Yi-Ting Chiu, Ariel Y Deutch, Wei Wang, Gavin P Schmitz, Karen Lu Huang, D Dewran Kocak, Pierre Llorach, Kasey Bowyer, Bei Liu, Noah Sciaky, Kunjie Hua, Chongguang Chen, Sarah E Mott, Jesse Niehaus, Jeffrey F DiBerto, Justin English, Jessica J Walsh, Grégory Scherrer, Melissa A Herman, Zhuhao Wu, William C Wetsel, Bryan L Roth
Psychedelic drugs like lysergic acid diethylamide (LSD) and psilocybin have emerged as potentially transformative therapeutics for many neuropsychiatric diseases, including depression, anxiety, post-traumatic stress disorder, migraine, and cluster headaches. LSD and psilocybin exert their psychedelic effects via activation of the 5-hydroxytryptamine 2A receptor (HTR2A). Here we provide a suite of engineered mice useful for clarifying the role of HTR2A and HTR2A-expressing neurons in psychedelic drug actions...
September 26, 2023: bioRxiv