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Preterm pregnancy

Jimmy K Limdi, Jennifer Farraye, Rachel Cannon, Elisabeth Woodhams, Francis A Farraye
The peak incidence of the inflammatory bowel diseases (IBDs) is between the second and fourth decades of life, which coincides with prime reproductive years. Unplanned or mistimed pregnancies may account for nearly half of all pregnancies and are associated with adverse consequences such as a higher risk of delayed preconceptual care, increased risk of preterm birth, low birth weight, and adverse maternal and neonatal outcomes. Increased IBD activity during pregnancy is also associated with adverse pregnancy-related outcomes, such as miscarriage, intrauterine growth retardation, and preterm birth...
March 16, 2019: Inflammatory Bowel Diseases
Ali Ovayolu, Gamze Ovayolu, Erbil Karaman, Tuncay Yuce, Abdulkadir Turgut, Nuray Bostancıeri
Objectives To evaluate the maternal serum endocan levels in pregnant women complicated by preterm premature rupture of membranes (PPROM) and to compare the results with healthy pregnancies. Methods This cohort study included 31 pregnant women with PPROM and 34 gestational age-matched healthy subjects in the third trimester of pregnancy. The blood for analysis was obtained on the day of diagnosis and serum endocan levels were measured using a commercially available enzyme-linked immunosorbent assay (ELISA) kit...
March 15, 2019: Journal of Perinatal Medicine
Selen Gürsoy Erzincan, N Cenk Sayin, Selcuk Korkmaz, Havva Sutcu, Cihan Inan, Isil Uzun Cilingir, Fusun G Varol
OBJECTIVE: To investigate whether myometrial thickness (MT) to cervical length (CL) ratio could be used in the prediction of preterm birth (PTB) in singleton pregnancies presented with threatened preterm labor (TPL). METHODS: After 48 h of successful tocolysis, MT was measured transabdominally from the fundal, mid-anterior walls and the lower uterine segment (LUS) in 46 pregnancies presented with TPL. MT measurements were divided into CL, individually. The main outcome was PTB before 37 weeks of gestation...
March 14, 2019: Archives of Gynecology and Obstetrics
Sara Milena Ramos Jaraba, Isabel C Garcés-Palacio
To explore the association between low birth weight and preterm birth with violence during pregnancy, we conducted a cross-sectional study by using the 2010 Colombian Demographic and Health Survey. We conducted bivariate analyses, binomial logistic regression, and stratified models by age, and 14,520 women were included. There was no association between violence and low birth weight. Nonetheless, an association with preterm birth in women aged over 35 was observed (OR 1.98, 95%CI 1.23, 3.17). Prenatal care appeared to be a protective factor for both outcomes...
March 15, 2019: Health Care for Women International
Emily C Keats, Batool A Haider, Emily Tam, Zulfiqar A Bhutta
BACKGROUND: Multiple-micronutrient (MMN) deficiencies often coexist among women of reproductive age in low- and middle-income countries. They are exacerbated in pregnancy due to the increased demands of the developing fetus, leading to potentially adverse effects on the mother and baby. A consensus is yet to be reached regarding the replacement of iron and folic acid supplementation with MMNs. Since the last update of this Cochrane Review in 2017, evidence from several trials has become available...
March 14, 2019: Cochrane Database of Systematic Reviews
Aireen Wingert, Jennifer Pillay, Meghan Sebastianski, Michelle Gates, Robin Featherstone, Kassi Shave, Ben Vandermeer, Lisa Hartling
OBJECTIVE: To systematically review screening and treatment effectiveness, and patient preferences, to inform recommendations by the Canadian Task Force on Preventive Health Care on screening for asymptomatic bacteriuria in pregnancy. DESIGN: We searched multiple databases (inception to September 2017) and grey literature sources for studies on screening effectiveness and patient preferences. For treatment with antibiotics, we searched three databases for systematic reviews and obtained search results of the Cochrane Pregnancy and Childbirth Group's Trials Register to update a Cochrane review...
March 13, 2019: BMJ Open
Yinghui Zhang, Jie Zhou, Yubo Ma, Li Liu, Qing Xia, Dazhi Fan, Wen Ai
Preterm birth continues to be an important problem in modern obstetrics and a large public health concern and is related to increased risk for neonatal morbidity and mortality. The aim of this study was to evaluate the data in the literature to determine the relationships between mode of delivery (cesarean section and vaginal birth) in the first pregnancy and the risk of subsequent preterm birth from a multi-year population based cohorts (PROSPERO registration number: 42018090788). Five electronic databases were searched...
2019: PloS One
Yajie Wang, Minzhi Wu, Xiangdong Gong, Liang Zhao, Jing Zhao, Chuanwu Zhu, Chancong Gong
Mother-to-child transmission of syphilis remains a major global public health issue, and elimination of congenital syphilis is one of the millennium development goals of the World Health Organization (1). In 2012, an estimated 930,000 maternal syphilis infections caused 350,000 adverse pregnancy outcomes, including 143,000 early fetal deaths and stillbirths, 62,000 neonatal deaths, 44,000 preterm or low-weight births, and 102,000 infected infants worldwide (2). In China, the number of congenital syphilis cases reported annually increased from 468 in 2000 to 10,032 in 2013; the corresponding national congenital syphilis incidence rate increased nearly 26-fold, from 2...
March 15, 2019: MMWR. Morbidity and Mortality Weekly Report
Vasilios Pergialiotis, Paraskevi Kotrogianni, Diamanto Koutaki, Evangelos Christopoulos-Timogiannakis, Nikolaos Papantoniou, Georgios Daskalakis
AbstractPurpose: To evaluate the potential association of abnormal cord coiling with adverse pregnancy outcomes. MATERIALS AND METHODS: We used the Medline (1966-2018), Scopus (2004-2018), (2008-2018), Embase (1980-2018), Cochrane Central Register of Controlled Trials CENTRAL (1999-2018) and Google Scholar (2004-2018) databases. The date of last search was set at 31 May 2018. Language, country or date restrictions were not applied during the literature research to prevent bias...
March 14, 2019: Journal of Maternal-fetal & Neonatal Medicine
M Yang, Y Wang, Y Chen, Y Zhou, Q Jiang
Globally, human immune deficiency virus (HIV)/acquired immune deficiency syndrome (AIDS) continues to be a major public health issue. With improved survival, the number of people living with HIV/AIDS is increasing, with over 2 million among pregnant women. Investigating adverse pregnant outcomes of HIV-infected population and associated factors are of great importance to maternal and infant health. A cross-sectional data collected from hospital delivery records of 4397 mother-infant pairs in southwestern China were analysed...
January 2019: Epidemiology and Infection
Arielle M Schreck, Hana F Mikdachi
Mucinous cystadenomas of the ovary are benign epithelial neoplasms that can grow rapidly during pregnancy. They may cause ovarian torsion, virilization, inferior vena cava syndrome, and even preterm labor and fetal growth restriction. Various theories exist regarding the pathogenesis of these tumors. One hypothesis suggests that they may arise from teratomas. Our case report describes synchronous mucinous cystadenomas and ovarian teratomas, as well as metachronous mucinous cystadenomas in patients with a history of ovarian teratoma...
January 3, 2019: Curēus
Gunilla Sydsjö, Malin Lindell Pettersson, Marie Bladh, Agneta Skoog Svanberg, Claudia Lampic, Elizabeth Nedstrand
BACKGROUND: Women of advanced age (40 years or older) are generally, at risk for pregnancy and delivery related problems. In addition, there is limited knowledge on being of advanced age and having been given Assisted Reproductive Treatment (ART) and its association with negative obstetric outcomes. Therefore, data from the Swedish Medical Birth Register was used to investigate pregnancy and neonatal outcomes for women aged 40 or more who had given birth. The secondary aim was to compare the obstetric outcomes of women who had used ART and women who had not undergone ART while adjusting for marital status across the age groups...
March 13, 2019: BMC Pregnancy and Childbirth
Ahmed M Maged, Amira Y Shoab, Eman A Hussein, Ahmed H Alsawaf, Doaa S Mahmoud, Ameer A AbdAllah, Sherif Dahab, Mohamed Darwish, Yahia Z Ali, Haitham Badran
OBJECTIVE:  To evaluate the effect of vaginal progesterone (P) administration during the second and third trimesters of pregnancy on Doppler velocimetry of uterine, umbilical, and middle cerebral vessels. STUDY DESIGN:  A prospective cohort study conducted on 80 women at risk for preterm labor. Uterine artery, umbilical artery, and middle cerebral artery (MCA) Doppler indices were measured before and after 1 week of administration of 200 mg twice daily vaginal P...
March 13, 2019: American Journal of Perinatology
Olivia J Carpinello, Alan H DeCherney, Micah J Hill
Since Barker's publication of "The fetal and infant origins of adult disease" in 1990, significant emphasis has been placed on the intrauterine environment and its effect on adult disease. Historical events such as the Dutch Famine and the 1918 Flu Pandemic have provided organic data about the epigenetic changes that can result from famine, infection, and stress. Mechanisms that allow for intrauterine survival may predispose to adult disease states when the fetus enters a world of abundance. As the field of in vitro fertilization (IVF) has developed and evolved, little attention has been paid to subtle yet significant differences in IVF offspring...
May 2018: Seminars in Reproductive Medicine
Naomi Cano Ibañez, Juan Miguel Martinez Galiano, Carmen Amezcua Prieto, Rocio Olmedo Requena, Aurora Bueno Cavanillas, Miguel Delgado Rodríguez
INTRODUCTION: Different diets during pregnancy might have an impact on the health as reflected by the birthweight of the newborn. The consumption of meat and meat products during pregnancy and its relationship with the newborn health status have been studied by several authors. The studies carried out show inconsistent results Objective: To analyse the association between maternal dietary intake of meat and meat products on the risk a newborn SGA. Methods: A matched case-control study of 518 cases and controls of pregnant women was performed in Spain...
October 25, 2018: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
Peter von Dadelszen
Sovio and Smith (BJOG 2019 xxxx) are to be congratulated for completing this important phase in the life of an outcome prediction/risk stratification model in attempting to convert the competing risks model (Akolekar et al. Fetal Diagn Ther 2013;33:8-15) used in the ASPRE trial (Rolnick et al. New Engl J Med 2017;377:613-622) into a risk score. The risk score was derived from the beta-co-efficients of the individual components of the competing risks model and tested in the Pregnancy Outcome Prediction (POP) study cohort and compared with the use of all competing risks variables as continuous variables, when relevant...
March 13, 2019: BJOG: An International Journal of Obstetrics and Gynaecology
Hyun Soo Park, Hayan Kwon, Dong Wook Kwak, Moon Young Kim, Hyun-Joo Seol, Joon-Seok Hong, Jae-Yoon Shim, Sae-Kyung Choi, Han-Sung Hwang, Min Jeong Oh, Geum Joon Cho, Kunwoo Kim, Soo-Young Oh
Background: We investigated whether there is a difference in elastographic parameters between pregnancies with and without spontaneous preterm delivery (sPTD) in women with a short cervix (≤ 25 mm), and examined the ability of elastographic parameters to predict sPTD in those women. Methods: E-CervixTM (WS80A; Samsung Medison, Seoul, Korea) elastography was used to examine the cervical strain. Elastographic parameters were compared between pregnancies with and without sPTD...
March 11, 2019: Journal of Korean Medical Science
Jing Wang, Qing-Wen Zhu, Xiao-Yan Cheng, Jiang-Yue Liu, Lin-Li Zhang, Yu-Mei Tao, Yu-Bao Cui, Ye Wei
OBJECTIVE: Abnormal changes in immune-mediated inflammation contribute to the pathogenesis of preeclampsia (PE). We aim to investigate the value of systemic immune inflammation indices-neutrophil-lymphocyte ratio (NLR) and monocyte-lymphocyte ratio (MLR)-to identify and evaluate the prognosis of patients with PE. METHODS: This study reviewed clinical records of 367 PE patients (162 with mild PE and 205 with severe PE), in addition to a control group of 172 normal pregnancies...
March 6, 2019: Journal of Reproductive Immunology
Archana B Patel, Kunal Kurhe, Amber Prakash, Savita Bhargav, Suchita Parepalli, Elizabeth V Fogleman, Janet L Moore, Dennis D Wallace, Hemant Kulkarni, Patricia L Hibberd
BACKGROUND: Although rates of preterm birth continue to increase globally, identification of preterm from low birth weight infants remains a challenge. The burden of low birth weight vs preterm is greatest in resource-limited settings, where gestational age (GA) prior to delivery is frequently not known because ultrasound in early pregnancy is not available and estimates of the date of the mother's last menstrual period (LMP) may not be reliable. An alternative option is to assess GA at birth to optimize referral and care of preterm newborns...
March 12, 2019: JMIR Research Protocols
Brikene Elshani, Vjosa Kotori, Armond Daci
ω-3-polyunsaturated fatty acids (ω-3 PUFAs) are widely used during pregnancy and gestational diabetes mellitus (GDM). ω-3 PUFAs are beneficial in the regulation of maternal and fetal metabolic function, inflammation, immunity, macrosomia (MAC), oxidative stress, preeclampsia, intrauterine growth, preterm birth, offspring metabolic function, and neurodevelopment. Dietary counseling is vital for improving therapeutic outcomes in patients with GDM. In maternal circulation, ω-3 PUFAs are transported via transporters, synthesis enzymes, and intracellular proteins, which activate nuclear receptors and play central roles in the cellular metabolic processes of placental trophoblasts...
March 11, 2019: Journal of Maternal-fetal & Neonatal Medicine
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