Daniela Giovannini, Francesca Antonelli, Arianna Casciati, Cinzia De Angelis, Maria Denise Astorino, Giulia Bazzano, Emiliano Fratini, Alessandro Ampollini, Monia Vadrucci, Evaristo Cisbani, Paolo Nenzi, Luigi Picardi, Anna Saran, Carmela Marino, Mariateresa Mancuso, Concetta Ronsivalle, Simonetta Pazzaglia
BACKGROUND AND PURPOSE: Medulloblastoma (MB) is a common primary brain cancer in children. Proton therapy in pediatric MB is intensively studied and widely adopted. Compared to photon, proton radiations offer potential for reduced toxicity due to the characteristic Bragg Peak at the end of their path in tissue. The aim of this study was to compare the effects of irradiation with the same dose of protons or photons in Patched1 heterozygous knockout mice, a murine model predisposed to cancer and non-cancer radiogenic pathologies, including MB and lens opacity...
April 11, 2024: Radiotherapy and Oncology