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https://read.qxmd.com/read/30761083/history-of-the-obesogen-field-looking-back-to-look-forward
#1
REVIEW
Jerrold J Heindel
The Obesogen field developed from two separate scientific research areas, endocrine disruptors and the Developmental Origins of Health and Disease (DOHaD). Endocrine Disrupting Chemicals (EDCs) are exogenous chemicals or mixtures of chemicals that interfere with the action of hormones. Exposure to EDCs during early development (DOHaD) has been shown to increase susceptibility to a variety of diseases including infertility, asthma, breast and prostate cancer, early puberty, susceptibility to infections, heart disease, autoimmune disease, and attention deficit hyperactivity disorder/learning disability...
2019: Frontiers in Endocrinology
https://read.qxmd.com/read/30755209/disaggregating-catastrophic-health-expenditure-by-disease-area-cross-country-estimates-based-on-the-world-health-surveys
#2
Annie Haakenstad, Matthew Coates, Andrew Marx, Gene Bukhman, Stéphane Verguet
BACKGROUND: Financial risk protection (FRP) is a key objective of national health systems and a core pillar of universal health coverage (UHC). Yet, little is known about the disease-specific distribution of catastrophic health expenditure (CHE) at the national level. METHODS: Using the World Health Surveys (WHS) from 39 countries, we quantified CHE, or household health spending that surpasses 40% of capacity-to-pay by key disease areas. We restricted our analysis to households in which the respondent used health care in the last 30 days and categorized CHE into disease areas included as WHS response options: maternal and child health (MCH); high fever, severe diarrhea, or cough; heart disease; asthma; injury; surgery; and other...
February 13, 2019: BMC Medicine
https://read.qxmd.com/read/30737767/trial-of-labor-after-cesarean-section-in-risk-pregnancies-a-population-based-cohort-study
#3
Sjur Lehmann, Elham Baghestan, Per Engebret Børdahl, Lorentz Muller Irgens, Svein Arvid Rasmussen
INTRODUCTION: In most pregnancies after a cesarean section, a trial of labor is an option. The objective of the study was to explore trial of labor and its failure in pregnancies with medical risk conditions, in a population with a high trial of labor rate. MATERIAL AND METHODS: In a cohort study (n=57 109), using data from the Medical Birth Registry of Norway 1989-2014, women with a second delivery after a first pregnancy cesarean section were included. Preterm, multiple, and non-cephalic deliveries were excluded...
February 8, 2019: Acta Obstetricia et Gynecologica Scandinavica
https://read.qxmd.com/read/30722754/ethnic-differences-in-risk-experiences-medical-needs-and-access-to-care-after-hurricane-sandy-in-new-jersey
#4
Joanna Burger, Michael Gochfeld, Clifton Lacy
This survey investigation assessed an economically challenged and largely minority population regarding concerns, evacuation status, medical needs and access to care during, and after, Hurricane Sandy by ethnicity status for patients using New Jersey's Federally Qualified Health Centers (FQHC). Data obtained contribute to understanding risk from disasters, and improving environmental justice for vulnerable populations following disasters. FQHCs provide medical and dental services for 5% of New Jersey 's population; 95% of those served are uninsured, underinsured, or live below the poverty level...
February 5, 2019: Journal of Toxicology and Environmental Health. Part A
https://read.qxmd.com/read/30711480/overdiagnosis-of-copd-in-subjects-with-unobstructed-spirometry-a-bold-analysis
#5
Lea Sator, Andreas Horner, Michael Studnicka, Bernd Lamprecht, Bernhard Kaiser, Mary Ann McBurnie, A Sonia Buist, Luisa Gnatiuc, David M Mannino, Christer Janson, Eric D Bateman, Peter Burney
BACKGROUND: There are several reports on underdiagnosis of COPD, while little is known about COPD overdiagnosis and overtreatment. We describe the overdiagnosis and the prevalence of spirometrically defined false positive COPD, as well as their relationship with overtreatment across 23 population samples in 20 countries participating in the BOLD Study between 2003-2012. METHODS: A false positive diagnosis of COPD was considered when participants reported a doctor's diagnosis of COPD, but post-bronchodilator spirometry was unobstructed (FEV1 /FVC>LLN)...
January 31, 2019: Chest
https://read.qxmd.com/read/30701873/gender-features-of-comorbidity-in-patients-with-coronary-artery-disease
#6
A N Sumin, E V Korok, A V Shcheglova, O L Barbarash
AIM: To study the factors associated with high levels of comorbidity in men and women with coronary artery disease (CAD). MATERIALS AND METHODS: The data analyzed 742 patients who were screened in the clinic of the research Institute CPSS in 2011, before planned operation coronary artery bypass grafting. All patients were divided into 2 groups: group I - men (n=595; 58 [54; 64] years), group II - women (n=147; 63 [57; 69] years). RESULTS: The analysis showed that the presence of arterial hypertension and atrial fibrillation prevailed in the group of women (p<0...
April 19, 2018: Terapevticheskiĭ Arkhiv
https://read.qxmd.com/read/30697107/chest-pain-as-a-possible-side-effect-of-pitavastatin-livalo
#7
Nada R AlZahrani, Amna F Yassin
Coronary heart disease is a serious complication of dyslipidemia. Pitavastatin is a more commonly prescribed medication for the treatment of dyslipidemia. Here, we report the case of a 37-year-old female, a known patient with well-controlled bronchial asthma. She was recently found to be dyslipidemic and started on pitavastatin calcium 4 mg once a day (OD). On the 10th day of treatment, she began to have crushing chest pain and was admitted to the hospital. All investigations for coronary heart disease came out negative...
January 2019: Journal of Family & Community Medicine
https://read.qxmd.com/read/30695733/protective-effect-of-heart-rate-variability-biofeedback-on-stress-induced-lung-function-impairment-in-asthma
#8
Niloofar Taghizadeh, Alireza Eslaminejad, Mohammad Reza Raoufy
Psychological stress can provoke airway constriction in asthmatic patients, which may be because of autonomic nervous system dysfunction in asthma. We investigated the effect of enhancing respiratory sinus arrhythmia using heart rate variability biofeedback (HRV-BF) on spirometry performance and HRV indices during stress induced by Stroop Color-Word interference test in asthmatic patients and healthy volunteers. Stress caused decrease in FEV1%, FVC%, and PEF% compared to baseline in asthmatic patients, but not in healthy subjects...
January 26, 2019: Respiratory Physiology & Neurobiology
https://read.qxmd.com/read/30688986/association-of-antibiotic-treatment-with-outcomes-in-patients-hospitalized-for-an-asthma-exacerbation-treated-with-systemic-corticosteroids
#9
Mihaela S Stefan, Meng-Shiou Shieh, Kerry A Spitzer, Penelope S Pekow, Jerry A Krishnan, David H Au, Peter K Lindenauer
Importance: Although professional society guidelines discourage use of empirical antibiotics in the treatment of asthma exacerbation, high antibiotic prescribing rates have been recorded in the United States and elsewhere. Objective: To determine the association of antibiotic treatment with outcomes among patients hospitalized for asthma and treated with corticosteroids. Design, Setting, and Participants: Retrospective cohort study of data of 19 811 adults hospitalized for asthma exacerbation and treated with systemic corticosteroids in 542 US acute care hospitals from January 1, 2015, through December 31, 2016...
January 28, 2019: JAMA Internal Medicine
https://read.qxmd.com/read/30687530/the-association-between-helicobacter-pylori-infection-and-liver-and-biliary-tract-disorders
#10
D Popescu, D Andronescu, P A Babes
Helicobacter Pylori (HP) persistently colonizes the stomach in about 50% of the globe population and it is the main risk factor for peptic ulcer, as well as for gastric adenocarcinoma and MALT gastric lymphoma. The treatment for HP revolutionized the management of the peptic ulcer disease, providing permanent healing in many cases. Preventing colonization of HP would be the primary prevention of gastric malignancy and peptic ulceration. At the same time, the presence of HP provides protection for some diseases (gastroesophageal reflux disease and its complications, esophageal adenocarcinoma, asthma), the eradication of the microorganism having negative repercussions...
April 2018: Current Health Sciences Journal
https://read.qxmd.com/read/30685854/comorbidities-associated-with-obstructive-sleep-apnea-a-retrospective-egyptian-study-on-244-patients
#11
Rania Ahmad Sweed, Salma Hassan, Nashwa Hassan Abd ElWahab, Soha Rashed Aref, Mahmoud Ibrahim Mahmoud
PURPOSE: The aim of the present study was to assess prevalence of associated comorbidities in a group of patients diagnosed with obstructive sleep apnea syndrome (OSAS). METHODS: This retrospective study enrolled 244 consecutive patients diagnosed by polysomnogram with OSAS between October 2010 and January 2015 after being referred to our Sleep-Related Breathing Disorders Unit, Chest Diseases Department, in the Alexandria Main University Hospital. RESULTS: Of 244 patients, 47% were men, mean age was 56...
January 26, 2019: Sleep & Breathing, Schlaf & Atmung
https://read.qxmd.com/read/30660711/traditional-chinese-medicine-ze-qi-tang-formula-inhibit-growth-of-non-small-cell-lung-cancer-cells-through-the-p53-pathway
#12
Zihang Xu, Fei Zhang, Yangzhuangzhuang Zhu, Fei Liu, Xiao Chen, Luyao Wei, Ning Zhang, Qin Zhou, Hairong Zhong, Chao Yao, Xiaowen Zhu, Chenyuan Gong, Shiguo Zhu, Chunpu Zou
ETHNOPHARMACOLOGICAL RELEVANCE: Ze-Qi-Tang (ZQT), a classic Chinese herbal formula, has been for over thousand years used for the treatment of several respiratory ailments like cough, asthma, hydrothorax and lung cancer. AIM OF STUDY: Cumulative literature on ZQT herbal formula reveals that its several constituent components are potent inducer of apoptosis in different cancer cells. However, the activity of ZQT against non-small-cell-lung cancer (NSCLC) has not been previously examined...
January 17, 2019: Journal of Ethnopharmacology
https://read.qxmd.com/read/30657578/neutrophil-elastase-inhibitor-suppresses-oxidative-stress-in-obese-asthmatic-rats-by-activating-keap1-nrf2-signaling-pathway
#13
J-Q Zheng, G-R Zhang, J Li, H-W Bi
OBJECTIVE: The aim of this study was to detect the oxidative stress response in the rat model of obesity, asthma and obese asthma. Meanwhile, we aimed to investigate the inhibitory effect of neutrophil elastase inhibitor (NEI) on cellular oxidative stress in the body and whether it exerted an effect on the oxidative stress response in obese asthma through the Kelch-like ECH-associated protein 1/nuclear factor E2-related factor 2 (Keap1/Nrf2) pathway. MATERIALS AND METHODS: The obesity and asthma models were established using a total of 70 Sprague-Dawley (SD) rats...
January 2019: European Review for Medical and Pharmacological Sciences
https://read.qxmd.com/read/30652591/development-and-validation-of-a-multiparameterized-artificial-neural-network-for-prostate-cancer-risk-prediction-and-stratification
#14
David A Roffman, Gregory R Hart, Michael S Leapman, James B Yu, Fangliang L Guo, Issa Ali, Jun Deng
PURPOSE: To develop and validate a multiparameterized artificial neural network (ANN) on the basis of personal health information for prostate cancer risk prediction and stratification. METHODS: The 1997 to 2015 National Health Interview Survey adult survey data were used to train and validate a multiparameterized ANN, with parameters including age, body mass index, diabetes status, smoking status, emphysema, asthma, race, ethnicity, hypertension, heart disease, exercise habits, and history of stroke...
December 2018: JCO Clinical Cancer Informatics
https://read.qxmd.com/read/30643208/discovery-of-%C3%AE-arrestin-biased-%C3%AE-2-adrenoceptor-agonists-from-2-amino-2-phenylethanol-derivatives
#15
Anthony Yiu-Ho Woo, Xin-Yue Ge, Li Pan, Gang Xing, Yong-Mei Mo, Rui-Juan Xing, Xiao-Ran Li, Yu-Yang Zhang, Irving W Wainer, Mao-Sheng Cheng, Rui-Ping Xiao
β-Arrestins are a small family of proteins important for signal transduction at G protein-coupled receptors (GPCRs). β-Arrestins are involved in the desensitization of GPCRs. Recently, biased ligands possessing different efficacies in activating the G protein- versus the β-arrestin-dependent signals downstream of a single GPCR have emerged, which can be used to selectively modulate GPCR signal transduction in such a way that desirable signals are enhanced to produce therapeutic effects while undesirable signals of the same GPCR are suppressed to avoid side effects...
January 14, 2019: Acta Pharmacologica Sinica
https://read.qxmd.com/read/30641540/silent-acute-myocarditis-in-eosinophilic-granulomatosis-with-polyangiitis
#16
Raquel Miriam Ferreira, Pedro Madureira, Teresa Pinho, Elisabete Martins, Sofia Pimenta, Lúcia Costa
Eosinophilic granulomatosis with polyangiitis is a rare multisystemic disorder, characterized by necrotizing vasculitis affecting small to medium-sized vessels, associated with asthma and eosinophilia. Cardiac involvement is the most important predictor of mortality and it seems to be more frequent in anti-neutrophil cytoplasmic antibodies-negative patients. Cardiomyopathy and congestive heart failure can occur but a significant proportion of patients are asymptomatic. We present a case of this condition in a 65-year-old woman with a past medical history of rhinosinusitis and recent episodes of asthma, that developed palpable purpura, sensory deficiency and excruciating pain mainly in the lower limbs...
October 2018: Acta Reumatológica Portuguesa
https://read.qxmd.com/read/30640517/current-status-and-future-opportunities-in-lung-precision-medicine-research-with-a-focus-on-biomarkers-an-american-thoracic-society-national-heart-lung-and-blood-institute-research-statement
#17
Ann Chen Wu, James P Kiley, Patricia J Noel, Shashi Amur, Esteban G Burchard, John P Clancy, Joshua Galanter, Maki Inada, Tiffanie K Jones, Jonathan A Kropski, James E Loyd, Lawrence M Nogee, Benjamin A Raby, Angela J Rogers, David A Schwartz, Don D Sin, Avrum Spira, Scott T Weiss, Lisa R Young, Blanca E Himes
BACKGROUND: Thousands of biomarker tests are either available or under development for lung diseases. In many cases, adoption of these tests into clinical practice is outpacing the generation and evaluation of sufficient data to determine clinical utility and ability to improve health outcomes. There is a need for a systematically organized report that provides guidance on how to understand and evaluate use of biomarker tests for lung diseases. METHODS: We assembled a diverse group of clinicians and researchers from the American Thoracic Society and leaders from the National Heart, Lung, and Blood Institute with expertise in various aspects of precision medicine to review the current status of biomarker tests in lung diseases...
December 15, 2018: American Journal of Respiratory and Critical Care Medicine
https://read.qxmd.com/read/30635198/racial-disparities-in-asthma-related-health-care-use-in-the-national-heart-lung-and-blood-institute-s-severe-asthma-research-program
#18
Anne M Fitzpatrick, Scott E Gillespie, David T Mauger, Brenda R Phillips, Eugene R Bleecker, Elliot Israel, Deborah A Meyers, Wendy C Moore, Ronald L Sorkness, Sally E Wenzel, Leonard B Bacharier, Mario Castro, Loren C Denlinger, Serpil C Erzurum, John V Fahy, Benjamin M Gaston, Nizar N Jarjour, Allyson Larkin, Bruce D Levy, Ngoc P Ly, Victor E Ortega, Stephen P Peters, Wanda Phipatanakul, Sima Ramratnam, W Gerald Teague
BACKGROUND: Despite advances in asthma care, disparities persist. Black patients are disproportionally affected by asthma and also have poorer outcomes compared with white patients. OBJECTIVE: We sought to determine associations between black and white patients and asthma-related health care use, accounting for complex relationships. METHODS: This study was completed as part of the National Heart, Lung, and Blood Institute's Severe Asthma Research Program, a prospective observational cohort...
January 8, 2019: Journal of Allergy and Clinical Immunology
https://read.qxmd.com/read/30633481/primary-care-for-persons-who-inject-drugs
#19
Adam J Visconti, Jarrett Sell, Aaron David Greenblatt
More than 750,000 persons in the United States inject opioids, methamphetamine, cocaine, or ketamine, and that number is increasing because of the current opioid epidemic. Persons who inject drugs (PWID) are at higher risk of infectious and noninfectious skin, pulmonary, cardiac, neurologic, and other causes of morbidity and mortality. Nonjudgmental inquiries about current drug use can uncover information about readiness for addiction treatment and identify modifiable risk factors for complications of injection drug use...
January 15, 2019: American Family Physician
https://read.qxmd.com/read/30627362/a-glance-at-black-cumin-nigella-sativa-and-its-active-constituent-thymoquinone-in-ischemia-a-review
#20
REVIEW
Zahra Oskouei, Maryam Akaberi, Hossein Hosseinzadeh
Objectives: Black cumin ( Nigella sativa ) belonging to Ranunculaceae family has a long history of medicinal use in various folk and traditional systems of medicine, including Iranian traditional medicine (ITM). These valuable medicinal seeds have been used traditionally against a variety of diseases such as dyspepsia, diabetes, headache, influenza and asthma. In addition, several scientific investigations have reported the therapeutic properties of N. sativa and thymoquinone (TQ), one of the most important constituent of black cumin, for treatment of a large number of diseases, including ischemia...
December 2018: Iranian Journal of Basic Medical Sciences
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