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https://read.qxmd.com/read/30770766/a-single-center-prospective-randomized-clinical-trial-to-investigate-the-optimal-removal-time-of-the-urinary-catheter-after-laparoscopic-anterior-resection-of-the-rectum-study-protocol-for-a-randomized-controlled-trial
#1
Lai Xu, Zhi-Yan Tao, Jun-Yang Lu, Guan-Nan Zhang, Hui-Zhong Qiu, Bin Wu, Guo-Le Lin, Tao Xu, Yi Xiao
BACKGROUND: Urinary catheter placement is essential before laparoscopic anterior resection for rectal cancer. Whether early removal of the catheter increases the incidence of urinary retention and urinary tract infection (UTI) is not clear. This study aims to determine the optimal time for removal of the urinary catheter after laparoscopic anterior resection of the rectum. METHODS/DESIGN: A total of 220 participants meeting the inclusion criteria will be randomly assigned to an experimental group or a control group...
February 15, 2019: Trials
https://read.qxmd.com/read/30761794/-the-effectiveness-of-the-integrated-approach-to-the-treatment-of-chronic-prostatitis-including-in-patients-with-benign-prostatic-hyperplasia
#2
A B Zhiborev, A G Martov
INTRODUCTION: Concurrent chronic prostatitis (CP) plays an important role in the pathogenesis and progression of benign prostatic hyperplasia (BPH), increasing the severity of lower urinary tract symptoms (LUTS), lowering the quality of life, and increasing the risk of acute urinary retention. However, in the management of patients with BPH, the role of CP is not always taken into account. AIM: To evaluate the effectiveness of integrated management of patients with CP and patients with co-occurring BPH and CP using a physiotherapeutic device Mavit for the treatment of inflammatory diseases of the prostate...
October 2018: Urologii︠a︡
https://read.qxmd.com/read/30753875/time-dependent-protective-effects-of-morphine-against-behavioral-and-morphological-deficits-in-an-animal-model-of-posttraumatic-stress-disorder
#3
Payman Raise Abdullahi, Abbas Ali Vafaei, Ali Ghanbari, Masoomeh Dadkhah, Ali Rashidy-Pour
Post-traumatic stress disorder (PTSD) arises after an individual has experienced a major traumatic event. Recent evidence suggests that acute morphine treatment may serve as a strategy to reduce PTSD development. In the present study, we investigated the time-dependent effects of morphine on behavioral and morphological deficits induced by the single prolonged stress (SPS), an experimental model of PTSD, in adult male rats. The rats were exposed to SPS (restraint for 2 h, forced swimming for 20 min, and ether anesthesia), and kept undistributed for 11 days...
February 9, 2019: Behavioural Brain Research
https://read.qxmd.com/read/30740258/study-on-screening-potential-allergenic-proteins-from-infant-milk-powders-based-on-human-mast-cell-membrane-chromatography-and-histamine-release-assays
#4
Ping Zhang, Yingdi Shi, Xiaoshuang He, Wei Sun, Yanni Lv, Xiaofang Hou
Cow's milk allergy is mainly observed in infants and young children. Most allergic reactions affect the skin, followed by the gastrointestinal and respiratory systems. Conventional diagnosis is based on positive allergy studies and evaluation of parameters including IgE and IgG1 levels, acute allergic skin response and anaphylactic shock reactions. We developed a cell membrane chromatographic (CMC) method based on human mast cells (HMC-1) for screening potential allergens in infant formula milk powders (IFMP)...
February 2019: Journal of Pharmaceutical Analysis
https://read.qxmd.com/read/30735333/robotic-simple-prostatectomy-plus-panniculectomy-and-giant-umbilical-hernia-repair
#5
Angelica Beatriz Hernandez, Luis G Medina, Pierre A Hueber, Felipe Placco Araujo Glina, Hannah Landsberger, Daniel Oberlin, Giovanni Cacciamani, Byron Lopez, Ketan Patel, Rene J Sotelo
INTRODUCTION: Simple prostatectomy is the gold standard for prostates >80 grams, robotic system has proven to help into speed the recovery of the patient and in morbid obesity the advantages of the robotic system can help to perform a suc¬cessful surgery. CASE: 80 years old male with morbid obesity (BMI 45) and several other comorbidities, with history of an umbilical hernia and obstructive lower urinary tract symptoms in acute urinary retention. PSA was 7 ng/dl, DRE demonstrates a >100gr prostate gland...
January 30, 2019: International Braz J Urol: Official Journal of the Brazilian Society of Urology
https://read.qxmd.com/read/30734011/systematic-review-of-interventions-for-the-prevention-and-treatment-of-postoperative-urinary-retention
#6
REVIEW
J Jackson, P Davies, N Leggett, M D Nugawela, L J Scott, V Leach, A Richards, A Blacker, P Abrams, J Sharma, J Donovan, P Whiting
Background: Postoperative urinary retention (PO-UR) is an acute and painful inability to void after surgery that can lead to complications and delayed hospital discharge. Standard treatment with a urinary catheter is associated with a risk of infection and can be distressing, undignified and uncomfortable. This systematic review aimed to identify effective interventions for the prevention and treatment of PO-UR that might be alternatives to urinary catheterization. Methods: Electronic databases were searched from inception to September 2017...
February 2019: BJS open
https://read.qxmd.com/read/30725252/probenecid-relieves-cerebral-dysfunction-of-sepsis-by-inhibiting-pannexin-1-dependent-atp-release
#7
Zhanqin Zhang, Yi Lei, Chaoying Yan, Xiaopeng Mei, Tao Jiang, Zhi Ma, Qiang Wang
Acute brain dysfunction and the following neurological manifestation are common complications in septic patients, which are associated with increased morbidity and mortality. However, the therapeutic strategy of this disorder remains a major challenge. Given the emerging role of a clinically approved drug, probenecid (PRB) has been recently identified as an inhibitor of pannexin 1 (PANX1) channel, which restrains extracellular ATP release-induced purinergic pathway activation and inflammatory response contributing to diverse pathological processes...
February 6, 2019: Inflammation
https://read.qxmd.com/read/30723031/overlay-repair-with-a-synthetic-collagen-scaffold-improves-the-quality-of-healing-in-a-rat-rotator-cuff-repair-model
#8
Mark Zhu, Mei Lin Tay, Karen Callon, Donna Tuari, Lei Zhao, Michael Dray, Jie Zhang, Nicola Dalbeth, Jacob Munro, Simon Young, Brendan Coleman, Dipika Patel, Jillian Cornish, David Musson
BACKGROUND: Augmenting repairs with extracellular matrix-based scaffolds is a common option for rotator cuff tears. In this study, a new collagen scaffold was assessed for its efficacy in augmenting rotator cuff repair. METHODS: The collagen scaffold was assessed in vitro for cytocompatibility and retention of tenocyte phenotype using alamarBlue assays, fluorescent imaging, and real-time polymerase chain reaction. Immunogenicity was assessed in vitro by the activation of human monocytes...
February 2, 2019: Journal of Shoulder and Elbow Surgery
https://read.qxmd.com/read/30719406/pelvic-neuroblastoma-presenting-with-acute-urinary-retention-and-acute-kidney-injury
#9
Lisa B E Shields, Dennis S Peppas, Eran Rosenberg
•Neuroblastomas are tumors that arise from primitive sympathetic ganglion cells and are rarely seen in the pelvic region.•Neuroblastomas are the most common extracerebral solid tumors in children under the age of five years.•Acute urinary retention due to extrinsic compression from a pelvic mass is a rare phenomenon in infants.•Pelvic neuroblastoma may cause acute urinary retention and acute kidney injury.
March 2019: Urology Case Reports
https://read.qxmd.com/read/30719081/efficacy-and-safety-of-fexapotide-triflutate-in-outpatient-medical-treatment-of-male-lower-urinary-tract-symptoms-associated-with-benign-prostatic-hyperplasia
#10
REVIEW
Neal Shore, Ronald Tutrone, Claus G Roehrborn
Male lower urinary tract symptoms (LUTS) is an increasingly important problem for the majority of late middle aged and elderly men. Fexapotide triflutate (FT) is a first in-class compound given by local injection via the transrectal intraprostatic route under ultrasound guidance. Data from >1700 FT and control injections in prospective randomized blinded controlled multicenter trials are reviewed and discussed in relation to current developments in the field of treatments for LUTS associated with benign prostatic hyperplasia (BPH)...
January 2019: Therapeutic Advances in Urology
https://read.qxmd.com/read/30716523/voxel-based-analysis-for-identification-of-urethro-vesical-subregions-predicting-urinary-toxicity-after-prostate-cancer-radiotherapy
#11
Eugenia Mylona, Oscar Acosta, Thibaut Lizee, Caroline Lafond, Gilles Crehange, Nicolas Magné, Sophie Chiavassa, Stéphane Supiot, Juan David Arango Ospina, Borris Campillo-Gimenez, Joel Castelli, Renaud de Crevoisier
BACKGROUND AND PURPOSE: To apply a voxel-based analysis to identify urethro-vesical symptom-related subregions (SRSs) associated with acute and late urinary toxicity in prostate cancer radiotherapy. MATERIALS AND METHODS: A total of 272 prostate cancer patients treated with IMRT/IGRT were prospectively analyzed. Each patient's CT was spatially normalized to a common coordinate system (CCS) via nonrigid registration. The obtained deformation fields were used to map the dose of each patient to the CCS...
February 1, 2019: International Journal of Radiation Oncology, Biology, Physics
https://read.qxmd.com/read/30713713/cell-therapy-for-ards-efficacy-of-endobronchial-versus-intravenous-administration-and-biodistribution-of-mapcs-in-a-large-animal-model
#12
Nayra Cardenes, Paola Aranda-Valderrama, Jonathan P Carney, Jacobo Sellares Torres, Diana Alvarez, Ergin Kocydirim, Julie A Wolfram Smith, Antony E Ting, Luigi Lagazzi, Zheming Yu, Scott Mason, Ernesto Santos, Brian J Lopresti, Mauricio Rojas
Introduction: Bone marrow-derived multipotent adult progenitor cells (MAPCs) are adult allogeneic adherent stem cells currently investigated clinically for use in acute respiratory distress syndrome (ARDS). To date, there is no agreement on which is the best method for stem cells delivery in ARDS. Here, we compared the efficacy of two different methods of administration and biodistribution of MAPC for the treatment of ARDS in a sheep model. Methods: MAPC were labelled with [18 F] fluoro-29-deoxy-D-glucose and delivered by endobronchial (EB) or intravenous route 1 hour after lipopolysaccharide infusion in sheep mechanically ventilated...
2019: BMJ Open Respiratory Research
https://read.qxmd.com/read/30711495/top-down-holmium-laser-enucleation-of-the-prostate-technical-aspects-and-early-outcomes
#13
Hazem Elmansy, Amr Hodhod, Ahmed Kotb, Owen Prowse, Walid Shahrour
OBJECTIVE: To clarify the key steps and evaluate the early results of the recently introduced Top-Down Holmium Laser Enucleation of the Prostate (HoLEP).1,2 This technique was developed to shorten the steep learning curve associated with the conventional approach. PATIENTS AND METHODS: Sixty patients with a median age of 73 years (54-88) underwent HoLEP between 2017 and 2018. The Top-Down technique was performed by one surgeon (H.E). We used a 100-W holmium: YAG Laser (VersaPulse PowerSuite, Lumenis, Yokneam, Israel) with a 550 μm laser fiber and a 28 Fr continuous flow resectoscope (Karl Storz, Germany)...
January 31, 2019: Urology
https://read.qxmd.com/read/30706153/risk-factors-and-impact-of-conversion-from-vats-to-open-lobectomy-analysis-from-a-national-database
#14
Stefano Bongiolatti, Alessandro Gonfiotti, Domenico Viggiano, Sara Borgianni, Leonardo Politi, Roberto Crisci, Carlo Curcio, Luca Voltolini
OBJECTIVE: The objective of the study is to analyse the causes and impact of conversion from VATS to thoracotomy identifying any possible pre-operative risk factors and related consequences. METHODS: Data from patient who underwent VATS lobectomy (VATS-L) for NSCLC at VATS Group participating centres were retrospectively analysed and divided in two groups: patients treated with VATS-L and patients who suffered from conversion. Predictors of conversion were assessed with univariate and multivariable exact logistic regression...
January 31, 2019: Surgical Endoscopy
https://read.qxmd.com/read/30706015/prostate-stereotactic-body-radiation-therapy-with-a-focal-simultaneous-integrated-boost-acute-toxicity-and-dosimetry-results-from-a-prospective-trial
#15
Andrew M McDonald, Michael C Dobelbower, Eddy S Yang, Grant M Clark, Rojymon Jacob, Robert Y Kim, Rex A Cardan, Richard Popple, Jeffrey W Nix, Soroush Rais-Bahrami, John B Fiveash
Purpose: This study aimed to report the early toxicity results of a prospective clinical trial of prostate stereotactic body radiation therapy (SBRT) to the entire prostate with a simultaneous integrated boost (SIB) to magnetic resonance imaging (MRI)-defined focal lesions. Methods and materials: Eligible patients included men with biopsy-proven prostate stage T1c to T2c adenocarcinoma, a Gleason score ≤7, and prostate-specific antigen values of ≤20 ng/mL, who had at least 1 focal lesion visible on MRI and a total prostate volume no greater than 120 cm3 ...
January 2019: Advances in Radiation Oncology
https://read.qxmd.com/read/30701577/dielectrophoretic-trapping-of-single-leukemic-cells-using-the-conventional-and-compact-optical-measurement-systems
#16
Hamideh Sharifi Noghabi, Mandy Soo, Avid Khamenehfar, Paul C H Li
Here we report a microfluidic same-single-cell analysis to study the inhibition of multidrug resistance (MDR) due to drug efflux on single leukemic cells. Drug efflux inhibition was investigated in the microfluidic chip using two different fluorescence detection systems, namely, a compact single-cell bioanalyzer (SCB) and the conventional optical detection system constructed from an inverted microscope and a microphotometer. More importantly, a compact signal generator was used to conduct dielectrophoretic (DEP) cell trapping together with the compact SCB...
January 30, 2019: Electrophoresis
https://read.qxmd.com/read/30687660/limbus-vertebral-fracture-presenting-as-cauda-equina-syndrome-masquerading-an-acute-disc-prolapse-a-rare-case-report-and-review-of-literature
#17
Nigil Sadanandan Palliyil, Ravi Ranjan Rai, Kedar Deogaonkar
Introduction: Limbus vertebral fracture is an uncommon injury described in adolescents. It refers to the separation of a bony fragment from the unfused ring apophysis of lumbar vertebral end plate. It usually presents with back pain with/without radiculopathy masquerading an acute disc prolapse. However, the presentation as acute cauda equina syndrome has seldom been reported. Case Report: A 15-year-old male presented to the casualty with a history of acute-onset low back pain and bilateral lower limb radicular pain with weakness, after lifting of a heavy Indian musical instrument (Dholak)...
July 2018: Journal of Orthopaedic Case Reports
https://read.qxmd.com/read/30683548/-lower-urinary-tracts-symptoms-after-female-genital-mutilation-a-review
#18
P Millet, M Vinchant, S Sharifzadehgan, S Vieillefosse, G Hatem-Gantzer, X Deffieux
INTRODUCTION: The purpose of this article is to summarise the data available in literature on Lower Urinary Tract Symptoms [lower urinary tract symptoms (LUTS)] after female genital mutilation (MSF). METHODS: Our review identified 177 publications, 14 of which were included in the article. RESULTS: With regard to short-term complications, the prevalence of Acute Urinary Retention (RAU) after MSF is estimated between 3% and 12%. With respect to long-term complications, the data is discordant on repeat urinary tract infections (IUR) after MSF with an estimated prevalence between 9% and 39%...
January 22, 2019: Progrès en Urologie
https://read.qxmd.com/read/30682438/learning-and-memory-impairments-associated-to-acetylcholinesterase-inhibition-and-oxidative-stress-following-glyphosate-based-herbicide-exposure-in-mice
#19
Yassine Ait Bali, Nour-Eddine Kaikai, Saadia Ba-M'hamed, Mohamed Bennis
Numerous clinical and epidemiological data have reported the deleterious effects of glyphosate on learning and memory. The ability of this herbicide to cross the blood-brain barrier may have adverse effects on the structure and various functions of the nervous system. This study was conducted to highlight the effects of Glyphosate-based herbicide (GBH) on these two functions in mice treated daily with 250 or 500 mg/kg following acute (unique administration), subchronic (6 weeks) and chronic (12 weeks) treatments...
January 22, 2019: Toxicology
https://read.qxmd.com/read/30682076/recovernow-a-mobile-tablet-based-therapy-platform-for-early-stroke-rehabilitation
#20
Michael Pugliese, Tim Ramsay, Rany Shamloul, Karen Mallet, Lise Zakutney, Dale Corbett, Sean Dukelow, Grant Stotts, Michel Shamy, Kumanan Wilson, Julien Guerinet, Dar Dowlatshahi
INTRODUCTION: Stroke survivors frequently experience a range of post-stroke deficits. Specialized stroke rehabilitation improves recovery, especially if it is started early post-stroke. However, resource limitations often preclude early rehabilitation. Mobile technologies may provide a platform for stroke survivors to begin recovery when they might not be able to otherwise. The study objective was to demonstrate the feasibility of RecoverNow, a tablet-based stroke recovery platform aimed at delivering speech and cognitive therapy...
2019: PloS One
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