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Post traumatic migraine

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https://read.qxmd.com/read/30773988/diagnostic-algorithms-to-study-post-concussion-syndrome-using-electronic-health-records-validating-a-method-to-capture-an-important-patient-population
#1
Jessica Dennis, Aaron Michael Yengo-Kahn, Paul Kirby, Gary S Solomon, Nancy J Cox, Scott L Zuckerman
Post-concussion syndrome (PCS) is characterized by persistent cognitive, somatic, and emotional symptoms after a mild traumatic brain injury (mTBI). Genetic and other biological variables may contribute to PCS etiology, and the emergence of biobanks linked to electronic health records (EHR) offers new opportunities for research on PCS. We sought to validate the use of EHR data of PCS patients by comparing two diagnostic algorithms deployed in the Vanderbilt University Medical Center de-identified database of 2...
February 16, 2019: Journal of Neurotrauma
https://read.qxmd.com/read/30690565/management-of-chronic-migraine-and-occipital-neuralgia-in-post-9-11-combat-veterans
#2
Karen A Williams, Robin M Lawson, Osvaldo H Perurena, John D Coppin
Introduction: The rate of chronic migraine (CM) has been shown to be 20% or greater in the post 9/11 combat veteran population with a history of traumatic brain injury, while the rate is much lower at 3-5% in the general population. Studies have shown that medications such as oral topiramate or intramuscular injections of onabotulinum toxin A (Botox) have been used for CM prevention, and occipital blocks have been shown to be helpful in treating occipital neuralgia and short-term relief of CM...
January 23, 2019: Military Medicine
https://read.qxmd.com/read/30592252/valproic-acid-and-epilepsy-from-molecular-mechanisms-to-clinical-evidences
#3
Michele Romoli, Petra Mazzocchetti, Renato D'Alonzo, Sabrina Siliquini, Victoria Elisa Rinaldi, Alberto Verrotti, Paolo Calabresi, Cinzia Costa
After more than a century from its discovery, valproic acid (VPA) still represents one of the most efficient antiepileptic drugs (AEDs). Pre and post-synaptic effects of VPA depend on a very broad spectrum of actions, including the regulation of ionic currents and the facilitation of GABAergic over glutamatergic transmission. As a result, VPA indirectly modulates neurotransmitter release and strengthens the threshold for seizure activity. However, even though participating to the anticonvulsant action, such mechanisms seem to have minor impact on epileptogenesis...
December 27, 2018: Current Neuropharmacology
https://read.qxmd.com/read/30553828/delta-opioid-receptor-agonists-are-effective-for-multiple-types-of-headache-disorders
#4
Laura S Moye, Alycia F Tipton, Isaac Dripps, Zoie Sheets, Aimee Crombie, Jonathan D Violin, Amynah A Pradhan
Headaches are highly disabling and are among the most common neurological disorders worldwide. Despite the high prevalence of headache, therapeutic options are limited. We recently identified the delta opioid receptor (DOR) as an emerging therapeutic target for migraine. In this study, we examined the effectiveness of a hallmark DOR agonist, SNC80, in disease models reflecting diverse headache disorders including: chronic migraine, post-traumatic headache (PTH), medication overuse headache by triptans (MOH), and opioid-induced hyperalgesia (OIH)...
December 13, 2018: Neuropharmacology
https://read.qxmd.com/read/30509333/narrative-review-of-the-pathophysiology-of-headaches-and-photosensitivity-in-mild-traumatic-brain-injury-and-concussion
#5
Christopher Mares, Jehane H Dagher, Mona Harissi-Dagher
The most common symptom of post-concussive syndrome (PCS) is post-traumatic headache (PTH) accompanied by photophobia. Post-traumatic headache is currently categorized as a secondary headache disorder with a clinical phenotype described by its main features and resembling one of the primary headache disorders: tension, migraine, migraine-like cluster. Although PTH is often treated with medication used for primary headache disorders, the underlying mechanism for PTH has yet to be elucidated. The goal of this narrative literature review is to determine the current level of knowledge of these PTHs and photophobia in mild traumatic brain injury (mTBI) in order to guide further research and attempt to discover the underlying mechanism to both symptoms...
December 4, 2018: Canadian Journal of Neurological Sciences. le Journal Canadien des Sciences Neurologiques
https://read.qxmd.com/read/30466384/lifestyle-modifications-as-therapy-for-medication-refractory-post-traumatic-headache-ptha-in-the-military-population-of-okinawa
#6
Virginia B Baker, Kathryn M Eliasen, Nawaz K Hack
OBJECTIVE: Our aim was 1) to reduce disability, as characterized by headache frequency, duration and severity in patients with post-traumatic headache (PTHA), 2) to reduce the number of medical boards and work limitations in patients with post traumatic headache, and 3) to reduce use of medical resources and clinic visits related to headache or migraine. BACKGROUND: Modifiable risk factors for PTHA include stressful life event, sleep disturbances, and medication overuse...
November 22, 2018: Journal of Headache and Pain
https://read.qxmd.com/read/30409039/post-traumatic-headache-pth-in-a-cohort-of-uk-compensation-claimants
#7
Russell Lane, Paul Davies
AIM: To explore post traumatic headache characteristics and risk factors in compensation claimants by observational retrospective cohort analysis. CASE RESULTS: Medicolegal reports on 116 consecutive compensation claimants aged 41.9 ± 15.0 years were reviewed 21 ± 14 months after injury. Eighty eight had suffered head and neck injuries, 21 reported only neck injury and seven had "other injuries". Ninety four percent of the head injuries were "mild"...
November 8, 2018: Cephalalgia: An International Journal of Headache
https://read.qxmd.com/read/30406901/fremanezumab-first-global-approval
#8
Sheridan M Hoy
Fremanezumab-vfrm (hereafter referred to as fremanezumab) [AJOVY™] is a fully humanized monoclonal antibody (IgG2Δa) developed by Teva Pharmaceuticals to selectively target calcitonin gene-related peptide (a vasodilatory neuropeptide involved in the pathophysiology of migraine). Its use has been associated with significant reductions in migraine frequency, the requirement for acute headache medication use and headache-related disability compared with placebo in multinational, phase III studies, and in September 2018 fremanezumab was approved by the US FDA for the preventive treatment of migraine in adults...
November 2018: Drugs
https://read.qxmd.com/read/30291550/a-short-review-of-the-treatment-of-headaches-using-osteopathic-manipulative-treatment
#9
REVIEW
John Whalen, Sheldon Yao, Adena Leder
PURPOSE OF REVIEW: This review highlights the importance of osteopathic manipulative treatment (OMT) in headache sufferers. OMT is a viable option for patients who either do not wish to use pharmaceuticals or who have contraindications to pharmaceuticals. Patients with headaches that are refractory to other treatment options may also be candidates for OMT. Multiple headache etiologies are amenable to this non-invasive treatment option and they will be reviewed here. Although there are advantages to using this treatment method, there are also shortcomings in the literature, which will be discussed...
October 5, 2018: Current Pain and Headache Reports
https://read.qxmd.com/read/30217120/tracking-patients-with-chronic-occipital-headache-after-occipital-nerve-decompression-surgery-a-case-series
#10
Pamela Blake, Rony-Reuven Nir, Carlton J Perry, Rami Burstein
Background The therapeutic benefit of nerve decompression surgeries for chronic headache/migraine are controversial. Aim To provide clinical characteristics of headache type and treatment outcome of occipital nerve decompression surgery. Methods A retrospective review of clinical records. Inclusion criteria were evidence of chronic occipital headache with and without migrainous features and tenderness of neck muscles, occipital allodynia, and inadequate response to prophylactic drugs. Results Surgical decompression of the greater and lesser occipital nerves provided complete and extended (3-6 years) relief of new daily persistent headache in case 3 (46 year old female), and of chronic post-traumatic headache in cases 4 and 6 (35 and 30 year old females, respectively), partial relief of chronic headache/migraine in cases 1 and 2 (41 year old female and 36 year old male), and no relief of episodic (cases 3 and 4) or chronic migraine (case 5, 52 year old male), or chronic tension-type headache (case 7, 31 year old male)...
September 14, 2018: Cephalalgia: An International Journal of Headache
https://read.qxmd.com/read/30175635/applications-of-carbonic-anhydrases-inhibitors-in-renal-and-central-nervous-system-diseases
#11
REVIEW
Claudiu T Supuran
There are tissues and organs, among which kidneys and the central nervous system (CNS), rich in various isoforms of the metalloenzyme carbonic anhydrase (CA, EC 4.2.1.1). Their role is to regulate pH, to provide bicarbonate or H+ ions for electrolyte secretion and possibly a metabolic one. Considering these two systems, CA inhibitors are clinically used mainly as diuretics and antiepileptics, but novel applications in the management of drug-induced renal injury, sleep apnea, migraine, lowering intracranial pressure, cognitive impairment, neuropathic pain, and cerebral ischemia have emerged...
October 2018: Expert Opinion on Therapeutic Patents
https://read.qxmd.com/read/30116914/psychological-distress-neuroticism-and-disability-associated-with-secondary-chronic-headache-in-the-general-population-the-akershus-study-of-chronic-headache
#12
Espen Saxhaug Kristoffersen, Kjersti Aaseth, Ragnhild Berling Grande, Christofer Lundqvist, Michael Bjørn Russell
BACKGROUND: Primary headaches are associated with psychological distress, neuroticism and disability. However, little is known about headache-related disability and psychological distress among people with secondary chronic headaches. METHODS: 30,000 persons aged 30-44 from the general population was screened for headache by a questionnaire. The responder rate was 71%. The International Classification of Headache Disorders with supplementary definitions for chronic rhinosinusitis and cervicogenic headache were used...
August 3, 2018: Journal of Headache and Pain
https://read.qxmd.com/read/30080968/on-chip-studies-of-magnetic-stimulation-effect-on-single-neural-cell-viability-and-proliferation-on-glass-and-nanoporous-surfaces
#13
Xiangchen Che, Joseph Boldrey, Xiaojing Zhong, Shalini Unnikandam-Veettil, Ian Schneider, David Jiles, Long Que
Transcranial magnetic stimulation (TMS) is a noninvasive neuromodulation technique, an FDA-approved treatment method for various neurological disorders such as depressive disorder, Parkinson's disease, post-traumatic stress disorder, and migraine. However, information concerning the molecular/cellular-level mechanisms of neurons under magnetic simulation (MS), particularly at the single neural cell level, is still lacking, resulting in very little knowledge of the effects of MS on neural cells. In this paper, the effects of MS on the behaviors of neural cell N27 at the single-cell level on coverslip glass substrate and anodic aluminum oxide (AAO) nanoporous substrate are reported for the first time...
August 29, 2018: ACS Applied Materials & Interfaces
https://read.qxmd.com/read/29971194/conditions-associated-with-essential-tremor-in-veterans-a-potential-role-for-chronic-stress
#14
Adrian Handforth, Gail A Parker
Background: Increased depression, hearing loss, dementia, alcoholism, and mortality in essential tremor patients remain unexplained. We investigated whether conditions associated with tremor are linked to chronic stress. Methods: The FY2013 Veterans Affairs database was queried for 38 selected dual diagnosis combinations in 5,854,223 veterans aged 21-95 years. Results: Post-traumatic stress disorder, anxiety, and depression were the most common psychiatric diagnoses in tremor patients, with the odds ratio exceeding 2 in all 15-year cohorts...
2018: Tremor and Other Hyperkinetic Movements
https://read.qxmd.com/read/29927799/central-visual-oscillopsia-case-report-and-review-of-the-literature
#15
Wallace Jones, William Silkworth, Nathaniel Dusto, Victoria S Pelak, Jean Berliner, Isabelle Buard, Benzi Kluger
Here we present a patient with persistent central visual oscillopsia, review the literature on this condition, and report results from an experimental intervention using repetitive transcranial magnetic stimulation. A 57-year-old man reported persistent visual oscillopsia after a traumatic brain injury suffered 20 years earlier. Symptoms were presumed to be of cortical origin given his normal eye movements, eye stability, and peripheral vestibular function. Furthermore, he reported oscillopsia with visual imagery during eye closure...
June 2018: Cognitive and Behavioral Neurology: Official Journal of the Society for Behavioral and Cognitive Neurology
https://read.qxmd.com/read/29771142/the-development-of-a-mouse-model-of-mtbi-induced-post-traumatic-migraine-and-identification-of-the-delta-opioid-receptor-as-a-novel-therapeutic-target
#16
Laura S Moye, Madeline L Novack, Alycia F Tipton, Harish Krishnan, Subhash C Pandey, Amynah Aa Pradhan
Background Post-traumatic headache is the most common and long-lasting impairment observed following mild traumatic brain injury, and frequently has migraine-like characteristics. The mechanisms underlying progression from mild traumatic brain injury to post-traumatic headache are not fully understood. The aim of this study was to develop a mouse model of post-traumatic headache and identify mechanisms and novel targets associated with this disorder. Methods We combined the closed head weight-drop method and the nitroglycerin chronic migraine model...
January 1, 2018: Cephalalgia: An International Journal of Headache
https://read.qxmd.com/read/29580567/association-of-depression-anxiety-and-post-traumatic-stress-disorder-with-migraine-data-from-kosovo
#17
Nexhmedin Shala, Shemsedin Dreshaj
INTRODUCTION: Migraine is ranked as the seventh leading cause of disability worldwide, and it is characterized by a manifestation of combined neurological, gastrointestinal, and autonomic symptoms linked with different provoking factors. AIM OF THE STUDY: This study investigates the association between migraine and PTSD, depression and anxiety in the Kosovo population during the post-war period. MATERIAL AND METHODS: 273 war survivors with headache were enrolled in the study and were divided into two groups: 153 individuals with confirmed migraine (the study group) and 120 individuals with non-migraine headaches (control group)...
August 2018: Neurologia i Neurochirurgia Polska
https://read.qxmd.com/read/29557322/is-concussion-a-risk-factor-for-epilepsy
#18
Richard Wennberg, Carmen Hiploylee, Peter Tai, Charles H Tator
BACKGROUND: Epidemiologic studies have suggested that concussion, or mild traumatic brain injury (mTBI), is associated with a twofold or greater increase in relative risk for the development of post-traumatic epilepsy. To assess the clinical validity of these findings, we analyzed the incidence of epilepsy in a large cohort of post-concussion patients in whom concussion was strictly defined according to international guidelines. METHODS: A retrospective cohort study of 330 consecutive post-concussion patients followed by a single concussion specialist...
May 2018: Canadian Journal of Neurological Sciences. le Journal Canadien des Sciences Neurologiques
https://read.qxmd.com/read/29522121/clinical-criteria-of-central-sensitization-in-chronic-pelvic-and-perineal-pain-convergences-pp-criteria-elaboration-of-a-clinical-evaluation-tool-based-on-formal-expert-consensus
#19
Amélie Levesque, Thibault Riant, Stéphane Ploteau, Jérôme Rigaud, Jean-Jacques Labat
Background: The evaluation of chronic pelvic and perineal pain (CPP) is often complex. The patient's description of the pain often appears to be disproportionate to the limited findings on physical examination and/or complementary investigations. The concept of central sensitization may allow better understanding and management of patients with CPP. Objective: The aim of this study was to elaborate a clinical evaluation tool designed to simply identify sensitization in pelvic pain...
October 1, 2018: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://read.qxmd.com/read/29503607/effect-of-somatic-experiencing-resiliency-based-trauma-treatment-training-on-quality-of-life-and-psychological-health-as-potential-markers-of-resilience-in-treating-professionals
#20
Neal E Winblad, Michael Changaris, Phyllis K Stein
Background: Individuals who treat trauma are at significant risk of vicarious traumatization and burnout. Somatic Experiencing® (SE®) is a resiliency-focused trauma treatment modality designed to address autonomic nervous system (ANS) dysregulation and its impacted physical health and mental health symptoms e.g., anxiety, depression, post-traumatic stress disorder, migraines, fibromyalgia, and chronic fatigue, etc. The SE® training supports the development of clinical skills to reduce physical health/mental health symptoms as well as increase clinician resilience...
2018: Frontiers in Neuroscience
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