Nuria Garatachea, Enzo Emanuele, Miguel Calero, Noriyuki Fuku, Yasumichi Arai, Yukiko Abe, Haruka Murakami, Motohiko Miyachi, Thomas Yvert, Zoraida Verde, Ma Ascensión Zea, Letizia Venturini, Catalina Santiago, Alejandro Santos-Lozano, Gabriel Rodríguez-Romo, Giovanni Ricevuti, Nobuyoshi Hirose, Alberto Rábano, Alejandro Lucia
The ApoE gene is associated with the risk of Alzheimer or cardiovascular disease but its influence on exceptional longevity (EL) is uncertain. Our primary purpose was to determine, using a case-control design, if the ApoE gene is associated with EL. We compared ApoE allele/genotype frequencies among the following cohorts: cases (centenarians, most with 1+ major disease condition; n=163, 100-111years) and healthy controls (n=1039, 20-85years) from Spain; disease-free cases (centenarians; n=79, 100-104years) and healthy controls (n=597, age 27-81years) from Italy; and cases (centenarians and semi-supercentenarians, most with 1+ major disease condition; n=729, 100-116years) and healthy controls (n=498, 23-59years) from Japan...
May 2014: Experimental Gerontology