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drugs used to increase irisin

Govand Yaseen Saber, Violet Kasabri, Mohammad Issa Saleh, Maysa Suyagh, Lana Halaseh, Ruba Jaber, Hana Abu-Hassan, Sundos Alalawi
Background Irisin and fibroblast growth factor 1 (FGF1) are intricately involved in metabolic syndrome (MetS) and prediabetes (preDM) pathophysiology. This study aimed to compare and correlate irisin and FGF1 plasma levels, adiposity, atherogenicity and hematological indices in 29 normoglycemic MetS and 30 newly diagnosed drug naive prediabetic (PreDM) MetS patients vs. 29 lean and normoglycemic controls. Materials and methods Irisin and FGF1 plasma levels were measured using colorimetric assays. Intergroup comparisons were conducted by analysis of variance (ANOVA)...
March 6, 2019: Hormone Molecular Biology and Clinical Investigation
Esengul Keleş, Filiz Fatime Turan
BACKGROUND: Most recently, a novel myokine, named irisin, was identified in human that expressed by skeletal muscle after exercise. Irisin increases energy expenditure by turning white adipose tissue into brown adipose tissue. Thus improves carbohydrate homeostasis in humans. Irisin is considered as a potential biomarker for obesity and metabolic syndrome. In recent years, numerous studies have been conducted about irisin with adults, although number of studies with newborns is limited...
2016: SpringerPlus
Huseyin Tugrul Çelik, Nermin Akkaya, Husamettin Erdamar, Sumeyye Gok, Fatmanur Kazanci, Bora Demircelik, Muzaffer Cakmak, Ramazan Yigitoglu
BACKGROUND: Hypertension and obesity are two major threats for public health. Up to the present, antihypertensive medications have been used to lower blood pressure, which seem to provide a better life with lower morbidity and mortality rates. Their effect on etiopathogenesis of hypertension is now an area of developing research. The association between hypertension and obesity also suggests the link between antihypertensive agents and energy hemostasis. We aimed to investigate the effects of antihypertensive treatment on the irisin, adropin, and perilipin levels in patients with essential hypertension and to compare them with healthy volunteers in terms of their effect on energy hemostasis...
2015: Clinical Laboratory
D Espes, J Lau, P O Carlsson
BACKGROUND: Irisin stimulates browning of white adipose tissue and improves metabolic control in mice. Betatrophin, another recently described hormone, improves metabolic control in mice by inducing β-cell proliferation. In vitro, irisin stimulates the expression of betatrophin in rat adipocytes. There is a great interest in developing drugs that target or use these hormones for the treatment of obesity and diabetes. We have previously reported on increased levels of betatrophin in people with Type 1 diabetes, but the levels of irisin are currently unknown...
September 2015: Diabetic Medicine: a Journal of the British Diabetic Association
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