keyword
https://read.qxmd.com/read/38510896/survival-rates-of-extremely-low-birth-weight-infants-in-a-tertiary-care-center-in-saudi-arabia
#21
JOURNAL ARTICLE
Mohammad Alhasoon
Introduction Extremely low birth weight (ELBW) refers to the condition in which an infant is born with a weight of less than one thousand grams (2.2 pounds) at birth. ELBW infants face significant challenges and are at increased risk for various medical complications and developmental issues. ELBW poses unique challenges for infants, families, and healthcare providers. Understanding the causes, consequences, and appropriate management strategies for ELBW is crucial for improving the survival rates of these vulnerable infants...
February 2024: Curēus
https://read.qxmd.com/read/38508104/non-invasive-prediction-model-of-histologic-chorioamnionitis-with-preterm-prelabour-rupture-of-membranes
#22
JOURNAL ARTICLE
Yan Hu, Zheng Ye, Nathan Obore, Xiaojun Guo, Hong Yu
BACKGROUND: The aim of this study is to identify risk factors associated with histological chorioamnionitis (HCA) and develop a predictive model for antepartum assessment of the risk of PPROM with HCA. METHODS: This study retrospectively analyzed pregnant women who experienced PPROM between 25 + 0 and 35 + 0 weeks of gestational age. The women were divided into two groups based on the presence or absence of HCA. Univariate and multivariate logistic regression analyses were conducted to identify maternal risk factors and develop a clinical prediction model for HCA...
March 16, 2024: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://read.qxmd.com/read/38507460/effects-of-osteopathic-manipulative-treatment-on-maternal-fetal-hemodynamics-in-third-trimester-pregnant-women-a-prospective-study
#23
JOURNAL ARTICLE
Maria Luisa Arruda Correia, Fernando Maia Peixoto Filho, Saint Clair Gomes Júnior, Guilherme Ramires de Jesus
OBJECTIVE: To evaluate the maternal-fetal hemodynamic effects after osteopathic manipulative treatment by measuring vital signs and Doppler velocimetry in third-trimester pregnant women. MATERIALS AND METHODS: This is a prospective study with pregnant women undergoing outpatient follow-up and hospitalized in a ward at Instituto Fernandes Figueira/Fiocruz, between August 2021 to August 2022, during the SARS-CoV-2 pandemic. This study was registered in REBEC under Register Number RBR-9q7kvg and approved by the ethics committee under number 32216620...
2024: PloS One
https://read.qxmd.com/read/38507091/timing-of-planned-cesarean-delivery-among-patients-with-two-previous-cesarean-sections
#24
JOURNAL ARTICLE
Noa Leybovitz-Haleluya, Alla Saban, Adi Yariv, Reli Hershkovitz
OBJECTIVES: The timing of planned repeat cesarean delivery (CD) is debateful in clinical practice. Planned repeat CD is typically scheduled before the spontaneous onset of labor to minimize the risk of uterine rupture during labor and the associated risk for fetal compromise. This timing should be balanced with the potential risk of delivering an infant who could benefit from additional maturation in utero. We aim to study the influence of gestational age at the time of repeat CD on maternal and fetal complications...
March 20, 2024: Archives of Gynecology and Obstetrics
https://read.qxmd.com/read/38506477/guidelines-of-the-polish-society-of-gynecologists-and-obstetricians-on-the-diagnosis-and-management-of-pregnancies-complicated-by-prelabor-rupture-of-the-membranes
#25
JOURNAL ARTICLE
Piotr Sieroszewski, Dorota Bomba-Opon, Krzysztof Czajkowski, Krzysztof Drews, Mariusz Grzesiak, Bozena Leszczynska-Gorzelak, Anna Scholz, Jaroslaw Kalinka, Katarzyna Kosinka-Kaczynska, Sebastian Kwiatkowski, Radzislaw Mierzynski, Krzysztof Preis, Mariola Ropacka-Lesiak, Malgorzata Swiatkowska-Freund, Miroslaw Wielgos, Mariusz Zimmer, Hubert Huras
No abstract text is available yet for this article.
March 20, 2024: Ginekologia Polska
https://read.qxmd.com/read/38505609/in-vivo-high-speed-microscopy-of-microbubbles-in-the-chorioallantoic-membrane-model
#26
JOURNAL ARTICLE
Rojin Anbarafshan, Carly Pellow, Kevin Kiezun, Hon Leong, David E Goertz
Rationale: The acoustic stimulation of microbubbles within microvessels can elicit a spectrum of therapeutically relevant bioeffects from permeabilization to perfusion shutdown. These bioeffects ultimately arise from complex interactions between microbubbles and microvascular walls, though such interactions are poorly understood particularly at high pressure, due to a paucity of direct in vivo observations. The continued development of focused ultrasound methods hinges in large part on establishing links between microbubble-microvessel interactions, cavitation signals, and bioeffects...
2024: Theranostics
https://read.qxmd.com/read/38503285/lysosomal-damage-sensing-and-lysophagy-initiation-by-spg20-itch
#27
JOURNAL ARTICLE
Pinki Gahlot, Bojana Kravic, Giulia Rota, Johannes van den Boom, Sophie Levantovsky, Nina Schulze, Elena Maspero, Simona Polo, Christian Behrends, Hemmo Meyer
Cells respond to lysosomal membrane permeabilization by membrane repair or selective macroautophagy of damaged lysosomes, termed lysophagy, but it is not fully understood how this decision is made. Here, we uncover a pathway in human cells that detects lipid bilayer perturbations in the limiting membrane of compromised lysosomes, which fail to be repaired, and then initiates ubiquitin-triggered lysophagy. We find that SPG20 binds the repair factor IST1 on damaged lysosomes and, importantly, integrates that with the detection of damage-associated lipid-packing defects of the lysosomal membrane...
March 14, 2024: Molecular Cell
https://read.qxmd.com/read/38503193/characterizing-of-intra-amniotic-inflammatory-changes-associated-with-chronic-inflammation-in-the-placenta-marked-by-elevated-amniotic-fluid-interferon-gamma-induced-protein-10-ip-10-in-pregnancies-complicated-by-preterm-prelabor-rupture-of-membranes
#28
JOURNAL ARTICLE
Nina Aberšek, Panagiotis Tsiartas, Ondrej Soucek, Ctirad Andrys, Ivana Musilova, Bo Jacobsson, Marian Kacerovsky
OBJECTIVES: This study aimed to determine the occurrence of intra-amniotic inflammatory changes associated with chronic inflammation in the placenta, marked by elevated levels of interferon gamma-induced protein 10 (IP-10) (≥2200 pg/mL) in the amniotic fluid of women with preterm prelabor rupture of membranes (PPROM). Specifically, the study investigated whether these intra-amniotic inflammatory changes were more common in women with microbial invasion of amniotic cavity (MIAC) and intra-amniotic inflammation (IAI), as indicated by increased amniotic fluid interleukin (IL)-6 concentration (≥3000 pg/mL)...
March 7, 2024: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://read.qxmd.com/read/38502502/isolation-of-the-inner-and-outer-membranes-of-the-chloroplast-envelope-from-angiosperms
#29
JOURNAL ARTICLE
Maryse A Block, Eric Maréchal
The outer and the inner membranes of the chloroplast envelope, also called OEM and IEM, have distinct lipid and protein compositions. They host molecular systems involved in the biogenesis of the organelle, its cellular function, and its communication with other compartments. Here we describe a method for the isolation of these two membranes starting from intact chloroplast preparations, with two alternative procedures based on the starting material. One was developed from spinach leaves, the other from pea leaves...
2024: Methods in Molecular Biology
https://read.qxmd.com/read/38502447/feto-maternal-interface-organ-on-chip-a-new-technology-to-study-ascending-infection
#30
JOURNAL ARTICLE
Giovana Fernanda Cosi Bento, Márcia Guimarães da Silva, Ramkumar Menon, Lauren S Richardson
Modeling human pregnancy is challenging as two subjects, the mother and fetus, must be evaluated in tandem. To understand pregnancy, parturition, and adverse pregnancy outcomes, the two feto-maternal interfaces (FMi) that form during gestation (i.e., the placenta and fetal membrane) need to be investigated to understand their biological roles, and organ dysfunction can lead to adverse outcomes. Adverse pregnancy outcomes such as preterm rupture of the membranes, spontaneous preterm birth, preeclampsia, intra-uterine growth restriction, and gestational diabetes rates are on the rise worldwide, highlighting the need for future studies and a better understanding of molecular and cellular pathways that contribute to disease onset...
2024: Methods in Molecular Biology
https://read.qxmd.com/read/38502037/length-of-hysterotomy-for-fetal-spina-bifida-repair-is-associated-with-prematurity-risk
#31
JOURNAL ARTICLE
Kanokwaroon Watananirun, Anna M L F Vargas, Simen Vergote, Liesbeth Lewi, Marcelo O L Filippo, Peter McCulloch, Roland Devlieger, Cleisson F A Peralta, Jan Deprest
OBJECTIVE: To investigate whether prenatal repair of spina bifida aperta through mini-hysterotomy results in less prematurity, as compared to standard hysterotomy, when adjusting for known prematurity risks. METHODS: We performed a bi-centric, propensity score matched, controlled study, that is, adjusting for factors earlier reported to result in premature delivery or membrane rupture, in consecutive women having prenatal repair either through stapled hysterotomy or sutured mini-hysterotomy (≤3...
March 19, 2024: Prenatal Diagnosis
https://read.qxmd.com/read/38501017/sub-acute-pain-after-childbirth-during-covid-19-pandemic-a-secondary-analysis-of-a-prospective-clinical-trial
#32
JOURNAL ARTICLE
Chin Wen Tan, Rehena Sultana, Azriel Nicol Chang, Hon Sen Tan, Ban Leong Sng
BACKGROUND: COVID-19 pandemic could bring great impact upon the psychological statuses of post-partum women, but no clear evidence was provided yet as to COVID-19 would also affect their pain profile during post-partum period. We determined if pain and psychological vulnerabilities, obstetric factors, and labor analgesia were associated with sub-acute pain after childbirth (SAPC; ongoing pain related to delivery at post-partum 4 weeks or more) during COVID-19 pandemic. METHODS: We included women having a singleton pregnancy of ≥36 gestational weeks...
March 30, 2024: Heliyon
https://read.qxmd.com/read/38499754/late-preterm-antenatal-steroid-use-and-infant-outcomes-in-a-single-center
#33
JOURNAL ARTICLE
Mitzi Go, Madison Wahl, Tova Kruss, Cindy T McEvoy
OBJECTIVE: To characterize late preterm antenatal steroids (AS) use and associated neonatal outcomes in a single academic center. STUDY DESIGN: Retrospective study of 503 singleton, mother-infant dyads delivered between 34 0/7 and 36 6/7 weeks gestation between January 1, 2016 and December 31, 2020. RESULTS: Forty-three percent did not receive AS (No AS) prior to delivery. Among AS treated, 50% were sub-optimal dosing. No AS had higher preterm premature rupture of membranes and maternal diabetes...
March 18, 2024: Journal of Perinatology: Official Journal of the California Perinatal Association
https://read.qxmd.com/read/38492714/systemic-lupus-erythematosus-is-associated-with-an-increased-frequency-of-spontaneous-preterm-births-systematic-review-and-meta-analysis
#34
REVIEW
Carolien N H Abheiden, Birgit S Blomjous, Ciska Slaager, Anadeijda J E M C Landman, Johannes C F Ket, Jane E Salmon, Jill P Buyon, Martijn W Heymans, Johanna I P DE Vries, Irene E M Bultink, Marjon A DE Boer
OBJECTIVE: Preterm birth (PTB) is one of the most frequent complications of pregnancies in women with systemic lupus erythematosus (SLE). The high indicated PTB proportion due to hypertensive disorders of pregnancy and/or fetal growth restriction is well known, and preventive measures as well as screening for early detection are performed. The risk of spontaneous PTB is less well recognized. The purpose of this study is to determine the proportions of spontaneous and indicated PTB in pregnancies of women with SLE DATA SOURCES: A systematic literature search using Pubmed, Embase, Web of Science and Google Scholar was performed in June 2021 STUDY ELIGIBILITY CRITERIA: Studies in pregnant women with SLE reporting spontaneous and indicated PTB rates were selected...
March 14, 2024: American Journal of Obstetrics and Gynecology
https://read.qxmd.com/read/38487473/developing-and-evaluating-a-predictive-model-for-neonatal-hyperbilirubinemia-based-on-ugt1a1-gene-polymorphism-and-clinical-risk-factors
#35
JOURNAL ARTICLE
Zhaoyang Cui, Wensheng Shen, Xuetong Sun, Yan Li, Ying Liu, Zhiyong Sun
BACKGROUND: Neonatal hyperbilirubinemia (NHB) is one of the most common diseases in the neonatal period. Without timely diagnosis and treatment, it can lead to long-term complications. In severe cases, it may even result in fatality. The UGT1A1 gene and clinical risk factors play important roles in the development and progression of NHB. METHODS: In this study, we conducted a cohort study and analyzed 3258 newborns from the Jilin Women And Children Health Hospital in northern China, including 372 children with hyperbilirubinemia...
2024: Frontiers in Pediatrics
https://read.qxmd.com/read/38486117/visual-outcomes-and-complications-of-combined-versus-sequential-pars-plana-vitrectomy-and-phacoemulsification-for-epiretinal-membrane
#36
JOURNAL ARTICLE
Yousef A Fouad, Mohamed K Soliman, Abdelrahman M Elhusseiny, Yit C Yang, Ahmed B Sallam
BACKGROUND: Symptomatic epiretinal membrane (ERM) often requires surgical intervention via pars plana vitrectomy (PPV), for which cataract development is a common complication. There is insufficient data on the visual outcomes and complications of combined phacovitrectomy (COMB) in comparison to sequential PPV with deferred cataract surgery (SEQ) for ERM. METHODS: A retrospective dataset analysis of 8 National Health Service ophthalmology departments. The main outcome measures were postoperative visual acuity (VA), operative complications, postoperative cystoid macular oedema (CMO) and recurrent ERM...
March 14, 2024: Eye
https://read.qxmd.com/read/38484186/a-bioinspired-immunostimulatory-system-for-inducing-powerful-antitumor-immune-function-by-directly-causing-plasma-membrane-rupture
#37
JOURNAL ARTICLE
Xiaoqu Hu, Hao Yin, Danli Xie, Tanzhou Chen, Yida Li, Hanqian Zeng, Mingdong Lu, Qinyang Wang
The Gasdermin protein is a membrane disruptor that can mediate immunogenic pyroptosis and elicit anti-tumor immune function. However, cancer cells downregulate Gasdermin and develop membrane repair mechanisms to resist pyroptosis. Therefore, an artificial membrane disruptor (AMD) that can directly mediate membrane rupture in pyroptosis-deficient cells and induce antitumor immune responses in a controllable manner will be valuable in preclinical and clinical research. A micron-scale Ce6-based AMD that can directly induce plasma membrane rupture (PMR) in gasdermin-deficient tumor cells is established...
March 14, 2024: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
https://read.qxmd.com/read/38482328/risk-factors-and-etiology-of-early-onset-neonatal-sepsis-in-northeastern-part-of-india-case-control-study
#38
JOURNAL ARTICLE
Sudesh Kumar, Piyali Bhattacharya, Simranjit Kaur, Prajna Ray, Nandita Chattopadhyay
BACKGROUND: Sepsis, the second most common cause of neonatal mortality, causes more than one million deaths annually. India has the highest incidence of clinical sepsis (17000/100000 live birth). OBJECTIVE: This study aimed to determine the risk factors and organisms of early-onset neonatal sepsis (EONS) in a tertiary care hospital in Northeast India. MATERIALS AND METHODS: It was a case-control study conducted in the neonatal unit of MGM Medical College, Kishanganj, Bihar, from January 2022 to April 2023...
January 2024: Journal of Family Medicine and Primary Care
https://read.qxmd.com/read/38480902/dysregulated-creb3-cleavage-at-the-nuclear-membrane-induces-karyoptosis-mediated-cell-death
#39
JOURNAL ARTICLE
Ga-Eun Lee, Geul Bang, Jiin Byun, Cheol-Jung Lee, Weidong Chen, Dohyun Jeung, Hyun-Jung An, Han Chang Kang, Joo Young Lee, Hye Suk Lee, Young-Soo Hong, Dae Joon Kim, Megan Keniry, Jin Young Kim, Jin-Sung Choi, Manolis Fanto, Sung-Jun Cho, Kwang-Dong Kim, Yong-Yeon Cho
Cancer cells often exhibit resistance to apoptotic cell death, but they may be vulnerable to other types of cell death. Elucidating additional mechanisms that govern cancer cell death is crucial for developing new therapies. Our research identified cyclic AMP-responsive element-binding protein 3 (CREB3) as a crucial regulator and initiator of a unique cell death mechanism known as karyoptosis. This process is characterized by nuclear shrinkage, deformation, and the loss of nuclear components following nuclear membrane rupture...
March 13, 2024: Experimental & Molecular Medicine
https://read.qxmd.com/read/38480588/photon-counting-ct-of-degenerative-changes-and-rupture-of-silicone-breast-implants-a-pilot-study
#40
JOURNAL ARTICLE
Claudia Neubauer, Oliver Gebler, Caroline Wilpert, Maxim Scherwitz, Niklas Efinger, Fabian Bamberg, Marisa Windfuhr-Blum, Jakob Neubauer
BACKGROUND: Accurate assessment of breast implants is important for appropriate clinical management. We evaluated silicone properties and diagnostic accuracy for characterizing silicone implants and detecting degenerative changes including rupture in photon-counting computed tomography (PCCT). METHODS: Over 16 months, we prospectively included patients with silicone implants and available breast magnetic resonance imaging (MRI) who received thoracic PCCT performed in prone position...
March 14, 2024: European Radiology Experimental
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