keyword
https://read.qxmd.com/read/38520024/sarcopenic-obesity-is-part-of-obesity-paradox-in-dementia-development-evidence-from-a-population-based-cohort-study
#1
JOURNAL ARTICLE
Junhan Zhang, Xiaona Na, Zhihui Li, John S Ji, Guowei Li, Haibing Yang, Yucheng Yang, Yuefeng Tan, Jian Zhang, Menglu Xi, Donghan Su, Huatang Zeng, Liqun Wu, Ai Zhao
BACKGROUND: Sarcopenic obesity, a clinical and functional condition characterized by the coexistence of obesity and sarcopenia, has not been investigated in relation to dementia risk and its onset. METHODS: We included 208,867 participants from UK biobank, who aged 60 to 69 years at baseline. Dementia diagnoses were identified using hospital records and death register data. Hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated using Cox proportional hazards models to evaluate the associations of obesity, sarcopenia, and sarcopenic obesity with dementia risk, stratified by sex...
March 22, 2024: BMC Medicine
https://read.qxmd.com/read/38515016/sarcopenia-in-subjects-with-alzheimer-s-disease-prevalence-and-comparison-of-agreement-between-egwsop1-egwsop2-and-fnih-criteria
#2
JOURNAL ARTICLE
Roberta Barone, Giulia Bramato, Valentina Gnoni, Alessia Giugno, Daniele Urso, Chiara Zecca, Salvatore Nigro, Marco Filardi, Giancarlo Logroscino
BACKGROUND: Sarcopenia is an age-related clinical syndrome characterized by the progressive loss of muscle mass and muscle strength. It appears to be closely linked to dementia, particularly Alzheimer's disease (AD); however, its prevalence among AD patients remains unclear. In this study, we assessed differences in sarcopenia prevalence between non-demented individuals and AD patients. Moreover, we assessed sex-specific differences in sarcopenia prevalence and explored the diagnostic value of the Muscle Quality Index (MQI) for diagnosing sarcopenia among AD patients...
March 22, 2024: BMC Geriatrics
https://read.qxmd.com/read/38510210/linking-sarcopenia-brain-structure-and-cognitive-performance-a-large-scale-uk-biobank-study
#3
JOURNAL ARTICLE
Tiril P Gurholt, Miguel Germán Borda, Nadine Parker, Vera Fominykh, Rikka Kjelkenes, Jennifer Linge, Dennis van der Meer, Ida E Sønderby, Gustavo Duque, Lars T Westlye, Dag Aarsland, Ole A Andreassen
Sarcopenia refers to age-related loss of muscle mass and function and is related to impaired somatic and brain health, including cognitive decline and Alzheimer's disease. However, the relationships between sarcopenia, brain structure and cognition are poorly understood. Here, we investigate the associations between sarcopenic traits, brain structure and cognitive performance. We included 33 709 UK Biobank participants (54.2% female; age range 44-82 years) with structural and diffusion magnetic resonance imaging, thigh muscle fat infiltration ( n = 30 561) from whole-body magnetic resonance imaging (muscle quality indicator) and general cognitive performance as indicated by the first principal component of a principal component analysis across multiple cognitive tests ( n = 22 530)...
2024: Brain communications
https://read.qxmd.com/read/38472505/the-prevalence%C3%A2-and-co-existence-of-geriatric-syndromes-in-older-patients-with-dementia-compared-to-those-without-dementia
#4
JOURNAL ARTICLE
Pinar Soysal, Lee Smith
BACKGROUND: This study aims to compare frequency and coexistence of geriatric syndromes in older patients with dementia to those without dementia. METHODS: 1392 patients admitted to geriatric outpatient clinics were evaluated. Evaluations for eleven geriatric syndromes including polypharmacy, malnutrition, fraility, sarcopenia, dysphagia, urinary incontinence, fear of falling, falls, insomnia, excessive daytime sleepiness, and orthostatic hypotension (OH) were carried out in consultation with the patient and the caregiver...
March 13, 2024: Aging Clinical and Experimental Research
https://read.qxmd.com/read/38448632/the-interaction-between-mediterranean-diet-and-intestinal-microbiome-relevance-for-preventive-strategies-against-frailty-in-older-individuals
#5
REVIEW
Andrea Ticinesi, Antonio Nouvenne, Nicoletta Cerundolo, Alberto Parise, Pedro Mena, Tiziana Meschi
Age-related changes in intestinal microbiome composition and function are increasingly recognized as pivotal in the pathophysiology of aging and are associated with the aging phenotype. Diet is a major determinant of gut-microbiota composition throughout the entire lifespan, and several of the benefits of a healthy diet in aging could be mediated by the microbiome. Mediterranean diet (MD) is a traditional dietary pattern regarded as the healthy diet paradigm, and a large number of studies have demonstrated its benefits in promoting healthy aging...
March 6, 2024: Aging Clinical and Experimental Research
https://read.qxmd.com/read/38404529/oral-intake-in-the-complete-lateral-position-as-a-compensatory-method-for-a-patient-with-severe-dysphagia-a-case-report
#6
Naoki Fukumura, Kuniko Makigami
BACKGROUND: We report a patient with severe dysphagia who was successfully treated using our newly developed swallowing rehabilitation method involving a complete lateral position. CASE: This case involved a 74-year-old male patient with dysphagia caused by multiple morbidities, including sarcopenia after panperitonitis, Wallenberg syndrome, and Lewy body dementia. We attempted oral feeding in the complete lateral position and observed that the bolus was moving as intended and was swallowed without penetration or aspiration...
2024: Progress in rehabilitation medicine
https://read.qxmd.com/read/38357313/sarcopenia-but-not-malnutrition-is-associated-with-fear-of-falling-in-older-patients-with-dementia
#7
JOURNAL ARTICLE
Saadet Koc Okudur, Lee Smith, Semen Gokce Tan, Veliye Yigitalp, Pinar Soysal
OBJECTIVE: Fear of falling (FoF) is common in patients with cognitive impairment. However, the role of sarcopenia and malnutrition, which are two important factors that cause falls, on FoF is unknown. The aim of this study was to explore the association between FoF and malnutrition and sarcopenia in older patients with dementia. METHODS: Two hundred and sixty-six dementia patients underwent comprehensive geriatric assessment. The Falls Efficacy Scale-International (FES-I) was applied to assign and classify FoF...
2024: Northern Clinics of Istanbul
https://read.qxmd.com/read/38267160/handgrip-strength-asymmetry-and-cognitive-impairment-risk-insights-from-a-seven-year-prospective-cohort-study
#8
JOURNAL ARTICLE
Tao-Chun Peng, Jeng-Min Chiou, Yen-Ching Chen, Jen-Hau Chen
OBJECTIVES: This study aimed to explore the links of handgrip strength and asymmetry with cognitive impairment. DESIGN: This was a seven-year prospective cohort study. SETTING AND PARTICIPANTS: We used data from wave 3 (2015-2017) to wave 5 (2019-2022) from the ongoing Taiwan Initiative of Geriatric Epidemiological Research (TIGER), with wave 3 as the baseline (n = 446). The study included community-dwelling participants aged 65 years or older...
January 2024: Journal of Nutrition, Health & Aging
https://read.qxmd.com/read/38267149/muscle-mass-loss-measured-with-portable-ultrasound-in-hospitalized-older-adults-the-ecosarc-study
#9
JOURNAL ARTICLE
Esther López Jiménez, Marta Neira Álvarez, Rocío Menéndez Colino, Marta Checa López, Concha Grau Jiménez, Patricia Pérez Rodríguez, Brian Vasquez Brolen, Estefanía Arias Muñana, Raquel Ramírez Martín, Cristina Alonso Bouzón, María Solange Amor Andrés, Cristina Bermejo Boixareu, Fátima Brañas, María Alcantud Ibáñez, Rubén Alcantud Córcoles, Elisa Belén Cortés Zamora, Elena Gómez Jiménez, Luis Romero Rizos, Almudena Avendaño Céspedes, Carmen Rosa Hernández Socorro, Pedro Abizanda
OBJECTIVES: The main objective was to analyze the evolution of muscle of the Quadriceps Rectus Femoris (QRF) between admission and discharge, in older adults hospitalized with an acute medical disease in Acute Geriatric Units (AGUs). DESIGN: Prospective multicentric observational cohort study. SETTING: Seven AGUs from University Hospitals in Spain. PARTICIPANTS: Hospitalized adults ≥ 70 years old, able to ambulate and without severe dementia...
January 2024: Journal of Nutrition, Health & Aging
https://read.qxmd.com/read/38179233/sarcopenia-and-diabetes-induced-dementia-risk
#10
JOURNAL ARTICLE
Mingyang Sun, Zhongyuan Lu, Wan-Ming Chen, Szu-Yuan Wu, Jiaqiang Zhang
This study aimed to investigate whether sarcopenia independently increases the risk of diabetes-induced dementia in elderly individuals diagnosed with type 2 diabetes mellitus. The study cohort consisted of a large sample of elderly individuals aged 60 years and above, who were diagnosed with type 2 diabetes mellitus between 2008 and 2018. To minimize potential bias and achieve covariate balance between the sarcopenia and non-sarcopenia groups, we employed propensity score matching. Various statistical analyses, including Cox regression models to assess dementia risk and associations, competing risk analysis to account for mortality and Poisson regression analysis for incidence rates, were used...
2024: Brain communications
https://read.qxmd.com/read/38149200/knowledge-mapping-of-exercise-and-physical-activity-research-in-older-adults-hotspots-bursts-and-trends-of-the-last-decade
#11
JOURNAL ARTICLE
Ya-Xi Luo, Ying-Hai Zhu, Xiu-Qing Yao
BACKGROUND AND OBJECTIVES: Global aging has increased the importance of health management in older adults. Exercise is a crucial strategy for healthy aging and has led to numerous scientific advancements due to its impact on age-related illnesses. We aim to investigate the research hotspots, bursts of knowledge base, and trends in the field of exercise and physical activity in older adults over the past decade and present them in a visual manner. METHODS: We searched and retrieved data from the Web of Science database, and performed a bibliometric analysis of publications on exercise and physical activity research in older adults from 2013 to 2022...
December 2023: Heliyon
https://read.qxmd.com/read/38135320/randomised-controlled-trial-combining-vitamin-e-functionalised-chocolate-with-physical-exercise-to-reduce-the-risk-of-protein-energy-malnutrition-in-predementia-aged-people-study-protocol-for-choko-age
#12
JOURNAL ARTICLE
Anna Pedrinolla, Masoud Isanejad, Cinzia Antognelli, Desirée Bartolini, Consuelo Borras, Valentina Cavedon, Gabriele Di Sante, Anna Migni, Cristina Mas-Bargues, Chiara Milanese, Claudia Baschirotto, Roberto Modena, Alessandra Pistilli, Mario Rende, Federico Schena, Anna Maria Stabile, Nicola Vincenzo Telesa, Sara Tortorella, Kay Hemmings, Jose Vina, Eivind Wang, Anne McArdle, Malcolm J Jackson, Massimo Venturelli, Francesco Galli
OBJECTIVE: Protein-energy malnutrition and the subsequent muscle wasting (sarcopenia) are common ageing complications. It is knowing to be also associated with dementia. Our programme will test the cytoprotective functions of vitamin E combined with the cortisol-lowering effect of chocolate polyphenols (PP), in combination with muscle anabolic effect of adequate dietary protein intake and physical exercise to prevent the age-dependent decline of muscle mass and its key underpinning mechanisms including mitochondrial function, and nutrient metabolism in muscle in the elderly...
December 22, 2023: BMJ Open
https://read.qxmd.com/read/38116709/association-between-dynapenia-and-cognitive-decline-in-community-dwelling-older-japanese-adults-the-iride-cohort-study
#13
JOURNAL ARTICLE
Sho Hatanaka, Hiroyuki Sasai, Takashi Shida, Yosuke Osuka, Narumi Kojima, Takahisa Ohta, Takumi Abe, Mari Yamashita, Shuichi P Obuchi, Tatsuro Ishizaki, Yoshinori Fujiwara, Shuichi Awata, Kenji Toba
AIM: Muscle mass and strength correlate with cognitive function; however, it remains unclear whether dynapenia (i.e., muscle weakness with preserved muscle mass) is relevant. This study aimed to explore whether dynapenia is associated with global cognitive function in community-dwelling older Japanese adults. METHODS: This cross-sectional study used data from the Integrated Research Initiative for Living Well with Dementia Cohort Study, which pooled data from five community-based geriatric cohorts...
December 20, 2023: Geriatrics & Gerontology International
https://read.qxmd.com/read/38102932/rationale-and-design-of-juntendo-sarcopenia-registration-to-explore-the-predictors-and-prognosis-of-sarcopenia-and-frailty-in-the-elderly-in-tokyo-justice-tokyo
#14
JOURNAL ARTICLE
Kei Matsuno, Daisuke Asaoka, Koji Sugano, Kazuhisa Takahashi, Katsumi Miyauchi
AIM: This study aimed to clarify the prevalence, predictors, and prognosis of frailty and sarcopenia in both cross-sectional and longitudinal study of the real world. METHODS: The JUSTICE-TOKYO study is a single-center, prospective observational study of elderly patients. Patients aged ≥65 years who regularly visited our center were enrolled and followed up for 4 years (n = 1042). The diagnosis of sarcopenia and frailty in the enrolled patients was based on the criteria established by the Asian Working Group for Sarcopenia and Japanese version of the Cardiovascular Health Study criteria, respectively...
December 16, 2023: Geriatrics & Gerontology International
https://read.qxmd.com/read/38086773/implication-of-grip-strength-assessment-for-the-management-of-body-weight-in-disability-prevention-in-older-adults
#15
JOURNAL ARTICLE
Shu Zhang, Rei Otsuka, Chikako Tange, Yukiko Nishita, Hiroshi Shimokata, Shosuke Satake, Hidenori Arai
BACKGROUND: Although body mass index (BMI) and grip strength (GS) are both predictors of disability, their joint effect on predicting incident disability remains uncertain. We examined whether the effect of BMI on incident disability can be modulated by GS in community-dwelling older people in Japan. METHODS: A total of 1486 community-dwellers in Japan (731 men and 755 women, aged 65-82 years) who participated in the 2nd to 7th waves of the National Institute for Longevity Sciences-Longitudinal Study of Aging (NILS-LSA) project, were followed up to 20 years...
December 12, 2023: Journal of Cachexia, Sarcopenia and Muscle
https://read.qxmd.com/read/38076545/associations-of-sarcopenia-sarcopenia-parameters-and-motoric-cognitive-risk-syndrome-in-chinese-older-adults
#16
JOURNAL ARTICLE
Dian Jiang, Xi Chen, Jundan Huang, Lina Wu, Yifei Chen, Hui Feng, Mingyue Hu
BACKGROUND: Motoric cognitive risk syndrome (MCR) is a pre-dementia symptom strongly predicting cognitive decline and dementia. Although advancements in elucidating the epidemiology of MCR, the evidence about the association between sarcopenia, sarcopenia parameters, and MCR remains scarce. OBJECTIVES: The purpose of this study was to determine the associations between sarcopenia, sarcopenia parameters, and MCR among community-dwelling Chinese older adults. METHODS: A total of 4,184 community-dwelling older adults from the China Health and Retirement Longitudinal Study (CHARLS) in the 2011 waves were included...
2023: Frontiers in Aging Neuroscience
https://read.qxmd.com/read/38064108/the-prevalence-of-excessive-daytime-sleepiness-and-associated-factors-in-older-diabetic-patients
#17
JOURNAL ARTICLE
Nezahat Muge Catikkas, Muhammed Tunc, Pinar Soysal
OBJECTIVES: Sleep disorders are a frequent health problem in older patients with diabetes mellitus (DM). There has been no study investigating the factors associated with excessive daytime sleepiness (EDS) in older diabetic patients. We aimed to investigate the prevalence and associated factors of EDS. METHODS: We performed a retrospective cross-sectional study in older diabetic patients. The Epworth Sleepiness Scale score of ≥ 11 points indicated EDS...
December 8, 2023: Aging Clinical and Experimental Research
https://read.qxmd.com/read/38050325/using-magnetic-resonance-imaging-to-measure-head-muscles-an-innovative-method-to-opportunistically-determine-muscle-mass-and-detect-sarcopenia
#18
JOURNAL ARTICLE
Miguel German Borda, Gustavo Duque, Mario Ulises Pérez-Zepeda, Jonathan Patricio Baldera, Eric Westman, Anna Zettergren, Jessica Samuelsson, Silke Kern, Lina Rydén, Ingmar Skoog, Dag Aarsland
BACKGROUND: Sarcopenia is associated with multiple adverse outcomes. Traditional methods to determine low muscle mass for the diagnosis of sarcopenia are mainly based on dual-energy X-ray absorptiometry (DXA), whole-body magnetic resonance imaging (MRI) and bioelectrical impedance analysis. These tests are not always available and are rather time consuming and expensive. However, many brain and head diseases require a head MRI. In this study, we aim to provide a more accessible way to detect sarcopenia by comparing the traditional method of DXA lean mass estimation versus the tongue and masseter muscle mass assessed in a standard brain MRI...
December 4, 2023: Journal of Cachexia, Sarcopenia and Muscle
https://read.qxmd.com/read/38046439/validation-of-sarc-f-proxy-for-the-screening-of-sarcopenia-in-older-patients-with-cognitive-impairment
#19
JOURNAL ARTICLE
Scott Lamers, Zaid Kasim, Wendy Daniella Rodríguez-García, Pishtiwan Kalmet, Stany Perkisas, Anne-Marie De Cock, Maurits Vandewoude
OBJECTIVES: The SARC-F is a validated questionnaire for the screening of sarcopenia in an older population. However, the clinical relevance of this self-reported questionnaire in patients with cognitive problems is questionable. This study aims to validate the SARC-F-Proxy as an alternative screening tool for sarcopenia in patients with cognitive impairment. METHODS: This cross-sectional study included hospitalised community-dwelling older adults aged 60 years or older with confirmed cognitive impairment...
December 2023: Journal of frailty, sarcopenia and falls
https://read.qxmd.com/read/37997713/sarcopenia-screened-with-sarc-f-and-subjective-memory-complaints-are-independently-associated-with-increased-risk-of-incident-dementia-among-cognitively-unimpaired-older-adults
#20
JOURNAL ARTICLE
C-L Li, H-Y Chang, Y-H Tsai
OBJECTIVES: The main aim of this study was to examine the association of sarcopenia and subjective memory complaints with the incidence of dementia in a population-based cohort of cognitively unimpaired older adults. DESIGN: Three-year longitudinal study. SETTINGS AND PARTICIPANTS: A total of 2163 community-dwelling persons aged 65 years or older who participated in the National Health Interview Survey in Taiwan, 2017. MEASUREMENTS: Sarcopenia was determined based on SARC-F, a self-reported symptom-based questionnaire that includes five components: strength, assistance walking, rise from a chair, climb stairs, and falls...
2023: Journal of Nutrition, Health & Aging
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