Zhen Zhou, Joanne Ryan, Mark R Nelson, Robyn L Woods, Suzanne G Orchard, Chao Zhu, Julia F M Gilmartin-Thomas, Michelle A Fravel, Alice J Owen, Anne M Murray, Sara E Espinoza, Michael E Ernst
BACKGROUND: The protective effects of allopurinol on physical function in older adults are not well understood, despite its potential to improve functional gains and reduce sarcopenia. This study aims to determine the association between allopurinol, persistent physical disability, and frailty in older gout patients. METHODS: This analysis used data from a randomized trial in an older cohort, ASPirin in Reducing Events in the Elderly (ASPREE). ASPREE recruited 19,114 participants aged ≥65 years without prior cardiovascular events, dementia, or independence-limiting physical disability at trial enrolment...
May 9, 2023: Journal of the American Geriatrics Society