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Sohail Abbas, Mohit Kumar, Dong-Wook Kim, Joondong Kim
ZnO is a potential candidate for photodetection utilizing the pyroelectric effect. Here, a self-biased and translucent photodetector with the configuration of Cu4 O3 /ZnO/FTO/Glass is designed and fabricated. In addition, the pyroelectric effect is effectively harvested using indium tin oxide (ITO), silver nanowires (AgNWs), and a blend of AgNWs-coated ITO as the transparent selective contact electrode. The improved rise times are observed from 1400 µs (bare condition; without the selective electrode) to 69, 60, 7 µs, and fall times from 720 µs (bare condition) to 80, 70, 10 µs for corresponding ITO, AgNWs, and AgNWs-coated ITO contact electrodes, respectively...
February 5, 2019: Small
J Vidal, B Bellosillo, C Santos Vivas, P García-Alfonso, A Carrato, M T Cano, R García-Carbonero, E Élez, F Losa, B Massutí, M Valladares-Ayerbes, J M Viéitez, J L Manzano, J Gallego, S Pairet, G Capellá, R Salazar, J Tabernero, E Aranda, C Montagut
Background: Extended RAS analysis is mandatory in metastatic colorectal cancer (mCRC) patients. The optimal threshold of RAS mutated subclones to identify patients most likely to benefit from anti-EGFR therapy is controversial. Our aim was to assess the clinical impact of detecting mutations in RAS, BRAF, PIK3CA and EGFRS492R in basal tissue tumour samples by using a highly sensitive Next Generation Sequencing (NGS) technology in mCRC patients treated with chemotherapy plus anti-EGFR or anti-VEGF...
January 23, 2019: Annals of Oncology: Official Journal of the European Society for Medical Oncology
Xiaoyan Wang, Shaoxiong Chen, Robert E Emerson, Howard H Wu, Harvey M Cramer, Kendra Curless, Hsim Yee Chang, Shaobo Zhang, Melissa L Randolph, Liang Cheng
OBJECTIVE: The aim of this study was to investigate epidermal growth factor receptor (EGFR) gene mutations and anaplastic lymphoma kinase (ALK) gene rearrangements using cytological specimens from the patients with a diagnosis of primary or metastatic lung non-small cell carcinoma. MATERIALS AND METHODS: A total 307 cases were submitted for EGFR mutational analysis and 265 cases for ALK analysis. The cytological specimen sources included lung, lymph node, liver, bone, adrenal gland, mesentery mass, and body fluids/bronchial brushing...
January 25, 2019: Applied Immunohistochemistry & Molecular Morphology: AIMM
Qian Liu, Jin Wang, Shuang Li, Guojie Li, Qingle Chen, Zhangyong Hong
Pyropheophorbide a (Pyro) is a promising photosensitizer; however, it has no tumor selectivity and enrichment capability. In our former work, the prepared folic acid-Pyro conjugates showed considerably improved tumor accumulation and photodynamic therapy (PDT) activity in cell- and animal-based studies. However, the targeting capability, selectivity and water solubility of the conjugate remain problematic. Here, we evaluated the installation of hydrophilic PEG chains as the linker between Pyro and FA, by avoiding direct conjugation of Pyro with FA, aiming to improve tumor selectivity and accumulation...
January 21, 2019: Journal of Pharmaceutical Sciences
Jayaraman Theerthagiri, Eduardo S F Cardoso, Guilherme V Fortunato, Gleison Antônio Casagrande, Baskar Senthilkumar, Jagannathan Madhavan, Gilberto Maia
Robust electrocatalysts towards the resourceful and sustainable generation of hydrogen by splitting of water via electrocatalytic hydrogen evolution reaction (HER) is a prerequisite to realize high-efficient energy research. High electroactive catalysts for hydrogen production with ultra-low loading of platinum (Pt) have been under exhaustive exploration to make the cutting edge and cost-effectively reasonable for water splitting. Herein, we reports the synthesis of hierarchically structured nickel pyrophosphate (β-Ni2P2O7) by precipitation method and nickel phosphate (Ni3(PO4)2) by two different synthetic routes viz...
January 9, 2019: ACS Applied Materials & Interfaces
Romina Rega, Oriella Gennari, Laura Mecozzi, Vito Pagliarulo, Alessia Bramanti, Pietro Ferraro, Simonetta Grilli
The numerous advantages of micro and nanostructures produced by electrospinning (ES) have stimulated enormous interest in this technology with potential application in several fields. However, ES has still some limitations in controlling the geometrical arrangement of the fibre mats so that expensive and time-consuming technologies are usually employed for producing ordered geometries. Here we present a technique that we call 'bipolar pyro-electrospinning' (b-PES) for generating ordered-arrays of fibre mats in a direct manner by using the bipolar pyroelectric field produced by a periodically poled lithium niobate crystal (PPLN)...
January 4, 2019: ACS Applied Materials & Interfaces
Pakkirisamy Thilagar, Sanjoy Mukherjee
Solid-state luminescence of organic dyes is an elusive frontier. Thus, understanding and designing solid-state stimuli responsive materials is not trivial, and is being continually pursued in recent times. 'Mechanoluminescence' (ML) or 'triboluminescence' (TL), which is associated with fracture or force initiated luminescence from a material, is finding new interests in very recent times. Fracturing the surfaces of organic crystals ordered in non-centrosymmetric space groups, can electronically excite the surface and neighboring molecules via piezo- or pyro- electric effects...
November 22, 2018: Angewandte Chemie
Tyler Florio, Ravi Kumar Lokareddy, Richard Gillilan, Gino Cingolani
Siw14 is a recently discovered inositol phosphatase implicated in suppressing prion propagation in Saccharomyces cerevisiae. In this paper, we used hybrid structural methods to decipher Siw14 molecular architecture. We found the protein exists in solution as an elongate monomer ~140 Å in length, containing an acidic N-terminal domain (NTD) and a basic C-terminal dual specificity phosphatase (DSP) domain, structurally similar to the glycogen phosphatase laforin. The two domains are connected by a protease susceptible linker and do not interact in vitro...
December 14, 2018: Biochemistry
Kun Zhao, Bangsen Ouyang, Ya Yang
The pyro-phototronic effect has been utilized to modulate photoexcited carriers, to enhance the photocurrent in semiconducting nanomaterials. However, most of these materials have low pyroelectric performances. Using radially polarized ferroelectric BaTiO3 materials with a pyroelectric coefficient of about 16 nC/cm2 K, we report a dramatic photocurrent enhancement due to ferro-pyro-phototronic effect. The fabricated device enables a fast sensing of 365-nm light illumination with a response time of 0.5 s at the rising edge, where the output current-time curve displays a sharp peak followed by a stable plateau...
May 25, 2018: iScience
Hiroya Taniguchi, Wataru Okamoto, Kei Muro, Kiwamu Akagi, Hiroki Hara, Tomohiro Nishina, Takeshi Kajiwara, Tadamichi Denda, Shuichi Hironaka, Toshihiro Kudo, Taroh Satoh, Takeharu Yamanaka, Yukiko Abe, Yoshiyuki Fukushima, Takayuki Yoshino
Detection of RAS and BRAF mutations is essential to determine the optimal treatment strategy for metastatic colorectal cancer (CRC). We prospectively evaluated the MEBGEN RASKET-B KIT (RASKET-B), a novel multiplex kit, simultaneously detecting 48 types of RAS mutations and the BRAF V600E mutation using Luminex xMAP technology. The aim was to obtain market approval for RASKET-B as an in vitro diagnostic (IVD) option in Japan. Genomic DNA was extracted from 302 formalin-fixed paraffin-embedded tissues obtained from CRC patients...
November 6, 2018: Neoplasia: An International Journal for Oncology Research
Ming Kong, Jianying Chao, Wei Zhuang, Peifang Wang, Chao Wang, Jun Hou, Zhaoshi Wu, Longmian Wang, Guang Gao, Yu Wang
Spatial and seasonal variations of particulate phosphorus (PP) in a large shallow, eutrophic Lake Taihu with different ecotypes (including a phytoplankton-dominated zone, lake center zone, estuary zone and macrophyte-dominated zone) were investigated. The results showed that particulate organic phosphorus (POP) was the dominant form of PP (>88.0%). The concentration of POP showed higher levels in the bloom-sensitive northwestern zone (phytoplankton-dominated zone and estuary zone) during warm seasons, phytoplankton blooms and input of exogenous particulate matter were the main sources of POP in the lake water...
October 25, 2018: International Journal of Environmental Research and Public Health
Kara M Harmatys, Marta Overchuk, Juan Chen, Lili Ding, Ying Chen, Martin G Pomper, Gang Zheng
We describe a simple and effective bioconjugation strategy to extend the plasma circulation of a low molecular weight targeted phototheranostic agent, which achieves high tumor accumulation (9.74 ± 2.26%ID/g) and high tumor-to-background ratio (10:1). Long-circulating pyropheophorbide (LC-Pyro) was synthesized with three functional building blocks: (1) a porphyrin photosensitizer for positron-emission tomography (PET)/fluorescence imaging and photodynamic therapy (PDT), (2) a urea-based prostate-specific membrane antigen (PSMA) targeting ligand, and (3) a peptide linker to prolong the plasma circulation time...
October 29, 2018: Bioconjugate Chemistry
Saeed Ahmad, Waheed Mumtaz Abbasi, Tayyeba Rehman
Background Belladonna and Pyrogenium are commonly used to treat fever in homeopathy. But in vivo antipyretic activity of these medicines is not reported yet. The study was conducted to evaluate the effectiveness of ultrahigh dilutions of Belladonna (Bell) and Pyrogenium (Pyro) in fever model of rabbits induced by Baker's yeast. Methods Healthy, local strain rabbits (♂ and ♀) were divided into seven groups (n=42): Normal control, negative control, standard control, pyro 1000c, pyro 200c, Bell 1000c and Bell 200c...
October 17, 2018: Journal of Complementary & Integrative Medicine
Yi-Chen Yu, Ying Jiang, Meng-Meng Yang, Sai-Nan He, Xia Xi, Ye-Tao Xu, Wen-Sheng Hu, Qiong Luo
BACKGROUND: Increasing epidemiological studies have confirmed the association between maternal preeclampsia and elevated blood pressure in their offspring. Though case-control or cohort studies have demonstrated long-term outcomes for the offspring of preeclampsia, it is still a question that how these changes were caused by genetic reasons or by preeclampsia itself. OBJECTIVE: In our study, we explored the potential epigenetic regulation of delta-like homolog 1-maternally expressed gene 3 (DLK1-MEG3) region in human umbilical vein endothelial cells (HUVECs), and its connection with endothelium-derived factors...
September 17, 2018: Journal of Hypertension
Bangsen Ouyang, Kewei Zhang, Ya Yang
Self-powered photodetectors are expected to play a crucial role in future nano-optoelectronic devices owing to their independent and sustainable operation. Based on the heterojunction between ZnO nanowires (NWs) and shuttle-like SnS, we design a self-powered photodetector exhibiting wide-range photoresponse and tunable spectral selectivity. Differently from conventional devices, a wavelength-induced photocurrent polarity is observed in the ZnO NWs/SnS photodetector, which enables the device to distinguish between photons in the UV and visible (VIS) regions...
March 23, 2018: iScience
Josephine Al-Alam, Ziad Fajloun, Asma Chbani, Maurice Millet
In order to assess the air quality in some Lebanese regions, a biomonitoring study based on honey as biomonitor candidate was conducted. For this, 18 samples of honey collected from four regions in Lebanon, were analyzed for their contamination by 16 polycyclic aromatic hydrocarbons (PAHs) and 22 polychlorinated biphenyls (PCBs). Samples were first extracted using a multi-residue extraction method based on the quick, easy, cheap, effective, rugged, and safe extraction method (QuEChERS) followed by a concentration step using Solid-phase microextraction (SPME) procedures...
September 10, 2018: Journal of Environmental Science and Health. Part A, Toxic/hazardous Substances & Environmental Engineering
Xiao-Qiao Wang, Chuan Fu Tan, Kwok Hoe Chan, Xin Lu, Liangliang Zhu, Sang-Woo Kim, Ghim Wei Ho
Utilization of ubiquitous low-grade waste heat constitutes a possible avenue towards soft matter actuation and energy recovery opportunities. While most soft materials are not all that smart relying on power input of some kind for continuous response, we conceptualize a self-locked thermo-mechano feedback for autonomous motility and energy generation functions. Here, the low-grade heat usually dismissed as 'not useful' is used to fuel a soft thermo-mechano-electrical system to perform perpetual and untethered multimodal locomotions...
August 24, 2018: Nature Communications
Antoni Delpino-Rius, Diana Cosovanu, Jordi Eras, Francesca Vilaró, Mercè Balcells, Ramon Canela-Garayoa
A total of 48 chlorophylls and derivatives were identified and successfully determined in tea and processed vegetable and fruit foodstuff by UHPLC with photodiode-array and mass spectrometry detection. The method allowed the proper separation of chlorophyll derivatives resulting from demetallation, dephytilation, decarbomethoxylation, epimerisation and copperisation. The method was performed in less than 12 min, using an optimised ternary gradient (MeOH, iPrOH, MeCN and H2 O with 10 mM of ammonium acetate) on an ACQUITY HSS T3 column...
September 21, 2018: Journal of Chromatography. A
Zhan Zhou, Yuhui Zheng, Cheng Cheng Zhang, Jinwei Gao, Yiping Tang, Qianming Wang
Carbonaceous materials have long been developed to utilize "nano-spaces" and numerous guest species could be encapsulated. A remarkable fluorescence difference has been observed after newly designed pyropheophorbide-a-appended carbon nanohorns were incorporated in a cellular medium and confocal microscopy was employed for the determination of the intracellular localization. Our study supported the role of carbon nanohorns as carriers of photodynamic therapy (PDT) agents and their heating behavior was discussed...
October 10, 2018: Photochemical & Photobiological Sciences
Shixiang Yao, Chibuike C Udenigwe
Post-translational modifications (PTMs) often occur in proteins and play a regulatory role in protein function. There is an increasing interest in the bioactivity of food protein-derived peptides, but the occurrence of PTMs and their influence on food peptide structure and behaviour remain largely unknown. In this study, the shotgun-based peptidomics strategy was used to identify the occurrence of PTMs in peptides generated from potato protein hydrolysis using digestive proteases. Diverse PTMs were found in the potato peptides, including acetylation of lysine, N-terminal of proteins and peptides, C-terminal amidation, de-amidation of asparagine/glutamine, methylation and trimethylation, methionine oxidation and N-terminal pyro-glutamyl residue formation...
July 2018: Royal Society Open Science
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