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photothermal therapy review

Austin C V Doughty, Ashley R Hoover, Elivia Layton, Cynthia K Murray, Eric W Howard, Wei R Chen
As a result of their unique compositions and properties, nanomaterials have recently seen a tremendous increase in use for novel cancer therapies. By taking advantage of the optical absorption of near-infrared light, researchers have utilized nanostructures such as carbon nanotubes, gold nanorods, and graphene oxide sheets to enhance photothermal therapies and target the effect on the tumor tissue. However, new uses for nanomaterials in targeted cancer therapy are coming to light, and the efficacy of photothermal therapy has increased dramatically...
March 7, 2019: Materials
Pradip Das, Parisa Fatehbasharzad, Miriam Colombo, Luisa Fiandra, Davide Prosperi
The integration of multiple imaging and therapeutic agents into a customizable nanoplatform for accurate identification and rapid prevention of cancer is attracting great attention. Among the available theranostic nanosystems, magnetic gold nanoparticles are particularly promising as they exhibit unique physicochemical properties that can support multiple functions, including cancer diagnosis by magnetic resonance imaging, X-ray computed tomography, Raman and photoacoustic imaging, drug delivery, and plasmonic photothermal and photodynamic therapies...
March 9, 2019: Trends in Biotechnology
M Ibrahim Khot, Helen Andrew, Hafdis S Svavarsdottir, Gemma Armstrong, Aaron J Quyn, David G Jayne
Oncologic thermal ablation involves the use of hyperthermic temperatures to damage and treat solid cancers. Thermal ablation is being investigated as a method of treatment in colorectal cancers and has the potential to complement conventional anticancer treatments in managing local recurrence and metastatic disease. Photothermal therapy utilizes photosensitive agents to generate local heat and induce thermal ablation. There is growing interest in developing nanotechnology platforms to deliver such photosensitive agents...
February 14, 2019: Clinical Colorectal Cancer
Rushikesh S Ambekar, Balasubramanian Kandasubramanian
Cancer is the second leading cause of death in the world with around 9.6 million deaths in 2018, approximately 70% of which occurred in the middle- and low-income countries; moreover, the economic impact of cancer is significant and escalating day by day. The total annual economic cost of cancer treatment in 2010 was estimated at approximately US$ 1.16 trillion. Researchers have explored cancer mitigation therapies such as chemo-thermal therapy, chemo-photothermal therapy and photodynamic-photothermal therapy...
March 6, 2019: Biomaterials Science
Li-Li Tan, Li Shang
Smart delivery systems have gained momentum over the last few decades due to their potential to realize enhanced therapeutic efficacy. Poly(glycidyl methacrylate)s (PGMAs), which spring up like mushrooms, have drawn great attention in the theranostics field, especially in multifunctional theranostic systems. The marriage of PGMAs with functional inorganic cores is expected to integrate diagnosis (e.g., fluorescence, X-ray computed tomography, magnetic resonance, photoacoustic and upconversion luminescence imaging), treatment, or multimodal synergistic therapies (e...
February 28, 2019: Macromolecular Rapid Communications
Wen Sun, Xueze Zhao, Jiangli Fan, Jianjun Du, Xiaojun Peng
As traditional phototherapy agents, boron dipyrromethene (BODIPY) photosensitizers have attracted increasing attention due to their high molar extinction coefficients, high phototherapy efficacy, and excellent photostability. After being formed into nanostructures, BODIPY-containing nano-photosensitizers show enhanced water solubility and biocompatibility as well as efficient tumor accumulation compared to BODIPY molecules. Hence, BODIPY nano-photosensitizers demonstrate a promising potential for fighting cancer...
February 20, 2019: Small
Seyyed Mojtaba Mousavi, Sadaf Soroshni, Seyyed Alireza Hashemi, Aziz Babapoor, Younes Ghasemi, Ali Mohammad Amani
At this article, graphene oxide Nano ribbons (GONRs) and its high potential for using in medical fields have been reviewed. Recently, Graphene Nano ribbons (GNRs) has been a field of interest in biological methods and disease treatment such as drug delivery, DNA applications, and photothermal cancer therapies. GNRs demonstrate more efficient properties rather than other graphene-based Nanomaterials due to their larger surface area. These novel properties made them into a remarkable substitute material for biological fields as they have different cytotoxic effects and almost nontoxic to human health and the environment...
February 20, 2019: Drug Metabolism Reviews
Jianjun Du, Ning Xu, Jiangli Fan, Wen Sun, Xiaojun Peng
Carbon dots (CDs), a kind of carbon material discovered accidentally, exhibit unexpected advantages in fluorescence imaging/sensing such as photostability, biocompatibility, and low toxicity. For emerging theranostics, an interdiscipline created by integrating therapy and diagnostics, CDs are good candidates when they are combined with targeted chemo/gene/photodynamic/photothermal therapeutic moieties. Here, the development of CDs in nanomedicine is reviewed from their use as original imaging agents and/or drug carriers to multifunctional theranostic systems...
February 18, 2019: Small
Chandran Murugan, Varsha Sharma, Rajesh Kumar Murugan, Gnanasekar Malaimegu, Anandhakumar Sundaramurthy
In recent years, novel two-dimensional (2D) nanomaterials are of great interest for diverse potential applications such as device fabrication, energy storage, sensing and theranostics because of their superlative physical features namely, large surface area, minimal thickness, tunable composition and easier surface modification methods. Rapid exploration in design and fabrication of 2D nano-structures have opened new avenue for cancer theranostics as it can encapsulate group of cancer cells and inflict major damage with great specificity in a non-invasive manner...
February 13, 2019: Journal of Controlled Release: Official Journal of the Controlled Release Society
Na Jin, Qing Zhang, Manyi Yang, Mingying Yang
Gold nanorods (AuNRs) have attracted widespread attention in the last few decades due to their potential applications in cancer photothermal therapy (CPTT). However, the utilization of AuNRs is restricted because of their high toxicity for cells and tissues. Numerous methods have been developed to solve this problem, among which the most convenient one is to coat AuNRs with biocompatible materials or replace their original toxic surfactant such as the hexadecyl-trimethyl ammonium bromide (CTAB). Organic polymers (OPs) are intensively researched due to their low toxicity and easy access to modification with functional groups (e...
February 14, 2019: Microscopy Research and Technique
Kevin M Vargas, Young-Seok Shon
Biomolecule-nanoparticle hybrids have proven to be one of most promising frontiers in biomedical research. In recent years, there has been an increased focus on the development of hybrid lipid-nanoparticle complexes (HLNCs) which inherit unique properties of both the inorganic nanoparticles and the lipid assemblies (i.e. liposomes, lipoproteins, solid lipid nanoparticles, and nanoemulsions) that comprise them. In combination of their component parts, HLNCs also gain new functionalities which are utilized for numerous biomedical applications (i...
February 7, 2019: Journal of Materials Chemistry. B, Materials for Biology and Medicine
Guangxu Lan, Kaiyuan Ni, Wenbin Lin
Phototherapy involves the irradiation of tissues with light, and is commonly implemented in the forms of photodynamic therapy (PDT) and photothermal therapy (PTT). Photosensitizers (PSs) are often needed to improve the efficacy and selectivity of phototherapy via enhanced singlet oxygen generation in PDT and photothermal responses in PTT. In both cases, efficient and selective delivery of PSs to the diseased tissues is of paramount importance. Nanoscale metal-organic frameworks (nMOFs), a new class of hybrid materials built from metal connecting points and bridging ligands, have been examined as nanocarriers for drug delivery due to their compositional and structural tunability, highly porous structures, and good biocompatibility...
January 15, 2019: Coordination Chemistry Reviews
Yifan Zhang, Kai Huang, Jing Lin, Peng Huang
Anisotropic Janus nanoparticles (JNPs), due to their several distinct merits, have been widely investigated for cancer theranostics. Firstly, the asymmetric modification of JNPs allows the independent release of multiple drugs. Secondly, the spatial separation of imaging materials effectively diminishes the signal interference and attenuation that usually take place in core-shell or alloy nanoparticles. Thirdly, their asymmetric composition contributes to the photothermal or potential gradient that could drive the motion of JNPs for dynamic drug delivery...
January 29, 2019: Biomaterials Science
Saeed Taghizadeh, Vahid Alimardani, Parvin Lohrasbi Roudbali, Younes Ghasemi, Elina Kaviani
Studies have shown that hepatocellular carcinoma (HCC) (the most important types of liver cancer) is the fifth most common cancer, and the third cause of mortality, globally. Although major progress has been made in the treatment and diagnosis of this disease, its eradication remains limited. Consequently, discovering new diagnosis and treatment methods is important. Cancer nanotechnology is an emerging field in medicine with the aim to accomplish advances in both cancer diagnosis and treatment. Gold nanoparticles (GNPs/ AuNPs) have attracted much attention, owing to their biocompatibility (bio-inertness, and low cytotoxicity), ability to chemically modify their surface by attaching multiple types of ligands, and their superior optical properties...
January 23, 2019: Photodiagnosis and Photodynamic Therapy
Surendranath Anju, Jayakumar Ashtami, P V Mohanan
2D materials have gained spectacular status across various scientific and technological disciplines owing to their exceptional unique properties. The very recent member of 2D family, Black Phosphorus monolayers, known as Phosphorene have attracted recent scientific attention since its first exfoliation and appreciable rediscovery in 2014. Compared to other 2D materials and graphene analogs, it has outstanding properties like tunable band gap, good carrier mobility, excellent ON-OFF current ratio, potent in vivo biocompatibility and non-toxic biodegradability...
April 2019: Materials Science & Engineering. C, Materials for Biological Applications
S Fatemeh Shams, Mohammad Reza Ghazanfari, Carolin Schmitz-Antoniak
Magnetic-plasmonic heterodimer nanostructures synergistically present excellent magnetic and plasmonic characteristics in a unique platform as a multipurpose medium for recently invented biomedical applications, such as magnetic hyperthermia, photothermal therapy, drug delivery, bioimaging, and biosensing. In this review, we briefly outline the less-known aspects of heterodimers, including electronic composition, interfacial morphology, critical properties, and present concrete examples of recent progress in synthesis and applications...
January 13, 2019: Nanomaterials
Seyed Mohammad Amini
This mini-review has investigated the recent progress regarding gold nanostructures capacities of energy absorption for thermal therapy applications. Unselective thermal therapy of malignant and normal tissues could lead to irreversible damage to healthy tissues without effective treatment on target malignant tissues. In recent years, there has been a considerable progress in the field of cancer thermal therapy for treating target malignant tissues using nanostructures. Due to the remarkable physical properties of the gold nanoparticle, it has been considered as an exceptional element for thermal therapy techniques...
January 2019: Journal of Thermal Biology
Krishanu Ghosal, Ashis Ghosh
Among the wide range of carbon family nanomaterials, carbon dots (CDs) one of the promising candidate which has attracted tremendous attention due to its unique advantages such as facile synthesis procedure, easy surface functionalization, outstanding water solubility, low toxicity and excellent photo-physical properties. Due to these unique advantages, CDs are extensively used in catalysis, electronics, sensing, power as well as in biological sectors. In this review we will discuss recent progress in synthesis, structure and fluorescence properties of CDs with special highlight on its biomedical applications, more precisely we will highlight on CDs, for drug/gene delivery, bioimaging and photothermal and photodynamic therapy applications...
March 2019: Materials Science & Engineering. C, Materials for Biological Applications
Kunmeng Li, Enlv Hong, Bing Wang, Zhiyu Wang, Liwen Zhang, Hu Ruixia, Baiqi Wang
The detection and treatment of cancer cells at an early stage are crucial for prolonging the survival time and improving the quality of life of patients. Upconversion nanoparticles (UCNPs) have unique physical and chemical advantages and likely provide a platform for detecting and treating cancer cells at an early stage. In this paper, the principle of UCNPs as chemical sensors based on fluorescence resonance energy transfer (FRET) has been briefly introduced. Research progress in such chemical sensors for detecting and analyzing bioactive substances and heavy metal ions at the subcellular level has been summarized...
December 20, 2018: Photodiagnosis and Photodynamic Therapy
Pingsheng Huang, Xiaoli Wang, Xiaoyu Liang, Jing Yang, Chuangnian Zhang, Deling Kong, Weiwei Wang
Immunotherapy is moving to the frontier of cancer treatment. Drug delivery systems (DDSs) have greatly advanced the development of cancer immunotherapeutic regimen and combination treatment. DDSs can spatiotemporally present tumor antigens, drugs, immunostimulatory molecules, or adjuvants, thus enabling the modulation of immune cells including dendritic cells (DCs) or T-cells directly in vivo and thereby provoking robust antitumor immune responses. Cancer vaccines, immune checkpoint blockade, and adoptive cell transfer have shown promising therapeutic efficiency in clinic, and the incorporation of DDSs may further increase antitumor efficiency while decreasing adverse side effects...
December 19, 2018: Acta Biomaterialia
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