keyword
https://read.qxmd.com/read/38518177/guidelines-of-the-international-headache-society-for-controlled-trials-of-pharmacological-preventive-treatment-for-persistent-post-traumatic-headache-attributed-to-mild-traumatic-brain-injury
#1
JOURNAL ARTICLE
Håkan Ashina, Hans-Christoph Diener, Cristina Tassorelli, Ann I Scher, Richard B Lipton, Patricia Pozo-Rosich, Alexandra J Sinclair, Catherine D Chong, Alan G Finkel, Messoud Ashina, Todd J Schwedt, David W Dodick, Gisela M Terwindt
BACKGROUND: Persistent headache attributed to traumatic injury to the head is divided into two subtypes, one attributed to moderate or severe traumatic injury and another attributed to mild traumatic injury (i.e., concussion). The latter is much more prevalent, in part because more than 90% of cases with traumatic brain injury are classified as mild. The pathophysiology of persistent post-traumatic headache is poorly understood and the underlying mechanisms are likely multifactorial. There is currently no approved treatment specifically for persistent post-traumatic headache, and management strategies rely on medications used for migraine or tension-type headache...
March 2024: Cephalalgia: An International Journal of Headache
https://read.qxmd.com/read/38465501/a-narrative-review-of-risk-factors-and-predictors-for-poor-outcome-and-prolonged-recovery-after-a-mild-traumatic-brain-injury
#2
REVIEW
Ioannis Mavroudis, Ioana-Miruna Balmus, Alin Ciobica, Mihai Hogas
Mild traumatic brain injuries (mTBI) are often caused by a blow to the head or a sudden jolt resulting in a wide range of physical, cognitive, and emotional temporary symptoms. Mild TBI diagnosis can be challenging and most commonly followed by post-concussion syndrome (PCS). When the symptoms are present for more than 3 months, prolonged post-concussive syndrome (PPCS) can be suspected. This review aims to identify and summarize the current status of the knowledge regarding the risk factors and predictors of the recovery from PCS and PPCS...
March 13, 2024: International Journal of Neuroscience
https://read.qxmd.com/read/38457314/do-preinjury-life-events-moderate-the-outcomes-of-mild-traumatic-brain-injuries-in-children-an-a-cap-study
#3
JOURNAL ARTICLE
Safira Dharsee, Ken Tang, Miriam H Beauchamp, William Craig, Quynh Doan, Stephen B Freedman, Jocelyn Gravel, Roger Zemek, Keith Owen Yeates
OBJECTIVE: To examine preinjury life events as moderators of postconcussive symptoms (PCS) and quality of life (QoL) in children with pediatric mild traumatic brain injury (mTBI) versus orthopedic injury (OI). METHODS: Participants were 633 children with mTBI and 334 with OI, ages 8-16.99, recruited from 5 pediatric emergency departments and followed for 6 months postinjury as part of a prospective cohort study. Preinjury life events were measured retrospectively using the Child and Adolescent Survey of Experiences, PCS using the Health and Behavior Inventory (HBI) and Post-Concussion Symptom Interview (PCS-I), and QoL using the Pediatric Quality of Life Inventory (PedsQL)...
March 8, 2024: Journal of Pediatric Psychology
https://read.qxmd.com/read/38334039/individualized-spectral-filters-alleviate-persistent-photophobia-headaches-and-migraines-in-active-duty-military-and-veterans-following-brain-trauma
#4
JOURNAL ARTICLE
Sandra Tosta, Mauricio Ferreira, Jeffrey Lewine, Adam Anderson
PURPOSE: Consistent with association between photophobia and headache, growing evidence suggests an underlying causal relationship between light sensitivity and central pain. We investigated whether an intervention to regulate light sensitivity by filtering only wavelengths causing difficulties for the specific individual could alleviate headaches/migraines resulting from traumatic brain injury (TBI). METHODS: Secondary data analysis of a clinical database including N  = 392 military personnel (97% men, 3% women), ranging in age from 20 to 51 years, diagnosed with TBI, persistent headaches/migraines, and light sensitivity...
February 9, 2024: Brain Injury
https://read.qxmd.com/read/38231270/serum-calcitonin-gene-related-peptide-in-patients-with-persistent-post-concussion-symptoms-including-headache-a-cohort-study
#5
JOURNAL ARTICLE
Peter Preben Eggertsen, Johan Palmfeldt, Henrik Winther Schytz, Debbie Hay, Rikke Katrine Jentoft Olsen, Jørgen Feldbæk Nielsen
BACKGROUND: Calcitonin gene-related peptide (CGRP) plays an important role in migraine pathophysiology, and post-traumatic headache (PTH) frequently presents with migraine-like features. Despite several clinical similarities, few studies have explored CGRP in PTH and concussion. This study investigates serum CGRP levels in patients with persistent post-concussion symptoms (PPCS), including PTH. METHODS: This cohort study was based on serum samples from individuals aged 18-30 years with PPCS who participated in a previously published randomized controlled trial of a non-pharmacological intervention...
January 17, 2024: Journal of Neurology
https://read.qxmd.com/read/38032832/characterizing-extreme-phenotypes-for-pain-interference-in-persons-with-chronic-pain-following-traumatic-brain-injury-a-nidilrr-and-va-tbi-model-systems-collaborative-project
#6
JOURNAL ARTICLE
Jeanne M Hoffman, Jessica M Ketchum, Stephanie Agtarap, Kristen Dams-O'Connor, Flora M Hammond, Aaron M Martin, Mitch Sevigny, William C Walker, Cynthia Harrison-Felix, Ross Zafonte, Risa Nakase-Richardson
OBJECTIVE: To define and characterize extreme phenotypes based on pain interference for persons with chronic pain following traumatic brain injury (TBI). SETTING: Eighteen Traumatic Brain Injury Model System (TBIMS) Centers. PARTICIPANTS: A total of 1762 TBIMS participants 1 to 30 years post-injury reporting chronic pain at their most recent follow-up interview. PRIMARY MEASURES: The Brief Pain Inventory (BPI) interference scale, sociodemographic, injury, functional outcome, pain, and treatment characteristics...
November 6, 2023: Journal of Head Trauma Rehabilitation
https://read.qxmd.com/read/38021687/the-magnitude-of-physical-and-sensory-impairments-in-post-traumatic-and-non-traumatic-cervicogenic-headaches-a-comparative-study
#7
JOURNAL ARTICLE
Mosab Amoudi, Qais Nairat
Background Cervicogenic headaches can significantly deteriorate the quality of life of patients and decrease their productivity. Few studies have been conducted to assess the magnitude of physical impairments among patients with non-traumatic and post-traumatic cervicogenic headaches. Therefore, this study was conducted to examine and compare the magnitude of cervical physical impairments among patients with post-traumatic cervicogenic headaches in contrast to patients with non-traumatic cervicogenic headaches, migraine, and a group of sex- and age-matched controls who did not have headaches...
October 2023: Curēus
https://read.qxmd.com/read/38009371/ninds-common-data-elements-for-post-traumatic-headache-a-project-from-the-american-headache-society-post-traumatic-headache-special-interest-section
#8
EDITORIAL
Catherine D Chong, Sait Ashina, Joshua Kamins, Ann Scher, Carlyn Patterson Gentile, Alan Finkel, Michael L Oshinsky, Todd J Schwedt
No abstract text is available yet for this article.
November 27, 2023: Headache
https://read.qxmd.com/read/37976502/acute-psychological-symptom-profiles-in-high-school-football-players-following-sport-related-concussion
#9
JOURNAL ARTICLE
Maryam Y Jawid, Kristen L Williams, Jacob Jo, Tyler M Hill, Olivia L Prosak, Amad Amedy, Trevor J Anesi, Douglas P Terry, Scott L Zuckerman
OBJECTIVE: In a cohort of high school football athletes, the authors sought to 1) describe the proportion of those with acute psychological symptoms postconcussion, 2) determine predictors of more acute psychological symptoms postconcussion, and 3) determine if acute psychological symptoms impact recovery. METHODS: A retrospective cohort study of high school football athletes (14-18 years of age) who sustained a sport-related concussion between November 2017 and April 2022 and presented to a multidisciplinary concussion center was performed...
November 17, 2023: Journal of Neurosurgery. Pediatrics
https://read.qxmd.com/read/37917826/hypersensitivity-to-opening-of-atp-sensitive-potassium-channels-in-post-traumatic-headache
#10
RANDOMIZED CONTROLLED TRIAL
Haidar M Al-Khazali, Rune H Christensen, David W Dodick, Basit Ali Chaudhry, Rami Burstein, Håkan Ashina
OBJECTIVE: To investigate whether levcromakalim (a KATP channel opener) induces migraine-like headache in people with persistent post-traumatic headache who had no known history of migraine. METHODS: In a randomized, double-blind, placebo-controlled, 2-way crossover trial, participants were randomly assigned to receive a 20-minute continuous intravenous infusion of levcromakalim (50 µg/mL) or placebo (isotonic saline) on two separate experimental days with a 1-week wash-out period in between...
November 2023: Cephalalgia: An International Journal of Headache
https://read.qxmd.com/read/37864847/hypersensitivity-to-pacap-38-in-post-traumatic-headache-a-randomized-clinical-trial
#11
JOURNAL ARTICLE
Haidar M Al-Khazali, Rune H Christensen, David W Dodick, Basit Ali Chaudhry, Faisal Mohammad Amin, Rami Burstein, Håkan Ashina
Pituitary adenylate cyclase-activating polypeptide-38 (PACAP-38), known for its role in migraine pathogenesis, has been identified as a novel drug target. Given the clinical parallels between post-traumatic headache (PTH) and migraine, we explored the possible role of PACAP-38 in the pathogenesis of PTH. To this end, we conducted a randomized, double-blind, placebo-controlled, 2-way crossover trial involving adult participants diagnosed with persistent PTH resulting from mild traumatic brain injury. Participants were randomly assigned to receive a 20-minute continuous intravenous infusion of either PACAP-38 (10 pmol/kg/min) or placebo (isotonic saline) on two separate experimental days, with a 1-week wash-out period in between...
October 21, 2023: Brain
https://read.qxmd.com/read/37831366/does-physiologic-post-concussion-disorder-cause-persistent-post-traumatic-headache
#12
REVIEW
Jacob I McPherson, Muhammad S Z Nazir, Barry S Willer, John J Leddy, Mohammad N Haider
PURPOSE OF REVIEW: One system classifies patients with symptoms after concussion into physiologic, vestibulo-ocular, cervicogenic, and mood/cognition post-concussion disorders (PCD) based upon the preponderance of specific symptoms and physical impairments. This review discusses physiologic PCD and its potential relationship to the development of persistent post-traumatic headaches (PPTH). RECENT FINDINGS: Headache is the most reported symptom after a concussion...
November 2023: Current Pain and Headache Reports
https://read.qxmd.com/read/37827931/real-life-study-of-the-use-of-oto-acoustic-emissions-in-the-diagnosis-of-intracranial-hypotension
#13
JOURNAL ARTICLE
J Pascaud, S Redon, M Elzière, A Donnet
BACKGROUND: The diagnosis of spontaneous or post-traumatic intracranial hypotension (IH) mainly relies on clinical features and neuro-imaging. However, the results of brain and spine magnetic resonance imaging are not always contributive. There is an interest for other non-invasive procedures, able to confirm or refute the diagnosis. The use of oto-acoustic emissions (OAE) was previously reported on isolated cases of IH associated with endolymphatic hydrops (ELH). The aim of this study was to assess the real-life utilization of this electrophysiological method in a larger population of suspected IH...
October 10, 2023: Revue Neurologique
https://read.qxmd.com/read/37808655/a-suite-of-engineered-mice-for-interrogating-psychedelic-drug-actions
#14
Yi-Ting Chiu, Ariel Y Deutch, Wei Wang, Gavin P Schmitz, Karen Lu Huang, D Dewran Kocak, Pierre Llorach, Kasey Bowyer, Bei Liu, Noah Sciaky, Kunjie Hua, Chongguang Chen, Sarah E Mott, Jesse Niehaus, Jeffrey F DiBerto, Justin English, Jessica J Walsh, Grégory Scherrer, Melissa A Herman, Zhuhao Wu, William C Wetsel, Bryan L Roth
Psychedelic drugs like lysergic acid diethylamide (LSD) and psilocybin have emerged as potentially transformative therapeutics for many neuropsychiatric diseases, including depression, anxiety, post-traumatic stress disorder, migraine, and cluster headaches. LSD and psilocybin exert their psychedelic effects via activation of the 5-hydroxytryptamine 2A receptor (HTR2A). Here we provide a suite of engineered mice useful for clarifying the role of HTR2A and HTR2A-expressing neurons in psychedelic drug actions...
September 26, 2023: bioRxiv
https://read.qxmd.com/read/37796114/plasma-calcitonin-gene-related-peptide-and-nerve-growth-factor-as-headache-and-pain-biomarkers-in-recently-deployed-soldiers-with-and-without-a-recent-concussion
#15
JOURNAL ARTICLE
Ann I Scher, James S McGinley, Lyndsey R VanDam, Amanda M Campbell, Xiyun Chai, Billy Collins, Scott A Klimp, Alan G Finkel, Karen Schwab, Richard B Lipton, Kirk W Johnson
OBJECTIVE: The objective of this study was to characterize the utility of calcitonin gene-related peptide (CGRP) and nerve growth factor (NGF) as potential biomarkers for headache and pain disorders in the post-military deployment setting. BACKGROUND: The need to improve recognition, assessment, and prognoses of individuals with posttraumatic headache or other pain has increased interest in the potential of CGRP and NGF as biomarkers. METHODS: The Warrior Strong Study (NCT01847040) is an observational longitudinal study of United States-based soldiers who had recently returned from deployment to Afghanistan or Iraq from 2009 to 2014...
October 5, 2023: Headache
https://read.qxmd.com/read/37710275/sudden-onset-headaches-in-paediatric-emergency-departments-diagnosis-and-management
#16
REVIEW
Léa Lenglart, Cécile Monteil, Eugenia Spreafico, Thomas Moulding, Luigi Titomanlio
Headache is one of the most common pain syndromes in the paediatric population. Headaches are classified as primary (migraine, tension-type headaches, trigeminal autonomic cephalalgia and other primary headaches) or secondary (e.g. post-traumatic). Non-febrile, non-traumatic headaches represent 1% of all paediatric emergency departments (PED) visits. Many patients present with an acute, moderate to severe pain, sometimes with a sudden onset. Sudden onset headache can be the main symptom of life-threatening neurological conditions as well as a sign of primary headaches such as thunderclap or stabbing headaches...
September 14, 2023: Italian Journal of Pediatrics
https://read.qxmd.com/read/37638410/sensory-hypersensitivities-are-associated-with-post-traumatic-headache-related-disability
#17
JOURNAL ARTICLE
Cecilia Martindale, Angela P Presson, Todd J Schwedt, K C Brennan, Melissa M Cortez
OBJECTIVE: To examine whether sensory hypersensitivity contributes to headache-related disability in a secondary analysis of patients with post-traumatic headache. BACKGROUND: Up to one-third of individuals with traumatic brain injuries report persistent headache 3 months post-injury. High rates of allodynia and photophobia have been observed in clinical studies and animal models of post-traumatic headache, but we do not fully understand how sensory amplifications impact post-traumatic headache-related disability...
August 28, 2023: Headache
https://read.qxmd.com/read/37480909/prevalence-of-and-risk-factors-for-post-traumatic-headache-in-civilian-patients-after-mild-traumatic-brain-injury-a-track-tbi-study
#18
JOURNAL ARTICLE
Håkan Ashina, David W Dodick, Jason Barber, Nancy R Temkin, Catherine D Chong, Jennifer S Adler, Ken Shubin Stein, Todd J Schwedt, Geoffrey T Manley
OBJECTIVE: To ascertain the prevalence of and risk factors for post-traumatic headache (PTH) attributed to mild traumatic brain injury (mTBI). PATIENTS AND METHODS: A prospective, longitudinal, multicenter cohort study of patients with mTBI and orthopedic trauma controls who were enrolled from February 26, 2014, to August 8, 2018. The baseline assessment was conducted as soon as possible following evaluation at the emergency department. Follow-ups were scheduled at 2 weeks, 3 months, 6 months, and 12 months postinjury...
July 21, 2023: Mayo Clinic Proceedings
https://read.qxmd.com/read/37458987/dissecting-the-relationship-between-neuropsychiatric-and-neurodegenerative-disorders
#19
REVIEW
Rohan Gupta, Dia Advani, Divya Yadav, Rashmi K Ambasta, Pravir Kumar
Neurodegenerative diseases (NDDs) and neuropsychiatric disorders (NPDs) are two common causes of death in elderly people, which includes progressive neuronal cell death and behavioral changes. NDDs include Alzheimer's disease, Parkinson's disease, Huntington's disease, amyotrophic lateral sclerosis, multiple sclerosis, and motor neuron disease, characterized by cognitive defects and memory impairment, whereas NPDs include depression, seizures, migraine headaches, eating disorders, addictions, palsies, major depressive disorders, anxiety, and schizophrenia, characterized by behavioral changes...
July 17, 2023: Molecular Neurobiology
https://read.qxmd.com/read/37456641/targeted-multidomain-intervention-for-complex-mtbi-protocol-for-a-multisite-randomized-controlled-trial-in-military-age-civilians
#20
JOURNAL ARTICLE
R J Elbin, Alicia Trbovich, Melissa N Womble, Anne Mucha, Sheri Fedor, Katie Stephenson, Cyndi Holland, Christina Dollar, Patrick Sparto, Kori Durfee, Charity G Patterson, Clair N Smith, Theodore J Huppert, David O Okonkwo, Michael W Collins, Anthony P Kontos
BACKGROUND: Mild traumatic brain injury (mTBI) affects ~18,000 military personnel each year, and although most will recover in 3-4 weeks, many experience persisting symptoms and impairment lasting months or longer. Current standard of care for U.S. military personnel with complex mTBI involves initial (<48 h) prescribed rest, followed by behavioral (e.g., physical activity, sleep regulation, stress reduction, hydration, nutrition), and symptom-guided management. There is growing agreement that mTBI involves different clinical profiles or subtypes that require a comprehensive multidomain evaluation and adjudication process, as well as a targeted approach to treatment...
2023: Frontiers in Neurology
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