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Roberto Fariña-Castro, Cristina Roque-Castellano, Manuel Artiles-Armas, Joaquín Marchena-Gómez
AIM: The number of nonagenarians undergoing surgery has increased considerably in recent decades as a result of population aging. Greater knowledge of the most influential factors affecting perioperative morbidity and mortality would improve the quality of care and provision of health resources for these patients. The objective of the present study was to analyze the perioperative mortality, and its most determinant factors, among nonagenarian patients who underwent a surgical procedure in the Department of General and Digestive Surgery...
February 13, 2019: Geriatrics & Gerontology International
Irene Martínez de Toda, Carmen Vida, Antonio Garrido, Mónica De la Fuente
Oxidative stress has been reported to increase with aging and although several age-related changes in redox parameters have been described, none of them have been verified as markers of the rate of aging and lifespan. Therefore, antioxidant (catalase, glutathione peroxidase and reductase activities and reduced glutathione) and oxidant (oxidized glutathione, basal superoxide anion and malondialdehyde concentrations) parameters were studied in whole blood cells from humans divided into different age groups (adult, mature, elderly, nonagenarian and centenarian) in a cross-sectional study...
February 11, 2019: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
Manasnun Kongwibulwut, Kevin Chiang, Jae Moo Lee, Ahmed I Eid, Napaporn Kongkaewpaisan, Kelsey Han, Ask Tybjærg Nordestgaard, David King, Noelle Saillant, April E Mendoza, George Velmahos, Haytham M A Kaafarani
BACKGROUND: The decision to emergently operate on nonagenarian patients (NONAs) can be complex due to the uncertainty about outcomes and goals of care at this advanced age. We sought to study: 1) the outcomes and predictors of mortality for NONAs undergoing emergency general surgery (EGS) and 2) the accuracy of ACS-NSQIP mortality risk calculator in this special population. METHODS: Using the 2007-2015 ACS-NSQIP database, we included all patients older than 90 years of age who underwent an emergent operation with a CPT code for "digestive system"...
February 7, 2019: Journal of Trauma and Acute Care Surgery
Michela Giustozzi, Maria Cristina Vedovati, Melina Verso, Luca Scrucca, Serenella Conti, Paolo Verdecchia, Giulio Bogliari, Lucia Pierpaoli, Giancarlo Agnelli, Cecilia Becattini
BACKGROUND: Patients aged 90 years or older are often excluded from or under-represented in clinical trials and cohort studies. The clinical benefit of anticoagulation in nonagenarians with atrial fibrillation (AF) remains undefined. OBJECTIVES: To assess the effectiveness and safety of oral anticoagulants in AF patients aged 90 years or older. METHODS: Non-valvular AF patients aged 90 years or older receiving direct oral anticoagulants (DOACs) or vitamin K antagonists (VKAs) were included in this observational multicentre study...
January 25, 2019: International Journal of Cardiology
Katie E Cherry, Bethany A Lyon, Emily O Boudreaux, Alyse B Blanchard, Jason L Hicks, Emily M Elliott, Leann Myers, Sangkyu Kim, S Michal Jazwinski
Background/Study Context. Adaptation to normative age-related declines in memory is an important but understudied aspect of successful aging. The purpose of the present study was to shed new light on memory self-efficacy and beliefs about memory and aging as two integral aspects of adult cognition with relevance to successful aging. METHODS: Young (19 to 27 years) and community-dwelling older adults (60 to 94 years) from the Louisiana Healthy Aging Study (LHAS) completed an adapted Memory Functioning Questionnaire (MFQ) which includes a memory self-efficacy subscale, the Memory Controllability Inventory (MCI), and the Aging Concerns Scale (ACS)...
February 1, 2019: Experimental Aging Research
Zuyun Liu, Ling Han, Qiushi Feng, Matthew E Dupre, Danan Gu, Heather G Allore, Thomas M Gill, Collin F Payne
BACKGROUND: China has transitioned from being one of the fastest-growing populations to among the most rapidly aging countries worldwide. In particular, the population of oldest-old individuals, those aged 80+, is projected to quadruple by 2050. The oldest-old represent a uniquely important group-they have high demand for personal assistance and the highest healthcare costs of any age group. Understanding trends in disability and longevity among the oldest-old-that is, whether successive generations are living longer and with less disability-is of great importance for policy and planning purposes...
February 1, 2019: BMC Medicine
Laura T Boitano, James C Iannuzzi, Adam Tanious, Jahan Mohebali, Samuel I Schwartz, David C Chang, W Darrin Clouse, Mark F Conrad
OBJECTIVES: There is a paucity of data guiding preoperative counselling on the need for discharge to a facility or non-home discharge (NHD) following elective endovascular repair of abdominal aortic aneurysms (EVAR). This study seeks to determine the preoperative predictors of NHD following EVAR in baseline home-dwelling patients and to determine whether NHD is associated with major post-discharge complications and readmission. METHODS: This retrospective cohort study utilized the National Surgical Quality Improvement Program Vascular Procedure Targeted database to identify elective EVAR cases admitted from home (2011 to 2015)...
January 25, 2019: Annals of Vascular Surgery
Da Zhou, Jiayue Ding, Jingyuan Ya, Liqun Pan, Chaobo Bai, Jingwei Guan, Zhongao Wang, Kexin Jin, Qi Yang, Xunming Ji, Ran Meng
Our previous study revealed that remote ischemic conditioning (RIC) reduced the incidence of stroke or TIA in octo- and nonagenarians with intracranial atherosclerotic stenosis (ICAS). Herein, we aimed to investigate whether RIC would influence the progression of white matter hyperintensities (WMHs) and cognitive impairment in the same group of patients. Fifty-eight patients with ICAS were randomly assigned in a 1:1 ratio to receive standard medical treatment with RIC (n=30) versus sham-RIC (n=28). The RIC protocol consisted of 5 cycles of alternating 5-min ischemia and 5-min reperfusion applied in the bilateral upper arms twice daily for 300 days...
January 28, 2019: Aging
Guy Ben-Betzalel, Yael Steinberg-Silman, Ronen Stoff, Nethanel Asher, Ronnie Shapira-Frommer, Jacob Schachter, Gal Markel
Immunotherapy with anti-programmed cell death-1 (PD-1) agents is an effective treatment for metastatic melanoma. Recent data hint at better response to therapy for patients over age 65 years. Patients with metastatic melanoma in their 80's and 90's pose a clinical challenge. We describe a cohort of 144 patients ≥65 years and analyse the efficacy and toxicity of anti-PD-1 therapy in ages 80-100 years compared with ages 65-79 years. Records of metastatic melanoma patients aged 65-100 years treated with anti-PD-1 were collected retrospectively...
January 12, 2019: European Journal of Cancer
Emiel O Hoogendijk, Maaike van der Noordt, Bregje D Onwuteaka-Philipsen, Dorly J H Deeg, Martijn Huisman, Linda Enroth, Marja Jylhä
OBJECTIVES: Little is known about sex differences in healthy life expectancy among the oldest old, the fastest growing segment of the older population. This study examines sex differences in total, healthy and unhealthy life expectancy among nonagenarians. METHODS: Longitudinal data of 884 older adults aged 90 and over participating in the Vitality 90+ study (Tampere, Finland) were used, including 2501 observations (health or death states) from 5 measurement waves between 2001 and 2014...
December 24, 2018: Experimental Gerontology
Nicholas Yohe, August Funk, Matthew Ciminero, Orry Erez, Ahmed Saleh
Introduction: From 2000 to 2010, the cohort of patients aged 85 to 94 years had the fastest growth rate increasing in size by approximately 30%. The need for total knee arthroplasty (TKA) continues to increase with a larger percentage of patients older than 80 years requiring TKA. The purpose of our study was to examine the rate and risks of 30-day complications and unplanned readmission in patients older than 80 years. Materials and Methods: The National Surgical Quality Improvement Project database for the years 2008 to 2014 was queried for patients older than 80 years undergoing TKA...
2018: Geriatric Orthopaedic Surgery & Rehabilitation
Islam Y Elgendy, Ahmed N Mahmoud, Ayman Elbadwai, Akram Y Elgendy, Mohamed A Omer, Michael Megaly, Mohammad K Mojadidi, Hani Jneid
OBJECTIVES: To compare the in-hospital outcomes of transcatheter aortic valve replacement (TAVR) versus surgical aortic valve replacement (SAVR) in nonagenarians. BACKGROUND: Data comparing the outcomes of TAVR versus SAVR in nonagenarians are limited. METHODS: Using the National Inpatient Sample years 2012-2014, hospitalization data were retrieved for subjects aged ≥90 years who underwent TAVR or SAVR for severe aortic stenosis. The incidence of in-hospital mortality and peri-procedural outcomes were compared using unadjusted, multivariate logistic regression, and propensity score matched analyses...
December 19, 2018: Catheterization and Cardiovascular Interventions
Carlos Lahoz, Juan Cardenas, Miguel Á Salinero-Fort, José M Mostaza
AIMS: The objective of the present study was to evaluate the prevalence of atrial fibrillation (AF) in nonagenarians living in the Community of Madrid, their clinical features, the use of anticoagulant therapy and factors associated with its use. METHODS: This was a cross-sectional study of 59 423 individuals aged ≥90 years, living in the Community of Madrid on 31 December 2015. Clinical information was obtained from a database that includes information from electronic medical records collected by 3881 general practitioners in primary care...
December 18, 2018: Geriatrics & Gerontology International
Silvia Pancani, Federica Vannetti, Francesco Sofi, Francesca Cecchi, Guido Pasquini, Laura Fabbri, Irene Eleonora Mosca, Claudio Macchi
ABSTRACTThis study aimed at assessing daily physical activity and its relationship with functional and cognitive status in nonagenarians. Cross-sectional study. 167 nonagenarians (124 women and 43 men, mean age 92 years ± 3) who participated in the Mugello study. Participants underwent daily step count through the SenseWear armband, which was considered as an indicator of physical activity. Other main variables were: handgrip strength, gait speed, depression, cognitive status and quality of life. The median value of steps per day was 883 and 658 in women and men, respectively, with a participant, in the women group, showing values up to 10,000...
December 18, 2018: International Psychogeriatrics
Alberto Montesanto, Daniela Pellegrino, Silvana Geracitano, Daniele La Russa, Vincenzo Mari, Sabrina Garasto, Fabrizia Lattanzio, Andrea Corsonello, Giuseppe Passarino
AIM: Centenarians represent a biological model of successful aging because they escaped/postponed most invalidating age-related diseases, such as cardiovascular diseases. The aim of the present study was to clarify whether a favorable cardiovascular risk profile increases the survival chances in long-lived people. METHODS: A total of 355 community-dwelling nonagenarians and centenarians living in Southern Italy were recruited in the study. Patients were classified as at low and high cardiovascular risk on the basis of serum cholesterol, diabetes, hypertension and smoking status...
December 16, 2018: Geriatrics & Gerontology International
Sameeha A Alshelleh, Ashraf O Oweis, Karem H Alzoubi
Background: Improvements in health care systems worldwide have had notable effects on the life expectancy of older individuals. As a result, nonagenarians are emerging as a separate age group with distinct health care needs. The aim of this study was to evaluate the incidence of acute kidney injury (AKI), the mortality rates, and length of in-hospital stay among nonagenarians. Methods: This is a retrospective case-control chart review of patients of age 90 years and above who were admitted to hospital...
2018: International Journal of Nephrology and Renovascular Disease
Elżbieta Olczak, Alina Kuryłowicz, Zofia Wicik, Paulina Kolodziej, Marta Cakala-Jakimowicz, Olga Buyanovskaya, Przemyslaw Slusarczyk, Malgorzata Mossakowska, Monika Puzianowska-Kuznicka
INTRODUCTION: Polymorphism of the glucocorticoid receptor gene (NR3C1) may modify protein abundance or function and therefore disturb human homeostasis. METHODS: Variant frequencies of the three NR3C1 polymorphisms, rs2963154, rs10515522 and rs2918418, selected in silico as associated with longevity, was analyzed in 552 DNA samples from 95 to 106-year-old individuals and in 284 samples of cord blood DNA from newborns. RESULTS: Frequencies of the TT genotypes of rs2963154 and rs10515522, and of the rs291841 CC genotype, were higher in the long-lived study subjects (p = 0...
December 12, 2018: Experimental Gerontology
Fergie J Ramos Tuarez, Jesus E Pino, Abdulah Alrifai, Mohamad Kabach, Elie Donath, Jorge Saona, Julio Grajeda Chavez, Ximena Torres Diaz, Marcelo Jimenez, Robert Chait
OBJECTIVES: To assess the impact of WATCHMAN™ on quality of life (QoL) in octogenarians and nonagenarians. BACKGROUND: QoL after WATCHMAN™ device in the elderly remains unknown. METHODS: This is a prospective and retrospective cohort study of patients that underwent WATCHMAN™ implantation in a tertiary cardiovascular center from April 1, 2015 to September 27, 2017. The primary outcome was a prospective assessment of QoL via the SF-12v2 Health Survey (SF-12v2) in those aged ≥80 and ≥90 years...
December 12, 2018: Catheterization and Cardiovascular Interventions
Gorka Fernández-Eulate, Ainhoa Alberro, Maider Muñoz-Culla, Miren Zulaica, Mónica Zufiría, Myriam Barandiarán, Igone Etxeberria, José Javier Yanguas, Maria Mercedes Gallardo, Nora Soberón, Ana María Lacosta, Virginia Pérez-Grijalba, Jesús Canudas, Noelia Fandos, Pedro Pesini, Manuel Sarasa, Begoña Indakoetxea, Fermin Moreno, Itziar Vergara, David Otaegui, Maria Blasco, Adolfo López de Munain
Many factors may converge in healthy aging in the oldest old, but their association and predictive power on healthy or functionally impaired aging has yet to be demonstrated. By detecting healthy aging and in turn, poor aging, we could take action to prevent chronic diseases associated with age. We conducted a pilot study comparing results of a set of markers (peripheral blood mononuclear cell or PBMC telomere length, circulating Aβ peptides, anti-Aβ antibodies, and ApoE status) previously associated with poor aging or cognitive deterioration, and their combinations, in a cohort of "neurologically healthy" (both motor and cognitive) nonagenarians ( n = 20) and functionally impaired, institutionalized nonagenarians ( n = 38) recruited between 2014 and 2015...
2018: Frontiers in Aging Neuroscience
Tapio Nevalainen, Arttu Autio, Binisha Hamal Mishra, Saara Marttila, Marja Jylhä, Mikko Hurme
Human endogenous retroviruses (HERV) are relics of ancient retroviral infections in our genome. Most of them have lost their coding capacity, but proviral RNA or protein have been observed in several disease states (e.g. in inflammatory and autoimmune diseases and malignancies). However, their clinical significance as well as their mechanisms of action have still remained elusive. As human aging is associated with several biological characteristics of these diseases, we now analyzed the aging-associated expression of the individual proviruses of two HERV families, HERV-K (91 proviruses) and HERV-W (213 proviruses) using genome-wide RNA-sequencing (RNA-seq)...
2018: PloS One
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