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JOURNAL ARTICLE
Sean P Gavan, Katherine Payne, Anne Barton
OBJECTIVE: Therapeutic drug monitoring (TDM) of tumour necrosis factor-α inhibitors (TNFi), by measuring drug levels and/or anti-drug antibodies, is being considered by various international bodies to improve patient health outcomes and the value of care for people with rheumatoid arthritis. Rheumatology care providers may perceive barriers to adopting TNFi TDM within their own clinical practice, limiting the potential for patients and health care systems to benefit. This study aimed to explore the barriers perceived by rheumatologists that may reduce their uptake of TNFi TDM for rheumatoid arthritis...
2024: Rheumatology Advances in Practice
#22
JOURNAL ARTICLE
Daniel Wendling, Omar Al Tabaa, Baptiste Chevet, Olivier Fakih, Roba Ghossan, Sophie Hecquet, Emmanuelle Dernis, Emmanuel Maheu, Alain Saraux, Florent L Besson, Guillermo Carvajal Alegria, Bernard Cortet, Bruno Fautrel, Renaud Felten, Jacques Morel, Sébastien Ottaviani, Solène Querellou-Lefranc, André Ramon, Adeline Ruyssen-Witrand, Raphaèle Seror, Anne Tournadre, Nathan Foulquier, Bernard Verlhac, Frank Verhoeven, Valérie Devauchelle-Pensec
OBJECTIVE: To develop recommendations for the routine management of patients with polymyalgia rheumatica (PMR) Methods: Following standard procedures, a systematic review of the literature by 5 supervised junior rheumatologists, based on the questions selected by the steering committee (5 senior rheumatologists), was used as the basis for working meetings, followed by a one-day plenary meeting with the working group (15 members), leading to the development of the wording and determination of the strength of the recommendations and the level of agreement of the experts...
April 5, 2024: Joint, Bone, Spine: Revue du Rhumatisme
#23
JOURNAL ARTICLE
Ayesha Iqbal, Madiha Ahmad, Kevin J Murray, Jison Sim, Terry J S Lund, Anthony J Andrade, Ariadna Perez-Sanchez, Michael J Mader, Elizabeth K Haro, Jason P Williams, Robert Nathanson, Nilam J Soni
INTRODUCTION: Point-of-care ultrasound (POCUS) can assist rheumatologists in monitoring disease activity, establishing diagnoses, and guiding procedural interventions. POCUS use has been increasing, but little is known about current use and barriers among rheumatologists. The purpose of this study was to characterize current POCUS use, training needs, and barriers to use among rheumatologists in practice. METHODS: A prospective observational study of all Veterans Affairs (VA) medical centers was conducted using a web-based survey sent to all chiefs of staff and rheumatology chiefs about current POCUS use, training needs, barriers, and policies...
April 6, 2024: Rheumatology and Therapy
#24
JOURNAL ARTICLE
Leo Caratsch, Christian Lechtenboehmer, Matteo Caorsi, Karine Oung, Fabio Zanchi, Yasser Aleman, Ulrich A Walker, Patrick Omoumi, Thomas Hügle
OBJECTIVE: Automated machine learning (autoML) platforms allow health care professionals to play an active role in the development of machine learning (ML) algorithms according to scientific or clinical needs. The aim of this study was to develop and evaluate such a model for automated detection and grading of distal hand osteoarthritis (OA). METHODS: A total of 13,690 hand radiographs from 2,863 patients within the Swiss Cohort of Quality Management (SCQM) and an external control data set of 346 non-SCQM patients were collected and scored for distal interphalangeal OA (DIP-OA) using the modified Kellgren/Lawrence (K/L) score...
April 4, 2024: ACR open rheumatology
#25
JOURNAL ARTICLE
Ivan Foeldvari, Marcela Bohn, Harry Petrushkin, S Angeles Han, Regitze Bangsgaard, Joan Calzada-Hernández, Tamas Constantin, Joke H de Boer, Jesus Díaz-Cascajosa, Clive Edelsten, Mia Glerup, Helene Ingels, Sebastian Kramer, Elisabetta Miserocchi, Ellen Nordal, Rotraud K Saurenmann, Gabriele Simonini, Ameenat Lola Solebo, Jan Titz, Jordi Anton
BACKGROUND: Juvenile idiopathic arthritis (JIA)-associated uveitis typically presents as a silent chronic anterior uveitis and can lead to blindness. Adherence to current screening guidelines is hampered by complex protocols which rely on the knowledge of specific JIA characteristics. The Multinational Interdisciplinary Working Group for Uveitis in Childhood identified the need to simplify screening to enable local eye care professionals (ECPs), who carry the main burden, to screen children with JIA appropriately and with confidence...
April 4, 2024: British Journal of Ophthalmology
#26
JOURNAL ARTICLE
Karoline Baquet-Walscheid, Thomas Rath, Arnd Heiligenhaus
Ocular manifestations of rheumatic diseases are common and contribute significantly to the morbidity and reduced quality of life of affected patients. Knowledge of typical clinical manifestations is important for the rheumatologist in order to support the reference of patients with corresponding symptoms for ophthalmological consultation at an early stage of disease, or to initiate regular screening examinations (e.g. in patients with Behçet's syndrome). Conversely, a (possibly urgent) rheumatological assessment is crucial for certain ophthalmological diseases, in order not to overlook a (possibly fatal) systemic associated disease...
April 4, 2024: Klinische Monatsblätter Für Augenheilkunde
#27
JOURNAL ARTICLE
April Barnado, Ryan P Moore, Henry J Domenico, Sarah Green, Alex Camai, Ashley Suh, Bryan Han, Katherine Walker, Audrey Anderson, Lannawill Caruth, Anish Katta, Allison B McCoy, Daniel W Byrne
OBJECTIVE: Positive antinuclear antibodies (ANAs) cause diagnostic dilemmas for clinicians. Currently, no tools exist to help clinicians interpret the significance of a positive ANA in individuals without diagnosed autoimmune diseases. We developed and validated a risk model to predict risk of developing autoimmune disease in positive ANA individuals. METHODS: Using a de-identified electronic health record (EHR), we randomly chart reviewed 2,000 positive ANA individuals to determine if a systemic autoimmune disease was diagnosed by a rheumatologist...
2024: Frontiers in Immunology
#28
JOURNAL ARTICLE
Marco Matucci-Cerinic, Francesco Ciccia, Rosario Foti, Alessandro Giunta, Francesco Loconsole, Francesca Prignano, Rossana Scrivo, Giampiero Girolomoni
BACKGROUND AND OBJECTIVES: Psoriasis (PsO) and psoriatic arthritis (PsA) are often undertreated and require a multidisciplinary approach. In recent years, patent expiration has allowed the introduction of tumor necrosis factor inhibitor (anti-TNF) biosimilars, which have stimulated a significant increase in the use of biological therapies. This article reports the findings of a multidisciplinary approach to achieve a consensus on the use of adalimumab in patients with PsO or PsA. METHODS: A voting panel of 36 Italian dermatologists and rheumatologists were chosen by eight Italian clinicians (the Board), to provide a consensus on the real-world management of PsO and PsA with adalimumab using the Delphi Method, comprising three survey rounds...
March 2024: Rheumatol Immunol Res
#29
JOURNAL ARTICLE
Nan Xu, Xuanhan Wang, Tiantian Dai, Nianxing Liu, Yimin Ding, Jinqiong Chen, Longlong Tian, Yuxuan Fang, Yongbin Zhang, Guoqing Li
To identify the value of salivary gland ultrasound (SGUS) combined with magnetic resonance imaging (MRI) and magnetic resonance sialography (MRS) in predicting the results of labial salivary gland biopsy (LSGB) in patients with suspected primary Sjögren syndrome (pSS), and construct a nomogram model to predict LSGB results. A total of 181 patients who were admitted with suspected pSS from December 2018 to April 2023 were examined and divided into a training set (n = 120) and a validation set (n = 61)...
April 3, 2024: Clinical Rheumatology
#30
Sawari S Bhagwatkar, Pallavi Harjpal, Prajyot Ankar
Rheumatoid arthritis (RA) is a systemic autoimmune disease with profound effects on joints and extra-articular organs. This case report explores the complex treatment approach for a 54-year-old female patient who is dealing with the dual diagnosis of RA and Sjogren's syndrome (SS). RA primarily involves joint inflammation and morning stiffness leading to significant disability, while SS, another autoimmune condition, manifests with autoantibodies and lymphocytic infiltration affecting exocrine glands. The patient presented with joint and low back pain, alongside reduced mobility, portraying a complex clinical picture...
March 2024: Curēus
#31
JOURNAL ARTICLE
Keisuke Izumi, Kanata Suzuki, Masahiro Hashimoto, Masahiro Jinzaki, Shigeru Ko, Tsutomu Takeuchi, Yuko Kaneko
The modified total Sharp score (mTSS) is often used as an evaluation index for joint destruction caused by rheumatoid arthritis. In this study, special findings (ankylosis, subluxation, and dislocation) are detected to estimate the efficacy of mTSS by using deep neural networks (DNNs). The proposed method detects and classifies finger joint regions using an ensemble mechanism. This integrates multiple DNN detection models, specifically single shot multibox detectors, using different training data for each special finding...
April 2, 2024: Scientific Reports
#32
JOURNAL ARTICLE
Daniel G Fernández-Ávila, Wilson Bautista-Molano, María Lorena Brance, María Gabriela Ávila Pedretti, Rubén Burgos Vargas, José Francisco Díaz Coto, Luis Arturo Gutiérrez, Marwin Gutiérrez, Enrique Giraldo Ho, Sebastián Eduardo Ibáñez Vodnizza, Edwin Jáuregui, Vanessa Ocampo, Penélope Esther Palominos, Daniel Ruben Palleiro Rivero, Guillermo Andrés Quiceno, Fernando Andrés Sommerfleck, Luis Enrique Vega Espinoza, Oscar Vega Hinojosa, Claudia Vera Barrezueta, Inés Corbacho, Vanesa Laura Cosentino, Annelise Goecke Sariego, Gustavo Gomes Resende, Lina María Saldarriaga-Rivera, Cesar Francisco Pacheco Tena, Gustavo Citera, Carlos Lozada, Roberto Ranza, Percival D Sampaio-Barros, Emilce Schneeberger, Enrique R Soriano
OBJECTIVE: Psoriatic arthritis (PsA) is chronic disease that compromise multiple domains, and might be associated with progressive joint damage, increased mortality, functional limitation, and considerably impaired quality of life. Our objective is to generate evidence-based recommendations on the management of PsA in PANLAR countries. METHODS: We used the Grading of Recommendations, Assessment, Development and Evaluation GRADEADOLOPMENT approach to adapt the 2019 recommendations of the European League Against Rheumatism (EULAR)...
April 1, 2024: Journal of Rheumatology
#33
EDITORIAL
Murray Baron
As the study by Jazayeri et al in this issue of The Journal of Rheumatology points out, the prevalence of unemployment in people with systemic sclerosis (SSc) is estimated at 40.5%, and SSc is associated with "presenteeism (ie, working while unwell), lack of participation in employment, and ultimately, absenteeism."1 This is of course true of patients with the many other musculoskeletal diseases that we as rheumatologists treat.
April 1, 2024: Journal of Rheumatology
#34
JOURNAL ARTICLE
Tayyeba Khursheed, Pavel Ovseiko, Sarah Dyball, Ran Nakashima, Ana Maria Arredondo Gonzalez, Alejandra Babini, Asgar Ali Kalla, Catherine Hill, Debashish Danda, Dzifa Dey, Lisa Traboco, Elena Nikiphorou, Ghita Harifi, Humeira Badshah, Ihsane Hmamouchi, Joan Marie Von Feldt, Júlia Boechat Farani, Laura Andreoli, Mariana Peixoto Guimarães, Carlos Enrique Toro Gutiérrez, Cristiana Sieiro Santos, Christina Duftner, Deshire Alpizar Rodriguez, Nelly Ziadé, Penélope Esther Palominos, Syed Atiqul Haq, Wilson Bautista-Molano, Yoshiya Tanaka, Laure Gossec, Vikas Agarwal, Grace C Wright, Laura Coates, Latika Gupta
OBJECTIVES: The primary aim of the CHANGE survey is to determine the current state of gender equity within rheumatology, and secondarily, to review the physician perspective on bullying, harassment and equipoise of opportunities within rheumatology. METHODS: The CHANGE e-survey is a cross-sectional self-reported questionnaire adapted from EULAR's gender equity in academic rheumatology task force. The survey was launched in January 2023; it is available in six languages and distributed widely via rheumatology organizations and social media...
2024: Rheumatology Advances in Practice
#35
Kei Kanata, Toshihiro Shirai, Yutaro Ito, Koshiro Ichijo, Masahiro Uehara
A 70-year-old woman had been treated with methotrexate for rheumatoid arthritis by a rheumatologist who opened a clinic near our hospital. In January of a certain year, she had respiratory symptoms of cough, sputum, and fever. Laboratory test results showed a white blood cell count of 8600/μL (neutrophil count of 5330/μL, lymphocyte count of 2490 μ/L), C-reactive protein (CRP) of 3.30 mg/dL. Chest radiography showed multiple infiltrative shadows in the right middle and lower lobes. Bronchoalveolar lavage fluid (BAL) lymphocyte count was increased (65...
2024: Respiratory Medicine Case Reports
#36
JOURNAL ARTICLE
Brygida Kwiatkowska, Magdalena Krajewska-Włodarczyk, Bogdan Batko, Maria Maślińska, Marcin Stajszczyk, Jerzy Świerkot, Piotr Wiland, Zbigniew Żuber, Krzysztof Tomasiewicz
As severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) evolves, infection management in vulnerable populations requires formalized guidance. Although low-virulence variants of SARS-CoV-2 remain predominant, they pose an increased risk of severe illness in adults with rheumatic and musculoskeletal diseases (RMDs). Several disease-specific (chronic long-grade inflammation, concomitant immunosuppression) and individual (advanced age, multimorbidity, pregnancy, vaccination status) factors contribute to excess risk in RMD populations...
2024: Reumatologia
#37
JOURNAL ARTICLE
Steven D Tran, Jean Lin, Carlos Galvez, Luke V Rasmussen, Jennifer Pacheco, Giovanni M Perottino, Kian J Rahbari, Charles D Miller, Jordan D John, Jonathan Theros, Kelly Vogel, Patrick V Dinh, Sara Malik, Umar Ramzan, Kyle Tegtmeyer, Nisha Mohindra, Jodi L Johnson, Yuan Luo, Abel Kho, Jeffrey Sosman, Theresa L Walunas
INTRODUCTION: Immune checkpoint inhibitor-induced inflammatory arthritis (ICI-IA) poses a major clinical challenge to ICI therapy for cancer, with 13% of cases halting ICI therapy and ICI-IA being difficult to identify for timely referral to a rheumatologist. The objective of this study was to rapidly identify ICI-IA patients in clinical data and assess associated immune-related adverse events (irAEs) and risk factors. METHODS: We conducted a retrospective study of the electronic health records (EHRs) of 89 patients who developed ICI-IA out of 2451 cancer patients who received ICI therapy at Northwestern University between March 2011 to January 2021...
2024: Frontiers in Immunology
#38
Maria Kokoti, Vasileios Zisis, Dimitrios Andreadis, Athina Bakopoulou
Sjögren's syndrome is a chronic, inflammatory autoimmune disorder characterized by lymphocyte infiltration of the exocrine glands. Notably, the rehabilitation of partially edentulous patients with Sjögren's syndrome is limited by the scarce availability of studies that could inform therapeutic modalities and potential challenges during clinical procedures. This case report aimed to present the oral rehabilitation of a patient with Sjögren's syndrome who received fixed partial dentures (FPDs)...
February 2024: Curēus
#39
JOURNAL ARTICLE
Onkarpreet K Jassel, Hasan Tahir, Sian Bamford, Paolo Giuffrida
Background Diagnostic delay of axial spondyloarthritis (axSpA) is a widely recognized issue worldwide, providing a great burden for patients with this disease. AxSpA is present in a significant proportion of patients with inflammatory bowel disease (IBD). This UK study primarily aims to identify the presence of inflammatory back pain (IBP) in patients attending IBD clinic. Further aims of this study include investigating if participants had received further referrals and diagnoses for their IBP and considering factors contributing to diagnostic delay...
February 2024: Curēus
#40
JOURNAL ARTICLE
Sharon Cowley, Patricia Harkins, Colm Kirby, Richard Conway, David J Kane
There is a growing appreciation that both giant cell arteritis (GCA) and polymyalgia rheumatica (PMR) are closely interrelated conditions that have significant overlap in aetiology, clinical characteristics and treatment regimens. Subclinical GCA in PMR is becoming increasingly recognised, and there is evolving evidence that this may be a more aggressive disease phenotype than PMR. Ultrasound (US) lends itself well as a screening tool for GCA in PMR; it is inexpensive, non-invasive, widely available, lacks ionising radiation, may be performed at the bedside and is recommended by EULAR as a first-line investigation for suspected GCA...
March 29, 2024: Annals of the Rheumatic Diseases
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