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Luoran Shang, Yunru Yu, Yuxiao Liu, Zhuoyue Chen, Tiantian Kong, Yuanjin Zhao
Natural fiber systems provide inspirations for artificial fiber spinning and applications. Through a long process of trial and error, great progress has been made in recent years. The natural fiber itself, especially silks, and the formation mechanism are better understood, and some of the essential factors are implemented in artificial spinning methods, benefiting from advanced manufacturing technologies. Besides, fiber-based materials produced via bioinspired spinning methods find an increasingly wide range of biomedical, optoelectronics, and environmental engineering applications...
February 15, 2019: ACS Nano
Lijun Geng, Xudong Yu, Yajuan Li, Yanqiu Wang, Yongquan Wu, Jujie Ren, Fengfeng Xue, Tao Yi
Biomolecule-based hydrogels have potential use in a wide range of applications such as controlled drug release, tissue engineering, and biofabrication. Herein, driven by specific interactions between ds-DNA (double-stranded DNA) and Zn2+ based metal-complexes, we report that the use of DNA as cross-linkers can enhance interactions between self-assembling Zn2+ complexes containing terpyridine and sugar groups in the generation of bioinspired hydrogels from solutions or suspensions. The gelation process is fast and straightforward without tedious steps and happens at room temperature...
February 15, 2019: Nanoscale
Xu Zhu, Christopher C McAtee, Corinna S Schindler
A bioinspired approach for the syntheses of herqulines B and C is reported that takes advantage of an L-tyrosine-derived diketopiperazine, a mycocyclosin analog, as a synthetic precursor. The strategy relies on a series of consecutive reductions to adjust the mycocyclosin oxidation state to that observed in the herquline class of natural products. The strained and distorted L-tyrosine-based biaryl system characteristic for mycocyclosin is selectively converted to the 1,4-diketone structural motif common to the herqulines via initial hypervalent iodine-mediated dearomatization and a subsequent directed Birch reduction, enabled by an intramolecular H-source...
February 14, 2019: Journal of the American Chemical Society
Jinlong Lu, Chi-Vinh Ngo, Subhash C Singh, Jianjun Yang, Wei Xin, Zhi Yu, Chunlei Guo
World is facing global issue of water scarcity where two- thirds of the population do not have access to safe drinking water. Water harvesting from ambient has a potential equivalent to around 10% of the fresh water available on the earth's surface, but it requires a special control in surface morphology for efficient water harvesting. Here, we report a novel facile physicochemical hybrid method that combines femtosecond laser structuring with hydrothermal treatment to create a surface with well-arranged hierarchical nanoneedle structures...
February 13, 2019: Langmuir: the ACS Journal of Surfaces and Colloids
Linping Wang, Yue Meng, Chunxiu Zhang, Hongbo Xiao, Yunlong Li, Yueming Tan, Qingji Xie
The photoelectrochemistry (PEC) performance of TiO2 is somewhat limited by its wide band gap and low quantum efficiency, and the innovation of its composite materials provides a promising solution for an improved performance. Herein, a composite of an Au nanorod@TiO2 core-shell nanostructure (AuNR@TiO2) and a melanin-like L-DOPA polymer (PD) is designed and prepared, where the outer-layer PD tethered by the TiO2-hydroxyl complexation and the AuNR core can intensify the long-wavelength light harvesting, and the AuNR@TiO2 core-shell structure can strengthen the hot-electron transfer to TiO2...
February 13, 2019: ACS Applied Materials & Interfaces
Ruipu Zhang, Yan Qin, Long Zhang, Sanzhong Luo
We report herein our mechanistic studies of the ortho-quinone-catalyzed aerobic oxidation of primary, secondary, and tertiary amines. Two different catalytic pathways were discovered for the reductive half reactions: for primary amines, the reaction was found to proceed via a transamination pathway, while the reactions with secondary amines and tertiary amines proceeded via hydride transfer. We also found that the amine substrates could significantly promote the regeneration of the ortho-quinone catalyst in the oxidative half reaction, in which a proton transfer occurs between the amine substrates and catechol derivatives (the reduced form of the ortho-quinone catalyst)...
February 12, 2019: Journal of Organic Chemistry
Sijo K Joseph, Natalia Kuritz, Eldad Yahel, Nadezda Lapshina, Gil Rosenman, Amir Natan
We employ Molecular Dynamics (MD) and Time-Dependent Density Functional Theory (TDDFT) to explore the fluorescence of hydrogen-bonded dimer and trimer structures of Cyclic FF (Phe-Phe) molecules. We show that in some of these configurations a photon can induce either an intra-molecular proton transfer, or an inter-molecular proton transfer that can occur in the excited S1 and S2 states. This proton transfer, taking place within the hydrogen bond, leads to a significant red-shift that can explain the experimentally observed visible fluorescence in biological and bioinspired peptide nanostructures with a β-sheet biomolecular arrangement...
February 12, 2019: Journal of Physical Chemistry. A
Amandeep Kaur, Elizabeth J New
The availability of electrons to biological systems underpins the mitochondrial electron transport chain (ETC) that powers living cells. It is little wonder, therefore, that the sufficiency of electron supply is critical to cellular health. Considering mitochondrial redox activity alone, a lack of oxygen (hypoxia) leads to impaired production of adenosine triphosphate (ATP), the major energy currency of the cell, whereas excess oxygen (hyperoxia) is associated with elevated production of reactive oxygen species (ROS) from the interaction of oxygen with electrons that have leaked from the ETC...
February 12, 2019: Accounts of Chemical Research
Chuanjiang He, Tingting Ye, Wenqi Teng, Zhi Fang, Wei-Shuyi Ruan, Guowu Liu, Hui Chen, Jizeng Sun, Lanlan Hui, Feng Sheng, Dingyi Pan, Chunming Yang, Yi Steve Zheng, Meng-Bo Luo, Ke Yao, Ben Wang
Layer-by-layer (LbL) assembly is widely applied as a coating technique for nanoscale control of architecture and related properties. However, its translational applications are limited by the time-consuming and laborious nature of the process. Inspired by the blood clotting process, herein, we develop a shear flow-driven LbL (SF-LbL) self-assembly approach that accelerates the adsorption rate of macromolecules by mechanically configuring the polymer chain via a coil-stretch transition, which effectively simplifies and speeds the diffusion-controlled assembly process...
February 12, 2019: ACS Nano
Chenyu Zheng, Yufeng Sheng, Yong Liu, Ying Wan, Guang Liu, Xutong Zhang, Meng Yang, Kai Kang, Jingping Liu, Kefeng Ma, Shengyuan Deng
Ultrasensitive electrochemiluminescence (ECL) detection can benefit substantially from the rational configuration of emitter-enhancer stereochemistry. Here, using zinc(II) meso-5,10,15,20-tetra(4-sulfonatophenyl)porphyrin (ZnTSPP) as a model, we demonstrate that both the ECL intensity and the photostability of this emitter were significantly improved when it was trapped in pyridyl-bridged β-cyclodextrin dimer (Py(CD)2 ); a synthetic enhancer that is ECL inactive. Through NMR characterization, we confirmed that ZnTSPP formed a clam-like inclusion complex involving pinning and pinching forces from the biocompatible container Py(CD)2 ...
February 12, 2019: Analytical and Bioanalytical Chemistry
H-W Huang, F E Uslu, P Katsamba, E Lauga, M S Sakar, B J Nelson
Bacteria can exploit mechanics to display remarkable plasticity in response to locally changing physical and chemical conditions. Compliant structures play a notable role in their taxis behavior, specifically for navigation inside complex and structured environments. Bioinspired mechanisms with rationally designed architectures capable of large, nonlinear deformation present opportunities for introducing autonomy into engineered small-scale devices. This work analyzes the effect of hydrodynamic forces and rheology of local surroundings on swimming at low Reynolds number, identifies the challenges and benefits of using elastohydrodynamic coupling in locomotion, and further develops a suite of machinery for building untethered microrobots with self-regulated mobility...
January 2019: Science Advances
Hao Cheng, Khalid Gadora, Zhen Wang, Huaqing Zhang, Wenxin Jiang, Xin Chen, Guochen Han, Yi Jin, Jianping Zhou, Lei Jiang, Yang Ding
Graphene oxide (GO) and its derivatives hold vast potential in biomedical applications because of their near-infrared (NIR) absorbance, large specific surface area, and abundant functional groups. However, their use is hampered by their insufficient biostability and biocompatibility; an effective solution to these issues is surface modification. Therefore, research has focused on bioinspired GO surface modifications that improve the biostability and biofunctions of the resulting compounds. Here, we highlight recent advances in the development of surface modifications to enable multidrug shielding, site-specific trafficking, and favorable biostability...
February 8, 2019: Drug Discovery Today
Eunjung Kim, Shweta Agarwal, Nayoung Kim, Fredrik Sydow Hage, Vincent Leonardo, Amy Gelmi, Molly M Stevens
Nucleic acid nanostructures have attracted significant interest as potential therapeutic and diagnostic platforms due to their intrinsic biocompatibility and biodegradability, structural and functional diversity, and compatibility with various chemistries for modification and stabilization. Among the fabrication approaches for such structures, the rolling circle techniques have emerged as particularly promising, producing morphologically round, flower-shaped nucleic acid particles: typically hybrid composites of long nucleic acid strands and inorganic magnesium pyrophosphate (Mg2 PPi)...
February 11, 2019: ACS Nano
Sylvain Grosjean, Mirella Wawryszyn, Hatice Mutlu, Stefan Bräse, Joerg Lahann, Patrick Theato
Bioinspiration has emerged as an important design principle in the rapidly growing field of materials science and especially its subarea, soft matter science. For example, biological cells form hierarchically organized tissues that not only are optimized and designed for durability, but also have to adapt to their external environment, undergo self-repair, and perform many highly complex functions. Being able to create artificial soft materials that mimic those highly complex functions will enable future materials applications...
February 10, 2019: Advanced Materials
Hao Wan, Chenlei Gu, Ying Gan, Weixin Wei, Kai Zhu, Ning Hu, Ping Wang
Drug efficacy and toxicity are key factors of drug development. Conventional 2D cell models or animal models have their limitations for the efficacy or toxicity assessment in preclinical assays, which induce the failure of candidate drugs or withdrawal of approved drugs. Human organs-on-chips (OOCs) emerged to present human-specific properties based on their 3D bioinspired structures and functions in the recent decade. In this review, basic definition and superiority of OOCs will be introduced. Moreover, a specific OOC, heart-on-a-chip (HOC) will be focused...
February 7, 2019: Current Pharmaceutical Design
Simona la Gatta, Francesco Milano, Gianluca M Farinola, Angela Agostiano, Mariangela Di Donato, Andrea Lapini, Paolo Foggi, Massimo Trotta, Roberta Ragni
The photosynthetic Reaction Center (RC) from the purple bacterium Rhodobacter sphaeroides has unique photoconversion capabilities, that can be exploited in assembly biohybrid devices for applications in solar energy conversion. Extending the absorption cross section of isolated RC through covalent functionalization with ad-hoc synthesized artificial antennas is a successful strategy to outperform the efficiency of the pristine photoenzyme under visible light excitation. Here we report a new heptamethine cyanine antenna that, upon covalent binding to RC, forms a biohybrid (hCyN7-RC) which, under white light excitation, has doubled photoconversion efficiency versus the bare photoenzyme...
February 2, 2019: Biochimica et biophysica acta. Bioenergetics
Ying Zhang, Wang Ren, Yu Zhu Fan, Jiang Xue Dong, Hui Zhang, Hong Qun Luo, Nian Bing Li
A simple and label-free fluorescence turn-on method is proposed for the discrimination and detection of epinephrine (Ep) and dopamine (DA) via polyethyleneimine (PEI)-initiated in situ copolymerization and excitation wavelength switch. The PEI solution in the presence of Ep, DA and the mixture of Ep and DA are denoted as PEp-PEI , PDA-PEI and MEp+DA , respectively. In this study, PEI aqueous solution medium initiates the auto-oxidization of Ep and DA and the bioinspired copolymerization. These resultant copolymers emit yellow-green fluorescence color with a fluorescence emission maximum at 515 nm...
April 25, 2019: Analytica Chimica Acta
Houwen Matthew Pan, Shengyang Chen, Tae-Sik Jang, Win Tun Han, Hyun-Do Jung, Yaning Li, Juha Song
Biofabrication technologies have endowed us with the capability to fabricate complex biological constructs. However, cytotoxic biofabrication conditions have been a major challenge for their clinical application, leading to a trade-off between cell viability and scalability of biofabricated constructs. Taking inspiration from nature, we proposed a cell protection strategy which mimicks the protected and dormant state of plant seeds in adverse external conditions and their germination in response to appropriate environmental cues...
February 1, 2019: Biofabrication
Shuo Li, Hedan Bai, Robert F Shepherd, Huichan Zhao
Soft materials possess several distinctive characteristics like controllable deformation, infinite degrees of freedom, and self-assembly that make them promising candidates for building soft machines, robots, and haptic interfaces. In this article, we review recent advances in intrinsically soft materials, and soft-material-enabled robots, machines, and haptic interfaces, with emphasis on two specific topics-bioinspired design and additive manufacturing. Biology is an abundant source of inspiration that many materials and systems use to mimic the functions or mechanisms of biological tissues, agents, and behaviors...
February 1, 2019: Angewandte Chemie
Kai Tao, Wen Hu, Bin Xue, Drahomir Chovan, Noam Brown, Linda J W Shimon, Oguzhan Maraba, Yi Cao, Syed A M Tofail, Damien Thompson, Junbai Li, Rusen Yang, Ehud Gazit
Peptide assemblies are ideal components for eco-friendly optoelectronic energy harvesting devices due to their intrinsic biocompatibility, ease of fabrication, and flexible functionalization. However, to date, their practical applications have been limited due to the difficulty in obtaining stable, high-performance devices. Here, it is shown that the tryptophan-based simplest peptide cyclo-glycine-tryptophan (cyclo-GW) forms mechanically robust (elastic modulus up to 24.0 GPa) and thermally stable up to 370 °C monoclinic crystals, due to a supramolecular packing combining dense parallel β-sheet hydrogen bonding and herringbone edge-to-face aromatic interactions...
February 1, 2019: Advanced Materials
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