Candida esophagitis in childrens

J A Laks, A Kiss, A I Dipchand
PURPOSE: There has been greater recognition of allergy and autoimmune disease in pediatric solid organ transplantation, however, their relationship with pediatric heart transplant is unclear. The purpose of this study was to explore post heart transplant immune dysregulation. METHODS: Retrospective chart review was carried out at a single center on children less than 18 years of age, transplanted between 2000 and 2018, who were at least 1 year post heart transplant without any history of immune dysregulation before transplant...
April 2020: Journal of Heart and Lung Transplantation
Mădălina Adriana Bordea, Alexandru Pîrvan, Dan Gheban, Ciprian Silaghi, Iulia Lupan, Gabriel Samașca, Lia Pepelea, Lia Monica Junie, Carmen Costache
OBJECTIVES: The aim of this study is to provide information about prevalence, etiology, risk factors, clinical characteristics and endoscopic features of various types of infectious esophagitis in children. METHODS: We performed a total of 520 upper gastrointestinal tract endoscopies in Pediatric Clinic II, Emergency Hospital for Children, Cluj-Napoca. Indications for endoscopy in our cohort were gastrointestinal tract symptoms such as dysphagia, heartburn, or appetite loss...
March 30, 2020: Journal of Clinical Medicine
Cristina Oana Mărginean, Lorena Elena Meliţ, Simona Mocan, Maria Oana Mărginean, Cristian Dan Mărginean
RATIONALE: Herpetic esophagitis (HE) is a common condition in immunosuppressed patients, but a rare entity in immunocompetent patients affecting especially male teenagers and young adults. PATIENT CONCERNS: We report the case of a 5-year-old male patient, with a history of allergic rhinitis admitted in our clinic for acute onset fever refractory to antipyretics, chest pain, anorexia, refusal of solid food, accepting only small amounts of fluids, odynophagia, and epigastric pain...
May 2019: Medicine (Baltimore)
Apoorva T Ramaswamy, Jae Seong No, Lillye Anderson, Aliza Solomon, Thomas Ciecierega, Elaine Barfield, Kimberly Chien, Felice Schnoll-Sussman, William R Reisacher
BACKGROUND: Eosinophilic esophagitis (EoE) is an inflammatory disease of the esophagus, producing failure to thrive in infants and dysphagia with food impaction in older children and adults. Although most people with EoE manifest atopic/allergic disease, the specific allergens to which immunoglobulin E (IgE) is directed, if any, have not yet been characterized. METHODS: Mucosal brush biopsy (MBB) and solid tissue biopsy (STB) specimens were prospectively obtained from 25 individuals with dysphagia and suspicion of EoE...
August 2019: International Forum of Allergy & Rhinology
Tim G J de Meij, Michiel P van Wijk, Aart Mookhoek, Andries E Budding
Sarcina ventriculi is a Gram-positive, obligate anaerobic coccus, with a characteristic morphology. Only 22 cases of human infections by this microorganism, including 7 in children, have been reported in literature so far. Affected subjects usually present with abdominal pain, nausea, vomiting, and delayed gastric emptying. However, life-threatening complications, like emphysematous gastritis and gastric perforation have also been described. Gastroparesis and gastric outlet obstruction have been considered as a potential etiologic factor...
2017: Frontiers in Medicine
Roeland E Wasmann, Eline W Muilwijk, David M Burger, Paul E Verweij, Catherijne A Knibbe, Roger J Brüggemann
Micafungin is a selective inhibitor of the synthesis of fungal 1,3-β-D-glucan, an essential component of the fungal cell wall. It is available as a powder for infusion only and is registered for the treatment of invasive and esophageal candidiasis in addition to prophylaxis of Candida infections in both adults and children. Average exposure after a single intravenous 100 mg dose in healthy adults is 133 mg h/L. Both exposure and maximum plasma concentration show linear dose proportional pharmacokinetics (PK) over a 0...
March 2018: Clinical Pharmacokinetics
William W Hope, Atsunori Kaibara, Michael Roy, Antonio Arrieta, Nkechi Azie, Laura L Kovanda, Daniel K Benjamin
The aim of this analysis was to identify therapeutic micafungin regimens for children that produce the same micafungin exposures known to be effective for the prevention and treatment of Candida infections in adults. Pediatric pharmacokinetic data from 229 patients between the ages of 4 months and <17 years were obtained from four phase I and two phase III clinical trials. Population pharmacokinetic models were used to simulate the proportion of children who had a steady-state area under the concentration-time curve at 24 hours (AUC24) of micafungin within the 10th to 90th percentile range observed in a population of adults receiving a dose of micafungin with established efficacy for invasive candidiasis (100 mg/day), i...
February 2015: Antimicrobial Agents and Chemotherapy
E Puzenat, G Bellaud, P Saugier-Veber, C Crémillieux, B Mignot, P Humbert, F Aubin
BACKGROUND: Polyglandular auto-immune syndrome type 1 (PAS-1) or auto-immune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED) is a rare autosomal recessive disorder linked to auto-immune regulator (AIRE) gene mutations. Herein, we report the case of a 3-year-old boy with APECED emphasizing the wide phenotypic variability and the extent of skin lesions. PATIENTS AND METHODS: A 3-year-old boy with a history of auto-immune hepatitis was referred for a generalized pruriginous urticaria-like eruption present for one month...
April 2014: Annales de Dermatologie et de Vénéréologie
Mozhgan Zahmatkeshan, Khadijesadat Najib, Bita Geramizadeh, Ebrahim Fallahzadeh, Mahmood Haghighat, Mohammad Hadi Imanieh
BACKGROUND: We sought to determine the clinical characteristics of pediatric esophagitis in southern Iran. METHODS: This cross-sectional study was conducted over a 4-year period, from 2005 to 2009, in Nemazee Hospital, a tertiary healthcare center in Shiraz, southern Iran. We consecutively included all pediatric patients (<18 years) who underwent endoscopy in our center and had pathology-confirmed diagnosis of esophagitis. Data regarding the patients' demographic characteristics, comorbidities, and clinical findings were recorded using a questionnaire...
June 2013: Iranian Journal of Medical Sciences
Eda Karadağ-Öncel, Senay Kenç, Selin Aytaç, Yusuf Aydemir, Gülin Hızal, Aysel Yüce, Ateş Kara
An esophageal stricture is one of the complications that may develop during cancer treatment in children. Although more commonly associated with radiotherapy, recurrent mucositis has also been implicated. Presented herein is a case of a patient with acute lymphoblastic leukemia who suffered recurrent attacks of severe mucositis. Initial management of ensuing dysphagia included antifungal treatment for candida esophagitis. A subsequent upper endoscopy due to persistence of dysphagia revealed the presence of an esophageal stricture...
January 2013: Turkish Journal of Pediatrics
Stephan Buderus, Hannah Sonderkötter, Gudrun Fleischhack, Michael J Lentze
UNLABELLED: Chemotherapy regimes in children with cancer often cause gastrointestinal side effects. Only limited data exist on the use of endoscopy in this group of patients. METHODS: Retrospective review over a time period of 8.5 years identified 57 endoscopies (49 upper endoscopies, four colonoscopies, three sigmoidoscopies, one rectoscopy) in 38 patients (mean age 12.8 years). Seventeen children (45%) had hematological malignancies and 21 (55%) had solid tumors...
August 2012: Pediatric Hematology and Oncology
G Michel
Intensified chemotherapy and hematopoietic stem cell transplantation result in severe and prolonged granulocytopenia with an increased risk of invasive fungal infections. The major fungal species that cause serious infections in cancer patients are Candida species and Aspergillus species. The main features of Candida infection in this context are oropharyngeal candidiasis and Candida esophagitis, chronic disseminated candidiasis, also known as hepatosplenic candidiasis, and candidemia. Aspergillus can cause severe lung infection but also sinusal or CNS infection...
May 2011: Archives de Pédiatrie: Organe Officiel de la Sociéte Française de Pédiatrie
Miguel Montejo, Guillermo Quindós
Micafungin is a semisynthetic lipopeptide developed from Coleophoma empetri, which blocks the synthesis of β-1,3-D-glucan, an essential component of the fungal wall, though non-competitive inhibition of β-1,3-D-glucan synthetase. Micafungin is a dose-dependent candidacidal agent with excellent in vitro efficacy against most Candida spp. including species resistant to amphotericin B, such as Candida lusitaniae, several azoles, such as C. glabrata or C. krusei, and isolates not susceptible to other echinocandins...
March 2011: Enfermedades Infecciosas y Microbiología Clínica
Mohammed Yahya Hasosah, Mahmmod Showail, Ashraf Al-Sahafi, Mohammed Satti, Kevan Jacobson
BACKGROUND: Infections of the esophagus are rare and most commonly seen in children with immune suppression resulting from malignancy, chronic metabolic or infectious disease, or immunosuppressive drug therapy. METHODS: An 18-month-old girl on inhaled corticosteroid for bronchial asthma presented with coffee-ground emesis and melena. Upper endoscopy revealed yellow-white plaques scattered over the mucosa of the distal esophagus. Biopsy results showed chronic esophagitis with features of reflux disease...
May 2009: World Journal of Pediatrics: WJP
Isidro Jarque, Miguel Angel Sanz
BACKGROUND: Invasive candidiasis is a severe infection among onco-hematological patients, with an attributable mortality around 40%. Micafungin has shown efficacy in antifungal prophylaxis among hematopoietic stem cell transplant recipients and in the treatment of esophageal candidiasis. AIMS: To assess the role of micafungin in the treatment of invasive candidiasis among onco-hematological patients. METHODS: Literature review. RESULTS: In a study on 126 patients with candidemia treated with micafungin, an overall response rate of 83% was reported...
March 31, 2009: Revista Iberoamericana de Micología
Theoklis E Zaoutis, Hasan S Jafri, Li-Min Huang, Franco Locatelli, Asher Barzilai, Wolfram Ebell, William J Steinbach, John Bradley, Jay M Lieberman, Chih-Cheng Hsiao, Nita Seibel, Hans-Juergen Laws, Melinda Gamba, Maria Petrecz, Arlene F Taylor, Kim M Strohmaier, Joseph W Chow, Nicholas A Kartsonis, Angela L Ngai
OBJECTIVE: We evaluated the safety, tolerability, and efficacy of caspofungin in pediatric patients with invasive aspergillosis, invasive candidiasis, or esophageal candidiasis. METHODS: This was a multicenter, prospective, open-label study in children 3 months to 17 years of age with proven or probable invasive aspergillosis, proven invasive candidiasis, or proven esophageal candidiasis. All of the patients received caspofungin 70 mg/m(2) on day 1, followed by 50 mg/m(2) per day (maximum: 70 mg/day), as primary or salvage monotherapy...
March 2009: Pediatrics
Jason A Daniels, Howard M Lederman, Anirban Maitra, Elizabeth A Montgomery
BACKGROUND: Common variable immunodeficiency (CVID) is characterized by a host of gastrointestinal (GI) lesions that can mimic other conditions. METHODS: We reviewed clinical documentation and samples from 132 separate GI biopsy or resection sites on 20 CVID patients obtained over a 26-year period, including biopsies from the colon (34), esophagus (19), small intestine (38), and stomach (35), a partial gastrectomy, small bowel resection, colectomy, 2 cholecystectomies, and 1 appendectomy...
December 2007: American Journal of Surgical Pathology
Fabio Pace, Stefano Pallotta, Spinello Antinori
PURPOSE OF REVIEW: To review recently published studies presenting novel and relevant information on some esophageal infectious, inflammatory and injurious diseases. RECENT FINDINGS: In the treatment of Candida esophagitis, fluconazole remains the treatment of choice, but clinical failures indicate new therapeutic opportunities, like two new echinocandins, micafungin and anidulafungin. Eosinophilic esophagitis is an increasingly recognized entity. New therapeutic insights come from a six-food elimination diet in children and from fluticasone propionate in adults; humanized monoclonal IgG antibody anti-interlukin-5, mepolizumab, has been shown to decrease eosinophilia and ameliorate symptoms...
July 2007: Current Opinion in Gastroenterology
L F Avila, A L Luis, J L Encinas, A M Andrés, O Suárez, L Martínez, A Fernández, A Queizán, J Murcia, P Olivares, L Lassaletta, J A Tovar
UNLABELLED: Esophageal replacement is a surgical procedure rarely indicated in children. It is used in esophageal atresia type I and long-gap atresia when anastomosis is not possible, corrosive strictures and other unusual causes. Type and location of the graft depend on etiology and surgeon preferences. We analyse our results of a large series of esophageal replacement. METHODS: . We reviewed esophageal replacements carried out in our department between January-1992 and December-2004...
October 2006: Cirugía Pediátrica: Organo Oficial de la Sociedad Española de Cirugía Pediátrica
Beata Fortak, Izabela Płaneta-Małecka, Jadwiga Trojanowska-Lipczyk, Elzbieta Czkwianianc, Eleonora Dyńiska, Beata Kozieł
UNLABELLED: The aim of the study was to demonstrate morphological traits of Candida-induced upper alimentary tract mucosa inflammation. The material for the study comprised 18 children aged 4 to 18 years treated at the I Department of Paediatrics and Gastroenterology, Institute Polish Mother Health Centre. In these children positive mycologic cultures were obtained from alimentary tract inflammed mucosa sections. Upper alimentary tract endoscopy was performed and macroscopic and microscopic evaluation was made...
2004: Wiadomości Parazytologiczne
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"