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Beata Guzow-Krzemińska, Tomasz Gąsior, Agnieszka Szalewska-Pałasz
Bacteria living in marine environment encounter various challenges and limitations, thus in order to survive, they need to employ efficient stress-response mechanisms. One of these mechanisms is the stringent response, where unusual nucleotides, guanosine tetra- and pentaphosphates, herald starvation and physico-chemical stresses. All so far sequenced free-living bacteria contain the gene(s) responsible for (p)ppGpp synthesis - rsh (named after Escherichia coli genes, relA and spoT). Two similar genes were identified mostly in β- and γ-proteobacteria while other bacteria have only one gene coding the dual function of (p)ppGpp synthesis and degradation...
2015: Acta Biochimica Polonica
Dawei Sun, Gina Lee, Jun Hee Lee, Hye-Yeon Kim, Hyun-Woo Rhee, Seung-Yeol Park, Kyung-Jin Kim, Yongsung Kim, Bo Yeon Kim, Jong-In Hong, Chankyu Park, Hyon E Choy, Jung Hoe Kim, Young Ho Jeon, Jongkyeong Chung
In nutrient-starved bacteria, RelA and SpoT proteins have key roles in reducing cell growth and overcoming stresses. Here we identify functional SpoT orthologs in metazoa (named Mesh1, encoded by HDDC3 in human and Q9VAM9 in Drosophila melanogaster) and reveal their structures and functions. Like the bacterial enzyme, Mesh1 proteins contain an active site for ppGpp hydrolysis and a conserved His-Asp-box motif for Mn(2+) binding. Consistent with these structural data, Mesh1 efficiently catalyzes hydrolysis of guanosine 3',5'-diphosphate (ppGpp) both in vitro and in vivo...
October 2010: Nature Structural & Molecular Biology
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