keyword
Keywords (Angiogenesis OR microvessel O...

(Angiogenesis OR microvessel OR neovascularization OR neovessel) AND plaque

https://read.qxmd.com/read/38522762/blockade-of-endothelial-adenosine-receptor-2a-suppresses-atherosclerosis-in-vivo-through-inhibiting-creb-alk5-mediated-endothelial-to-mesenchymal-transition
#1
JOURNAL ARTICLE
Yongfeng Cai, Yaqi Zhou, Qiuhua Yang, Jiean Xu, Qingen Da, Qian Ma, Dingwei Zhao, Tammy Lu, Ha Won Kim, David Fulton, Xuejun Jiang, Neal L Weintraub, Kunzhe Dong, Suowen Xu, Mei Hong, Zhiping Liu, Yuqing Huo
Cardiovascular diseases (CVDs) are the leading cause of death worldwide, and morbidity and mortality rates continue to rise. Atherosclerosis constitutes the principal etiology of CVDs. Endothelial injury, inflammation, and dysfunction are the initiating factors of atherosclerosis. Recently, we reported that endothelial adenosine receptor 2A (ADORA2A), a G protein-coupled receptor (GPCR), plays critical roles in neovascularization disease and cerebrovascular disease. However, the precise role of endothelial ADORA2A in atherosclerosis is still not fully understood...
March 22, 2024: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://read.qxmd.com/read/38514208/extracellular-vesicles-in-heart-failure
#2
JOURNAL ARTICLE
Alexander E Berezin, Alexander A Berezin
Physiologically, extracellular vesicles (EVs) have been implicated as crucial mediators of immune response, cell homeostasis, angiogenesis, cell differentiation and growth, and tissue repair. In heart failure (HF) they may act as regulators of cardiac remodeling, microvascular inflammation, micro environmental changes, tissue fibrosis, atherosclerosis, neovascularization of plaques, endothelial dysfunction, thrombosis, and reciprocal heart-remote organ interaction. The chapter summaries the nomenclature, isolation, detection of EVs, their biologic role and function physiologically as well as in the pathogenesis of HF...
2024: Advances in Clinical Chemistry
https://read.qxmd.com/read/38493669/effect-of-combining-evolocumab-with-statin-on-carotid-intraplaque-neovascularization-in-patients-with-premature-coronary-artery-disease-epoch
#3
JOURNAL ARTICLE
Yanyan Han, Ling Ren, Xiang Fei, Jingjing Wang, Tao Chen, Jun Guo, Qi Wang
BACKGROUND AND AIMS: We aimed to explore the effect of PCSK9 inhibitor based on the background of statin on carotid intraplaque neovascularization (IPN) assessed by serial contrast-enhanced ultrasound (CEUS) analysis in Chinese patients with premature coronary artery disease (PCAD). METHODS: 41 patients were included to receive treatments with biweekly evolocumab (n = 22) or placebo (n = 19) in addition to statin therapy for 52 weeks. All patients were newly diagnosed with PCAD and treatments were initiated at baseline of the observations...
February 13, 2024: Atherosclerosis
https://read.qxmd.com/read/38479436/assessment-of-atherosclerotic-plaque-morphology-using-contrast-enhanced-ultrasound-and-its-impact-on-primary-cardiovascular-events-following-simultaneous-carotid-endarterectomy-and-coronary-artery-bypass-grafting
#4
JOURNAL ARTICLE
Agnė Gimžauskaitė, Einius Trumpa, Saulius Lukoševičius, Jurgita Plisienė, Aleksandras Antuševas, Linas Velička, Rimantas Benetis, Algidas Basevičius, Donatas Inčiūra
OBJECTIVE: The incidence of stroke after on-pump cardiac surgery during the perioperative period can affect up to 2% of patients, and is frequently linked to carotid artery disease. Notably, in patients with significant unilateral carotid artery stenosis of 80%-99%, the risk of stroke reaches 4%. Among individuals undergoing coronary artery bypass grafting (CABG), 3% to 10% exhibit significant carotid artery stenosis. To mitigate the risk of stroke and mortality, patients can undergo either simultaneous or staged carotid endarterectomy and CABG...
March 13, 2024: Vascular
https://read.qxmd.com/read/38470152/clinical-risk-factors-and-features-on-computed-tomography-angiography-in-high-risk-carotid-artery-plaque-in-patients-with-type-2-diabetes
#5
JOURNAL ARTICLE
Luca Mezzetto, Davide Mastrorilli, Elisa Zanetti, Enrico Scoccia, Barbara Pecoraro, Andrea Sboarina, Alessandro Mantovani, Gian F Veraldi
BACKGROUND: High-risk carotid artery plaque (HPR) is associated with a markedly increased risk of ischemic stroke. The aims of this study were: 1) to examine the prevalence of HRP in a cohort of asymptomatic adults with type 2 diabetes (T2D); 2) to investigate the relationship between HRP, established cardiovascular risk factors and computed tomography angiography (CTA) profile; and 3) to assess whether the presence of HRP is associated with an increased risk of major adverse cardiovascular events (MACE)...
March 12, 2024: International Angiology: a Journal of the International Union of Angiology
https://read.qxmd.com/read/38462483/association-between-vascular-calcification-and-intraplaque-hemorrhage-in-coronary-atherosclerosis-from-autopsy-the-hisayama-study
#6
JOURNAL ARTICLE
Toshiaki Nakano, Hiromasa Kitamura, Jun Hata, Kenji Maki, Yoshinao Oda, Takanari Kitazono, Toshiharu Ninomiya
AIMS: Vascular calcification is observed in advanced atherosclerotic lesions. Vascular calcification is considered to increase the risk of intraplaque hemorrhage and subsequent plaque destabilization; however, there is limited pathohistoological evidence of the association between vascular calcification and intraplaque hemorrhage. The aim of this study was to investigate the association between vascular calcification and intraplaque hemorrhage in the coronary arteries. METHODS: We examined 374 coronary arteries obtained from the autopsy samples of 126 deceased individuals...
March 9, 2024: Journal of Atherosclerosis and Thrombosis
https://read.qxmd.com/read/38441044/lower-glut1-and-unchanged-mct1-in-alzheimer-s-disease-cerebrovasculature
#7
JOURNAL ARTICLE
Manon Leclerc, Cyntia Tremblay, Philippe Bourassa, Julie A Schneider, David A Bennett, Frédéric Calon
The brain is a highly demanding organ, utilizing mainly glucose but also ketone bodies as sources of energy. Glucose transporter-1 (GLUT1) and monocarboxylates transporter-1 (MCT1) respectively transport glucose and ketone bodies across the blood-brain barrier. While reduced glucose uptake by the brain is one of the earliest signs of Alzheimer's disease (AD), no change in the uptake of ketone bodies has been evidenced yet. To probe for changes in GLUT1 and MCT1, we performed Western immunoblotting in microvessel extracts from the parietal cortex of 60 participants of the Religious Orders Study...
March 5, 2024: Journal of Cerebral Blood Flow and Metabolism
https://read.qxmd.com/read/38434558/association-between-periprocedural-myocardial-injury-and-neointimal-characteristics-in-patients-with-in-stent-restenosis-an-optical-coherence-tomography-study
#8
JOURNAL ARTICLE
Youcheng Shen, Xi Wang, Ning Gu, Zhijiang Liu, Jidong Rong, Changyin Shen, Wei Zhang, Panke Chen, Yi Deng, Chancui Deng, Shuai Ma, Yongchao Zhao, Ranzun Zhao, Bei Shi
BACKGROUND: The relationship between neointimal characteristics of in-stent restenosis (ISR) and periprocedural myocardial injury (PMI) remains unclear. Therefore, this study aimed to investigate the relationship between PMI and neointimal characteristics of ISR by using optical coherence tomography (OCT). METHODS: This was a retrospective study. We enrolled 140 patients diagnosed with ISR with normal baseline high-sensitivity troponin T (hs-cTnT) levels who underwent OCT and subsequent revascularization by means of drug-coated balloon (DCB) or drug-eluting stent (DES) between October 2018 and October 2022 in the Affiliated Hospital of Zunyi Medical University...
February 15, 2024: Cardiovascular Diagnosis and Therapy
https://read.qxmd.com/read/38430261/crosstalk-of-human-coronary-perivascular-adipose-derived-stem-cells-with-vascular-cells-role-of-tissue-factor
#9
JOURNAL ARTICLE
Gemma Arderiu, Maria Teresa Bejar, Anna Civit-Urgell, Esther Peña, Lina Badimon
The coronary perivascular adipose tissue (cPVAT) has been associated to the burden of cardiovascular risk factors and to the underlying vessel atherosclerotic plaque severity. Although the "outside to inside" hypothesis of PVAT-derived-adipokine regulation of vessel function is currently accepted, whether the resident mesenchymal stem cells (ASCs) in PVAT have a regulatory role on the underlying vascular arterial smooth muscle cells (VSMCs) is not known. Here, we investigated the interactions between resident PVAT-ASCs and VSMCs...
March 2, 2024: Basic Research in Cardiology
https://read.qxmd.com/read/38427471/contrast-enhanced-ultrasound-evaluation-of-plaque-vulnerability-and-the-relationship-between-peripheral-blood-leukocytes
#10
JOURNAL ARTICLE
Qi Qiao, Bingshuang Wang, Minzhe Xu, Zhengqin Qi
OBJECTIVE: To evaluate plaque vulnerability by carotid contrast-enhanced ultrasound (CEUS) and to analyze the correlation between plaque vulnerability and peripheral blood leukocyte classification. MATERIALS AND METHODS: 135 patients with carotid plaque were examined by contrast-enhanced ultrasound. Plaque vulnerability was assessed by semiquantitative visual classification. Baseline clinical data and peripheral leukocyte classification were collected. Ordered logistic regression was used to analyze the correlation between plaque neovascularization grade and peripheral leukocyte classification count...
March 1, 2024: Clinical Hemorheology and Microcirculation
https://read.qxmd.com/read/38426865/glp-1-receptor-agonists-and-vascular-protection
#11
REVIEW
Brady Park, Ehab Bakbak, Hwee Teoh, Aishwarya Krishnaraj, Fallon Dennis, Adrian Quan, Ori D Rotstein, Javed Butler, David A Hess, Subodh Verma
Atherosclerotic cardiovascular disease is a chronic condition that often co-presents with type 2 diabetes and obesity. Glucagon-like peptide-1 receptor agonists (GLP-1RAs) are incretin mimetics endorsed by major professional societies for improving glycemic status and reducing atherosclerotic risk in people living with type 2 diabetes. While the cardioprotective efficacy of GLP-1RAs and their relationship with traditional risk factors are well-established, there is a paucity of publications that have summarized the potentially direct mechanisms through which GLP-1RAs mitigate atherosclerosis...
March 1, 2024: American Journal of Physiology. Heart and Circulatory Physiology
https://read.qxmd.com/read/38415148/effect-of-moderate-intensity-statin-on-carotid-intraplaque-neovascularization-of-coronary-artery-disease-a-retrospective-cohort-study
#12
JOURNAL ARTICLE
Yanyan Han, Ling Ren, Xiang Fei, Jingjing Wang, Tao Chen, Jun Guo, Qi Wang
BACKGROUND: Statin treatment can reduce atherosclerotic plaque as detected via invasive intracoronary methods. However, few studies have evaluated the effect of moderate-intensity statin therapy on carotid intraplaque neovascularization (IPN) using semiquantitative indices. This study thus aimed to assess the effect of statin on the carotid IPN of coronary artery disease with contrast-enhanced ultrasound (CEUS). METHODS: In this noncontrol, retrospective, cohort study, 35 inpatients who underwent coronary angiography, serial CEUS, and laboratory evaluations were consecutively enrolled from June 2020 to December 2022 at the Department of Cardiology, Chinese PLA General Hospital...
February 1, 2024: Quantitative Imaging in Medicine and Surgery
https://read.qxmd.com/read/38399624/psoriasis-what-is-new-in-markers-of-disease-severity
#13
REVIEW
Mircea Tampa, Madalina Irina Mitran, Cristina Iulia Mitran, Clara Matei, Simona Roxana Georgescu
Introduction . Psoriasis is a chronic inflammatory skin disease and is the result of the interaction between numerous external and internal factors. Psoriasis presents a wide range of skin manifestations encompassing individual lesions varying from pinpoint to large plaques that can evolve into generalised forms. The lesions mirror the pathophysiological mechanisms involved in psoriasis pathogenesis, such as inflammation, dysregulation of immune response, uncontrolled proliferation of keratinocytes and angiogenesis...
February 18, 2024: Medicina
https://read.qxmd.com/read/38365464/arterial-adventitial-vasa-vasorum-density-reflects-the-progression-of-unstable-plaques-a-retrospective-clinical-study
#14
JOURNAL ARTICLE
Jiemei Yang, Penghao Gao, Qiannan Li, Tengyu Wang, Shuyuan Guo, Jingyu Zhang, Tianyi Zhang, Guodong Wu, Yuanyuan Guo, Zeng Wang, Ye Tian
OBJECTIVE: Arterial adventitial vasa vasorum (AVV) plays an important role in the occurrence and development of atherosclerotic (AS) disease. AS is a systemic disease, and plaque is not only a local vascular event, but also occurs at multiple sites throughout the vascular bed. Currently, effective anti-AVV therapies are lacking. Therefore, we posed the following scientific questions: "does human carotid adventitial vasa vasorum density reflect plaque neovascularization and intimal-media hyperplasia in carotid?"; and "is it possible to reduce human AVV density by sonodynamic therapy (SDT)?" METHODS: A retrospective study was conducted on 160 patients with carotid atherosclerosis...
February 15, 2024: Ultrasound in Medicine & Biology
https://read.qxmd.com/read/38336828/radiation-effects-on-retinal-layers-revealed-by-oct-oct-a-and-perimetry-as-a-function-of-dose-and-time-from-treatment
#15
JOURNAL ARTICLE
Michelle R Tamplin, Jui-Kai Wang, Elaine M Binkley, Mona K Garvin, Daniel E Hyer, John M Buatti, H Culver Boldt, Isabella M Grumbach, Randy H Kardon
Optical coherence tomography (OCT) has become a key method for diagnosing and staging radiation retinopathy, based mainly on the presence of fluid in the central macula. A robust retinal layer segmentation method is required for identification of the specific layers involved in radiation-induced pathology in individual eyes over time, in order to determine damage driven by radiation injury to the microvessels and to the inner retinal neurons. Here, we utilized OCT, OCT-angiography, visual field testing, and patient-specific dosimetry models to analyze abnormal retinal layer thickening and thinning relative to microvessel density, visual function, radiation dose, and time from radiotherapy in a cross-sectional cohort of uveal melanoma patients treated with 125 I-plaque brachytherapy...
February 9, 2024: Scientific Reports
https://read.qxmd.com/read/38289515/cellular-and-molecular-mechanisms-of-mast-cells-in-atherosclerotic-plaque-progression-and-destabilization
#16
REVIEW
Daniel Elieh-Ali-Komi, Ilze Bot, Mónica Rodríguez-González, Marcus Maurer
Mast cells (MCs) are commonly recognized for their crucial involvement in the pathogenesis of allergic diseases, but over time, it has come to light that they also play a role in the pathophysiology of non-allergic disorders including atherosclerosis. The involvement of MCs in the pathology of atherosclerosis is supported by their accumulation in atherosclerotic plaques upon their progression and the association of intraplaque MC numbers with acute cardiovascular events. MCs that accumulate within the atherosclerotic plaque release a cocktail of mediators through which they contribute to neovascularization, plaque progression, instability, erosion, rupture, and thrombosis...
January 30, 2024: Clinical Reviews in Allergy & Immunology
https://read.qxmd.com/read/38284727/targeting-ferroptosis-a-novel-strategy-for-the-treatment-of-atherosclerosis
#17
JOURNAL ARTICLE
Yifan Zhang, Chengshi Jiang, Ning Meng
Since ferroptosis was reported in 2012, its application prospects in various diseases have been widely considered, initially as a treatment direction for tumors. Recent studies have shown that ferroptosis is closely related to the occurrence and development of atherosclerosis. The primary mechanism is to affect the occurrence and development of atherosclerosis through intracellular iron homeostasis, ROS and lipid peroxide production and metabolism, and a variety of intracellular signaling pathways. Inhibition of ferroptosis is effective in inhibiting the development of atherosclerosis, and it can bring a new direction for treating atherosclerosis...
January 26, 2024: Mini Reviews in Medicinal Chemistry
https://read.qxmd.com/read/38258662/myeloid-phd2-conditional-knockout-improves-intraplaque-angiogenesis-and-vascular-remodeling-in-a-murine-model-of-venous-bypass-grafting
#18
JOURNAL ARTICLE
Thijs J Sluiter, Renée J H A Tillie, Alwin de Jong, Jenny B G de Bruijn, Hendrika A B Peters, Remco van de Leijgraaf, Raghed Halawani, Michelle Westmaas, Lineke I W Starink, Paul H A Quax, Judith C Sluimer, Margreet R de Vries
BACKGROUND: Intraplaque angiogenesis occurs in response to atherosclerotic plaque hypoxia, which is driven mainly by highly metabolically active macrophages. Improving plaque oxygenation by increasing macrophage hypoxic signaling, thus stimulating intraplaque angiogenesis, could restore cellular function and neovessel maturation, and decrease plaque formation. Prolyl hydroxylases (PHDs) regulate cellular responses to hypoxia. We therefore aimed to elucidate the role of myeloid PHD2, the dominant PHD isoform, on intraplaque angiogenesis in a murine model for venous bypass grafting...
January 23, 2024: Journal of the American Heart Association
https://read.qxmd.com/read/38252755/circulating-sex-specific-markers-of-plaque-instability-in-women-and-men-with-severe-carotid-atherosclerosis
#19
JOURNAL ARTICLE
Karina Gasbarrino, Huaien Zheng, Stella S Daskalopoulou
BACKGROUND: Sex-specific differences in plaque composition and instability underscore the need to explore circulating markers for better prediction of high-risk plaques. This cross-sectional study aims to (1) investigate differences in lipid, immune, and adipokine circulating profiles between men and women with stable versus unstable plaques and (2) identify circulating markers that can better classify men and women according to plaque instability. METHODS: Preoperative blood samples and plaque specimens were collected from consecutive men and women with carotid artery stenosis ≥50% and who underwent a carotid endarterectomy between 2009 and 2018...
February 2024: Stroke; a Journal of Cerebral Circulation
https://read.qxmd.com/read/38205964/study-on-the-consistency-of-angiogenesis-in-carotid-plaque-evaluated-by-contrast-enhanced-ultrasound-and-superb-microvascular-imaging-and-its-correlation-with-stroke-occurrence
#20
JOURNAL ARTICLE
Mingqiu Li, Ruijun Guo
OBJECTIVES: This study aimed to investigate the value of contrast-enhanced ultrasound (CEUS) and superb microvascular imaging (SMI) in evaluating angiogenesis in carotid artery plaques and prognosis in stroke patients. METHODS: Sixty-one patients with carotid atherosclerotic plaques were selected. All patients received conventional ultrasound, CEUS, and SMI examination, including 32 patients with cerebral infarction and 29 patients without cerebral infarction. The results of CEUS and SMI neovascularization of patients were graded 0, 1, and 2 points according to the image characteristics...
January 11, 2024: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
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