perform various exercises in patients with hamstring injuries. The Functional Assessment Scale for Hamstring Injury questionnaire is currently available in English, German, and Greek...
January 22, 2019: Disability and Rehabilitation
F Proust, S Bracard, J-P Lejeune, L Thines, X Leclerc, G Penchet, J Bergé, X Morandi, J-Y Gauvrit, K Mourier, F Ricolfi, M Lonjon, J Sedat, B Bataille, J Droineau, T Civit, E Magro, I Pelissou-Guyotat, H Cebula, K Lallouche, P David, E Emery, P Courthéoux, J-R Vignes, J Bénichou, N Aghakani, P-H Roche, E Gay, P Bessou, J Guabrillargues, B Irthum
BACKGROUND: Current aging of the population with good physiological status and the increasing incidence of subarachnoid hemorrhage (SAH) in elderly patients has enhanced the benefit of treatment in terms of independence and long-term quality of life (QoL). METHODS: From November 1, 2008 to October 30, 2012, 351 patients aged 70 years or older with aneurysmal SAH underwent adapted treatment: endovascular coiling (EV) for 228 (65%) patients, microsurgical clipping (MS) for 75 (29...
October 16, 2018: Neuro-Chirurgie
Fashe Markos Cherinet, Sophia Yoseph Tekalign, Dereje Hayilu Anbesse, Zewdu Yenegeta Bizuneh
BACKGROUND: Low vision and blindness are major public health problems. A vast burden of worlds visually impaired live in low-income settings especially in sub Saharan Africa. In such settings the blindness is associated with considerable disability and excess mortality, resulting in huge economic and social consequence. The main purpose of this study was to determine the prevalence and associated factors of low vision and blindness among patients at St. Paul's hospital millenium medical college...
September 3, 2018: BMC Ophthalmology
Dietmar Zinner, Anagaw Atickem, Jacinta C Beehner, Afework Bekele, Thore J Bergman, Ryan Burke, Sofya Dolotovskaya, Peter J Fashing, Spartaco Gippoliti, Sascha Knauf, Yvonne Knauf, Addisu Mekonnen, Amera Moges, Nga Nguyen, Nils Chr Stenseth, Christian Roos
The large-bodied, terrestrial primates in the tribe Papionini are among the most intensely studied animals in the world, yet for some members of this tribe we know comparatively little about their evolutionary history and phylogeography. Geladas (Theropithecus gelada Rüppell, 1835), endemic primates of the Ethiopian highlands, are largely unstudied both in genetic diversity and intrageneric phylogeny. Currently, a northern and central subspecies and one isolated southern population are recognized, of which the central is classified as Least Concern, the northern as Vulnerable, and the southern is not yet assessed...
2018: PloS One
Addisu Mekonnen, Eli K Rueness, Nils Chr Stenseth, Peter J Fashing, Afework Bekele, R Adriana Hernandez-Aguilar, Rose Missbach, Tanja Haus, Dietmar Zinner, Christian Roos
BACKGROUND: Species with a restricted geographic distribution, and highly specialized habitat and dietary requirements, are particularly vulnerable to extinction. The Bale monkey (Chlorocebus djamdjamensis) is a little-known arboreal, bamboo-specialist primate endemic to the southern Ethiopian Highlands. While most Bale monkeys inhabit montane forests dominated by bamboo, some occupy forest fragments where bamboo is much less abundant. We used mitochondrial DNA (mtDNA) sequences to analyse the genetic structure and evolutionary history of Bale monkeys covering the majority of their remaining distribution range...
July 10, 2018: BMC Evolutionary Biology
Tariku Mekonnen Gutema, Anagaw Atickem, Afework Bekele, Claudio Sillero-Zubiri, Mohammed Kasso, Diress Tsegaye, Vivek V Venkataraman, Peter J Fashing, Dietmar Zinner, Nils C Stenseth
Carnivore populations are declining globally due to range contraction, persecution and prey depletion. One consequence of these patterns is increased range and niche overlap with other carnivores, and thus an elevated potential for competitive exclusion. Here, we document competition between an endangered canid, the Ethiopian wolf (EW), and the newly discovered African wolf (AW) in central Ethiopia. The diet of the ecological specialist EW was dominated by rodents, whereas the AW consumed a more diverse diet also including insects and non-rodent mammals...
May 2018: Royal Society Open Science
Fashe Muluneh, Merja R Häkkinen, Rami El-Dairi, Markku Pasanen, Risto O Juvonen
RATIONALE: The toxic metabolites of pyrrolizidine alkaloids (PAs) are initially formed by cytochrome P450-mediated oxidation reactions and primarily eliminated as glutathione (GSH) conjugates. Although the reaction between the reactive metabolites and GSH can occur spontaneously, the role of the cytosolic enzymes in the process has not been studied. METHODS: The toxic metabolites of selected PAs (retrorsine, monocrotaline, senecionine, lasiocarpine, heliotrine or senkirkine) were generated by incubating them in 100 mM phosphate buffer (pH 7...
August 30, 2018: Rapid Communications in Mass Spectrometry: RCM
Pål Trosvik, Eric J de Muinck, Eli K Rueness, Peter J Fashing, Evan C Beierschmitt, Kadie R Callingham, Jacob B Kraus, Thomas H Trew, Amera Moges, Addisu Mekonnen, Vivek V Venkataraman, Nga Nguyen
BACKGROUND: The gelada monkey (Theropithecus gelada), endemic to the Ethiopian highlands, is the only graminivorous primate, i.e., it feeds mainly on grasses and sedges. In spite of known dental, manual, and locomotor adaptations, the intestinal anatomy of geladas is similar to that of other primates. We currently lack a clear understanding of the adaptations in digestive physiology necessary for this species to subsist on a graminoid-based diet, but digestion in other graminivores, such as ruminants, relies heavily on the microbial community residing in the gastrointestinal (GI) system...
May 5, 2018: Microbiome
Addisu Mekonnen, Peter J Fashing, Eric J Sargis, Vivek V Venkataraman, Afework Bekele, R Adriana Hernandez-Aguilar, Eli K Rueness, Nils Chr Stenseth
Studies of the effects of habitat fragmentation and degradation on primate positional behavior, strata use, and substrate utilization offer valuable insights into the behavioral and ecological flexibility of primates whose habitats have undergone extensive anthropogenic disturbance. In this study, we evaluated how positional behavior, strata use, and substrate utilization differed between Bale monkeys (Chlorocebus djamdjamensis)-bamboo-eating cercopithecids endemic to the southern Ethiopian Highlands-occupying continuous versus fragmented forests...
May 2018: American Journal of Primatology
Theodore Hueckel, Stefano Sacanna
Increasing significance is being placed on the synthesis of smart colloidal particles, since the route to various meta-materials has been outlined through their bottom-up self-assembly. Unfortunately, making particles with well-defined shape and surface chemistry often requires considerable effort and time, and as such, they are available only in restrictive yields. Here we report a synthetic methodology, which we refer to as mix-and-melt reactions (MMR), that allows for rapid prototyping and mass production of anisotropic core-shell colloids...
April 24, 2018: ACS Nano
Addisu Mekonnen, Peter J Fashing, Afework Bekele, R Adriana Hernandez-Aguilar, Eli K Rueness, Nils Chr Stenseth
BACKGROUND: Understanding the effects of habitat modification on the feeding strategies of threatened species is essential to designing effective conservation management plans. Bale monkeys (Chlorocebus djamdjamensis) are endemic to the rapidly shrinking montane forests of the southern Ethiopian Highlands. Most populations inhabit continuous bamboo forest subsisting largely on the young leaves and shoots of a single species of bamboo. Because of habitat disturbance in recent decades, however, there are now also several dozen small populations inhabiting isolated forest fragments where bamboo has been degraded...
February 6, 2018: BMC Ecology
Kelil Abu, Addisu Mekonnen, Afework Bekele, Peter J Fashing
Understanding the basic natural history of threatened primate taxa is crucial to developing and implementing successful conservation strategies for them. Data on feeding ecology and activity patterns are particularly important for identifying the strategies through which primates invest time and foraging effort towards survival and reproduction at a given locale. Here, we report the results of the first study of the diet and activity budget of Arsi geladas, a population of < 1000 individuals endemic to a heavily disturbed region of the southern Ethiopian Highlands and believed to represent a new taxon of geladas...
March 2018: Primates; Journal of Primatology
T Heller, S Goblirsch, S Bahlas, M Ahmed, M-T Giordani, C Wallrauch, E Brunetti
In human immunodeficiency virus (HIV) co-infected tuberculosis (TB) patients with negative acid-fast bacilli smears, chest radiography (CXR) is usually the first imaging step in the diagnostic work-up. Ultrasound, also in the form of focused assessment with sonography for TB-HIV (FASH), is an additional imaging modality used to diagnose extra-pulmonary TB (EPTB). Findings from 82 patients with abdominal TB diagnosed by ultrasound were analysed and compared with CXR results. Enlarged abdominal lymph nodes were seen in 75...
March 1, 2013: International Journal of Tuberculosis and Lung Disease
Yuanyuan Wang, Xiao-Feng Yang, Yaogang Zhong, Xueyun Gong, Zheng Li, Hua Li
Vicinal dithiol-containing proteins (VDPs) play a key role in cellular redox homeostasis and are responsible for many diseases. Here, we develop a red fluorescent light-up probe FAsH for the highly selective and sensitive detection of VDPs using the environment-sensitive 2-(4-dimethylaminophenyl)-4-(2-carboxyphenyl)-7-diethylamino-1-benzopyrylium (F1) as the fluorescent reporter and cyclic dithiaarsane as the targeting unit. FAsH is almost nonfluorescent in aqueous solution. However, it exhibits intense fluorescence emission upon binding to reduced bovine serum albumin (rBSA, selected as the model protein)...
January 1, 2016: Chemical Science
Brian J Cusack, Trish E Parsons, Seth M Weinberg, Alexandre R Vieira, Heather L Szabo-Rogers
Craniofacial development relies on coordinated tissue interactions that allow for patterning and growth of the face. We know a priori that the Wingless, fibroblast growth factor, Hedgehog and transforming growth factor-beta growth factor signaling pathways are required for the development of the face, but how they contribute to the shape of the face is largely untested. Here, we test how each signaling pathway contributes to the overall morphology of the zebrafish anterior neurocranium. We tested the contribution of each signaling pathway to the development of the ethmoid plate during three distinct time periods: the time of neural crest migration [10 hour post fertilization (hpf)]; once the neural crest is resident in the face (20 hpf); and finally at the time at which the cartilaginous condensations are being initiated (48 hpf)...
May 2017: Journal of Anatomy
Addisu Mekonnen, Peter J Fashing, Afework Bekele, R Adriana Hernandez-Aguilar, Eli K Rueness, Nga Nguyen, Nils Chr Stenseth
Understanding the extent to which primates in forest fragments can adjust behaviorally and ecologically to changes caused by deforestation is essential to designing conservation management plans. During a 12-month period, we studied the effects of habitat loss and degradation on the Ethiopian endemic, bamboo specialist, Bale monkey (Chlorocebus djamdjamensis) by comparing its habitat quality, activity budget, ranging ecology and habitat use in continuous forest and two fragments. We found that habitat loss and fragmentation resulted in major differences in vegetation composition and structure between forest types...
July 2017: American Journal of Primatology
Zhenhua Wu, Senzhi Zhao, David M Fash, Zhenwu Li, William J Chain, John A Beutler
In the decade since the discovery of englerin A (1) and its potent activity in cancer models, this natural product and its analogues have been the subject of numerous chemical, biological, and preclinical studies by many research groups. This review summarizes published findings and proposes further research directions required for entry of an englerin analogue into clinical trials for kidney cancer and other conditions.
March 24, 2017: Journal of Natural Products
Nga Nguyen, Laura M Lee, Peter J Fashing, Niina O Nurmi, Kathrine M Stewart, Taylor J Turner, Tyler S Barry, Kadie R Callingham, C Barret Goodale, Bryce S Kellogg, Ryan J Burke, Emily K Bechtold, Megan J Claase, G Anita Eriksen, Sorrel C Z Jones, Jeffrey T Kerby, Jacob B Kraus, Carrie M Miller, Thomas H Trew, Yi Zhao, Evan C Beierschmitt, Malcolm S Ramsay, Jason D Reynolds, Vivek V Venkataraman
OBJECTIVES: The birth process has been studied extensively in many human societies, yet little is known about this essential life history event in other primates. Here, we provide the most detailed account of behaviors surrounding birth for any wild nonhuman primate to date. MATERIALS AND METHODS: Over a recent ∼10-year period, we directly observed 15 diurnal births (13 live births and 2 stillbirths) among geladas (Theropithecus gelada) at Guassa, Ethiopia. During each birth, we recorded the occurrence (or absence) of 16 periparturitional events, chosen for their potential to provide comparative evolutionary insights into the factors that shaped birth behaviors in humans and other primates...
May 2017: American Journal of Physical Anthropology
Tom Heller, Eric A Mtemang'ombe, Michaëla A M Huson, Charlotte C Heuvelings, Sabine Bélard, Saskia Janssen, Sam Phiri, Martin P Grobusch
Ultrasound is increasingly used in point-of-care applications and has great potential to support the diagnosis of infectious diseases, especially in resource-limited settings. A cross-sectional study was performed involving 100 Malawian patients with a clinical indication for ultrasound. Furthermore, the literature on point-of-care ultrasound (POCUS) in Sub-Saharan Africa was reviewed to establish its applicability, most frequent indications, findings, and implications for treatment, and therefore relevance in POCUS curricula, with a main focus on infectious diseases...
March 2017: International Journal of Infectious Diseases: IJID
Heinz Lohrer, Tanja Nauck, Vasileios Korakakis, Nikos Malliaropoulos
BACKGROUND: The FASH (Functional Assessment Scale for Acute Hamstring Injuries) questionnaire has been recently developed as a disease-specific self-administered questionnaire for use in Greek, English, and German languages. Its psychometric qualities (validity and reliability) were tested only in Greek-speaking patients mainly representing track and field athletes. As hamstring injuries represent the most common football injury, we tested the validity and reliability of the FASH-G (G = German version) questionnaire in German-speaking footballers suffering from acute hamstring injuries...
October 24, 2016: Journal of Orthopaedic Surgery and Research
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