keyword
https://read.qxmd.com/read/38525160/erratum-sex-based-differences-and-risk-factors-for-comorbid-nonalcoholic-fatty-liver-disease-in-patients-with-bipolar-disorder-a-cross-sectional-retrospective-study-corrigendum
#21
(no author information available yet)
[This corrects the article DOI: 10.2147/DMSO.S428523.].
2024: Diabetes, Metabolic Syndrome and Obesity
https://read.qxmd.com/read/38524957/olanzapine-samidorphan-for-schizophrenia-a-systematic-review-and-meta-analysis
#22
REVIEW
Dhyuti Gupta, Alok Singh
BACKGROUND AND OBJECTIVE: United States Food and Drug Administration (USFDA) recently approved a novel combination of olanzapine-samidorphan (OLZSAM) for managing olanzapine-associated adverse events (weight gain) in adult patients with schizophrenia and bipolar disorder. To opine about the safety and efficacy of OLZSAM, authors performed a systematic review and meta-analysis to convene justifiable evidence. METHODS: A thorough literature search was performed through the databases Embase, Cochrane Library, PubMed, and clinicaltrials...
January 2024: Indian Journal of Psychological Medicine
https://read.qxmd.com/read/38524086/kratom-induced-psychiatric-decompensation-and-paranoid-delusions
#23
Matthew Awad, Hugh H Burke, Scott A Oakman
Kratom is a plant extract readily available for purchase in the USA. It is known to produce both stimulant and opioid-related effects, predisposing it to abuse. The long-term effects of kratom are poorly understood. In rare cases, serious side effects have been reported. Here, we report a case of a patient with a history of bipolar type schizoaffective disorder presenting with acute onset paranoia and delusions. The patient had been hospitalized seven times previously with psychotic symptoms, with no reported history of paranoid delusional thought content in previous admissions...
February 2024: Curēus
https://read.qxmd.com/read/38524072/electroconvulsive-therapy-for-the-treatment-of-somatic-delusions
#24
Brittnie Phan, Chong Yang
Somatic delusions occur in various psychiatric disorders and are associated with higher mortality and lower quality of life. In this case report, we present a 68-year-old man with the diagnosis of schizoaffective disorder, bipolar type with associated somatic delusions, and auditory hallucinations. His somatic delusions were alleviated by the 20th ECT treatment with additional clinical improvements in his speech, thought processes, and judgment. This case report supports the utilization of ECT for patients with schizoaffective disorder and somatic delusions...
February 2024: Curēus
https://read.qxmd.com/read/38523770/utilization-of-cultural-formulation-interview-to-understand-the-factors-affecting-treatment-adherence-and-help-seeking-in-mood-disorders-a-qualitative-study-from-western-india
#25
JOURNAL ARTICLE
Kartik Singhai, Jitender Aneja, Mukesh Swami, Pratibha Gehlawat
INTRODUCTION: Treatment adherence rates among patients of affective disorders remain sub-par across the world. Sociocultural factors affecting the same remain poorly understood. The current study aimed to explore and conceptualize the same. METHODOLOGY: The study utilized a qualitative grounded and phenomenological approach study design. The patients who fulfilled the Diagnostic and Statistical Manual of Mental Disorders - Fifth edition (DSM-5) criteria of unipolar depression or bipolar affective disorder, and were presently under our treatment for at least three months and currently in remission, aged 18-60 years, and were able to understand Hindi or English, scored less than 6 on the Medication Adherence Rating Scale were included...
February 2024: Indian Journal of Psychiatry
https://read.qxmd.com/read/38523768/a-prospective-study-of-suicidal-behavior-in-young-patients-of-depressive-episodes-with-hidden-bipolarity-exposed-to-selective-serotonin-reuptake-inhibitor
#26
JOURNAL ARTICLE
Manoj Kumar, Rudraprasad Acharya, Nitu Mallik, Arghya Pal, Malay Kumar Ghosal
BACKGROUND: Treatment of depressive episodes in young patients is challenging owing to several reasons such as poor diagnostic stability and atypical presentation. Evidence regarding treating such patients with antidepressants such as selective serotonin reuptake inhibitor (SSRI) is not clear. METHODS: Fifty patients aged 10-24 years diagnosed with depressive episodes and drug-free for at least 3 months were rated on Beck's Depression Inventory (BDI), The Mood Disorder Questionnaire (MDQ), and Beck Scale for Suicidal Ideation (BSS)...
February 2024: Indian Journal of Psychiatry
https://read.qxmd.com/read/38523642/prediction-of-antipsychotics-efficacy-based-on-a-polygenic-risk-score-a-real-world-cohort-study
#27
JOURNAL ARTICLE
Marco De Pieri, Marco Ferrari, Giorgio Pistis, Franziska Gamma, Franca Marino, Armin Von Gunten, Philippe Conus, Marco Cosentino, Chin-Bin Eap
Background: Response to antipsychotics is subject to a wide interindividual variability, due to genetic and non-genetic factors. Several single nucleotide polymorphisms (SNPs) have been associated with response to antipsychotics in genome-wide association studies (GWAS). Polygenic risk scores (PRS) are a powerful tool to aggregate into a single measure the small effects of multiple risk alleles. Materials and methods: We studied the association between a PRS composed of SNPs associated with response to antipsychotics in GWAS studies (PRSresponse ) in a real-world sample of patients (N = 460) with different diagnoses (schizophrenia spectrum, bipolar, depressive, neurocognitive, substance use disorders and miscellaneous)...
2024: Frontiers in Pharmacology
https://read.qxmd.com/read/38523595/alcohol-drinking-dna-methylation-and-psychiatric-disorders-a-multi-omics-mendelian-randomization-study-to-investigate-causal-pathways
#28
JOURNAL ARTICLE
Xiaoqiang Shi, Meng Li, Jianhua Yao, Ming D Li, Zhongli Yang
BACKGROUND AND AIMS: Whether alcohol-related DNA methylation has a causal effect on psychiatric disorders has not been investigated. Furthermore, a comprehensive investigation into the causal relationship and underlying mechanisms linking alcohol consumption and psychiatric disorders has been lacking. This study aimed to evaluate the causal effect of general alcohol intake and pathological drinking behaviors on psychiatric disorders, alcohol-associated DNA methylation on gene expression and psychiatric disorders, and gene expression on psychiatric disorders...
March 25, 2024: Addiction
https://read.qxmd.com/read/38523512/missed-conceptions-about-paediatric-bipolar-disorder-a-reply-and-discussion-of-dmdd
#29
JOURNAL ARTICLE
Gin S Malhi, Erica Bell
No abstract text is available yet for this article.
March 25, 2024: Acta Neuropsychiatrica
https://read.qxmd.com/read/38522473/prenatal-insomnia-disorder-may-predict-concurrent-and-postpartum-psychopathology-a-longitudinal-study
#30
JOURNAL ARTICLE
Laura Palagini, Mario Miniati, Lorenza Driul, Marco Colizzi, Carla Comacchio, Angelo Gemignani, Matteo Balestrieri
While insomnia symptoms may be a risk factor for mental disturbances, few studies evaluated "Insomnia Disorder" and its relationship with perinatal psychopathology. Pregnant women were recruited during their last routine assessment before being hospitalized for delivery during the 3rd trimester at the Gynaecological Unit of the University Hospital of Ferrara and Udine, Italy, from January 2022 to January 2023. Our assessment included baseline evaluation (T0), and evaluations at 1 month (T1) and 3 months (T2) in the postpartum period, with specific questionnaires for insomnia disorder, such as Sleep Condition Indicator, mood and anxiety symptoms and psychosocial functioning, such as Edinburgh Postnatal Depression Scale, Mood Disorder Questionnaire, State-Trait Anxiety Inventory, Work and Social Adjustment Scale...
March 24, 2024: Journal of Sleep Research
https://read.qxmd.com/read/38522432/early-experience-with-the-new-dora-daridorexant-in-patients-with-insomnia-disorder-and-comorbid-mental-disturbances-results-of-a-naturalistic-study-with-3%C3%A2-months-follow-up
#31
JOURNAL ARTICLE
Laura Palagini, Gaspare Alfi, Riccardo Gurrieri, Eric Annuzzi, Valerio Caruso, Matteo Gambini, Giovanna Grenno, Marco Trivella, Silvio Presta, Mario Miniati, Stefano Pini, Giulio Perugi, Angelo Gemignani
Insomnia disorder may affect mental health, increasing suicidal risk. Targeting insomnia is crucial in the clinical practice. Sixty-six consecutive patients with insomnia disorder according with the DSM-5-TR criteria were treated with the dual orexin receptor antagonist, daridorexant 50 mg. Baseline (T0), 1 month (T1) and 3 month (T2) evaluations were performed. Insomnia severity (Insomnia Severity Index), mood, anxiety symptoms and suicidal risk (Beck Depression Inventory-II, Young Mania Rating Scale, Self-Reported Anxiety Scale, Suicidal Ideation Scale), dysfunctional insomnia-cognitive factors and pre-sleep arousal (Dysfunctional Beliefs About Sleep, Pre-Sleep Arousal Scale) were evaluated...
March 24, 2024: Journal of Sleep Research
https://read.qxmd.com/read/38521135/pathogenesis-or-a-response-to-lithium-a-novel-perspective-for-mitochondrial-mass-fluctuation-of-na%C3%A3-ve-t-cells-in-patients-with-bipolar-disorder
#32
JOURNAL ARTICLE
Zhenni Chen, Bingqi Wang, Yiran Huang, Xiaofan Wang, Wanzhen Li, Min Wang
BACKGROUND: Immune imbalances are associated with the pathogenesis and pharmacological efficacy of bipolar disorder (BD). The underlying mechanisms remain largely obscure but may involve immunometabolic dysfunctions of T-lymphocytes. METHODS: We investigated if inflammatory cytokines and the immunometabolic function of T-lymphocytes, including frequencies of subsets, mitochondrial mass (MM), and low mitochondrial membrane potential (MMPLow ) differed between BD patients (n = 47) and healthy controls (HC, n = 43)...
March 21, 2024: Journal of Affective Disorders
https://read.qxmd.com/read/38519416/effects-of-erythropoietin-on-cognitive-impairment-and-prefrontal-cortex-activity-across-affective-disorders-a-randomized-double-blinded-placebo-controlled-trial
#33
JOURNAL ARTICLE
Julian Macoveanu, Jeff Zarp Petersen, Johanna Mariegaard, Andreas Elleby Jespersen, Katrine Cramer, Caroline Fussing Bruun, Helle Østergaard Madsen, Martin Balslev Jørgensen, Maj Vinberg, Patrick M Fisher, Gitte Moos Knudsen, Ida Hageman, Hannelore Ehrenreich, Lars Vedel Kessing, Kamilla Woznica Miskowiak
BACKGROUND: Persistent cognitive impairment is frequent across bipolar disorder (BD) and major depressive disorder (MDD), highlighting an urgent need for pro-cognitive treatments. AIM: This study investigated effects of erythropoietin (EPO) on cognitive impairment and dorsal prefrontal cortex (dPFC) activity in affective disorders. METHODS: In this randomized, double-blinded, placebo-controlled trial, cognitively impaired patients with remitted BD or MDD received 1 weekly recombinant human EPO (40,000 IU/mL) or saline infusion for a 12-week period...
March 22, 2024: Journal of Psychopharmacology
https://read.qxmd.com/read/38518857/molecular-mechanisms-of-quetiapine-bidirectional-regulation-of-bipolar-depression-and-mania-based-on-network-pharmacology-and-molecular-docking-evidence-from-computational-biology
#34
JOURNAL ARTICLE
Chuanjun Zhuo, Chao Li, Hongjun Tian, Ranli Li, Feng Jia, Lina Wang, Xiaoyan Ma, Lei Yang, Qiuyu Zhang, Ying Zhang, Kaifang Yao
BACKGROUND: Quetiapine monotherapy is recommended as the first-line option for acute mania and acute bipolar depression. However, the mechanism of action of quetiapine is unclear. Network pharmacology and molecular docking were employed to determine the molecular mechanisms of quetiapine bidirectional regulation of bipolar depression and mania. METHODS: Putative target genes for quetiapine were collected from the GeneCard, SwissTargetPrediction, and DrugBank databases...
March 20, 2024: Journal of Affective Disorders
https://read.qxmd.com/read/38518412/multi-modality-fusion-transformer-with-spatio-temporal-feature-aggregation-module-for-psychiatric-disorder-diagnosis
#35
JOURNAL ARTICLE
Guoxin Wang, Fengmei Fan, Sheng Shi, Shan An, Xuyang Cao, Wenshu Ge, Feng Yu, Qi Wang, Xiaole Han, Shuping Tan, Yunlong Tan, Zhiren Wang
Bipolar disorder (BD) is characterized by recurrent episodes of depression and mild mania. In this paper, to address the common issue of insufficient accuracy in existing methods and meet the requirements of clinical diagnosis, we propose a framework called Spatio-temporal Feature Fusion Transformer (STF2Former). It improves on our previous work - MFFormer by introducing a Spatio-temporal Feature Aggregation Module (STFAM) to learn the temporal and spatial features of rs-fMRI data. It promotes intra-modality attention and information fusion across different modalities...
March 19, 2024: Computerized Medical Imaging and Graphics: the Official Journal of the Computerized Medical Imaging Society
https://read.qxmd.com/read/38518409/how-do-lipids-fit-into-the-picture-of-severe-mental-health-disorders-a-missing-pathophysiologic-link-or-just-a-consequence-of-behavior-and-treatment
#36
JOURNAL ARTICLE
Eva C Schulte, Thomas G Schulze
No abstract text is available yet for this article.
March 21, 2024: European Neuropsychopharmacology: the Journal of the European College of Neuropsychopharmacology
https://read.qxmd.com/read/38517222/new-pharmacotherapies-to-tackle-the-unmet-needs-in-bipolar-disorder-a-focus-on-acute-suicidality
#37
REVIEW
Georgios D Kotzalidis, Federica Fiaschè, Alessandro Alcibiade, Laura Monti, Federica Di Segni, Marianna Mazza, Gabriele Sani
INTRODUCTION: Suicidal behavior is relatively frequent in patients with bipolar disorder (BD) and constitutes their most frequent cause of death. Suicide rates remain high in patients with BD despite adherence to guidelines recommending lithium as first line, and/or antidepressants, antipsychotics, psychotherapy, psychosocial interventions, and electroconvulsive therapy. Hence the need to identify more effective and rapid anti-suicide interventions. AREAS COVERED: To tackle the unmet needs of pharmacotherapy, we investigated the PubMed database on 24-25 January 2024 using strategies like ('acute suicid*'[ti] OR 'suicide crisis syndrome' OR 'acute suicidal affective disturbance') AND (lithium[ti] OR clozapine[ti]), which obtained 3 results, and ('acute suicid*'[ti] OR 'suicide crisis syndrome' OR 'acute suicidal affective disturbance') AND (ketamine[ti] OR esketamine[ti] OR NMDA[ti] OR glutamat*[ti]), which yielded 14 results...
March 22, 2024: Expert Opinion on Pharmacotherapy
https://read.qxmd.com/read/38516433/schizencephaly-associated-with-bipolar-affective-disorder
#38
Rahul Rama Rao, Anish Bandalore Satheesha Reddy, Dhanushia P, Abhay Koul
Schizencephaly is a rare congenital anomaly characterized by the formation of abnormal clefts in the brain. Despite the association of psychotic symptoms with various brain abnormalities or insults, their occurrence in individuals with schizencephaly is relatively infrequent. The association of bipolar disorder, with or without psychosis, with schizencephaly is rarer. A systematic search on PubMed using "Schizencephaly AND Bipolar Disorder" yielded only four case studies specifically addressing the connection between these two conditions...
February 2024: Curēus
https://read.qxmd.com/read/38515671/arginine-metabolomics-in-mood-disorders
#39
JOURNAL ARTICLE
Angelo Zinellu, Sara Tommasi, Stefania Sedda, Arduino A Mangoni
Alterations of nitric oxide (NO) homeostasis have been described in mood disorders. However, the analytical challenges associated with the direct measurement of NO have prompted the search for alternative biomarkers of NO synthesis. We investigated the published evidence of the association between these alternative biomarkers and mood disorders (depressive disorder or bipolar disorder). Electronic databases were searched from inception to the June 30, 2023. In 20 studies, there was a trend towards significantly higher asymmetric dimethylarginine (ADMA) in mood disorders vs...
March 30, 2024: Heliyon
https://read.qxmd.com/read/38514458/vitamin-b12-overdose-may-trigger-the-onset-of-mixed-state-bipolar-disorder-a-case-report
#40
JOURNAL ARTICLE
Albert Stachura, Łukasz Banaszek, Katarzyna Jurkin, Łukasz Święcicki
No abstract text is available yet for this article.
March 21, 2024: Bipolar Disorders
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