keyword
https://read.qxmd.com/read/38537069/controversies-in-terlipressin-and-transplantation-in-the-united-states-how-do-we-meld-the-two
#1
JOURNAL ARTICLE
Eric M Przybyszewski, Robert M Wilechansky, Paige McLean Diaz, Andrew S Allegretti, Lisa B VanWagner, Giuseppe Cullaro, Josh Levitsky, Pere Ginès, Salvatore Piano, Sumeet K Asrani, Kavish R Patidar
Hepatorenal syndrome-acute kidney injury (HRS-AKI) is a severe complication of cirrhosis that carries a poor prognosis. The recent Food and Drug Administration approval of terlipressin has substantial implications for managing HRS-AKI and liver allocation in the United States (US). Terlipressin has been available in Europe for over a decade, and several countries have adapted policy changes such as Model for End-Stage Liver Disease (MELD) score "lock" for HRS-AKI. In this article, we outline the European experience with terlipressin use and explore the question of whether terlipressin treatment for HRS-AKI should qualify for MELD score "lock" in the US in those who respond to therapy...
March 28, 2024: Liver Transplantation
https://read.qxmd.com/read/38536546/prognostic-genomic-alterations-in-patients-undergoing-liver-resection-for-hepatocellular-carcinoma
#2
JOURNAL ARTICLE
S B Nordkild, L B Ahlborn, C W Yde, J M Kugler, J Klubien, D Akdag, G L Willemoe, S D Nielsen, Hans-Christian Pommergaard
INTRODUCTION: Genetic mutations and amplifications found in hepatocellular carcinoma (HCC) have a potentially prognostic impact. The aim of this study was to investigate the prognostic value of mutations and amplifications in HCC from patients that were liver resected. METHODS: Patients liver resected for HCC at Copenhagen University Hospital Rigshospitalet between May 2014 and January 2018 were included. DNA from freshly frozen tumour tissue was investigated with TruSight Oncology 500...
March 27, 2024: Molecular Biology Reports
https://read.qxmd.com/read/38526023/review-article-recent-advances-in-ascites-and-acute-kidney-injury-management-in-cirrhosis
#3
REVIEW
Danielle Adebayo, Florence Wong
BACKGROUND: Better understanding of disease pathophysiology has led to advances in managing ascites and its associated complications including hepatorenal syndrome-acute kidney Injury (HRS-AKI), especially medicinal and interventional advances. AIM: To review the latest changes in the management of ascites and HRS-AKI. METHODS: A literature search was conducted in Pubmed, using the keywords cirrhosis, ascites, renal dysfunction, acute kidney injury, hepatorenal syndrome, beta-blockers, albumin, TIPS and vasoconstrictors, including only publications in English...
March 25, 2024: Alimentary Pharmacology & Therapeutics
https://read.qxmd.com/read/38514268/-research-progress-on-the-role-of-hepatitis-b-virus-dna-integration-in-chronic-hepatitis-b
#4
JOURNAL ARTICLE
Y M Chen, J Liu, C W Zhu, L Zhu
Chronic hepatitis B virus (HBV) infection will greatly contribute to raising the occurrence probability of cirrhosis and hepatocellular carcinoma in patients. Although existing antiviral treatment regimens have a certain effect on delaying disease progression and improving prognosis, it is still not effective in attaining functional cures. Hepatitis B virus DNA integration may be one of the reasons for this phenomenon. Therefore, this paper reviews the possible mechanisms of HBV DNA integration in maintaining chronic inflammation of the liver, evading existing antiviral treatment methods, and inducing hepatocellular carcinoma so as to further deepen the understanding of the role of HBV DNA integration in the occurrence and development of chronic hepatitis B, providing ideas and references for formulating better treatment strategies...
February 20, 2024: Zhonghua Gan Zang Bing za Zhi, Zhonghua Ganzangbing Zazhi, Chinese Journal of Hepatology
https://read.qxmd.com/read/38514067/a-rare-autopsy-case-of-aggressive-combined-hepatocellular-cholangiocarcinoma-in-59-year-old-female
#5
JOURNAL ARTICLE
Ahmed A Ahmed, Brandon Gehris, Michelle McDonald, Suhair Al Salihi, L Maximilian Buja
Combined hepatocellular-cholangiocarcinoma (cHCC-CC) is a liver tumor with features of both hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (ICC). It consists of intermingled malignant biliary and hepatic tissue and thus a distinct entity, rather than two separate coexisting malignancies. A 59-year-old female with a history of hepatitis C and cirrhosis presented with abdominal pain and altered mental status. She developed hematemesis, and despite extensive interventions, she expired one day after her initial presentation...
January 2024: Annals of Clinical and Laboratory Science
https://read.qxmd.com/read/38512249/vibration-controlled-transient-elastography-scores-to-predict-liver-related-events-in-steatotic-liver-disease
#6
JOURNAL ARTICLE
Huapeng Lin, Hye Won Lee, Terry Cheuk-Fung Yip, Emmanuel Tsochatzis, Salvatore Petta, Elisabetta Bugianesi, Masato Yoneda, Ming-Hua Zheng, Hannes Hagström, Jérôme Boursier, José Luis Calleja, George Boon-Bee Goh, Wah-Kheong Chan, Rocio Gallego-Durán, Arun J Sanyal, Victor de Lédinghen, Philip N Newsome, Jian-Gao Fan, Laurent Castéra, Michelle Lai, Stephen A Harrison, Céline Fournier-Poizat, Grace Lai-Hung Wong, Grazia Pennisi, Angelo Armandi, Atsushi Nakajima, Wen-Yue Liu, Ying Shang, Marc de Saint-Loup, Elba Llop, Kevin Kim-Jun Teh, Carmen Lara-Romero, Amon Asgharpour, Sara Mahgoub, Mandy Sau-Wai Chan, Clemence M Canivet, Manuel Romero-Gomez, Seung Up Kim, Vincent Wai-Sun Wong
IMPORTANCE: Metabolic dysfunction-associated steatotic liver disease (MASLD) is currently the most common chronic liver disease worldwide. It is important to develop noninvasive tests to assess the disease severity and prognosis. OBJECTIVE: To study the prognostic implications of baseline levels and dynamic changes of the vibration-controlled transient elastography (VCTE)-based scores developed for the diagnosis of advanced fibrosis (Agile 3+) and cirrhosis (Agile 4) in patients with MASLD...
March 21, 2024: JAMA
https://read.qxmd.com/read/38505873/kdm4a-as1-promotes-cell-proliferation-migration-and-invasion-via-the-mir-4306-stx6-axis-in-hepatocellular-carcinoma
#7
JOURNAL ARTICLE
Wei Cao, Yuhan Ren, Ying Liu, Guoshu Cao, Zhen Chen, Fan Wang
As a primary liver malignancy, hepatocellular carcinoma (HCC) is commonly induced by chronic liver disease and cirrhosis. Bioinformatics analysis reveals that long noncoding RNA KDM4A antisense RNA 1 (KDM4A-AS1) may be aberrantly expressed in HCC and its abnormal expression might influence prognosis in patients. We conducted this study to illustrate the functions and mechanism of KDM4A-AS1 in regulating HCC malignant cell behavior. KD-M4A-AS1, microRNA (miR)-4306 and messenger RNA syntaxin 6 (STX6) expression was examined by reverse transcription-quantitative polymerase chain reaction (RT-qPCR)...
2024: Critical Reviews in Eukaryotic Gene Expression
https://read.qxmd.com/read/38502914/lower-uromodulin-serum-levels-are-associated-with-poorer-prognosis-in-patients-with-cirrhosis-and-hepatorenal-syndrome-type-2
#8
JOURNAL ARTICLE
Eva Maria Schleicher, Simon Johannes Gairing, Darko Castven, Charlotte Sophie Hock, Henrike Dobbermann, Sophia Heinrich, Myriam Meineck, Leonard Kaps, Peter Robert Galle, Julia Weinmann-Menke, Marc Nguyen-Tat, Jens Uwe Marquardt, Christian Labenz
Hepatorenal syndrome (HRS) is associated with a dismal prognosis in patients with cirrhosis, and therapeutic options are limited. Biomarkers to identify patients with poor response to therapy are urgently needed. This study aimed to evaluate the predictive value of serum levels of Uromodulin (sUMOD) in patients with cirrhosis and HRS treated with terlipressin and albumin (T/A). In total, 156 patients (81 patients with HRS treated with T/A, 42 patients with cirrhosis without kidney injury and 33 patients with cirrhosis with prerenal acute kidney injury (AKI)) were included...
March 19, 2024: American Journal of Physiology. Gastrointestinal and Liver Physiology
https://read.qxmd.com/read/38499836/prognostic-value-of-liver-stiffness-in-patients-hospitalized-for-acute-decompensated-heart-failure-a-meta-analysis
#9
JOURNAL ARTICLE
Noemi Macerola, Laura Riccardi, Enrico Di Stasio, Massimo Montalto, Antonio Gasbarrini, Maurizio Pompili, Matteo Garcovich
PURPOSE: Heart failure (HF) is a major health problem affecting millions of people worldwide. In the latest years, many efforts have been made to identify predictors of poor prognosis in these patients. The aim of this systematic review and meta-analysis was to enlighten the correlation between liver stiffness (LS), assessed by Shear Wave Elastography techniques, and HF, particularly focusing on the prognostic value of LS on cardiovascular outcomes. METHODS: We searched the PUBMED databases (up to May 1st, 2023) for studies that enlightened the correlation between LS and cardiovascular outcomes in patients hospitalized for acute decompensated heart failure (ADHF)...
March 18, 2024: Journal of Ultrasound
https://read.qxmd.com/read/38499728/routes-to-diagnosis-for-hepatocellular-carcinoma-patients-predictors-and-associations-with-treatment-and-mortality
#10
JOURNAL ARTICLE
Anya Burton, Jennifer Wilburn, Robert J Driver, David Wallace, Sean McPhail, Tim J S Cross, Ian A Rowe, Aileen Marshall
BACKGROUND: Hepatocellular carcinoma (HCC) incidence has increased rapidly, and prognosis remains poor. We aimed to explore predictors of routes to diagnosis (RtD), and outcomes, in HCC cases. METHODS: HCC cases diagnosed 2006-2017 were identified from the National Cancer Registration Dataset and linked to Hospital Episode Statistics and the RtD metric. Multivariable logistic regression was used to explore associations between RtD, diagnosis year, 365-day mortality and receipt of potentially curative treatment...
March 18, 2024: British Journal of Cancer
https://read.qxmd.com/read/38497931/racial-and-ethnic-disparities-in-alcohol-associated-liver-disease-in-the-united-states-a-systematic-review-and-meta-analysis
#11
JOURNAL ARTICLE
Ahmad Anouti, Karim Seif El Dahan, Nicole E Rich, Jeremy Louissaint, William M Lee, Sarah R Lieber, Juan Pablo Arab, Bill Y Zhang, Mausam J Patel, Chanattha Thimphittaya, Luis Antonio Díaz, Dyanna L Gregory, Julia Kozlitina, Lisa B VanWagner, Andrea C King, Mack C Mitchell, Amit G Singal, Thomas G Cotter
BACKGROUND: Alcohol-associated liver disease (ALD), encompassing alcohol-associated hepatitis and alcohol-associated cirrhosis, is rising in the United States. Racial and ethnic disparities are evident within ALD; however, the precise nature of these disparities is poorly defined. METHODS: We conducted a search of the PubMed/MEDLINE and EMBASE databases to identify studies published from inception through September 2023 that reported ALD incidence, prevalence, and mortality within the United States, stratified by race and ethnicity...
April 1, 2024: Hepatology Communications
https://read.qxmd.com/read/38495463/comparison-of-a-novel-score-nod-aclf-to-other-established-prognostic-scores-for-prediction-of-mortality-in-apasl-aclf-patients-a-cohort-study-from-a-tertiary-care-center-of-north-india
#12
JOURNAL ARTICLE
Ajay K Patwa, Khushboo Yadav, Virendra Atam, Kauser Usman, Satyendra K Sonkar, Shyam C Chaudhary, Vivek Kumar, Kamal K Sawlani, Kamlesh K Gupta, Munna L Patel, Dandu H Reddy, Harish Gupta, Medhavi Gautam, Satish Kumar, Amit Kumar, Ambuj Yadav, Deepak Bhagchandani, Mahak Lamba, Abhishek Singh, Ajay K Mishra
BACKGROUND: Commonly used prognostic scores for acute on-chronic liver failure (ACLF) have complex calculations. We tried to compare the simple counting of numbers and types of organ dysfunction to these scores, to predict mortality in ACLF patients. METHODS: In this prospective cohort study, ACLF patients diagnosed on the basis of Asia Pacific Association for Study of the Liver (APASL) definition were included. Severity scores were calculated. Prognostic factors for outcome were analysed...
2024: Journal of Clinical and Experimental Hepatology
https://read.qxmd.com/read/38495288/predicting-major-adverse-cardiovascular-events-after-orthotopic-liver-transplantation-using-a-supervised-machine-learning-model-a-cohort-study
#13
JOURNAL ARTICLE
Jonathan Soldera, Leandro Luis Corso, Matheus Machado Rech, Vinícius Remus Ballotin, Lucas Goldmann Bigarella, Fernanda Tomé, Nathalia Moraes, Rafael Sartori Balbinot, Santiago Rodriguez, Ajacio Bandeira de Mello Brandão, Bruno Hochhegger
BACKGROUND: Liver transplant (LT) patients have become older and sicker. The rate of post-LT major adverse cardiovascular events (MACE) has increased, and this in turn raises 30-d post-LT mortality. Noninvasive cardiac stress testing loses accuracy when applied to pre-LT cirrhotic patients. AIM: To assess the feasibility and accuracy of a machine learning model used to predict post-LT MACE in a regional cohort. METHODS: This retrospective cohort study involved 575 LT patients from a Southern Brazilian academic center...
February 27, 2024: World Journal of Hepatology
https://read.qxmd.com/read/38495286/contemporary-concepts-of-prevention-and-management-of-gastroesophageal-variceal-bleeding-in-liver-cirrhosis-patients
#14
EDITORIAL
Dmitry Victorovich Garbuzenko
This editorial describes the contemporary concepts of prevention and management of gastroesophageal variceal bleeding in liver cirrhosis (LC) patients according to the current guidelines. Gastroesophageal variceal bleeding is the most dangerous complication of portal hypertension in LC patients. Risk stratification and determination of an individual approach to the choice of therapeutic measures aimed at their prevention and management has emerged as one of the top concerns in modern hepatology. According to the current guidelines, in the absence of clinically significant portal hypertension, etiological and non-etiological therapies of LC is advisable for the primary preventing gastroesophageal variceal bleeding, whereas its presence serves as an indication for the administration of non-selective β-blockers, among which carvedilol is the drug of choice...
February 27, 2024: World Journal of Hepatology
https://read.qxmd.com/read/38495283/changes-in-the-etiology-of-liver-cirrhosis-and-the-corresponding-management-strategies
#15
EDITORIAL
Jin-Jin Dai, Yue-Ying Liu, Zhen-Hua Zhang
We read with interest the article by Xing Wang, which was published in the recent issue of the World Journal of Hepatology 2023; 15: 1294-1306. This article focuses particularly on the prevalence and trends in the etiology of liver cirrhosis (LC), prognosis for patients suffering from cirrhosis-related complications and hepatocellular carcinoma (HCC), and management strategies. The etiology of cirrhosis varies according to geographical, economic, and population factors. Viral hepatitis is the dominant cause in China...
February 27, 2024: World Journal of Hepatology
https://read.qxmd.com/read/38493049/lower-nkg2d-expression-in-hepatic-natural-killer-cells-predicts-poorer-prognosis-for-chronic-hepatitis-b-patients-with-cirrhosis
#16
JOURNAL ARTICLE
Yangqing Ma, Dabing Ping, Kai Huang, Yanyan Tao, Yuan Peng, Xin Sun, Chenghai Liu
OBJECTIVE: Natural killer cells (NK) acts a central player of the immune system in liver cirrhosis. The aim of this study was to examine the expression of activating intra-hepatic NK cell group 2D (NKG2D) in patients with chronic hepatitis B (CHB) and analyzed the correlation between NKG2D expression and prognosis of liver cirrhosis in these patients. METHODS: This was a cross-section study. Subjects with liver biopsy or sponge hemangioma surgery were included. The primary outcome was the NKG2D expression on intra-hepatic NK cells and their subtype cells in patients with CHB-related liver cirrhosis...
March 15, 2024: Human Immunology
https://read.qxmd.com/read/38492132/prophylaxis-of-hepatic-encephalopathy-current-and-future-drug-targets
#17
REVIEW
Sudhir Maharshi, Barjesh Chander Sharma
Hepatic encephalopathy is described by a broad spectrum of neurological and psychiatric aberrations resulting due to advanced liver dysfunction. It is a neurological disorder due to hepatic insufficiency and/or portosystemic shunts. Its clinical presentation includes neuropsychiatric dysfunction ranging from subclinical changes to comatose state. It is a sign of poor prognosis in cirrhotics with a high 1-year mortality. Each episode of hepatic encephalopathy leads to high hospitalization rate, poor prognosis and raised burden of healthcare...
March 16, 2024: Hepatology International
https://read.qxmd.com/read/38488679/the-associations-between-fibrosis-changes-and-liver-related-events-in-patients-with-metabolic-dysfunction-associated-steatotic-liver-disease
#18
JOURNAL ARTICLE
Hye Won Lee, Kun Hee Kim, Sang Hoon Ahn, Han Chu Lee, Jonggi Choi
BACKGROUND: The prognosis of metabolic dysfunction-associated steatotic liver disease (MASLD) is associated with liver fibrosis. We investigated the associations between changes in liver stiffness measurement (LSM) over 3-year period and the development of cirrhosis or hepatocellular carcinoma (HCC) in patients with MASLD. METHODS: This study involved patients with MASLD who underwent transient elastography at baseline and 3 years after baseline from 2012 to 2020...
March 15, 2024: Liver International: Official Journal of the International Association for the Study of the Liver
https://read.qxmd.com/read/38487027/prevalence-and-effect-on-prognosis-of-sarcopenia-in-patients-with-primary-biliary-cholangitis
#19
JOURNAL ARTICLE
Jiaqi Yang, Shuangshuang Jiang, Qingling Fan, Didi Wen, Yansheng Liu, Kemei Wang, Hui Yang, Changcun Guo, Xinmin Zhou, Guanya Guo, Yulong Shang, Ying Han
BACKGROUND: Sarcopenia adversely affects the treatment outcomes in Cirrhosis and NAFLD. However, such research is limited in primary biliary cholangitis (PBC) patients. This study was performed to examine the prevalence of sarcopenia and its impact on PBC patients' prognoses. METHODS: This study enrolled confirmed PBC patients who had an abdominal CT scan. Sarcopenia was determined by the L3-skeletal muscle index with a Chinese population-based cut-off value. Laboratory test values and liver stiffness measurements values were obtained from the electronic medical records...
2024: Frontiers in Medicine
https://read.qxmd.com/read/38486819/infections-increase-the-risk-of-decompensation-and-death-in-patients-with-early-alcohol-related-liver-disease
#20
JOURNAL ARTICLE
Stine Johansen, Simon Langkjær, Ditlev Nytoft Rasmussen, Mads Israelsen, Nikolaj Torp, Katrine Lindvig, Maria Kjærgaard, Johanne Kragh Hansen, Camilla Dalby Hansen, Katrine Thorhauge, Peter Andersen, Sönke Detlefsen, Helene Bæk Juel, Ulrik Stenz Justesen, Torben Hansen, Aleksander Krag, Maja Thiele
BACKGROUND & AIMS: Infections are frequent in patients with cirrhosis and worsen prognosis. We evaluated the incidence of infections and their impact on decompensation and death in patients with early alcohol-related liver disease (ALD) during long-term follow-up. METHODS: We performed a prospective cohort study of patients in secondary care with a history of excess alcohol intake, no prior decompensation, and with liver biopsies along with clinical investigations conducted at baseline...
April 2024: JHEP reports: innovation in hepatology
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