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cardiopulmonary function testing

Walid K Abdelbasset, Gaber S Soliman, Ahmed A Elshehawy, Saud M Alrawaili
Background: Impairment of peripheral skeletal muscle function is a common phenomenon in patients with cystic fibrosis (CF) in addition to great clinical connotations, such as lack of exercise tolerance and decrease of health-related quality of life. There is very limited data on the effects of maximal exercise on muscle fatiguability and exercise capacity in children with cystic fibrosis. Objectives: The aim of this study was to evaluate the effect of progressive maximal exercise training of the lower extremities on exercise capacity and muscle fatiguability in children with cystic fibrosis...
December 2018: African Health Sciences
Alcides Rocha, Flavio F Arbex, Priscila A Sperandio, Frederico Mancuso, Mathieu Marillier, Anne-Catherine Bernard, Maria Clara N Alencar, Denis E O Donnell, J Alberto Neder
Impaired aerobic function is a potential mechanism of exercise intolerance in patients with combined cardiorespiratory disease. We investigated the pathophysiological and sensory consequences of a low Δ O2 uptake (V̇O2 )/Δ work rate (WR) relationship during incremental exercise in patients with coexisting chronic obstructive pulmonary disease (COPD) and systolic heart failure (HF).After clinical stabilisation, 51 COPD-HF patients performed an incremental cardiopulmonary exercise test to symptom limitation...
February 14, 2019: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
Twan Ten Haaf, Carl Foster, Romain Meeusen, Bart Roelands, Maria Francesca Piacentini, Selma van Staveren, Leo Koenderman, Jos J de Koning
The aim of this study is to investigate whether the change in (sub)maximal heart rate after intensified training is associated with the change in performance. Thirty subjects were recruited who performed cardiopulmonary exercise tests to exhaustion 2 weeks before (pre), 1 week after (post) and 5 weeks after (follow-up) an 8-day non-competitive amateur cycling event (TFL). The exercise volume during the TFL was 7.7 fold the volume during the preparation period. Heart rate and cardiopulmonary parameters were obtained at standardised absolute submaximal workloads (low, medium and high intensity) and at peak level each test...
February 14, 2019: European Journal of Sport Science
Erhan Çapkın, Seyhan Bilge Keskin, Murat Karkucak, Ahmet Ayar
Background/aim: The purpose of this study was to investigate possible effects of anti-TNF alpha therapy on cardiorespiratory fitness and physical functional capacity of patients with ankylosing spondylitis (AS). Materials and methods: Twenty-eight AS patients meeting the modified New York criteria with active disease state and an equivalent number of healthy individuals as the control were prospectively enrolled. Physical working capacity and aerobic exercise capacity of the participants were determined by using cardiopulmonary exercise tests, performed before and 4 months after initiation of anti-TNF alpha therapy...
February 11, 2019: Turkish Journal of Medical Sciences
Craig A Williams, Kyle C A Wedgwood, Hossein Mohammadi, Katie Prouse, Owen W Tomlinson, Krasimira Tsaneva-Atanasova
Cystic fibrosis (CF) is a debilitating chronic condition, which requires complex and expensive disease management. Exercise has now been recognised as a critical factor in improving health and quality of life in patients with CF. Hence, cardiopulmonary exercise testing (CPET) is used to determine aerobic fitness of young patients as part of the clinical management of CF. However, at present there is a lack of conclusive evidence for one limiting system of aerobic fitness for CF patients at individual patient level...
2019: PloS One
Carolyn J Peddle-McIntyre, Favil Singh, Rajesh Thomas, Robert U Newton, Daniel A Galvão, Vinicius Cavalheri
BACKGROUND: Patients with advanced lung cancer have a high symptom burden, which is often complicated by coexisting conditions. These issues, combined with the indirect effects of cancer treatment, can cumulatively lead patients to continued deconditioning and low exercise capacity. This is a concern as exercise capacity is considered a measure of whole body health, and is critical in a patient's ability to participate in life activities and tolerate difficult treatments. There is evidence that exercise training improves exercise capacity and other outcomes, such as muscle force and health-related quality of life (HRQoL), in cancer survivors...
February 11, 2019: Cochrane Database of Systematic Reviews
Andrew F Cumpstey, Magdalena Minnion, Bernadette O Fernandez, Monika Mikus-Lelinska, Kay Mitchell, Daniel S Martin, Michael P W Grocott, Martin Feelisch
The chemical and functional interactions between Reactive Oxygen (ROS), Nitrogen (RNS) and Sulfur (RSS) species allow organisms to detect and respond to metabolic and environmental stressors, such as exercise and altitude exposure. Whether redox markers and constituents of this 'Reactive Species Interactome' (RSI) differ in concentration between arterial and venous blood is unknown. We hypothesised that such measurements may provide useful insight into metabolic/redox regulation at the whole-body level and would be consistent between individuals exposed to identical challenges...
January 22, 2019: Redox Biology
Ekaterina Baryshnikova, Umberto Di Dedda, Marco Ranucci
OBJECTIVES: Coagulation point-of-care tests for the diagnosis and management of bleeding commonly are used in cardiac surgery. Recently, a new viscoelastic point-of-care device, Quantra (HemoSonics, Charlottesville, VA), which is based on sonic estimation of elasticity via resonance sonorheometry, entered the market. Prior studies have compared the Quantra parameters with conventional coagulation tests and thromboelastography or rotational thromboelastography, but no study has assessed the correlation of the platelet-derived Quantra parameter platelet contribution to stiffness (PCS) with platelet function assays...
January 4, 2019: Journal of Cardiothoracic and Vascular Anesthesia
Stephanie Thompson, Natasha Wiebe, Gabor Gyenes, Rachelle Davies, Jeyasundar Radhakrishnan, Michelle Graham
BACKGROUND: The prevalence of hypertension among people with chronic kidney disease is high with over 60% of people not attaining recommended targets despite taking multiple medications. Given the health and economic implications of hypertension, additional strategies are needed. Exercise is an effective strategy for reducing blood pressure in the general population; however, it is not known whether exercise would have a comparable benefit in people with moderate to advanced chronic kidney disease and hypertension...
February 8, 2019: Trials
Roger van Groenendael, Remi Beunders, Jan Hofland, Wim J Morshuis, Matthijs Kox, Lucas T van Eijk, Peter Pickkers
BACKGROUND: The cardiac surgery-induced systemic inflammatory response may induce postoperative hemodynamic instability and impairment of renal function. EA-230, a linear tetrapeptide (A-Q-G-V), is derived from the beta chain of the human chorionic gonadotropin pregnancy hormone. It has shown immunomodulatory and renoprotective effects in several animal models of systemic inflammation. In phase 1 and phase 2a studies, these immunomodulatory effects were confirmed during human experimental endotoxemia, and EA-230 was found to have an excellent safety profile...
February 6, 2019: JMIR Research Protocols
Ratna Farida Soenarto, Arif Mansjoer, Nurmiati Amir, Maipe Aprianti, Aries Perdana
Background: Postoperative cognitive dysfunction (POCD) is commonly observed following cardiac surgery. The utilization of cardiopulmonary bypass (CPB) is associated with many possible mechanisms to cause POCD. However, there is no evidence confirming that CPB alone is the cause of POCD. Objectives: The current study aimed at evaluating several factors suspected to cause POCD following cardiac surgery in Cipto Mangunkusumo Hospital, Jakarta, Indonesia. Methods: The current prospective cohort study was conducted on 54 patients who were candidates for cardiac surgery...
December 2018: Anesthesiology and Pain Medicine
Gian Luca Vita, Claudia Stancanelli, Luca Gentile, Costanza Barcellona, Massimo Russo, Gianluca Di Bella, Giuseppe Vita, Anna Mazzeo
Hereditary transthyretin amyloidosis (hATTR) is a life-threatening multisystemic disease with sensory-motor peripheral neuropathy, cardiomyopathy and dysautonomia. Although the six-minute walk test (6MWT) is one of the most popular clinical tests to assess functional exercise capacity in cardiopulmonary and neuromuscular diseases, little is known about 6MWT in evaluating hATTR patients. A prospective single-center pilot study was performed in twenty hATTR patients, comparing 6MWT with widely used outcome measures...
November 14, 2018: Neuromuscular Disorders: NMD
Anna Kuo, Joshua J Todd, Jessica W Witherspoon, Tokunbor A Lawal, Jeffery Elliott, Irene C Chrismer, Monique O Shelton, Muslima S Razaqyar, Minal S Jain, Ruhi Vasavada, Melissa Waite, Bart Drinkard, Darren Michael, Alicia Richarte, Carsten G Bönnemann, Katherine G Meilleur
BACKGROUND: RYR1-related disorders (RYR1-RD), are a spectrum of genetic neuromuscular disorders. Affected individuals frequently experience fatigue yet appropriate tools to assess RYR1-RD-associated fatigue remain underdeveloped. OBJECTIVE: This study assessed the reliability and validity of two self-report questionnaires, the multidimensional fatigue inventory (MFI-20) and adult/pediatric functional assessment of chronic illness-fatigue (FACIT-F/Peds-FACIT-F) as potential fatigue measures in RYR1-RD affected individuals...
2019: Journal of Neuromuscular Diseases
Yi-Jen Chen, Hung-Pin Tu, Chia-Ling Lee, Wei-Chun Huang, Jin-Shiou Yang, Cyuan-Fong Li, Chia-Hsin Chen, Ko-Long Lin
Background: The 6-minute walk test (6MWT) and cardiopulmonary exercise test (CPET) are exercise tests associated with physical function, quality of life and hemodynamic data in patients with pulmonary arterial hypertension (PAH). This study was conducted to assess correlations between exercise capacity, quality of life and disease functional classification, and to analyze the value of comprehensive assessments in predicting mortality in patients with PAH. Methods: Fifty-four patients with PAH were enrolled...
January 2019: Acta Cardiologica Sinica
Myrto Boukovala, Jan Müller, Peter Ewert, Alfred Hager
With rising survival rates of patients with congenital heart disease (CHD), functional health variables have become the key aspect in treatment evaluation. The effectiveness of various treatment options on the health-related quality of life (HRQoL) and the objectively measured exercise capacity as peak oxygen uptake (VO2 peak) remains rather unclear and hence, its investigation is the primary aim of this study. Data from 1014 patients (≥14-years-old, various CHD) were retrospectively reviewed. The patients had completed at least twice the SF-36 questionnaire on HRQoL prior to a cardiopulmonary exercise test...
January 8, 2019: American Journal of Cardiology
Michael H-G Li, Vladimir Bolshinsky, Hilmy Ismail, Kate Burbury, Kwok M Ho, Babak Amin, Alexander Heriot, Bernhard Riedel
PURPOSE: Preoperative fitness training has been listed as a top ten research priority in anesthesia. We aimed to capture the current practice patterns and perspectives of anesthetists and colorectal surgeons in Australia and New Zealand regarding preoperative risk stratification and prehabilitation to provide a basis for implementation research. METHODS: During 2016, we separately surveyed fellows of the Australian and New Zealand College of Anaesthetists (ANZCA) and members of the Colorectal Society of Surgeons in Australia and New Zealand (CSSANZ)...
January 28, 2019: Canadian Journal of Anaesthesia, Journal Canadien D'anesthésie
A Montalto, V Piazza, F Albi, R Gherlia, C Contento, A Palermo, F Musumeci
BACKGROUND: Pump speed optimization in patients implanted with a ventricular assist device represents a major challenge during the follow-up period. We present our findings on whether combined invasive hemodynamic ramp tests and cardiopulmonary exercise testing (CPX) can help optimize patient management. METHODS: Eighteen patients implanted with a HeartMate 3 (HM3) device underwent ramp tests with right heart catheterization (including central venous pressure [CVP], pulmonary artery pressure, pulmonary capillary wedge pressure [PCWP], and blood pressure) and echocardiography...
June 30, 2018: Transplantation Proceedings
Vasileios Stavrou, Afroditi K Boutou, George D Vavougios, Chaido Pastaka, Konstantinos I Gourgoulianis, Yiannis Koutedakis, Zoe Daniil, Eleni Karetsi
The aim of this study was to investigate the relationship between cardiopulmonary exercise testing (CPET) and the presence of obstructive sleep apnea syndrome (OSAS) in order to provide an innovative tool to identify patients with OSAS. A prospective nested case control design was adopted. A consecutive population of male volunteers referred to a Sleep Unit was subjected to nocturnal polysomnography, full lung function testing and maximal CPET. A stepwise linear discriminant function analysis (DFA) was applied to construct a model which could identify individuals with moderate-to-severe OSAS from healthy controls...
January 23, 2019: Respiratory Physiology & Neurobiology
Bryant Priromprintr, Michael J Silka, Jonathan Rhodes, Anjan S Batra
BACKGROUND: The long-term benefits of Melody valve implant for right ventricular outflow tract conduit obstruction or insufficiency on exercise capacity are undefined. METHODS: As part of the Melody valve clinical trial, 136 patients with congenital heart disease underwent serial cardiopulmonary exercise testing prior to, 6 months after, and annually for up to 5 years postimplant. RESULTS: Mean age at Melody valve implantation was 22.4 ± 0...
December 29, 2018: American Heart Journal
Mahmoud Zaqout, Kristof Vandekerckhove, Nathalie Michels, Laurent Demulier, Thierry Bove, Katrien François, Julie De Backer, Stefaan De Henauw, Daniel De Wolf
OBJECTIVE: To investigate the status of body mass index (BMI) in adult people with congenital heart disease (ACHD). METHODS: Five hundred thirty-nine adults with CHD (53.8% men) were seen in the outpatient clinic from 2013 to 2015 and compared to a reference population (n = 1737). The severity of CHD was categorized as mild, moderate, and severe according to standard guidelines. Patients were categorized based on BMI as underweight (<18.5), overweight (25-30), or obese (>30)...
January 25, 2019: Congenital Heart Disease
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