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JOURNAL ARTICLE
Kevin M Gibas, Dianne Auld, Stephanie Parente, Jean Horoho, Leonard A Mermel
External ventricular drains (EVDs) are medical devices that are inserted into the ventricles of the brain to drain excess fluid, manage intracranial hypertension, monitor intracranial pressure, and administer medications. Unintentional disconnections and breaks or fractures (breaks) of EVDs or associated drainage system components can result in cerebrospinal fluid (CSF) leakage and increased risk for EVD-associated infections. After replacement of Integra Life Sciences EVD systems with Medtronic Duet EVD systems at Rhode Island Hospital in mid-September 2023, a threefold increase was observed in the prevalence of positive CSF cultures, from 2...
April 11, 2024: MMWR. Morbidity and Mortality Weekly Report
#2
JOURNAL ARTICLE
Małgorzata Ewa Pihut, Jolanta Kostrzewa-Janicka, Magdalena Orczykowska, Joanna Biegańska-Banaś, Marta Gibas-Stanek, Andrzej Gala
BACKGROUND: Temporomandibular disorders (TMD) are a group of conditions that affect the function of the masticatory muscles, temporomandibular joints and surrounding structures. OBJECTIVES: The objective of the preliminary investigation was to develop an initial questionnaire for emotional assessment, pre-designed for TMD patients, and provide guidance for further management through referral to psychological and/or psychiatric counseling. Additionally, we aimed to compare the results of tests carried out in TMD patients with those of healthy subjects...
2024: Dental and Medical Problems
#3
JOURNAL ARTICLE
Sybren de Hoog, Thomas J Walsh, Sarah A Ahmed, Ana Alastruey-Izquierdo, Barbara D Alexander, Maiken Cavling Arendrup, Esther Babady, Feng-Yan Bai, Joan-Miquel Balada-Llasat, Andrew Borman, Anuradha Chowdhary, Andrew Clark, Robert C Colgrove, Oliver A Cornely, Tanis C Dingle, Philippe J Dufresne, Jeff Fuller, Jean-Pierre Gangneux, Connie Gibas, Heather Glasgow, Yvonne Graser, Jacques Guillot, Andreas H Groll, Gerhard Haase, Kimberly Hanson, Amanda Harrington, David L Hawksworth, Randall T Hayden, Martin Hoenigl, Vit Hubka, Kristie Johnson, Julianne V Kus, Ruoyu Li, Jacques F Meis, Michaela Lackner, Fanny Lanternier, Sixto M Leal, Francesca Lee, Shawn R Lockhart, Paul Luethy, Isabella Martin, Kyung J Kwon-Chung, Wieland Meyer, M Hong Nguyen, Luis Ostrosky-Zeichner, Elizabeth Palavecino, Preeti Pancholi, Peter G Pappas, Gary W Procop, Scott A Redhead, Daniel D Rhoads, Stefan Riedel, Bryan Stevens, Kaede Ota Sullivan, Paschalis Vergidis, Emmanuel Roilides, Amir Seyedmousavi, Lili Tao, Vania A Vicente, Roxana G Vitale, Qi-Ming Wang, Nancy L Wengenack, Lars Westblade, Nathan Wiederhold, Lewis White, Christina M Wojewoda, Sean X Zhang
No abstract text is available yet for this article.
March 5, 2024: Journal of Clinical Microbiology
#4
David Sender, Benjamin Hulsey, Connie Cañete-Gibas, Nathan Wiederhold, Jung Keun Lee, Abigail Finley, Catherine Cruz, Mary E White
KEY CLINICAL MESSAGE: We report on a dog with immune-mediated hemolytic anemia (IMHA) treated with immunomodulatory therapy that developed phaeohyphomycosis and Aspergillus citrinoterreus infections. This is the first reported case of A. citrinoterreus in dogs. It details cytological and microbiological findings leading to diagnosis and highlights the importance of investigating new lesions in immunocompromised patients. ABSTRACT: A 5-year-old Staffordshire terrier mix treated with immunosuppressive therapy for IMHA was diagnosed with concurrent disseminated A...
February 2024: Clinical Case Reports
#5
JOURNAL ARTICLE
Kevin M Gibas, Peter F Rebeiro, Meredith Brantley, Samantha Mathieson, Laurie Maurer, April C Pettit
PURPOSE: Incident HIV remains an important public health issue in the US South, the region leading the nation in HIV incidence, rural HIV cases, and HIV-related deaths. Late diagnoses drive incident HIV and understanding factors driving late diagnoses is critical for developing locally relevant HIV testing and prevention interventions, decreasing HIV transmission, and ending the HIV epidemic. METHODS: Retrospective cohort study utilizing Tennessee Department of Health (TDH) surveillance data and US Census Bureau data...
February 15, 2024: Journal of Rural Health
#6
JOURNAL ARTICLE
Kevin M Gibas, Aima A Ahonkhai, Alexander Huang, Chelsea van Wyk, Fatimah I Tsiga-Ahmed, Baba M Musa, Mahmoud U Sani, Carolyn M Audet, C William Wester, Muktar H Aliyu
As persons with HIV live longer as the result of antiretroviral therapy, morbidity from HIV-associated noncommunicable diseases (NCDs) is increasing. The Vanderbilt-Nigeria Building Research Capacity in HIV and Noncommunicable Diseases program is a training platform created with the goal of training a cohort of successful Nigerian investigators to become leaders in HIV-associated NCD research. We describe survey findings from two week-long workshops in Kano, Nigeria, where trainees received instruction in implementation science and grant writing...
February 13, 2024: American Journal of Tropical Medicine and Hygiene
#7
JOURNAL ARTICLE
Marta Gibas-Stanek, Piotr Pełka, Małgorzata Pihut
The objective of this study was to review the current knowledge based on in vitro and in vivo studies, that evaluated the enamel damage connected with removal of metal and ceramic orthodontic brackets taking into account different debonding methods. Brackets fracture was also assessed. The protocol for this study was constructed according to the PRISMA statement. The literature review was performed in MEDLINE via PubMed, Cochrane and Scopus databases in May 2021. The searching was repeated in Journal of Stomatology, Orthodontic Forum and grey literature was screened using Google Scholar...
October 30, 2023: Folia Medica Cracoviensia
#8
Gibae Kim, Xiyan Hou, Woong Sub Byun, Gyudong Kim, Dnyandev B Jarhad, Grim Lee, Young Eum Hyun, Jinha Yu, Chang Soo Lee, Shuhao Qu, Eugene Warnick, Zhan-Guo Gao, Ji Yong Kim, Seunghee Ji, Hyunwoo Shin, Jong-Ryoul Choi, Kenneth A Jacobson, Hyuk Woo Lee, Sang Kook Lee, Lak Shin Jeong
No abstract text is available yet for this article.
January 23, 2024: Journal of Medicinal Chemistry
#9
EDITORIAL
Magdalena Gibas-Dorna, Wioletta Żukiewicz-Sobczak
The concept of sustainable nutrition is focused on an optimal and health-promoting diet that is culturally acceptable, easily accessible, and eco-friendly by reducing environmental costs for present and future generations [...].
January 10, 2024: Nutrients
#10
JOURNAL ARTICLE
Kotryna Skardžiūtė, Kotryna Kvederavičiūtė, Inga Pečiulienė, Milda Narmontė, Povilas Gibas, Janina Ličytė, Saulius Klimašauskas, Edita Kriukienė
We present a method, named Mx-TOP, for profiling of three epigenetic regulatory layers-chromatin accessibility, general DNA modification, and DNA hydroxymethylation-from a single library. The approach is based on chemo-enzymatic covalent tagging of unmodified CG sites and hydroxymethylated cytosine (5hmC) along with GC sites in chromatin, which are then mapped using tag-selective base-resolution TOP-seq sequencing. Our in-depth validation of the approach revealed its sensitivity and informativity in evaluating chromatin accessibility and DNA modification interactions that drive transcriptional regulation...
December 20, 2023: Cell Chemical Biology
#11
Benjamin A Doran, Robert Y Chen, Hannah Giba, Vivek Behera, Bidisha Barat, Anitha Sundararajan, Huaiying Lin, Ashley Sidebottom, Eric G Pamer, Arjun S Raman
UNLABELLED: The human gut microbiome contains many bacterial strains of the same species ('strain-level variants'). Describing strains in a biologically meaningful way rather than purely taxonomically is an important goal but challenging due to the genetic complexity of strain-level variation. Here, we measured patterns of co-evolution across >7,000 strains spanning the bacterial tree-of-life. Using these patterns as a prior for studying hundreds of gut commensal strains that we isolated, sequenced, and metabolically profiled revealed widespread structure beneath the phylogenetic level of species...
December 5, 2023: bioRxiv
#12
COMMENT
Shawn R Lockhart, Dallas J Smith, Jeremy A W Gold
Dermatophyte infections (a.k.a. ringworm, tinea) affect an estimated 20%-25% of the world's population. In North America, most dermatophytoses are caused by Trichophyton rubrum or Trichophyton mentagrophytes species complexes. Severe and antifungal-resistant dermatophytoses are a growing global public health problem. A new species of the T. mentagrophytes species complex, Trichophyton indotineae , has recently emerged and is notable for the severe infections it causes, its propensity for antifungal resistance, and its global spread...
December 19, 2023: Journal of Clinical Microbiology
#13
JOURNAL ARTICLE
Piotr Gibała, Anna Jarosz-Lesz, Zuzanna Sołtysiak-Gibała, Jakub Staniczek, Rafał Stojko
This retrospective study aimed to investigate the impact of microorganisms identified in the reproductive tract on disorders during the early adaptation period in newborns. A cohort of 823 patients and cervical canal cultures were analyzed to identify the presence of microorganisms. Newborns included in the study were divided into two groups due to the number of pathogens identified in the swab from the cervical canal of the mother. The first group consisted of newborns whose mothers had one pathogen identified (N = 637), while the second group consisted of newborns whose mothers had two or more pathogens identified (N = 186)...
October 30, 2023: Journal of Clinical Medicine
#14
JOURNAL ARTICLE
Sybren de Hoog, Thomas J Walsh, Sarah A Ahmed, Ana Alastruey-Izquierdo, Barbara D Alexander, Maiken Cavling Arendrup, Esther Babady, Feng-Yan Bai, Joan-Miquel Balada-Llasat, Andrew Borman, Anuradha Chowdhary, Andrew Clark, Robert C Colgrove, Oliver A Cornely, Tanis C Dingle, Philippe J Dufresne, Jeff Fuller, Jean-Pierre Gangneux, Connie Gibas, Heather Glasgow, Yvonne Gräser, Jacques Guillot, Andreas H Groll, Gerhard Haase, Kimberly Hanson, Amanda Harrington, David L Hawksworth, Randall T Hayden, Martin Hoenigl, Vit Hubka, Kristie Johnson, Julianne V Kus, Ruoyu Li, Jacques F Meis, Michaela Lackner, Fanny Lanternier, Sixto M Leal, Francesca Lee, Shawn R Lockhart, Paul Luethy, Isabella Martin, Kyung J Kwon-Chung, Wieland Meyer, M Hong Nguyen, Luis Ostrosky-Zeichner, Elizabeth Palavecino, Preeti Pancholi, Peter G Pappas, Gary W Procop, Scott A Redhead, Daniel D Rhoads, Stefan Riedel, Bryan Stevens, Kaede Ota Sullivan, Paschalis Vergidis, Emmanuel Roilides, Amir Seyedmousavi, Lili Tao, Vania A Vicente, Roxana G Vitale, Qi-Ming Wang, Nancy L Wengenack, Lars Westblade, Nathan Wiederhold, Lewis White, Christina M Wojewoda, Sean X Zhang
The rapid pace of name changes of medically important fungi is creating challenges for clinical laboratories and clinicians involved in patient care. We describe two sources of name change which have different drivers, at the species versus the genus level. Some suggestions are made here to reduce the number of name changes. We urge taxonomists to provide diagnostic markers of taxonomic novelties. Given the instability of phylogenetic trees due to variable taxon sampling, we advocate to maintain genera at the largest possible size...
October 26, 2023: Journal of Clinical Microbiology
#15
JOURNAL ARTICLE
Vincent Rathkolb, Marianna T Traugott, Andreas Heinzel, Marko Poglitsch, Judith Aberle, Farsad Eskandary, Agnes Abrahamowicz, Martin Mueller, Petra Knollmueller, Tarik Shoumariyeh, Jasmin Stuflesser, Ivan Seeber, Georg Gibas, Hannah Mayfurth, Viktoria Tinhof, Lukas Schmoelz, Markus Zeitlinger, Christian Schoergenhofer, Bernd Jilma, Bernd Genser, Wolfgang Hoepler, Sara Omid, Mario Karolyi, Christoph Wenisch, Rainer Oberbauer, Alexander Zoufaly, Manfred Hecking, Roman Reindl-Schwaighofer
Despite the similar clinical outcomes after renin-angiotensin system (RAS) inhibitor (RASi) continuation or withdrawal in COVID-19, the effects on angiotensin-converting enzyme 2 (ACE2) and RAS metabolites remain unclear. In a substudy of the randomized controlled Austrian Corona Virus Adaptive Clinical Trial (ACOVACT), patients with hypertension and COVID-19 were randomized 1:1 to either RASi continuation (n = 30) or switch to a non-RASi medication (n = 29). RAS metabolites were analyzed using a mixed linear regression model (n = 30)...
November 17, 2023: IScience
#16
JOURNAL ARTICLE
Teresa Kamińska-Gibas, Joanna Szczygieł, Annemiek Blasweiler, Łukasz Gajda, Ebru Yilmaz, Patrycja Jurecka, Ludmiła Kolek, Marek Ples, Ilgiz Irnazarow
Iron uptake, transport, and storage require the involvement of several proteins, including ferroportin (fpn), the sole known iron efflux transporter. Due to its critical function fpn has been studied, particularly in humans. Here, we characterized the ferroportin gene in common carp (Cyprinus carpio L.) and performed RNA-seq analysis to evaluate its constitutive transcription levels across different tissues. Our results indicate that C. carpio possesses two functional fpns with distinct expression patterns, highlighting the potential for functional divergence and expression differentiation among fpns in this species...
September 28, 2023: Fish & Shellfish Immunology
#17
Bianca E Ituarte, Connie Cañete-Gibas, Nathan P Wiederhold, Liset Olarte
We report the first known human case of Kneiffiella palmae in the medical literature. K. palmae was isolated from a pulmonary nodule in a 7-year-old male with chronic granulomatous disease. The mold was identified as K. palmae at a national reference laboratory, where 17 other human respiratory samples tested positive for K. palmae from 2013 to 2021. Optimal antimicrobial treatment is unknown, but azoles and amphotericin B demonstrated in vitro activity against each tested isolate.
September 2023: Medical Mycology Case Reports
#18
REVIEW
Z Oruba, M Gibas-Stanek, M Pihut, M Cześnikiewicz-Guzik, W Stós
Patients with periodontitis often require an inter-disciplinary approach, including orthodontic treatment, for effective rehabilitation of masticatory function, aesthetics and quality of life. The aim of this narrative review was to comprehensively discuss literature focusing on the biology, indications and inter-disciplinary connections related to the orthodontic approach in patients with periodontitis and to present clinical concepts in accordance with valid guidelines. The outcomes of the experimental studies indicate that orthodontic tooth movement (OTM) can be performed safely for teeth with reduced periodontium, provided infection and inflammation are controlled...
September 8, 2023: Australian Dental Journal
#19
JOURNAL ARTICLE
Gibae Kim, Xiyan Hou, Woong Sub Byun, Gyudong Kim, Dnyandev B Jarhad, Grim Lee, Young Eum Hyun, Jinha Yu, Chang Soo Lee, Shuhao Qu, Eugene Warnick, Zhan-Guo Gao, Ji Yong Kim, Seunghee Ji, Hyunwoo Shin, Jong-Ryoul Choi, Kenneth A Jacobson, Hyuk Woo Lee, Sang Kook Lee, Lak Shin Jeong
Based on hA2A AR structures, a hydrophobic C8-heteroaromatic ring in 5'-truncated adenosine analogues occupies the subpocket tightly, converting hA2A AR agonists into antagonists while maintaining affinity toward hA3 AR. The final compounds of 2,8-disubstituted- N 6 -substituted 4'-thionucleosides, or 4'-oxo, were synthesized from d-mannose and d-erythrono-1,4-lactone, respectively, using a Pd-catalyst-controlled regioselective cross-coupling reaction. All tested compounds completely antagonized hA2A AR, including 5d with the highest affinity ( K i,A2A = 7...
August 21, 2023: Journal of Medicinal Chemistry
#20
REVIEW
Oskar Wojciech Wiśniewski, Bartłomiej Czyżniewski, Wioletta Żukiewicz-Sobczak, Magdalena Gibas-Dorna
COVID-19 is highly linked with hyperinflammation and dysfunction of the immune cells. Studies have shown that adequate nutrition, a modifiable factor affecting immunity and limiting systemic inflammation, may play an adjunct role in combating the negative consequences of SARS-CoV-2 infection. Due to the global lockdown conditions, the COVID-19 pandemic has contributed, among others, to restrictions on fresh food availability and changes in lifestyle and eating behaviors. The aim of this paper was to review the data regarding eating habits in European countries within the general population of adults and some specific subpopulations, including obese, diabetic, and psychiatric patients, during the COVID-19 pandemic...
August 4, 2023: Nutrients
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