Sheng Yang, Chuan Qin, Man Chen, Yun-Hui Chu, Yue Tang, Luo-Qi Zhou, Hang Zhang, Ming-Hao Dong, Xiao-Wei Pang, Lian Chen, Long-Jun Wu, Dai-Shi Tian, Wei Wang
Microglia, the major resident immune cells in the central nervous system, serve as the frontline soldiers against cerebral ischemic injuries, possibly along with metabolic alterations. However, signaling pathways involved in the regulation of microglial immunometabolism in ischemic stroke remain to be further elucidated. In this study, using single-nuclei RNA sequencing, a microglial subcluster up-regulated in ischemic brain tissues is identified, with high expression of Igf1 and Trem2, neuroprotective transcriptional signature and enhanced oxidative phosphorylation...
December 27, 2023: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)