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https://read.qxmd.com/read/30756272/neuro-radiological-characteristics-of-adult-diffuse-grade-ii-and-iii-insular-gliomas-classified-according-to-who-2016
#1
Compes Paloma, Tabouret Emeline, Etcheverry Amandine, Colin Carole, Appay Romain, Cordier Nicolas, Mosser Jean, Chinot Olivier, Delingette Hervé, Girard Nadine, Dufour Henry, Metellus Philippe, Figarella-Branger Dominique
INTRODUCTION: The phenotypic heterogeneity of diffuse gliomas is still inconsistently explained by known molecular abnormalities. Here, we report the molecular and radiological features of diffuse grade WHO II and III gliomas involving the insula and its potential impact on prognosis. METHODS: Clinical, pathological, molecular and neuro-radiological features of 43 consecutive patients who underwent a surgical resection between 2006 and 2013 for a grade II and III gliomas involving the insula was retrospectively analyzed...
February 11, 2019: Journal of Neuro-oncology
https://read.qxmd.com/read/30742784/plasticity-of-the-maternal-vasculature-during-pregnancy
#2
George Osol, Nga Ling Ko, Maurizio Mandalà
Maternal cardiovascular changes during pregnancy include an expansion of plasma volume, increased cardiac output, decreased peripheral resistance, and increased uteroplacental blood flow. These adaptations facilitate the progressive increase in uteroplacental perfusion that is required for normal fetal growth and development, prevent the development of hypertension, and provide a reserve of blood in anticipation of the significant blood loss associated with parturition. Each woman's genotype and phenotype determine her ability to adapt in response to molecular signals that emanate from the fetoplacental unit...
February 10, 2019: Annual Review of Physiology
https://read.qxmd.com/read/30735586/change-in-gray-matter-volume-and-cerebral-blood-flow-in-patients-with-burning-mouth-syndrome
#3
Young Chan Lee, Geon-Ho Jahng, Chang-Woo Ryu, Jae Yong Byun
BACKGROUND: The purpose of this study was to evaluate alterations in gray matter volume (GMV) and cerebral blood flow (CBF) using structural MRI and arterial spin labeling (ASL) perfusion MRI, respectively, in burning mouth syndrome (BMS) patients. METHODS: We prospectively enrolled 12 patients with BMS and 14 healthy controls. Volumetric T1-weighted magnetization-prepared rapid gradient-echo imaging and pseudo-continuous ASL were performed to obtain GMV and CBF, respectively...
February 8, 2019: Journal of Oral Pathology & Medicine
https://read.qxmd.com/read/30724816/effect-of-pravastatin-pretreatment-and-hypercapnia-on-intestinal-microvascular-oxygenation-and-blood-flow-during-sepsis
#4
Jan Schulz, Christian Vollmer, Richard Truse, Inge Bauer, Christopher Beck, Olaf Picker, Anna Herminghaus
INTRODUCTION: In septic patients, adequate microvascular oxygenation (μHBO2) of the intestine is vital for their outcome. Recent studies suggest that statins can ameliorate septic microcirculation in a variety of tissues. However, the effect on intestinal microvascular oxygenation and blood flow is largely unknown. Furthermore, there are indications that statin therapy might not be beneficial in the presence of hypercapnia, as observed in septic ARDS patients. Therefore, the present study explores the effect of pravastatin with and without additional moderate acute hypercapnia on intestinal microvascular oxygenation and blood flow in experimental sepsis...
February 1, 2019: Shock
https://read.qxmd.com/read/30720216/the-blood-pressure-paradox-in-acute-ischemic-stroke
#5
Lan Hong, Xin Cheng, Longting Lin, Andrew Bivard, Yifeng Ling, Kenneth Butcher, Qiang Dong, Mark Parsons
OBJECTIVE: To explore the association of post-stroke baseline blood pressure with cerebral collateral flow and functional outcome in acute ischemic patients with large vessel occlusion/stenosis. METHODS: Patients identified with large vessel occlusion/stenosis with baseline multimodal computed tomography, follow-up imaging, and complete clinical profiles were included. A 90-day modified Rankin Scale of 0-1 was defined as an excellent functional outcome. Cerebral collateral flow was quantified by the volume ratio of tissue within the delay time>3 seconds perfusion lesion with severely delayed contrast transit (delay time>3s/delay time>6s)...
February 5, 2019: Annals of Neurology
https://read.qxmd.com/read/30718162/cerebral-hemodynamics-during-neonatal-cerebrospinal-fluid-removal
#6
Stefano Bembich, Gabriele Cont, Jenny Bua, Giulia Paviotti, Sergio Demarini
BACKGROUND: Standard treatment of neonatal posthemorrhagic hydrocephalus is cerebrospinal fluid removal. The aim of this study was to assess how much cerebrospinal fluid volume removal, by ventricular reservoir taps, is needed to improve cerebral hemodynamics and oxygenation in neonatal posthemorrhagic hydrocephalus. METHODS: Cerebral hemodynamics and oxygenation were continuously monitored by near-infrared spectroscopy in four newborns (one term and three preterm) during 28 ventricular reservoir taps...
January 8, 2019: Pediatric Neurology
https://read.qxmd.com/read/30717765/partial-volume-correction-for-arterial-spin-labeling-using-the-inherent-perfusion-information-of-multiple-measurements
#7
Yang Liu, Ze Wang, Ruihua Liang, Zhengrong Liang, Hongbing Lu
BACKGROUND: Arterial spin labeling (ASL) provides a noninvasive way to measure cerebral blood flow (CBF). The CBF estimation from ASL is heavily contaminated by noise and the partial volume (PV) effect. The multiple measurements of perfusion signals in the ASL sequence are generally acquired and were averaged to suppress the noise. To correct the PV effect, several methods were proposed, but they were all performed directly on the averaged image, thereby ignoring the inherent perfusion information of mixed tissues that are embedded in multiple measurements...
February 4, 2019: Biomedical Engineering Online
https://read.qxmd.com/read/30715769/cortical-pattern-of-reduced-perfusion-in-hearing-loss-revealed-by-asl-mri
#8
Sara Ponticorvo, Renzo Manara, Josef Pfeuffer, Arianna Cappiello, Sofia Cuoco, Maria Teresa Pellecchia, Renato Saponiero, Donato Troisi, Claudia Cassandro, Marta John, Alfonso Scarpa, Ettore Cassandro, Francesco Di Salle, Fabrizio Esposito
Age-related hearing loss (HL) can be related to brain dysfunction or structural damage and may result in cerebral metabolic/perfusion abnormalities. Arterial spin labeling (ASL) magnetic resonance imaging (MRI) allows investigating noninvasively brain perfusion changes. Pseudocontinuous ASL and T1-weighted MRI (at 3 T) and neuropsychological testing (Montreal Cognitive Assessment) were performed in 31 HL (age range = 47-77 years, mean age ± SD = 63.4 ± 8.4 years, pure-tone average [PTA] HL > 50 dB) and 28 normal hearing (NH; age range = 48-78 years, mean age ± SD = 59...
February 4, 2019: Human Brain Mapping
https://read.qxmd.com/read/30715003/perioperative-intravenous-tranexamic-acid-reduces-blood-transfusion-in-primary-cementless-total-hip-arthroplasty
#9
Andrea Sandri, Bogdan Florentin Mimor, Alessandro Ditta, Eliana Finocchio, Vinicio Danzi, Pierluigi Piccoli, Dario Regis, Bruno Magnan
BACKGROUND AND AIM OF THE WORK: Blood loss and transfusion requirements are common in total hip arthroplasty. Tranexamic acid is one of the most interesting options to reduce the need for blood transfusions in a variety of surgical settings. The aim of this study was to assess the efficacy of perioperative intravenous traxexamic acid regarding blood transfusion rate and volume of transfused blood without increasing adverse events after primary elective cementless total hip arthroplasty...
January 10, 2019: Acta Bio-medica: Atenei Parmensis
https://read.qxmd.com/read/30712134/defining-cutoff-values-for-early-prediction-of-delayed-cerebral-ischemia-after-subarachnoid-hemorrhage-by-ct-perfusion
#10
Vesna Malinova, Ioannis Tsogkas, Daniel Behme, Veit Rohde, Marios Nikos Psychogios, Dorothee Mielke
Early prediction of delayed cerebral ischemia (DCI) after aneurysmal subarachnoid hemorrhage (aSAH) is essential to prevent infarction. CT perfusion (CTP) is used to identify perfusion deficits and to guide treatment decisions. In this study, we aimed to evaluate CTP parameters and to establish cutoff values for DCI prediction in the early phase after aSAH. Whole-brain CTP was performed on day 3 after aSAH. These CTP parameters were analyzed: cerebral blood flow (CBF), cerebral blood volume (CBV), mean transit time (MTT), time to peak (TTP), time to start (TTS), and time to drain (TTD)...
February 2, 2019: Neurosurgical Review
https://read.qxmd.com/read/30702208/interferon-free-therapy-as-the-cause-of-white-matter-tracts-and-cerebral-perfusion-recovery-in-patients-with-chronic-hepatitis-c
#11
Joanna Bladowska, Tomasz Pawłowski, Katarzyna Fleischer-Stępniewska, Brygida Knysz, Krzysztof Małyszczak, Agnieszka Żelwetro, Weronika Rymer, Małgorzata Inglot, Marta Waliszewska-Prosół, Maria Ejma, Przemysław Podgórski, Anna Zimny, Marek Sąsiadek
The purpose of this study was to assess cerebral microstructural and perfusion changes in patients with chronic hepatitis C virus (HCV) infection before and after interferon-free therapy, using advanced magnetic resonance (MR) techniques. Eleven HCV-positive patients underwent diffusion tensor imaging (DTI) and perfusion weighted imaging (PWI) using a 1.5T MR unit, before and 24 weeks after completion of interferon-free therapy. DTI fractional anisotropy (FA) and apparent diffusion coefficient (ADC) values were obtained from 14 white matter tracts...
January 31, 2019: Journal of Viral Hepatitis
https://read.qxmd.com/read/30702064/-a-study-of-uterine-hemodynamics-using-three-dimensional-power-doppler-sonography-in-patients-with-adenomyosis
#12
K Yakovenko, T Tamm, Ye Yakovenko
The goal of the work was the investigation of volumetric blood flow parameters in uterine body of women of different ages suffering from various forms of adenomyosis, in three-dimensional angio mode, in order to search for objective differential-diagnostic criteria of this pathology. The main study group included 46 women aged 18 to 45 who were diagnosed with II-III degree adenomyosis at ultrasound examination of pelvic organs according to the conventional procedure in a two-dimensional mode. The control group included 111 healthy women aged 18 to 45 years old...
December 2018: Georgian Medical News
https://read.qxmd.com/read/30694370/quantitative-contrast-enhanced-ultrasound-of-renal-perfusion-a-technology-for-the-assessment-of-early-diabetic-nephropathy-in-cynomolgus-macaques-with-type-2-diabetes-mellitus
#13
Jieli Luo, Jianshe Chen, Yang Sun, Hang Zhou, Kailun Xu, Fengbo Huang, Pintong Huang
PURPOSE: The aim of this study was to investigate the effectiveness of contrast-enhanced ultrasound (CEUS) in predicting early nephropathy in cynomolgus macaques with spontaneous type 2 diabetes mellitus (T2DM). METHODS: Six cynomolgus macaques with spontaneous T2DM and six normal cynomolgus macaques (Group 1) were included in this study. The time-intensity curve was used to obtain parameters such as peak values, red blood volume (RBV), red blood flow (RBF), time to peak (TTP), and mean transit time (MTT)...
January 29, 2019: Abdominal Radiology
https://read.qxmd.com/read/30681358/effect-of-contrast-medium-injection-rate-on-computed-tomography-derived-renal-perfusion-estimates-obtained-with-the-maximum-slope-method-in-healthy
#14
Sang-Kwon Lee, Cheolhyun Kim, Sooa Yoon, Jihye Choi
OBJECTIVE To evaluate the effect of contrast medium injection rate on CT-derived renal perfusion estimates obtained with the maximum slope method in healthy small dogs. ANIMALS 6 healthy sexually intact male purpose-bred Beagles. PROCEDURES All dogs underwent CT perfusion analysis 3 times in a crossover design, receiving a different contrast medium injection rate (1.5, 3.0, and 4.5 mL/s) each time, with a 1-week interval between imaging sessions. All CT images were obtained at the level of the left renal hilus...
February 2019: American Journal of Veterinary Research
https://read.qxmd.com/read/30678863/aldosterone-the-mineralocorticoid-receptor-and-mechanisms-of-cardiovascular-disease
#15
Morag J Young, Gail K Adler
The mineralocorticoid receptor (MR) and aldosterone play a critical role in the regulation of plasma volume homeostasis and are critical for the control of normal physiological regulation blood pressure (BP) and organ perfusion and as a potent mediator of hypertension. Aldosterone and the MR also play a key role in regulating tissue volume expansion in many tissues, via the regulation of hypertrophy and/or hyperplasia of cardiac or vascular smooth muscle cells and through regulation of the extra cellular matrix (ECM) and tissue fibrosis...
2019: Vitamins and Hormones
https://read.qxmd.com/read/30672174/-effects-of-tongdu-tiaoshen-acupuncture-on-cerebral-blood-flow-in-patients-with-high-risk-of-cerebral-ischemic-stroke-based-on-asl-and-pwi-technique
#16
Sifang Chen, Wei Han, Shanbin Sun, Guoqing Zhang, Ling Zhang
OBJECTIVE: To observe the effects of " Tongdu Tiaoshen " acupuncture on cerebral blood flow in high-risk patients of cerebral ischemic stroke based on arterial spin labeling (ASL) and perfusion-weighted imaging (PWI), and to evaluate the clinical efficacy. METHODS: A total of 180 patients with transient ischemic attacks (TIA) / minor ischemic stroke (MIS) were randomly divided into an acupuncture A group, an acupuncture B group and a medication group, 60 cases in each group...
September 12, 2018: Zhongguo Zhen Jiu, Chinese Acupuncture & Moxibustion
https://read.qxmd.com/read/30663173/the-role-of-ct-perfusion-in-defining-the-clinically-relevant-core-infarction-to-guide-thrombectomy-selection-in-patients-with-acute-stroke
#17
Hussam Shaker, Muhib Khan, Todd Mulderink, Tracy J Koehler, Raymond Scurek, Tricia Tubergen, Laurel Packard, Justin Singer, Paul Mazaris, Jiangyong Min, Nabil Wees, Nadeem Khan, Tamer Abdelhak
BACKGROUND AND PURPOSE: Infarct core assessment on presentation is important to evaluate salvageable tissue to select patients for thrombectomy. Our study aims to evaluate the correlation between infarct core volume measured by computed tomography (CT) perfusion (CTP) and magnetic resonance diffusion-weighted imaging (MR-DWI) in patients with acute large-vessel occlusion. METHODS: We studied patients who underwent CTP on presentation to the emergency department for stroke symptoms...
January 20, 2019: Journal of Neuroimaging: Official Journal of the American Society of Neuroimaging
https://read.qxmd.com/read/30661915/allogenic-endothelial-progenitor-cell-transplantation-increases-flap-survival-through-an-upregulation-of-enos-and-vegf-on-venous-flap-survival-in-rabbits
#18
Zeyuan Jin, Chenglun Yao, Keshav Poonit, Tao Han, Sunlong Li, Zihuai Huang, Hede Yan
BACKGROUND: Endothelial progenitor cells (EPCs) are one type of bone marrow hematopoietic stromal cells which play a vital role in neovascularization and tissue repair. In this study, we investigated whether EPCs promote flap survival in a rabbit venous model. MATERIALS AND METHODS: EPCs were customized from CHI Scientific, Inc, China. Thirty-six rabbits were randomly assigned to either the sham group (n = 12), the control group (n = 12) or the EPC transplantation group (n = 12)...
January 11, 2019: Journal of Plastic, Reconstructive & Aesthetic Surgery: JPRAS
https://read.qxmd.com/read/30660996/osteogenic-magnesium-incorporated-into-plga-tcp-porous-scaffold-by-3d-printing-for-repairing-challenging-bone-defect
#19
Yuxiao Lai, Ye Li, Huijuan Cao, Jing Long, Xinluan Wang, Long Li, Cairong Li, Qingyun Jia, Bin Teng, Tingting Tang, Jiang Peng, David Eglin, Mauro Alini, Dirk W Grijpma, Geoff Richards, Ling Qin
Bone defect repair is a challenging clinical problem in musculoskeletal system, especially in orthopaedic disorders such as steroid associated osteonecrosis (SAON). Magnesium (Mg) as a biodegradable metal with properly mechanical properties has been investigating for a long history. In this study, Mg powder, poly (lactide-co-glycolide) (PLGA), β-tricalcium phosphate (β-TCP) were the elements to formulate a novel porous PLGA/TCP/Mg (PTM) scaffolds using low temperature rapid prototyping (LT-RP) technology...
January 7, 2019: Biomaterials
https://read.qxmd.com/read/30659643/dependence-of-the-mr-signal-on-the-magnetic-susceptibility-of-blood-studied-with-models-based-on-real-microvascular-networks
#20
Xiaojun Cheng, Avery J L Berman, Jonathan R Polimeni, Richard B Buxton, Louis Gagnon, Anna Devor, Sava Sakadžić, David A Boas
PURPOSE: The primary goal of this study was to estimate the value of <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"> <mml:mi>β</mml:mi> </mml:math> , the exponent in the power law relating changes of the transverse relaxation rate and intra-extravascular local magnetic susceptibility differences as <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"> <mml:mrow> <mml:msup> <mml:mrow> <mml:mi>Δ</mml:mi> <mml:msub> <mml:mi>R</mml:mi> <mml:mn>2</mml:mn> </mml:msub> </mml:mrow> <mml:mrow> <mml:mrow/> <mml:mo>∗</mml:mo> </mml:mrow> </mml:msup> <mml:mo>∝</mml:mo> <mml:msup> <mml:mrow> <mml:mo>(</mml:mo> <mml:mi>Δ</mml:mi> <mml:mi>χ</mml:mi> <mml:mo>)</mml:mo> </mml:mrow> <mml:mi>β</mml:mi> </mml:msup> </mml:mrow> </mml:math> ...
January 18, 2019: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
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