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https://read.qxmd.com/read/30780062/salivary-melatonin-onset-in-youth-at-familial-risk-for-bipolar-disorder
#1
Neera Ghaziuddin, Wael Shamseddeen, Holli Bertram, Melvin McInnis, Holly C Wilcox, Philip B Mitchell, Janice M Fullerton, Gloria M P Roberts, Anne L Glowinski, Masoud Kamali, Emma Stapp, Leslie A Hulvershorn, John Nurnberger, Roseanne Armitage
Melatonin secretion and polysomnography (PSG) were compared among a group of healthy adolescents who were at high familial risk for bipolar disorder (HR) and a second group at low familial risk (LR). Adolescent participants (n = 12) were a mean age 14 ± 2.3 years and included 8 females and 4 males. Saliva samples were collected under standardized condition light (red light) and following a 200 lux light exposure over two consecutive nights in a sleep laboratory. Red Light Melatonin onset (RLMO) was defined as saliva melatonin level exceeding the mean of the first 3 readings plus 2 standard deviations...
February 6, 2019: Psychiatry Research
https://read.qxmd.com/read/30779437/comorbidity-of-alcohol-use-and-other-psychiatric-disorders-and-suicide-mortality-data-from-the-south-korea-national-health-insurance-cohort-2002-2013
#2
Subin Park, Soo Jung Rim, MinKyung Jo, Min Geu Lee, Chul Eung Kim
OBJECTIVE: Previous studies have indicated that alcohol use disorders (AUD) and other psychiatric disorders increase the risk of suicide mortality. However, little research has investigated the concomitant effect of comorbid psychiatric disorders on suicide mortality. This study aimed to investigate the effect of comorbid AUD on suicide mortality of individuals with another psychiatric disorder using a national data sample. METHODS: We used the National Health Insurance Service-National Sample Cohort (NHIS-NSC) data from 2002-2013...
February 19, 2019: Alcoholism, Clinical and Experimental Research
https://read.qxmd.com/read/30779416/fine-mapping-scan-of-bipolar-disorder-susceptibility-loci-in-latino-pedigrees
#3
Suzanne Gonzalez, Erika Villa, Marco Rodriguez, Mercedes Ramirez, Juan Zavala, Regina Armas, Albana Dassori, Javier Contreras, Henriette Raventós, Deborah Flores, Alvaro Jerez, Alfonso Ontiveros, Humberto Nicolini, Michael Escamilla
We previously identified bipolar disorder (BD) susceptibility loci on 8q24, 14q32, and 2q12-14 in a genome-wide nonparametric linkage screen in a Latino cohort. We now perform a fine mapping analysis using a dense map of additional SNPs to identify BD susceptibility genes within these regions. One thousand nine hundred and thirty-eight individuals with Latino ancestry (880 individuals with BD Type I or Schizoaffective, Bipolar Type) from 416 Latino pedigrees from the United States, Mexico, Costa Rica, and Guatemala were genotyped with 3,074 SNPs to provide dense coverage of the 8q24 (11...
February 19, 2019: American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics
https://read.qxmd.com/read/30779092/diet-quality-and-eating-patterns-in-euthymic-bipolar-patients
#4
D Łojko, M Stelmach-Mardas, A Suwalska
OBJECTIVE: As mood disorders and obesity are interrelated, and both are linked to increased morbidity and mortality, risk factors for obesity should be identified and closely monitored in patients with bipolar disorder (BD). The aim of this study was to determine the diet quality of BD patients and to investigate its putative associations with comorbid obesity and disorders of carbohydrate metabolism, as well as the relationship between diet and clinical features of BD. PATIENTS AND METHODS: Eating patterns in 113 euthymic BD patients and 160 healthy control subjects were assessed using data obtained from a food frequency questionnaire...
February 2019: European Review for Medical and Pharmacological Sciences
https://read.qxmd.com/read/30778423/-evolution-of-the-levels-of-the-caregiver-burden-in-bipolar-patients-family-members-who-participated-in-a-psychoeducational-workshop
#5
Carlos A Vinacour, Graciela Rodríguez Méndez, Rocío García, Brenda Young
PURPOSE: Caregiver burden is a variable which measures the impact of a chronic disease on the people who are closer to the patient. Different investigations have shown that the burden suffered by family members of patients with bipolar disorder is similar to that suffered by the relatives of schizophrenic patients and superior to the excessive strain caused by chronic diseases, such as diabetes. Lowering burden levels has been proved to improve family members' welfare and also to reduce patients' relapse indexes...
July 2018: Vertex: Revista Argentina de Psiquiatriá
https://read.qxmd.com/read/30775452/the-link-between-thyroid-autoimmunity-depression-and-bipolar-disorder
#6
Neringa Jucevičiūtė, Birutė Žilaitienė, Rosita Aniulienė, Virginija Vanagienė
Depression and bipolar disorder are two major psychiatric illnesses whose pathophysiology remains elusive. Newly emerging data support the hypothesis that the dysfunction of the immune system might be a potential factor contributing to the development of these mental disorders. The most common organ affected by autoimmunity is the thyroid; therefore, the link between autoimmune thyroid disorders and mental illnesses has been studied since the 1930s. The aim of this review is to discuss the associations between thyroid autoimmunity, depression and bipolar disorder...
2019: Open Medicine (Warsaw, Poland)
https://read.qxmd.com/read/30774035/the-use-of-component-wise-gradient-boosting-to-assess-the-possible-role-of-cognitive-measures-as-markers-of-vulnerability-to-pediatric-bipolar-disorder
#7
Isabelle E Bauer, Robert Suchting, Tamsyn E Van Rheenen, Mon-Ju Wu, Benson Mwangi, Danielle Spiker, Giovana B Zunta-Soares, Jair C Soares
BACKGROUND AND AIMS: Cognitive impairments are primary hallmarks symptoms of bipolar disorder (BD). Whether these deficits are markers of vulnerability or symptoms of the disease is still unclear. This study used a component-wise gradient (CGB) machine learning algorithm to identify cognitive measures that could accurately differentiate pediatric BD, unaffected offspring of BD parents, and healthy controls. METHODS: 59 healthy controls (HC; 11.19 ± 3.15 yo; 30 girls), 119 children and adolescents with BD (13...
February 18, 2019: Cognitive Neuropsychiatry
https://read.qxmd.com/read/30773147/distinct-temporal-brain-dynamics-in-bipolar-disorder-and-schizophrenia-during-emotion-regulation
#8
Liwen Zhang, Hui Ai, Esther M Opmeer, Jan-Bernard C Marsman, Lisette van der Meer, Henricus G Ruhé, André Aleman, Marie-José van Tol
BACKGROUND: Disturbances in emotion regulation (ER) are characteristic of both patients with bipolar disorder (BD) and schizophrenia (SZ). We investigated the temporal dynamics of brain activation during cognitive ER in BD and SZ to understand the contribution of temporal characteristics of disturbed ER to their unique and shared symptomatology. METHOD: Forty-six participants performed an ER-task (BD, n = 15; SZ, n = 16; controls, n = 15) during functional magnetic resonance imaging, in which they were instructed to use cognitive reappraisal techniques to regulate their emotional responses...
February 18, 2019: Psychological Medicine
https://read.qxmd.com/read/30772748/spanish-validation-of-the-barcelona-temps-a-questionnaire-in-patients-with-bipolar-disorder-and-general-population
#9
Esther Jiménez, Caterina Del Mar Bonnín, Brisa Solé, Jose Sánchez-Moreno, María Reinares, Carla Torrent, Imma Torres, Estela Salagre, Cristina Varo, Victoria Ruíz, Anna Giménez, Antoni Benabarre, Luís Gutiérrez-Rojas, Jorge Cervilla, Pilar A Sáiz, M Paz García-Portilla, Julio Bobes, Benedikt L Amann, Anabel Martínez-Arán, Eduard Vieta
BACKGROUND: The Temperament Evaluation of the Memphis, Pisa, Paris, and San Diego (TEMPS-A) is a self-administered questionnaire intended to assess five affective temperaments: depressive, cyclothymic, hyperthymic, irritable and anxious. Our objective was to examine the psychometric properties of the TEMPS-A using a sample comprised by patients with bipolar disorder (BD) and healthy controls (HC) and to determine cut-off scores for each temperament. METHODS: Five hundred and ninety-eight individuals (327 BD and 271 HC) completed the TEMPS-A...
February 12, 2019: Journal of Affective Disorders
https://read.qxmd.com/read/30772745/effects-of-illness-duration-on-cognitive-performances-in-bipolar-depression-are-mediated-by-white-matter-microstructure
#10
Elisa M T Melloni, Sara Poletti, Benedetta Vai, Irene Bollettini, Cristina Colombo, Francesco Benedetti
BACKGROUND: Cognitive deficits are a core feature of bipolar disorder (BD), and persist during the euthymic phase. White matter (WM) microstructural abnormalities are widely considered a structural marker of BD. Features of illness chronicity, such as illness duration and number of mood episodes, have been associated with worsening of both clinical profile and brain structural alterations. This study examined the role of WM integrity as a possible mediator between illness duration and cognitive performances in a sample of BD patients...
February 8, 2019: Journal of Affective Disorders
https://read.qxmd.com/read/30772744/peripheral-expression-of-long-non-coding-rnas-in-bipolar-patients
#11
Arezou Sayad, Mohammad Taheri, Mir Davood Omrani, Hamid Fallah, Vahid Kholghi Oskooei, Soudeh Ghafouri-Fard
BACKGROUND: Long non-coding RNAs (lncRNAs) have established roles in the pathogenesis of diverse human disorders including neuropsychiatric disorders. METHODS: In the current study, we evaluated expression levels of six apoptosis-related lncRNAs (CCAT2, TUG1, PANDA, NEAT1, FAS-AS1 and OIP5-AS1) in the peripheral blood of bipolar disorder (BD) patients and healthy subjects to assess their contribution in the pathogenesis of BD. RESULTS: CCAT2, TUG1 and PANDA were up-regulated in total BD patients compared with total healthy subjects (P values = 0...
February 11, 2019: Journal of Affective Disorders
https://read.qxmd.com/read/30772743/whole-exome-sequencing-identifies-variants-associated-with-structural-mri-markers-in-patients-with-bipolar-disorders
#12
Mi-Ryung Han, Kyu-Man Han, Aram Kim, Wooyoung Kang, Youbin Kang, June Kang, Eunsoo Won, Woo-Suk Tae, Yunjung Cho, Byung-Joo Ham
BACKGROUND: Bipolar disorder (BD) is one of the most heritable psychiatric disorders. A growing number of whole-exome sequencing (WES) studies for BD has been performed, however, no research has examined the association between single nucleotide variants (SNVs) from WES and structural magnetic resonance imaging (MRI) data. METHODS: We sequenced whole-exomes in 53 patients with BD and 82 healthy control participants at an initial discovery stage and investigated the impacts of SNVs in risk genes from WES analysis on the cortical gray-matter thickness and integrity of white matter tracts and in the following stage...
February 11, 2019: Journal of Affective Disorders
https://read.qxmd.com/read/30772379/genome-scale-transcriptional-regulatory-network-models-of-psychiatric-and-neurodegenerative-disorders
#13
Jocelynn R Pearl, Carlo Colantuoni, Dani E Bergey, Cory C Funk, Paul Shannon, Bijoya Basu, Alex M Casella, Rediet T Oshone, Leroy Hood, Nathan D Price, Seth A Ament
Transcriptional regulatory changes in the developing and adult brain are prominent features of brain diseases, but the involvement of specific transcription factors (TFs) remains poorly understood. We integrated brain-specific DNase footprinting and TF-gene co-expression to reconstruct a transcriptional regulatory network (TRN) model for the human brain. We identified key regulator TFs whose predicted target genes were enriched for differentially expressed genes in the prefrontal cortex of individuals with psychiatric and neurodegenerative diseases...
January 31, 2019: Cell Systems
https://read.qxmd.com/read/30771137/impact-of-the-cyp2d6-phenotype-on-hyperprolactinemia-development-as-an-adverse-event-of-treatment-with-atypical-antipsychotic-agents-in-pediatric-patients
#14
Raluca Grădinaru, Nicoleta Andreescu, Laura Nussbaum, Liana Suciu, Maria Puiu
BACKGROUND: Treatment with atypical antipsychotics is today the election therapy for different types of psychosis, but there is a high incidence of endocrine and metabolic disturbances. One of the major enzymes involved in the metabolism of antipsychotics is CYP2D6. Depending on the existing CYP2D6 alleles, the metabolic capacity of the enzyme may vary from very low to very high, so that patients can be grouped into four phenotypic groups: slow, intermediate, extensive (normal), and fast metabolizers...
February 15, 2019: Irish Journal of Medical Science
https://read.qxmd.com/read/30770235/long-acting-injectable-antipsychotics-lais-for-maintenance-treatment-of-bipolar-and-schizoaffective-disorders-a-systematic-review
#15
REVIEW
Isabella Pacchiarotti, Jari Tiihonen, Georgios D Kotzalidis, Norma Verdolini, Andrea Murru, José Manuel Goikolea, Marc Valentí, Alberto Aedo, Eduard Vieta
Long-Acting Injectable Antipsychotics (LAIs) are used to overcome non-compliance in psychoses, mainly schizophrenia spectrum disorders. We aimed to summarize available evidence of studies comparing the efficacy of LAIs to placebo or oral medications for Bipolar Disorder (BD) and/or Schizoaffective Disorder (SAD). We searched six databases from inception to 28-March-2018, using the strategy: long-acting antipsychotics AND (bipolar disorder OR schizoaffective disorder OR mania OR manic OR bipolar depression)...
February 12, 2019: European Neuropsychopharmacology: the Journal of the European College of Neuropsychopharmacology
https://read.qxmd.com/read/30769297/risk-of-recurrence-of-mood-disorders-during-pregnancy-and-the-impact-of-medication-a-systematic-review
#16
REVIEW
Anja W M M Stevens, Peter J J Goossens, Elise A M Knoppert-van der Klein, Stasja Draisma, Adriaan Honig, Ralph W Kupka
BACKGROUND: Mood disorders can be difficult to treat during pregnancy. There is still lack of evidence whether pregnancy influences their natural course and whether continuation of pharmacotherapy, despite potential risks for the unborn child, is beneficial in preventing recurrence of mood episodes during pregnancy. METHODS: Systematic review conducted according to the PRISMA guidelines, searching Pubmed, PsycINFO, Embase and Cochrane databases up till January 9th, 2018...
February 7, 2019: Journal of Affective Disorders
https://read.qxmd.com/read/30768412/common-polygenic-variations-for-psychiatric-disorders-and-cognition-in-relation-to-brain-morphology-in-the-general-pediatric-population
#17
Silvia Alemany, Philip R Jansen, Ryan L Muetzel, Natália Marques, Hanan El Marroun, Vincent W V Jaddoe, Tinca J C Polderman, Henning Tiemeier, Danielle Posthuma, Tonya White
OBJECTIVE: To examine the relationship between polygenic scores (PGS) for five major psychiatric disorders and two cognitive traits with brain MRI morphological measurements in a large population-based sample of children. Additionally, we tested whether differences in brain morphology mediated associations between PGS for psychiatric disorders and related behavioral phenotypes. METHOD: The participants included 1,139 children from the Generation R Study assessed at 10 years-of-age with genotype and neuroimaging data available...
January 9, 2019: Journal of the American Academy of Child and Adolescent Psychiatry
https://read.qxmd.com/read/30768403/psychotic-like-experiences-in-offspring-of-parents-with-bipolar-disorder-and-community-controls-a-longitudinal-study
#18
Iria Mendez, David Axelson, Josefina Castro-Fornieles, Danella Hafeman, Tina R Goldstein, Benjamin I Goldstein, Rasim Diler, Roger Borras, John Merranko, Kelly Monk, Mary Beth Hickey, Boris Birmaher
OBJECTIVE: To compare the prevalence and risk factors associated with Psychotic-Like-Experiences (PLE) in offspring of parents with bipolar disorder (BP) and offspring of community control parents. METHOD: Delusional and hallucinatory subclinical psychotic experiences were evaluated at intake and longitudinally in a cohort study of 390 offspring of BP parents and 247 offspring of control parents aged 6-18 years old. The sample was followed up every 2.5 years on average for 8...
November 2, 2018: Journal of the American Academy of Child and Adolescent Psychiatry
https://read.qxmd.com/read/30768400/a-longitudinal-study-of-family-functioning-in-offspring-of-bipolar-parents
#19
Amit Shalev, John Merranko, Tina Goldstein, David J Miklowitz, David Axelson, Benjamin I Goldstein, David Brent, Kelly Monk, Mary Beth Hickey, Danella M Hafeman, Dara Sakolsky, Rasim Diler, Boris Birmaher
OBJECTIVE: To compare the longitudinal course of family functioning in offspring of parents with bipolar disorder (BD), offspring of parents with non-BD psychopathology, and offspring of healthy control parents (HC). METHOD: Offspring of BD parents (256 parents and 481 offspring), non-BD parents (82 parents and 162 offspring) and HC parents (88 parents and 175 offspring) ages 7-18 at intake, from the Bipolar Offspring Study (BIOS), were followed for an average of 4...
December 18, 2018: Journal of the American Academy of Child and Adolescent Psychiatry
https://read.qxmd.com/read/30768396/structural-brain-alterations-in-youth-with-psychosis-and-bipolar-spectrum-symptoms
#20
Maria Jalbrzikowski, David Freedman, Catherine E Hegarty, Eva Mennigen, Katherine H Karlsgodt, Loes M Olde Loohuis, Roel A Ophoff, Raquel E Gur, Carrie E Bearden
OBJECTIVE: Adults with established diagnoses of serious mental illness (bipolar disorder and schizophrenia) exhibit structural brain abnormalities, yet less is known about how such abnormalities manifest earlier in development. METHOD: We analyzed the cross-sectional data publicly available from the Philadelphia Neurodevelopmental Cohort (PNC). Structural magnetic resonance neuroimaging data (sMRI) were collected on a subset of the PNC (N=989, ages 9-22 years old)...
January 17, 2019: Journal of the American Academy of Child and Adolescent Psychiatry
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