keyword
https://read.qxmd.com/read/38537707/prevalence-of-antimicrobial-use-and-healthcare-associated-infections-in-the-uae-results-from-the-first-nationwide-point-prevalence-survey
#1
JOURNAL ARTICLE
Najiba Abdulrazzaq, Ayman Chkhis
OBJECTIVES: The WHO's Global Antimicrobial Resistance Surveillance System (GLASS) 2017-2018 reported a significant increase in antimicrobial resistance among nosocomial pathogens. This was the first national point of prevalence survey in United Arab Emirates. METHODS: A one-day multicenter cross-sectional survey using a unified web-based platform was conducted in forty-four hospitals across the country from 3 to 23 November 2019 to estimate the prevalence of antimicrobial use and healthcare-associated infections among both governmental and private sectors...
March 25, 2024: Infectious diseases now
https://read.qxmd.com/read/38516737/management-of-a-complex-fistula-involving-abdominal-wall-small-bowel-colon-and-bladder
#2
JOURNAL ARTICLE
Mishal Gillani, Seth A Rosen
Successful surgical management of a chronic complex abdominal fistula requires thoughtful pre-operative evaluation and planning and often benefits from a multi-disciplinary approach. Initially, attention is focused on controlling sepsis and ensuring adequate hydration and electrolyte replacement. Next, efforts to optimize nutrition and engage the patient in prehabilitation are prioritized. Simultaneously, imaging is used to gain detailed assessment of anatomy. We present a challenging case involving a Jackson-Pratt (JP) drain from prior surgery causing a complex intra-abdominal fistula...
March 22, 2024: American Surgeon
https://read.qxmd.com/read/38465159/an-unexpected-turn-management-of-a-life-threatening-infection-following-liposuction-procedure
#3
Marwa Morgom, Doaa M Eisa, Hanna Ali, Leena Saeed
This case report presents a rare case of necrotizing fasciitis (NF) following liposuction and lipofilling surgery in a young woman. Despite prompt diagnosis and aggressive management with multiple debridements, broad-spectrum antibiotics, and supportive care, the patient experienced a protracted course with severe complications, including intra-abdominal collection recurrence, heart failure, and sepsis. The presence of resistant bacteria (extended-spectrum beta-lactamases (ESBLs)-producing Escherichia coli and methicillin-resistant Staphylococcus aureus (MRSA)) further challenged the treatment...
February 2024: Curēus
https://read.qxmd.com/read/38463734/recurrent-vaginal-evisceration-of-abdominal-contents-with-subsequent-resection-of-necrotic-omentum-in-a-35-year-old-woman
#4
Crista E Horton, Ahmad Baghdadi, Jennine Putnick, Trevor Gravely
Vaginal evisceration is a rare surgical emergency in which intra-abdominal contents protrude through a dehisced vaginal cuff, which can lead to bowel ischemia and abdominal sepsis. This condition occurs due to vaginal cuff weakness secondary to prior surgeries or trauma. Recurrence after repair is rare and few cases have been documented. Here we present a young woman with multiple prior gynecologic surgeries who presented with eviscerated small bowel and omentum from her vagina five months following surgical treatment of a previous vaginal evisceration...
March 2024: Journal of Surgical Case Reports
https://read.qxmd.com/read/38435215/antifungal-use-in-perforated-peptic-ulcer-disease-a-western-australian-perspective
#5
JOURNAL ARTICLE
Nikitha Boyapati, Vidya Willis, Amanda Foster, David Fletcher
Background Perforated peptic ulcer disease has a high mortality rate, and there is consensus regarding the use of antifungals in the management of immunocompromised patients; however, there is variability in the utilization of antifungals in the non-immunocompromised cohort. This study aims to describe the current practice related to the use of antifungals in perforated peptic ulcer disease in Western Australia and to determine the peri-operative morbidity and mortality in the immunocompromised and non-immunocompromised cohort receiving antifungals...
February 2024: Curēus
https://read.qxmd.com/read/38412528/typhoid-fever-presenting-with-ileal-perforation-and-gastric-perforation
#6
M M Muhammed, K J Bwala, J O Okoruwa
Typhoid fever is caused by Salmonella typhi and Salmonella paratyphi. It is a disease of developing countries and is seen among people of low socio-economic status. Patients can develop complications like typhoid intestinal perforation which is associated with higher mortality. A 15-year-old female presented to the emergency pediatric unit with fever, abdominal pain and abdominal distension. She was septic, in respiratory distress, and had marked generalized abdominal tenderness with guarding. An assessment of generalized peritonitis secondary to typhoid intestinal perforation was made...
January 31, 2024: West African Journal of Medicine
https://read.qxmd.com/read/38405692/a-fungal-metabolic-regulator-underlies-infectious-synergism-during-candida-albicans-staphylococcus-aureus-intra-abdominal-co-infection
#7
Saikat Paul, Olivia A Todd, Kara R Eichelberger, Christine Tkaczyk, Bret R Sellman, Mairi C Noverr, James E Cassat, Paul L Fidel, Brian M Peters
Candida albicans and Staphylococcus aureus are two commonly associated pathogens that cause nosocomial infections with high morbidity and mortality. Our prior and current work using a murine model of polymicrobial intra-abdominal infection (IAI) uncovered synergistic lethality that was driven by Candida -induced upregulation of functional S. aureus ⍺-toxin leading to polymicrobial sepsis and organ damage. In order to determine the candidal effector(s) mediating enhanced virulence, an unbiased screen of C...
February 15, 2024: bioRxiv
https://read.qxmd.com/read/38383244/risk-factors-of-acute-respiratory-distress-syndrome-in-sepsis-caused-by-intra-abdominal-infections-a-retrospective-study
#8
JOURNAL ARTICLE
Yuteng Ma, Chengrui Zhu, Xiaochun Ma, Baosen Zhou, Ming Dong
BACKGROUND: Intra-abdominal infections are frequently associated with acute respiratory distress syndrome, which significantly affects patient prognosis. However, little is known about the specific risk factors of acute respiratory distress syndrome in sepsis caused by intra-abdominal infections. METHODS: This retrospective study included adult patients with intra-abdominal sepsis admitted to the intensive care unit of a tertiary teaching hospital in China between June 2017 and June 2022...
February 20, 2024: Surgery
https://read.qxmd.com/read/38367772/epidemiology-treatment-and-outcomes-of-infected-pancreatic-necrosis-in-france-a-bicenter-study
#9
JOURNAL ARTICLE
Yousra Kherabi, Claire Michoud, Khanh Villageois-Tran, Frédéric Bert, Mathieu Pioche, Agnès Lefort, Philippe Lévy, Vinciane Rebours, Virginie Zarrouk
INTRODUCTION: Acute necrotizing pancreatitis (ANP) mortality increases when pancreatic necrosis is infected (IPN). Current treatment of IPN relies on prolonged antibiotic therapies associated with a step-up strategy of drainage. The objective of this study was to analyze IPN treatment outcomes in two referral centers in France. METHODS: Data of consecutive patients with documented IPN hospitalized in two expert centers in France between 2014 and 2019 were retrospectively reviewed...
February 15, 2024: Infectious diseases now
https://read.qxmd.com/read/38354980/epidemiology-and-outcomes-of-infections-during-extracorporeal-membrane-oxygenation-in-adult-patients-with-covid-19-ards-a-single-center-study
#10
JOURNAL ARTICLE
Divya Rakesh Joshi, Ram Gopalakrishnan, C Selvi, Nandini Sethuraman, V R Yamunadevi, V Ramasubramanian, P Senthur Nambi, M Yogesh, Thangaraj Paul Ramesh
BACKGROUND: There is a scarcity of data regarding nosocomial infections in patients with COVID-19 treated with ECMO. This observational study from India aims to describe the epidemiology and microbiology of infections in patients with COVID-19 associated ECMO. METHODS: This is an ambi-directional observational study of COVID-19 ECMO patients admitted from April 2021 to June 2022 in a tertiary care hospital. The total number of sepsis episodes for each patient was recorded and were categorized as bloodstream infections (BSI), pneumonias, skin and soft tissue infections (SSTI), invasive candidiasis (IC), catheter associated urinary tract infection (CAUTI), intra-abdominal infections (IAI), and Clostridioides difficile infections...
February 12, 2024: Indian Journal of Medical Microbiology
https://read.qxmd.com/read/38351497/author-reply-what-do-we-mean-by-source-control-and-what-are-we-trying-to-accomplish-with-an-open-abdomen-in-severe-complicated-intra-abdominal-sepsis
#11
JOURNAL ARTICLE
William B Risinger, Jason W Smith
No abstract text is available yet for this article.
February 14, 2024: Journal of Trauma and Acute Care Surgery
https://read.qxmd.com/read/38341816/use-of-pus-metagenomic-next-generation-sequencing-for-efficient-identification-of-pathogens-in-patients-with-sepsis
#12
JOURNAL ARTICLE
Zhendong Chen, Tingting Ye, Yuxi He, Aijun Pan, Qing Mei
The positive detection rate of blood metagenomic next-generation sequencing (mNGS) was still too low to meet clinical needs, while pus from the site of primary infection may be advantageous for identification of pathogens. To assess the value of mNGS using pus in patients with sepsis, thirty-five samples were collected. Pathogen identification and mixed infection diagnosis obtained by use of mNGS or cultivation methods were compared. Fifty-three aerobic or facultative anaerobes, 59 obligate anaerobes and 7 fungi were identified by the two methods...
February 11, 2024: Folia Microbiologica
https://read.qxmd.com/read/38340759/safety-and-efficacy-of-autologous-haematopoietic-stem-cell-transplantation-with-low-dose-cyclophosphamide-mobilisation-and-reduced-intensity-conditioning-versus-standard-of-care-in-refractory-crohn-s-disease-asticlite-an-open-label-multicentre-randomised-controlled
#13
JOURNAL ARTICLE
James O Lindsay, Daniel Hind, Lizzie Swaby, Hannah Berntsson, Mike Bradburn, Uday Bannur C, Jennifer Byrne, Christopher Clarke, Lauren Desoysa, Ben Dickins, Shahida Din, Richard Emsley, Gemma A Foulds, John Gribben, Christopher Hawkey, Peter M Irving, Majid Kazmi, Ellen Lee, Amanda Loban, Alan Lobo, Yashwant Mahida, Gordon W Moran, Diana Papaioannou, Miles Parkes, Andrew Peniket, A Graham Pockley, Jack Satsangi, Sreedhar Subramanian, Simon Travis, Emily Turton, Ben Uttenthal, Sergio Rutella, John A Snowden
BACKGROUND: A previous controlled trial of autologous haematopoietic stem-cell transplantation (HSCT) in patients with refractory Crohn's disease did not meet its primary endpoint and reported high toxicity. We aimed to assess the safety and efficacy of HSCT with an immune-ablative regimen of reduced intensity versus standard of care in this patient population. METHODS: This open-label, multicentre, randomised controlled trial was conducted in nine National Health Service hospital trusts across the UK...
February 7, 2024: Lancet. Gastroenterology & Hepatology
https://read.qxmd.com/read/38328327/computerized-tomography-guided-therapeutic-percutaneous-puncture-catheter-drainage-combined-with-somatostatin-for-severe-acute-pancreatitis-an-analysis-of-efficacy-and-safety
#14
JOURNAL ARTICLE
Xue-Lan Zheng, Wan-Ling Li, Yan-Ping Lin, Ting-Long Huang
BACKGROUND: Severe acute pancreatitis (SAP), a condition with rapid onset, critical condition and unsatisfactory prognosis, poses a certain threat to human health, warranting optimization of relevant treatment plans to improve treatment efficacy. AIM: To evaluate the efficacy and safety of computerized tomography-guided therapeutic percutaneous puncture catheter drainage (CT-TPPCD) combined with somatostatin (SS) in the treatment of SAP. METHODS: Forty-two SAP patients admitted to The Second Affiliated Hospital of Fujian Medical University from June 2020 to June 2023 were selected...
January 27, 2024: World Journal of Gastrointestinal Surgery
https://read.qxmd.com/read/38318959/postoperative-intra-abdominal-hypertension-predicts-worse-hospital-outcomes-in-children-after-cardiac-surgery%C3%AF-a-pilot-study
#15
JOURNAL ARTICLE
Yunyi Zhang, Shuhua Luo, Yuxuan Xie, Yue Wang, Yibing Fang, Shouping Wang, Lijing Deng
OBJECTIVES: To determine the incidence and characteristics of postoperative intra-abdominal hypertension in paediatric patients undergoing open-heart surgery. METHODS: This single-centre study included consecutive children (aged <16 years) who underwent open-heart surgery between July 2020 and February 2021. Patients who entered the study were followed until in-hospital death or hospital discharge. The study consisted of 2 parts. Part I was a prospective observational cohort study, which was designed to discover the association between exposures and IAH...
February 6, 2024: Interdiscip Cardiovasc Thorac Surg
https://read.qxmd.com/read/38298320/severe-sepsis-secondary-to-toxic-megacolon-revealing-an-inflammatory-bowel-disease
#16
Omar Mhammedi Alaoui, Badie Douqchi, Islam Bella, Imane Ghazi, Ilias Benaini, Ilias El Kadiri Boutchich, Ilyass Laaribi, Ghizlane El Aidouni, Houssam Bkiyar, Mohammed Bouziane, Brahim Housni
Patients with inflammatory bowel disease can present with numerous infectious complications, including intra-abdominal abscess, perforations of the intestine, fistula formation, and the occurrence of septicemia. Toxic megacolon (TM) is a potentially fatal complication of inflammatory bowel disease (IBD) and is associated with high morbidity and mortality. In this case report, we report a 49-year-old male patient who was admitted to the intensive care unit for the management of severe sepsis that was secondary to an inaugural toxic megacolon complicating a silent inflammatory bowel disease, with a Lichtiger score of 11...
January 2024: Curēus
https://read.qxmd.com/read/38284399/novel-textbook-outcomes-following-emergency-laparotomy-delphi-exercise
#17
JOURNAL ARTICLE
David N Naumann, Aneel Bhangu, Adam Brooks, Matthew Martin, Bryan A Cotton, Mansoor Khan, Mark J Midwinter, Lyndsay Pearce, Douglas M Bowley, John B Holcomb, Ewen A Griffiths
BACKGROUND: Textbook outcomes are composite outcome measures that reflect the ideal overall experience for patients. There are many of these in the elective surgery literature but no textbook outcomes have been proposed for patients following emergency laparotomy. The aim was to achieve international consensus amongst experts and patients for the best Textbook Outcomes for non-trauma and trauma emergency laparotomy. METHODS: A modified Delphi exercise was undertaken with three planned rounds to achieve consensus regarding the best Textbook Outcomes based on the category, number and importance (Likert scale of 1-5) of individual outcome measures...
January 3, 2024: BJS Open
https://read.qxmd.com/read/38264298/treatment-of-complex-desmoid-tumors-in-familial-adenomatous-polyposis-syndrome-by-intestinal-transplantation
#18
JOURNAL ARTICLE
Emilio Canovai, Andrew Butler, Susan Clark, Andrew Latchford, Ashish Sinha, Lisa Sharkey, Charlotte Rutter, Neil Russell, Sara Upponi, Irum Amin
BACKGROUND: Desmoid tumors are fibroblastic lesions which often have an unpredictable and variable clinical course. In the context of familial adenomatous polyposis (FAP), these frequently occur intra-abdominally, especially in the small-bowel mesentery resulting in sepsis, fistulation, and invasion of the abdominal wall and retroperitoneum. In selected cases where other modalities have failed, the most radical option is to perform a total enterectomy and intestinal transplantation (ITx)...
February 2024: Transplantation Direct
https://read.qxmd.com/read/38263964/epidemiology-and-risk-factors-for-mortality-in-critically-ill-patients-with-pancreatic-infection
#19
JOURNAL ARTICLE
Marie Dejonckheere, Massimo Antonelli, Kostoula Arvaniti, Koen Blot, Ben CreaghBrown, Dylan W de Lange, Jan De Waele, Mieke Deschepper, Yalim Dikmen, George Dimopoulos, Christian Eckmann, Guy Francois, Massimo Girardis, Despoina Koulenti, Sonia Labeau, Jeffrey Lipman, Fernando Lipovestky, Emilio Maseda, Philippe Montravers, Adam Mikstacki, JoseArtur Paiva, Cecilia Pereyra, Jordi Rello, JeanFrancois Timsit, Dirk Vogelaers, Stijn Blot
BACKGROUND: The AbSeS -classification defines specific phenotypes of patients with intra-abdominal infection based on the (1) setting of infection onset (community-acquired, early onset, or late-onset hospital-acquired), (2) presence or absence of either localized or diffuse peritonitis, and (3) severity of disease expression (infection, sepsis, or septic shock). This classification system demonstrated reliable risk stratification in intensive care unit (ICU) patients with intra-abdominal infection...
January 2024: J Intensive Med
https://read.qxmd.com/read/38227165/nanoemulsions-and-nanocapsules-loaded-with-melaleuca-alternifolia-essential-oil-for-sepsis-treatment
#20
JOURNAL ARTICLE
Mariana Alves Battisti, Larissa Constantino, Débora Fretes Argenta, Flávio Henrique Reginatto, Felipe Dal Pizzol, Thiago Caon, Angela Machado Campos
Sepsis represents a complex clinical syndrome that results from a harmful host response to infection. The infections most associated with sepsis are pneumonia, intra-abdominal infection, and urinary tract infection. Tea tree oil (TTO) has shown high antibacterial activity; however, it exhibits low aqueous solubility and high volatility, which have motivated its nanoencapsulation. In this study, the performance of nanoemulsions (NE) and nanocapsules (NC) loaded with TTO was compared. These systems were prepared by spontaneous emulsification and nanoprecipitation methods, respectively...
January 16, 2024: Drug Delivery and Translational Research
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