keyword
Keywords (Angiogenesis OR microvessel O...

(Angiogenesis OR microvessel OR neovascularization OR neovessel) AND plaque

https://read.qxmd.com/read/38205654/higher-noncalcified-plaque-volume-is-associated-with-increased-plaque-vulnerability-and-vascular-inflammation
#21
JOURNAL ARTICLE
Keishi Suzuki, Daisuke Kinoshita, Haruhito Yuki, Takayuki Niida, Tomoyo Sugiyama, Taishi Yonetsu, Makoto Araki, Akihiro Nakajima, Lena Marie Seegers, Damini Dey, Hang Lee, Iris McNulty, Masamichi Takano, Tsunekazu Kakuta, Kyoichi Mizuno, Ik-Kyung Jang
BACKGROUND: Recently, it was reported that noncalcified plaque (NCP) volume was an independent predictor for cardiac events. Pericoronary adipose tissue (PCAT) attenuation is a marker of vascular inflammation and has been associated with increased cardiac mortality. The aim of this study was to evaluate the relationships between NCP volume, plaque vulnerability, and PCAT attenuation. METHODS: Patients who underwent preintervention coronary computed tomography angiography and optical coherence tomography were enrolled...
January 2024: Circulation. Cardiovascular Imaging
https://read.qxmd.com/read/38184922/melatonin-inhibits-the-formation-of-intraplaque-neovessels-in-apoe-mice-via-ppar%C3%AE-rhoa-rock-pathway
#22
JOURNAL ARTICLE
YuFan Jiang, Wei Tong, Yueyang Li, Qiang Ma, YunDai Chen
BACKGROUND: According to former research, the atherosclerotic plaque is thought to be aggravated by intraplaque neovessels (IPN) and intraplaque hemorrhage (IPH). Intriguingly, a lower incidence of IPH was found in plaque treated with melatonin. In this study, we attempted to investigate the impact and underlying mechanism regarding the influences of melatonin upon IPN. METHODS: A mouse model was established by subjecting the high fat diet (HFD)-fed ApoE-/- mice to tandem stenosis (TS) surgery with melatonin and GW9662, a PPARγ antagonist, being given by gavage...
December 28, 2023: Biochemical and Biophysical Research Communications
https://read.qxmd.com/read/38177160/a-pilot-optical-coherence-tomography-angiography-classification-of-retinal-neovascularization-in-retinopathy-of-prematurity
#23
JOURNAL ARTICLE
Xi Chen, Ryan Imperio, Christian Viehland, Pujan R Patel, Du Tran-Viet, Shwetha Mangalesh, S Grace Prakalapakorn, Sharon F Freedman, Joseph A Izatt, Cynthia A Toth
Extraretinal neovascularization is a hallmark of treatment-requiring retinopathy of prematurity (ROP). Optical coherence tomography angiography (OCTA) offers vascular flow and depth information not available from indirect ophthalmoscopy and structural OCT, but OCTA is only commercially available as a tabletop device. In this study, we used an investigational handheld OCTA device to study the vascular flow in and around retinal neovascularization in seven preterm infants with treatment-requiring ROP and contrasted them to images of vascular flow in six infants of similar age without neovascular ROP...
January 4, 2024: Scientific Reports
https://read.qxmd.com/read/38160866/the-therapeutic-efficacy-and-mechanism-action-of-si-cao-formula-in-the-treatment-of-psoriasis-a-pilot-clinical-investigation-and-animal-validation
#24
JOURNAL ARTICLE
Xinxin Wu, Qi Zheng, Fang Shen, Jiankun Song, Yue Luo, Xiaoya Fei, Wencheng Jiang, Shaoqiong Xie, Xin Ma, Le Kuai, Ruiping Wang, Xiaojie Ding, Miao Li, Ying Luo, Bin Li
ETHNOPHARMACOLOGICAL RELEVANCE: Psoriasis is a chronic inflammation and relapsing disease that affected approximately 100 million individuals worldwide. In previous clinical study, it was observed that the topical application of Si Cao Formula (SCF) ameliorated psoriasis skin lesions and reduced the recurrence rate of patients over a period of three months. However, the precise mechanism remains unclear. AIM OF THE STUDY: The objective of this study was to assess the effectiveness and safety of SCF in patients diagnosed with psoriasis and explore the molecular mechanisms that contribute to SCF's therapeutic efficacy in psoriasis treatment...
December 29, 2023: Journal of Ethnopharmacology
https://read.qxmd.com/read/38137496/intraplaque-neovascularization-cd68-and-inos2-macrophage-infiltrate-intensity-are-associated-with-atherothrombosis-and-intraplaque-hemorrhage-in-severe-carotid-atherosclerosis
#25
JOURNAL ARTICLE
Ioan Alexandru Balmos, Mark Slevin, Klara Brinzaniuc, Adrian Vasile Muresan, Horatiu Suciu, Gyopár Beáta Molnár, Adriana Mocian, Béla Szabó, Előd Ernő Nagy, Emőke Horváth
BACKGROUND: Atherosclerosis is a progressive disease that results from endothelial dysfunction, inflammatory arterial wall disorder and the formation of the atheromatous plaque. This results in carotid artery stenosis and is responsible for atherothrombotic stroke and ischemic injury. Low-grade plaque inflammation determines biological stability and lesion progression. METHODS: Sixty-seven cases with active perilesional inflammatory cell infiltrate were selected from a larger cohort of patients undergoing carotid endarterectomy...
December 11, 2023: Biomedicines
https://read.qxmd.com/read/38131554/relevance-of-multicolor-imaging-its-component-channels-and-fundus-autofluorescence-in-describing-macular-telangiectasia-type-2-mactel-lesion-characteristics
#26
JOURNAL ARTICLE
Kiran Chandran, Anantharaman Giridhar, Sachin Desai, Mahesh Gopalakrishnan, V P Indu, Sobha Sivaprasad
PURPOSE: The aim of the study was to describe imaging characteristics and detection rates of phenotypic features in macular telangiectasia type-2 (MacTel) on multicolor (MC), blue reflectance (BR), green reflectance (GR), infrared reflectance (IR), and fundus autofluorescence (FAF) and to evaluate sensitivity, specificity, and predictive values across modalities. METHODS: In this monocentric observational study, 282 eyes of 148 patients with MacTel underwent color fundus photograph, MC, BR, GR, IR, FAF, spectral-domain optical coherence tomography (SD-OCT), OCT-angiography (OCT-A), and fundus fluorescein angiography (FFA)...
January 1, 2024: Indian Journal of Ophthalmology
https://read.qxmd.com/read/38131548/iodine-125-brachytherapy-for-choroidal-melanoma-by-using-ocuprosta-seeds-with-indigenous-non-collimated-plaques-our-initial-experience
#27
JOURNAL ARTICLE
Subina Narang, Awadesh K Pandey, Gurbir Kaur, Mannat Giran, Sanjay K Saxena, Sandeep Moudgil, Dinesh K Walia, Uma Handa, Vijay K Meena, Ravinder Kaur, Melvin Astrahan
PURPOSE: Brachytherapy is the gold-standard treatment for choroidal melanoma. This study evaluated iodine-125 brachytherapy by using Ocuprosta seeds with indigenous non-collimated plaques in Asian patients. METHODS: Retrospective single-center study in a tertiary care hospital of 12 eyes with choroidal melanoma in 12 Asian patients who underwent brachytherapy with Ocuprosta seeds fixed on non-collimated plaques and had a follow-up of at least 32 months (mean: 42...
January 1, 2024: Indian Journal of Ophthalmology
https://read.qxmd.com/read/38125586/multifunctional-liposomes-co-encapsulating-epigallocatechin-3-gallate-egcg-and-mirna-for-atherosclerosis-lesion-elimination
#28
JOURNAL ARTICLE
Dandan Li, Danni Liu, Yaoqi Wang, Qi Sun, Ran Sun, Jie Zhang, Xiaoxuan Hong, Ran Huo, Shuang Zhang, Chunying Cui
Atherosclerosis (AS) is a chronic inflammatory disease, characterized by a lipid accumulated plaque. Anti-oxidative and anti-inflammation and lipid metabolism promoting therapeutic strategies have been applied for atherosclerosis treatment. However, the therapeutic effect of a single therapeutic method is limited. It is suggested that a combination of these two strategies could help prevent lipid accumulation caused by inflammation and oxidative stress, and also promote lipid efflux from atherosclerotic plaque, to normalize arteries to the maximum extent...
December 19, 2023: Nanoscale advances
https://read.qxmd.com/read/38105636/pediatric-psoriasis-understanding-pathological-conditions-and-advances-in-treatment
#29
REVIEW
Akimichi Morita, Hidehisa Saeki
Psoriasis is a long-lasting skin disease that primarily affects the skin, nails, and joints and is characterized by inflammation. Genetic factors contribute to its development and environmental triggers can worsen symptoms. Pathologically, psoriasis is characterized by uncontrolled keratinocyte proliferation and abnormal differentiation, and histological features include acanthosis with inflammatory cell infiltration and neovascularization. Psoriasis often starts in childhood, with about one-third of cases beginning during this time...
February 2024: Journal of Dermatology
https://read.qxmd.com/read/38094473/retracted-diagnostic-performance-of-atherosclerotic-carotid-plaque-neovascularization-with-contrast-enhanced-ultrasound-a-meta-analysis
#30
Computational And Mathematical Methods In Medicine
[This retracts the article DOI: 10.1155/2022/7531624.].
2023: Computational and Mathematical Methods in Medicine
https://read.qxmd.com/read/38081570/retrospective-analysis-of-radiation-induced-complications-of-uveal-melanoma-patients-treated-with-brachytherapy-in-the-era-of-anti-vegf
#31
JOURNAL ARTICLE
Naomi Hasegawa, Bin S Teh, Kevin Tran, Forrest Ivey, Devin Olek, Ramiro Pino, Alice Z Chuang, Maria E Bretana, Edward Brian Butler, Amy C Schefler
PURPOSE: To associate clinical factors and radiation doses delivered by iodine-125 plaque brachytherapy to visual outcomes and development of radiation-induced ocular complications in patients with uveal melanoma in the era of anti-vascular endothelial growth factor (anti-VEGF) injections. DESIGN: Retrospective cohort study. METHODS: A retrospective chart review was performed for 225 patients treated with iodine-125 brachytherapy for uveal melanoma...
December 9, 2023: American Journal of Ophthalmology
https://read.qxmd.com/read/38053620/autophagy-of-umbilical-cord-mesenchymal-stem-cells-induced-by-rapamycin-conduces-to-pro-angiogenic-function-of-the-conditioned-medium
#32
JOURNAL ARTICLE
Wenya Wang, Xiao Li, Chaochu Cui, Guotian Yin, Wenjie Ren, Xianwei Wang
Angiogenesis is critical for wound healing and tissue repair. Umbilical cord mesenchymal stem cells (UCMSCs)-conditioned medium has certain actions to promote angiogenesis, and is expected for wound healing and tissue repair. However, recent studies showed that the pro-angiogenic efficacy of unprocessed MSCs-conditioned medium is low, and insufficient for tissue repair. Autophagy is a process for protein recycling and a contributor for cell exocrine, which may enhance pro-angiogenic efficacy of the conditioned medium by stimulating cytokine release from UCMSCs...
December 2023: Biochemistry and Biophysics Reports
https://read.qxmd.com/read/38045355/behavioral-and-neuropathological-features-of-alzheimer-s-disease-are-attenuated-in-5xfad-mice-treated-with-intranasal-ghk-peptide
#33
Matthew Tucker, Gerald Yu Liao, Joo Young Park, Manuela Rosenfeld, Jackson Wezeman, Ruby Mangalindan, Dan Ratner, Martin Darvas, Warren Ladiges
Efforts to find disease modifying treatments for Alzheimer's disease (AD) have met with limited success in part because the focus has been on testing drugs that target a specific pathogenic mechanism. Multiple pathways have been implicated in the pathogenesis of AD. Hence, the probability of more effective treatment for AD is likely increased by using an intervention that targets more than one pathway. The naturally occurring peptide GHK (glycyl-L-histidyl-L-lysine), as a GHK-Cu complex, supports angiogenesis, remodeling, and tissue repair, has anti-inflammatory and antioxidant properties, and has been shown to improve cognitive performance in aging mice...
November 21, 2023: bioRxiv
https://read.qxmd.com/read/38034389/endothelial-nitric-oxide-synthase-enos-s1176-phosphorylation-status-governs-atherosclerotic-lesion-formation
#34
JOURNAL ARTICLE
Tung D Nguyen, Nur-Taz Rahman, William C Sessa, Monica Y Lee
OBJECTIVE: We have previously demonstrated the in vivo importance of the Akt-eNOS substrate-kinase relationship, as defective postnatal angiogenesis characteristic of global Akt1-null mice is rescued when bred to 'gain-of-function' eNOS S1176D mutant mice. While multiple studies support the vascular protective role of endothelial NO generation, the causal role of Akt1-dependent eNOS S1176 phosphorylation during atherosclerotic plaque formation is not yet clear. APPROACH AND RESULTS: We herein bred congenic 'loss-of-function' eNOS S1176A and 'gain-of-function' eNOS S1176D mutant mice to the exacerbated atherogenic Akt1-/- ; ApoE-/- double knockout mice to definitively test the importance of Akt-mediated eNOS S1176 phosphorylation during atherogenesis...
2023: Frontiers in Cardiovascular Medicine
https://read.qxmd.com/read/38023368/long-non%C3%A2-coding-rna-peg13-regulates-endothelial-cell-senescence-through-the-microrna%C3%A2-195-irs1-axis
#35
JOURNAL ARTICLE
Qin Huang, Haiwen Zhou, Songping Yu
Atherosclerosis is a chronic inflammatory disease characterized by endothelial dysfunction and plaque formation. The present study aimed to elucidate the pathological role of the long non-coding RNA (lncRNA) paternally expressed 13 ( PEG13 ) in the onset and progression of atherosclerosis. Specifically, its effects on human umbilical vein endothelial cell (HUVEC) proliferation, angiogenesis, senescence and senescence-associated secretory phenotype (SASP)-related factors were investigated using cell proliferation, cellular angiogenesis, β-galactosidase staining, reverse transcription-quantitative PCR and enzyme-linked immunosorbent assays...
December 2023: Experimental and Therapeutic Medicine
https://read.qxmd.com/read/38003727/leucine-rich-alpha-2-glycoprotein-1-accumulates-in-complicated-atherosclerosis-and-promotes-calcification
#36
JOURNAL ARTICLE
Lucile Grzesiak, Ana Amaya-Garrido, Guylène Feuillet, Nicole Malet, Audrey Swiader, Marie-Kerguelen Sarthou, Amandine Wahart, Damien Ramel, Stéphanie Gayral, Joost Peter Schanstra, Julie Klein, Muriel Laffargue
Atherosclerosis is the primary cause of cardiovascular disease. The development of plaque complications, such as calcification and neo-angiogenesis, strongly impacts plaque stability and is a good predictor of mortality in patients with atherosclerosis. Despite well-known risk factors of plaque complications, such as diabetes mellitus and chronic kidney disease, the mechanisms involved are not fully understood. We and others have identified that the concentration of circulating leucine-rich α-2 glycoprotein 1 (LRG1) was increased in diabetic and chronic kidney disease patients...
November 20, 2023: International Journal of Molecular Sciences
https://read.qxmd.com/read/37996309/novel-targets-for-molecular-imaging-of-inflammatory-processes-of-carotid-atherosclerosis-a-systematic-review
#37
REVIEW
Louise Maes, Louis Versweyveld, Nicholas R Evans, John J McCabe, Peter Kelly, Koen Van Laere, Robin Lemmens
Computed tomography angiography (CTA), magnetic resonance angiography (MRA) and 18 F-FDG-PET have proven clinical value when evaluating patients with carotid atherosclerosis. In this systematic review, we will focus on the role of novel molecular imaging tracers in that assessment and their potential strengths to stratify stroke risk. We systematically searched PubMed, Embase, the Web of Science Core Collection, and Cochrane Library for articles reporting on molecular imaging to noninvasively detect or characterize inflammation in carotid atherosclerosis...
November 22, 2023: Seminars in Nuclear Medicine
https://read.qxmd.com/read/37981958/cholesterol-crystals-induce-mechanical-trauma-inflammation-and-neo-vascularization-in-solid-cancers-as-in-atherosclerosis
#38
JOURNAL ARTICLE
George S Abela, Venkat R Katkoori, Dorothy R Pathak, Harvey L Bumpers, Monika Leja, Zain Ul Abideen, Manel Boumegouas, Daniel Perry, Anas Al-Janadi, James E Richard, Carlo Barnaba, Ilce G Medina Meza
BACKGROUND AND AIMS: Cancer and atherosclerosis share common risk factors and inflammatory pathways that promote their proliferation via vascular endothelial growth factor (VEGF). Because CCs cause mechanical injury and inflammation in atherosclerosis, we investigated their presence in solid cancers and their activation of IL-1β, VEGF, CD44, and Ubiquityl-Histone H2B (Ub-H2B), that promote cancer growth. METHODS: Tumor specimens from eleven different types of human cancers and atherosclerotic plaques were assessed for CCs, free cholesterol content and IL1-β by microscopy, immunohistochemistry, and biochemical analysis...
November 2023: American heart journal plus: cardiology research and practice
https://read.qxmd.com/read/37961542/loss-of-trem2-exacerbates-parenchymal-amyloid-pathology-but-diminishes-caa-in-tg-swdi-mice
#39
Rui Zhong, Yingzheng Xu, Jesse W Williams, Ling Li
Alzheimer's disease (AD) is a progressive neurodegenerative disease, and it is the most common cause of dementia worldwide. Recent genome-wide association studies (GWAS) identified TREM2 (triggering receptor expressed on myeloid cells 2) as one of the major risk factors for AD. TREM2 is a surface receptor expressed on microglia and largely mediates microglial functions and immune homeostasis in the brain. The functions of TREM2 in AD pathogenesis, including in the formation of the key pathology parenchymal amyloid-β (Aβ) plaques, have been investigated by introducing Trem2 deficiency in AD mouse models...
November 5, 2023: bioRxiv
https://read.qxmd.com/read/37941846/diagnostic-accuracy-of-superb-microvascular-imaging-for-detecting-intraplaque-neovascularization-a-systematic-review-and-meta-analysis
#40
JOURNAL ARTICLE
Lina Zhao, Yubo Han, Yanling Che, Xuesong Zhang, Min Luo, Jinzhu Li
BACKGROUND: Atherosclerotic plaques can cause carotid artery stenosis, and "vulnerable plaques" can even lead to ischemic stroke. The objective of this study was to assess the accuracy of superb microvascular imaging (SMI) for the detection of carotid intraplaque neovascularization (IPN) in patients with atherosclerotic plaques. METHODS: We searched the Cochrane Library, Embase, Medline, and Wanfang databases until January 17, 2023. We included original studies with information on diagnostic accuracy of SMI for the evaluation of carotid IPN...
October 31, 2023: Cardiovascular Diagnosis and Therapy
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