keyword
https://read.qxmd.com/read/38482403/huaier-granule-improves-liver-inflammation-and-fibrosis-and-prevents-recurrence-in-hepatitis-b-virus-related-hepatocellular-carcinoma
#21
JOURNAL ARTICLE
Qionglan Wu, Jinhua Zeng, Jianxing Zeng, Yao Huang
BACKGROUND: There is basic research suggesting that Huaier granule can inhibit liver cirrhosis and hepatocellular carcinoma (HCC), but this conclusion has not been clinically verified. We analyzed the distant cancer tissue of two groups of hepatitis B virus (HBV) related HCC with/without Huaier granule, to clarify the effect of Huaier granule on liver inflammation, liver fibrosis, and postoperative recurrence. METHODS: We collected clinicopathological data of HCC patients who received two surgery procedures at Mengchao Hepatobiliary Hospital of Fujian Medical University in China from January 2014 to December 2020...
February 29, 2024: Translational Cancer Research
https://read.qxmd.com/read/38481914/the-leukemoid-reaction-in-severe-alcoholic-hepatitis-a-case-report
#22
Siva Reddy, Sachin Agrawal, Sunil Kumar, Sourya Acharya
Alcoholic hepatitis (AH) is a clinicopathologic illness caused by excessive alcohol abuse and is a precursor of cirrhosis. The leukemoid reaction (LR) is characterized by a strikingly raised granulocyte count of 40,000-50,000 cells/mm3 . The LR usually suggests an acute inflammatory reaction. It is usually mistaken for chronic myeloid leukemia. The initial phase of leukocytosis occurs due to the releasing of cells from the bone marrow with more immature cells, causing a left upper shift in the ratio of immature to mature neutrophils and macrophages...
February 2024: Curēus
https://read.qxmd.com/read/38473913/hemochromatosis-ferroptosis-ros-gut-microbiome-and-clinical-challenges-with-alcohol-as-confounding-variable
#23
REVIEW
Rolf Teschke
Hemochromatosis represents clinically one of the most important genetic storage diseases of the liver caused by iron overload, which is to be differentiated from hepatic iron overload due to excessive iron release from erythrocytes in patients with genetic hemolytic disorders. This disorder is under recent mechanistic discussion regarding ferroptosis, reactive oxygen species (ROS), the gut microbiome, and alcohol abuse as a risk factor, which are all topics of this review article. Triggered by released intracellular free iron from ferritin via the autophagic process of ferritinophagy, ferroptosis is involved in hemochromatosis as a specific form of iron-dependent regulated cell death...
February 25, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38473314/prevalence-of-and-impact-on-the-outcome-of-myosteatosis-in-patients-with-hepatocellular-carcinoma-a-systematic-review-and-meta-analysis
#24
REVIEW
Aikaterini Kamiliou, Vasileios Lekakis, George Xynos, Evangelos Cholongitas
BACKGROUND: Limited data exist on the prevalence of myosteatosis (i.e., excess accumulation of fat in skeletal muscles) in hepatocellular carcinoma (HCC) patients, and no systematic review or meta-analysis has been conducted in this context. METHODS: We searched for articles published from inception until November 2023 to assess the prevalence of myosteatosis in patients with HCC. RESULTS: Ten studies with 3316 patients focusing on myosteatosis and HCC were included...
February 27, 2024: Cancers
https://read.qxmd.com/read/38473009/diagnosis-management-and-prognosis-of-cystic-fibrosis-related-liver-disease-in-children
#25
REVIEW
Dana-Teodora Anton-Păduraru, Alice Nicoleta Azoicăi, Felicia Trofin, Alina Mariela Murgu, Dana Elena Mîndru, Ana Simona Bocec, Codruța Olimpiada Iliescu Halițchi, Gabriela Rusu Zota, Diana Păduraru, Eduard Vasile Nastase
Cystic fibrosis (CF) is a multifaceted disorder predominantly investigated for its pulmonary manifestations, yet patients with CF also exhibit a spectrum of extrapulmonary manifestations, notably those involving the hepatobiliary system. The latter constitutes the third leading cause of morbidity and mortality in individuals with CF. Cystic fibrosis-related liver disease (CFLD), with an escalating prevalence, manifests diverse clinical presentations ranging from hepatomegaly to cirrhosis and hepatopulmonary syndrome...
March 3, 2024: Diagnostics
https://read.qxmd.com/read/38472016/a-new-scoring-system-for-predicting-the-outcome-of-hepatocellular-carcinoma-patients-without-microvascular-invasion-a-large-scale-multicentre-study
#26
JOURNAL ARTICLE
Ju-Xian Sun, Zhe Yang, Jia-Yi Wu, Jie Shi, Hong-Ming Yu, Mao-Lin Yan, Shu-Sen Zheng, Shu-Qun Cheng
BACKGROUND: The prognosis of HCC patients without MVI (so called M0) is highly heterogeneous and the need for adjuvant therapy is still controversial. METHODS: Patients with HCC with M0 who underwent liver resection (LR) or liver transplantation (LT) as an initial therapy were included. The Eastern Hepatobiliary Surgery Hospital (EHBH)-M0 score was developed from a retrospective cohort to form the training cohort. The classification which was developed using multivariate cox regression analysis was externally validated...
February 13, 2024: HPB: the Official Journal of the International Hepato Pancreato Biliary Association
https://read.qxmd.com/read/38469818/dysphagia-and-stenosis-secondary-to-intramural-esophageal-pseudodiverticulosis
#27
JOURNAL ARTICLE
Carlos Boix Clemente, Laura Peño Muñoz, Lidia Martí Romero, Gloria Alemany Pérez, María Dolores Pérez Zahonero, Pablo Olcina Domínguez, Vanesa Martínez Escapa, Clara Navarro Peiró
We present the case of a patient with smoking, alcoholism, cirrhosis and HIV who was endoscopically diagnosed with esophageal candidiasis due to an episode of dysphagia. After treatment with antifungals and PPIs, the patient remained asymptomatic for almost 3 years. He presented an event of food impaction that was resolved by an upper endoscopy in which an esophageal stenosis and multiple esophageal pseudodiverticulosis were visualized. The biopsies only showed chronic nonspecific esophagitis. The stenosis was dilated with a balloon and PPIs were continued, with good response...
March 12, 2024: Revista Española de Enfermedades Digestivas
https://read.qxmd.com/read/38469112/outcomes-of-critically-ill-patients-with-liver-failure-who-require-mechanical-ventilation-a-retrospective-single-center-study
#28
JOURNAL ARTICLE
Atsuyoshi Mita, Sari Shimizu, Takashi Ichiyama, Takateru Yamamoto, Akinori Yamaguchi, Kosuke Sonoda, Kotaro Mori, Tomokatsu Yamada, Hiroyuki Nakamura, Hiroshi Imamura
BACKGROUND AND AIMS: Critically ill patients with liver failure have high mortality. Besides the management of organ-specific complications, liver transplantation constitutes a definitive treatment. However, clinicians may hesitate to introduce mechanical ventilation for patients on liver transplantation waitlists because of poor prognosis. This study investigated the outcomes of intensive care and ventilation support therapy effects in patients with liver failure. METHODS: This single-center study retrospectively enrolled 32 consecutive patients with liver failure who were admitted to the intensive care unit from January 2014 to December 2020...
March 2024: Health Science Reports
https://read.qxmd.com/read/38468254/routine-evaluation-of-hbv-specific-t-cell-reactivity-in-chronic-hepatitis-b-using-a-broad-spectrum-t-cell-epitope-peptide-library-and-elispot-assay
#29
JOURNAL ARTICLE
Yandan Wu, Xiaotao Liu, Yuan Mao, Ruixue Ji, Lingzhi Xia, Zining Zhou, Yan Ding, Pinqing Li, Yu Zhao, Min Peng, Jie Qiu, Chuanlai Shen
BACKGROUND: The clinical routine test of HBV-specific T cell reactivity is still limited due to the high polymorphisms of human leukocyte antigens (HLA) in patient cohort and the lack of universal detection kit, thus the clinical implication remains disputed. METHODS: A broad-spectrum peptide library, which consists of 103 functionally validated CD8+ T-cell epitopes spanning overall HBsAg, HBeAg, HBx and HBpol proteins and fits to the HLA polymorphisms of Chinese and Northeast Asian populations, was grouped into eight peptide pools and was used to establish an ELISpot assay for enumerating the reactive HBV-specific T cells in PBMCs...
March 11, 2024: Journal of Translational Medicine
https://read.qxmd.com/read/38463371/efficacy-of-transjugular-intrahepatic-portosystemic-shunts-in-treating-cirrhotic-esophageal-gastric-variceal-bleeding
#30
JOURNAL ARTICLE
Xiao-Gang Hu, Jian-Ji Dai, Jun Lu, Gang Li, Jia-Min Wang, Yi Deng, Rui Feng, Kai-Ping Lu
BACKGROUND: Esophageal-gastric variceal bleeding (EGVB) represents a severe complication among patients with cirrhosis and often culminates in fatal outcomes. Interventional therapy, a rapidly developing treatment modality over the past few years, has found widespread application in clinical practice due to its minimally invasive characteristics. However, whether transjugular intrahepatic portosystemic shunt (TIPS) treatment has an impact on patient prognosis remains controversial. AIM: To probing the efficacy of TIPS for treating cirrhotic EGVB and its influence on the prognosis of patients afflicted by this disease...
February 27, 2024: World Journal of Gastrointestinal Surgery
https://read.qxmd.com/read/38463353/correlation-between-serum-markers-and-transjugular-intrahepatic-portosystemic-shunt-prognosis-in-patients-with-cirrhotic-ascites
#31
JOURNAL ARTICLE
Xiao-Gang Hu, Xiao-Xian Yang, Jun Lu, Gang Li, Jian-Ji Dai, Jia-Min Wang, Yi Deng, Rui Feng
BACKGROUND: Individuals with refractory ascites in the context of liver cirrhosis typically face an adverse prognosis. The transjugular intrahepatic portosystemic shunt (TIPS) is an efficacious intervention, but there is a lack of reliable tools for postoperative prognosis assessment. Previously utilized clinical biochemical markers, such as the serum albumin concentration (Alb), sodium (Na+ ) concentration, and serum creatinine (Scr), have limited predictive value. Therefore, the quest for novel, specific biomarkers to evaluate the post-TIPS prognosis in patients with liver cirrhosis and refractory ascites holds significant practical importance...
February 27, 2024: World Journal of Gastrointestinal Surgery
https://read.qxmd.com/read/38460715/clinical-biochemical-and-histological-features-related-to-treatment-response-and-prognosis-in-autoimmune-hepatitis
#32
JOURNAL ARTICLE
Ludmila Resende Guedes, Guilherme Grossi Lopes Cançado, Bruno Campos Santos, Luma Dos Santos Jacomassi, Mateus Jorge Nardelli, Fernanda Maria Farage Osório, Luciana Costa Faria, Cláudia Alves Couto
INTRODUCTION AND OBJECTIVES: Autoimmune hepatitis (AIH) is a rare disease with a complex and not fully understood pathogenesis. Prognostic factors that might influence treatment response, relapse rates, and transplant-free survival are not well established. This study investigates clinical and biochemical markers associated with response to immunosuppression in patients with AIH. MATERIALS AND METHODS: This retrospective cohort study included 101 patients with AIH treated with immunosuppressants and followed at the Federal University of Minas Gerais, Brazil, from 1990 to 2018...
March 7, 2024: Annals of Hepatology
https://read.qxmd.com/read/38455627/co-incidence-of-covid-19-and-hepatocellular-carcinoma-during-pregnancy-double-punches-to-disease-severity-and-mortality
#33
JOURNAL ARTICLE
Azzaki Abubakar, Fauzi Yusuf, Sarah Firdausa, Desi Maghfirah, Andrie Gunawan, Cut M Yeni, Fitrah Sari
Hepatocellular carcinoma (HCC), a considerable leading cause of cancer-related deaths worldwide, is the most common primary liver cancer with poor prognosis and outcome. Many advances in prevention, screening, and new technologies in diagnostics and therapy have been achieved, but its incidence and mortality remain increasing. Co-infection of another viral disease in HCC patients with pregnancy might exacerbate the condition and double the mortality rate. The aim of this case report was to describe the co-infection of coronavirus disease 2019 (COVID-19) in an HCC patient during pregnancy...
December 2023: Narra J
https://read.qxmd.com/read/38454374/outcomes-of-pregnancies-complicated-by-cirrhosis-a-retrospective-cohort-study
#34
JOURNAL ARTICLE
Zhangmin Tan, Peizhen Zhang, Jin Zhou, Chuo Li, Chengfang Xu, Yuzhu Yin
BACKGROUND: Although pregnancy complicated by liver cirrhosis is rare, women with cirrhosis experience increased adverse pregnancy outcomes. This study aimed to evaluate pregnancy outcomes in women with liver cirrhosis and develop a predictive model using maternal factors for preterm birth in such pregnancies. METHODS: A retrospective analysis was conducted on pregnancy outcomes of a cirrhosis group (n = 43) and a non-cirrhosis group (n = 172) in a university hospital between 2010 and 2022...
March 7, 2024: BMC Pregnancy and Childbirth
https://read.qxmd.com/read/38448371/spp2-plays-a-role-in-the-tumorigenesis-of-hepatocellular-carcinoma-a-bioinformatic-based-analysis
#35
JOURNAL ARTICLE
Honghua Peng, Yang Liu, Zewen Song
OBJECTIVES: Hepatocellular carcinoma (HCC) patients at the same stage exhibit different prognosis, and the underlying molecular mechanism remains unclear. This study aims to identify the key genes impacting the prognosis of HCC patients. METHODS: Differentially expressed gene analyses were performed between HCC samples and normal ones, and between patients with long overall survival (OS) and those with short OS, in TCGA-LIHC and GSE14520 datasets. The Kaplan-Meier method with log-rank test was used to evaluate the role of secreted phosphoprotein 2 (SPP2) in the prognosis of HCC patients...
December 28, 2023: Zhong Nan da Xue Xue Bao. Yi Xue Ban, Journal of Central South University. Medical Sciences
https://read.qxmd.com/read/38445668/towards-holistic-integrative-medicine-based-management-strategy-of-liver-cirrhosis
#36
EDITORIAL
Deli Zou, Zhiping Yang, Xingshun Qi, Daiming Fan
No abstract text is available yet for this article.
March 7, 2024: Expert Review of Gastroenterology & Hepatology
https://read.qxmd.com/read/38439005/preventive-and-therapeutic-effects-of-rifaximin-on-hepatic-encephalopathy-with-differential-application-dosages-and-strategies-a-network-meta-analysis
#37
JOURNAL ARTICLE
Guihua Fang, Shuna Liu, Bin Liu
BACKGROUND: Hepatic encephalopathy (HE) is a neuropsychiatric syndrome that affects the prognosis of patients with liver disease and is considered an independent risk factor for hospitalization and death. Rifaximin has been approved for HE treatment. This review will analyze the effect of rifaximin on different stages of HE with differential application dosages and strategies by traditional and network meta-analyses. METHODS: We performed a systematic search of PubMed, EmBase, and Cochrane Library databases up to February 26, 2023, to identify randomized controlled trials (RCTs) about rifaximin for the prevention and treatment of HE...
March 4, 2024: BMC Gastroenterology
https://read.qxmd.com/read/38438672/prognosis-of-lspd-versus-tips-for-the-treatment-of-esophagogastric-variceal-bleeding-in-cirrhosis
#38
JOURNAL ARTICLE
Biao Chen, Jingxuan Wang, Weiyong Sheng, Bingqing Ma, Peng Xu, Xing Cheng, Weiyi Cheng, Chengjun Cai, Guoliang Wang, Wenming Pan, Chidan Wan, Chuansheng Zheng, Ping Cheng, Jinxiang Zhang
BACKGROUND: This study aimed to compare postoperative complications in patients with esophagogastric variceal bleeding (EVB) who underwent laparoscopic splenectomy combined with pericardial devascularization (LSPD) versus transjugular intrahepatic portosystemic shunt (TIPS) procedures. METHODS: A retrospective collection of medical records was conducted from January 2014 to May 2020 at Union Hospital, Tongji Medical College, Huazhong University of Science and Technology...
March 4, 2024: Surgical Endoscopy
https://read.qxmd.com/read/38434313/d-dimer-to-platelet-count-ratio-as-a-novel-indicator-for-predicting-prognosis-in-hbv-related-decompensated-cirrhosis
#39
JOURNAL ARTICLE
Xia He, QiuMing Ding
BACKGROUND: Hepatitis B virus-related decompensated cirrhosis (HBV-DC) is a critical illness with a low survival rate. Timely identification of prognostic indicators is crucial for risk stratification and personalized management of patients. The present study aimed to investigate the potential of the D-dimer-to-platelet count ratio (DPR) as a prognostic indicator for HBV-DC. METHODS: A retrospective review of medical records was conducted for 164 patients diagnosed with HBV-DC...
March 15, 2024: Heliyon
https://read.qxmd.com/read/38433869/protocol-to-evaluate-the-efficacy-and-safety-of-tolvaptan-in-patients-with-refractory-ascites-after-liver-resection-an-open-label-single-arm-phase-i-ii-study
#40
JOURNAL ARTICLE
Yosuke Namba, Tsuyoshi Kobayashi, Shintaro Kuroda, Masakazu Hashimoto, Daisuke Takei, Sotaro Fukuhara, Ko Oshita, Keiso Matsubara, Naruhiko Honmyo, Ryosuke Nakano, Hiroshi Sakai, Hiroyuki Tahara, Masahiro Ohira, Kentaro Ide, Hideki Ohdan
BACKGROUND: In patients with chronic liver diseases such as cirrhosis, massive ascites after hepatic resection is the cause of prolonged hospitalization and worsening prognosis. Recently, the efficacy of tolvaptan in refractory ascites has been reported; however, there are no reports on the efficacy or safety of tolvaptan for refractory ascites after hepatic resection. This study aims to evaluate the efficacy of early administration of tolvaptan in patients with refractory ascites after hepatic resection...
March 2024: International journal of surgery protocols
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