keyword
https://read.qxmd.com/read/38536558/a-deep-learning-model-for-translating-ct-to-ventilation-imaging-analysis-of-accuracy-and-impact-on-functional-avoidance-radiotherapy-planning
#1
JOURNAL ARTICLE
Zhen Hou, Youyong Kong, Junxian Wu, Jiabing Gu, Juan Liu, Shanbao Gao, Yicai Yin, Ling Zhang, Yongchao Han, Jian Zhu, Shuangshuang Li
PURPOSE: Radiotherapy planning incorporating functional lung images has the potential to reduce pulmonary toxicity. Free-breathing 4DCT-derived ventilation image (CTVI) may help quantify lung function. This study introduces a novel deep-learning model directly translating planning CT images into CTVI. We investigated the accuracy of generated images and the impact on functional avoidance planning. MATERIALS AND METHODS: Paired planning CT and 4DCT scans from 48 patients with NSCLC were randomized to training (n = 41) and testing (n = 7) data sets...
March 27, 2024: Japanese Journal of Radiology
https://read.qxmd.com/read/38536038/impaired-muscle-oxygenation-despite-normal-pulmonary-function-in-uncomplicated-type-2-diabetes
#2
JOURNAL ARTICLE
Islem Jlali, Imen Touil, Hassen Ibn Hadj Amor, Mohamed Amine Bouzid, Omar Hammouda, Elsa Heyman, Pierre Fontaine, Hamdi Chtourou, Remi Rabasa-Lhoret, Georges Baquet, Semah Tagougui
Long-term hyperglycemia in individuals with type 2 diabetes can detrimentally impact pulmonary function and muscle oxygenation. As a result, these factors can impede the body's adaptation to physical exertion. We aimed to evaluate the oxygen pathway during maximal exercise among overweight/obese individuals with uncomplicated type 2 diabetes, in comparison with a group of matched overweight/obese individuals without diabetes, specifically concentrating on the effects on pulmonary function and muscle oxygenation...
March 27, 2024: American Journal of Physiology. Endocrinology and Metabolism
https://read.qxmd.com/read/38535421/a-more-comfortable-method-for-hydrostatic-weighing-head-above-water-at-total-lung-capacity
#3
JOURNAL ARTICLE
Erin White, Silas Bergen, Annabelle Berggren, Lillian Brinkman, Brianna Carman, Lucas Crouse, Emma Hoffmann, Sara Twedt
Hydrostatic weighing (HW) requires full submersion with the lungs at residual volume (RV) which is uncomfortable. Therefore, the purpose of this study was to find a more comfortable way to complete HW. A HW system was used to complete three comparisons: comparison 1: change in head position (head above water vs. head below water (HAW vs. HBW)), comparison 2: change in lung volume (total lung capacity (TLC) vs. RV), and comparison 3: change in head and lung volume changes. Participants were separated by males ( n = 64) and females ( n = 58)...
February 28, 2024: Journal of Functional Morphology and Kinesiology
https://read.qxmd.com/read/38535061/thoracic-biometry-in-patients-with-congenital-diaphragmatic-hernia-a-magnetic-resonance-imaging-study
#4
JOURNAL ARTICLE
Erick George Neștianu, Septimiu Popescu, Dragoș Ovidiu Alexandru, Laura Giurcăneanu, Radu Vlădăreanu
This is a retrospective study investigating biometric measurements using magnetic resonance imaging (MRI) examinations in congenital diaphragmatic hernia (CDH). CDH is one of the more common causes of pulmonary hypoplasia, with grave consequences for the fetus. Inclusion criteria were patients diagnosed with CDH as the only observed anomaly, who underwent MRI examination after the second-trimester morphology ultrasound. The patients came from three university hospitals in Bucharest, Romania. In total, 19 patients were included in the study after applying exclusion criteria...
March 18, 2024: Diagnostics
https://read.qxmd.com/read/38535011/lung-ultrasound-reproducibly-outperforms-computed-tomography-in-the-detection-of-extravascular-lung-water-in-patients-undergoing-haemodialysis
#5
JOURNAL ARTICLE
John P Corcoran, Mark Hew, Ben Attwood, Murali Shyamsundar, Sheera Sutherland, Kristine Ventura, Rachel Benamore, Victoria St Noble, Hania E Piotrowska, Christopher W Pugh, Christian B Laursen, Fergus V Gleeson, Najib M Rahman
BACKGROUND: Lung ultrasound (LUS) is increasingly used as an extension of physical examination, informing clinical diagnosis, and decision making. There is particular interest in the assessment of patients with pulmonary congestion and extravascular lung water, although gaps remain in the evidence base underpinning this practice as a result of the limited evaluation of its inter-rater reliability and comparison with more established radiologic tests. METHODS: 30 patients undergoing haemodialysis were prospectively recruited to an observational cohort study (NCT01949402)...
March 11, 2024: Diagnostics
https://read.qxmd.com/read/38533761/the-influence-of-microwave-ablation-parameters-on-the-positioning-of-trocar-in-different-cancerous-tissues-a-numerical-study
#6
JOURNAL ARTICLE
Vellavalapalli Satish, Ramjee Repaka
The present study analyzed the microwave ablation of cancerous tumors located in six major cancer-prone organs and estimated the significance of input power and treatment time parameters in the apt positioning of the trocar into the tissue during microwave ablation. The present study has considered a three-dimensional two-compartment tumour-embedded tissue model. FEA based COMSOL Multiphysics software with inbuilt bioheat transfer, electromagnetic waves, heat transfer in solids and fluids, and laminar flow physics has been used to obtain the numerical results...
March 27, 2024: Electromagnetic Biology and Medicine
https://read.qxmd.com/read/38531338/first-in-vivo-experiment-with-pulmvalve-endobronchial-valve-feasibility-efficiency-and-safety
#7
JOURNAL ARTICLE
Jingwei Liu, Difei Chen, Yanhui Yu, Yu Deng, Ruijin Lu, Jing Zhang, Shiyue Li
INTRODUCTION: Endoscopic Lung Volume Reduction (ELVR) with endobronchial valves has been widely recognized for treating hyperinflation in advanced COPD and emphysema patients. The main challenges include the technical complexity of upper lobe implantation and the number of endobronchial valves required. These issues might be addressed by placing larger-diameter valves in the lobar bronchus. This study evaluated the feasibility, efficiency, and safety of the new valve PulmValve (model PV-13) in porcine models...
March 26, 2024: Respiration; International Review of Thoracic Diseases
https://read.qxmd.com/read/38530178/case-323-minute-pulmonary-meningothelial-like-nodules
#8
JOURNAL ARTICLE
Furkan Ufuk, Emel Kilicarslan, Ferda Bir, Goksel Altinisik
A 70-year-old woman with a 6-year history of asthma, a 12-year history of diabetes mellitus, and who did not smoke presented to the pulmonology clinic with dyspnea and cough. Chest CT performed 5 years earlier for similar symptoms revealed multiple pulmonary nodules. However, she was lost to follow-up before the work-up was concluded. Otherwise, her medical history was unremarkable. Family history included maternal endometrial cancer. Physical examination revealed partial oxygen saturation of 98%, respiratory rate of 18 breaths per minute, and heart rate of 77 beats per minute...
March 2024: Radiology
https://read.qxmd.com/read/38530051/vessel-and-airway-characteristics-in-one-year-ct-defined-rapid-emphysema-progression-spiromics
#9
JOURNAL ARTICLE
Sarah E Gerard, Timothy M Dougherty, Prashant Nagpal, Dakai Jin, MeiLan K Han, John D Newell, Punam K Saha, Alejandro P Comellas, Christopher B Cooper, David Couper, Spyridon Fortis, Junfeng Guo, Nadia N Hansel, Richard E Kanner, Ella A Kazeroni, Fernando J Martinez, Amin Motahari, Robert Paine Iii, Stephen Rennard, Joyce D Schroeder, Prescott G Woodruff, R Graham Barr, Benjamin M Smith, Eric A Hoffman
Rationale: Rates of emphysema progression vary in chronic obstructive pulmonary disease (COPD), and the relationship with vascular and airway pathophysiology remain unclear. Objective: We sought to determine if indices of peripheral (segmental and beyond) pulmonary arterial (PA) dilation measured via computed tomography (CT) are associated with a 1-year index of emphysema (EI: %voxels<-950HU) progression. Methods: 599 GOLD 0-3 former and never-smokers were evaluated from the SubPopulations and InterMediate Outcome Measures in COPD Study (SPIROMICS) cohort: rapid-emphysema-progressors (RP, n=188; 1-year ΔEI>1%), non-progressors (NP, n=301; 1-year ΔEI±0...
March 26, 2024: Annals of the American Thoracic Society
https://read.qxmd.com/read/38529345/factors-most-strongly-associated-with-breathlessness-in-a-population-aged-50-64-years
#10
JOURNAL ARTICLE
Max Olsson, Anders J Björkelund, Jacob Sandberg, Anders Blomberg, Mats Börjesson, David Currow, Andrei Malinovschi, Magnus Sköld, Per Wollmer, Kjell Torén, Carl Johan Östgren, Gunnar Engström, Magnus Ekström
BACKGROUND: Breathlessness is a troublesome and prevalent symptom in the population, but knowledge of related factors is scarce. The aim of this study was to identify the factors most strongly associated with breathlessness in the general population and to describe the shapes of the associations between the main factors and breathlessness. METHODS: A cross-sectional analysis was carried out of the multicentre population-based Swedish CArdioPulmonary bioImage Study (SCAPIS) of adults aged 50 to 64 years...
March 2024: ERJ Open Research
https://read.qxmd.com/read/38529319/extracorporeal-membrane-oxygenation-in-acute-respiratory-failure-due-to-hemorrhagic-alveolitis-in-a-patient-with-acute-myeloblastic-leukemia
#11
Martina Cuccarelli, Lorenzo Schiavoni, Felice Eugenio Agrò, Giuseppe Pascarella, Fabio Costa, Rita Cataldo, Massimiliano Carassiti, Alessia Mattei
Introduction . Extracorporeal membrane oxygenation (ECMO) support for severe acute respiratory distress syndrome (ARDS) is nowadays widely used with notable results on the overall survival as reported in the ELSO registry near to 55% at 90 days. This is the reason why ECMO teams force the use of this extreme technique to several populations, even though there is still a lack of data about its use on hematological patients. Case Report . A 39-year-old woman without a history of previous diseases, but a new diagnosis of acute myeloblastic leukemia (AML) was admitted to intensive care unit (ICU) for worsening hypoxia and respiratory acidosis, presenting an ARDS with PaO2 /FiO2 < 100 in spontaneous breathing treated with noninvasive ventilation via full-face mask...
2024: Case Reports in Critical Care
https://read.qxmd.com/read/38529079/automated-plaque-detection-and-agatston-score-estimation-on-non-contrast-ct-scans-a-multicenter-study
#12
Andrew M Nguyen, Jianfei Liu, Tejas Sudharshan Mathai, Peter C Grayson, Ronald M Summers
Coronary artery calcification (CAC) is a strong and independent predictor of cardiovascular disease (CVD). However, manual assessment of CAC often requires radiological expertise, time, and invasive imaging techniques. The purpose of this multicenter study is to validate an automated cardiac plaque detection model using a 3D multiclass nnU-Net for gated and non-gated non-contrast chest CT volumes. CT scans were performed at three tertiary care hospitals and collected as three datasets, respectively. Heart, aorta, and lung segmentations were determined using TotalSegmentator, while plaques in the coronary arteries and heart valves were manually labeled for 801 volumes...
February 14, 2024: ArXiv
https://read.qxmd.com/read/38528524/respiratory-entrainment-related-reverse-triggering-in-mechanically-ventilated-children
#13
JOURNAL ARTICLE
Robert G T Blokpoel, Ruben B R Brandsema, Alette A Koopman, Jefta van Dijk, Martin C J Kneyber
BACKGROUND: The underlying pathophysiological pathways how reverse triggering is being caused are not fully understood. Respiratory entrainment may be one of these mechanisms, but both terms are used interchangeably. We sought to characterize reverse triggering and the relationship with respiratory entrainment among mechanically ventilated children with and without acute lung injury. METHODS: We performed a secondary phyiology analysis of two previously published data sets of invasively mechanically ventilated children < 18 years with and without lung injury mechanically ventilated in a continuous or intermittent mandatory ventilation mode...
March 25, 2024: Respiratory Research
https://read.qxmd.com/read/38527984/ultrastructural-changes-of-lung-tissue-under-conditions-of-experimental-obesity-and-smoking
#14
JOURNAL ARTICLE
Yuliia Kuzyk, Olena Mazur, Yuryj Bisyarin
Obesity can cause respiratory disorders inflicted by adipose tissue accumulation and the numerous cytokines adipocytes produce. Smoking is, first of all, associated with a wide range of lung diseases characterized by diffuse changes in the lung tissue and a decrease in the respiratory volume of the lungs. The study aimed to investigate the ultrastructural changes in the lungs of sexually mature male rats under conditions of experimental obesity and smoking. The total sample of experimental animals consisted of 120 rats, divided into four groups: the control group (n=30) - conditionally healthy rats fed on a standard diet; a group of rats subjected to isolated exposure to tobacco smoke (n=30); a group of experimentally obese rats (n=30) and a group of experimentally obese rats simultaneously exposed to tobacco smoke (n=30) - feeding using a high-fat diet with exposure to a chamber with tobacco smoke...
2024: Romanian Journal of Morphology and Embryology
https://read.qxmd.com/read/38526698/compensatory-expansion-of-the-right-middle-lobe-volumetric-and-functional-analysis-of-the-changes-after-right-upper-or-lower-lobectomy
#15
JOURNAL ARTICLE
Takamasa Shibazaki, Shohei Mori, Satoshi Arakawa, Yo Tsukamoto, Takeo Nakada, Yusuke Takahashi, Takashi Ohtsuka
The right middle lobe often poorly expands after right upper lobectomy. Postoperative pulmonary function may be inferior after right upper lobectomy than after right lower lobectomy due to poor expansion of the middle lobe. This study examined the difference in the postoperative right middle lobe expansion and pulmonary function between right upper and right lower lobectomy. Patients who underwent right upper or right lower lobectomy through video-assisted thoracic surgery (n = 82) were enrolled in this retrospective study...
March 25, 2024: Updates in Surgery
https://read.qxmd.com/read/38526478/development-of-a-multivariable-prediction-model-for-prolonged-air-leak-after-lung-resection
#16
JOURNAL ARTICLE
Akiisa Omura, Ryu Kanzaki, Hirokazu Watari, Sachi Kawagishi, Ryo Tanaka, Tomohiro Maniwa, Makoto Fujii, Jiro Okami
OBJECTIVES: Prolonged air leak (PAL) is a common complication of lung resection. Research on predictors of PAL using a digital drainage system (DDS) remains insufficient. In this study, we investigated the predictive factors of PAL to establish a novel early postoperative prediction model for PAL. METHODS: A retrospective cohort study and validation study were conducted. We examined patients who underwent lung resection with DDS at our institute. The relationship between the clinical factors and measurements of the DDS, including the difference between the set and measured intrapleural pressure (named: additional negative pressure [ANP]) at postoperative hour (POH) 3, with PAL was analyzed...
January 2024: World Journal of Surgery
https://read.qxmd.com/read/38526466/postoperative-pulmonary-complications-in-patients-undergoing-upper-abdominal-surgery-risk-factors-and-predictive-models
#17
JOURNAL ARTICLE
Shivam Garg, Vishnukanth Govindaraj, Dharm Prakash Dwivedi, Kalayarasan Raja, Elamurugan Palanivel Theerthar
Postoperative pulmonary complications (PPCs) are unexpected disorders that occur up to 30 days after surgery, affecting the patient's clinical status and requiring therapeutic intervention. Therefore, it becomes important to assess the patient preoperatively, as many of these complications can be minimized with proper perioperative strategies following a thorough preoperative checkup. Herein, we describe the PPCs and risk factors associated with developing PPCs in patients undergoing upper abdominal surgery...
March 25, 2024: Monaldi Archives for Chest Disease
https://read.qxmd.com/read/38524066/upstaging-of-tuberculosis-in-the-post-covid-19-era-a-case-series
#18
Neeru Malik, Meenakshi Sidhar, Nidhi Prabha Sehgal, Anurag Gupta, Ishita Gupta
The COVID-19 pandemic has significantly impacted the global health system as well as the social and economic impact on tuberculosis (TB) treatment and diagnostic services. A high volume of patients diagnosed and treated for TB were impacted by the pandemic restrictions, particularly reduced access to TB services provided by the National Tuberculosis Elimination Programme in India; this in turn increased the number of deaths due to TB. The Indian healthcare system has been struggling with the eradication of TB, and this additional worldwide health crisis caused by SARS-CoV-2 has put the Indian healthcare system under severe stress...
February 2024: Curēus
https://read.qxmd.com/read/38522361/endobronchial-silicone-spigot-in-prolonged-air-leaks-nationwide-study-on-outcomes-and-risk-factors-for-treatment-failure
#19
JOURNAL ARTICLE
Jumpei Taniguchi, Shotaro Aso, Jo Taisuke, Hiroki Matsui, Kiyohide Fushimi, Hideo Yasunaga
BACKGROUND: The endobronchial silicone spigot, also known as the endobronchial Watanabe spigot, is used in bronchoscopic interventions to manage prolonged pulmonary air leakage. However, the outcomes of this procedure have not been thoroughly investigated. METHODS: Using a Japanese national inpatient database from April 2014 to March 2022, we assessed the clinical characteristics and outcomes of all eligible patients who received the endobronchial spigot. We also investigated risk factors associated with treatment failure...
March 23, 2024: Respiratory Investigation
https://read.qxmd.com/read/38521181/relationship-between-lung-volumes-and-heterogeneity-in-the-response-to-elexacaftor-tezacaftor-ivacaftor-in-patients-with-cystic-fibrosis-and-advanced-lung-disease
#20
JOURNAL ARTICLE
Andrea Gramegna, Gianfranco Alicandro, Chiara Premuda, Francesca Lucca, Lucia Pinali, Mariangela Retucci, Valentina Vespro, Maria Carmela Andrisani, Gianpaolo Carraffiello, Francesco Amati, Sonia Volpi, Stefano Aliberti, Marco Cipolli, Francesco Blasi
BACKGROUND: The effects of elexacaftor/tezacaftor/ivacaftor (ETI) on respiratory outcomes for people with CF (pwCF) were demonstrated by several clinical trials, mainly based on simple spirometry. However, gains in lung function may vary greatly between patients, but predictors of FEV1 change after treatment are still missing. RESEARCH QUESTION: Which ventilatory parameters are involved in the heterogeneity of FEV1 change after 12-month ETI treatment in pwCF with advanced lung disease? STUDY DESIGN: AND METHODS: This was a multicenter, observational, prospective cohort study at two major CF centers in Italy...
March 21, 2024: Chest
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