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https://read.qxmd.com/read/30742862/nitric-oxide-in-the-dorsal-periaqueductal-gray-mediates-the-panic-like-escape-response-evoked-by-exposure-to-hypoxia
#1
Gabriel Gripp Fernandes, Alana Tercino Frias, Ailton Spiacci Jr, Lucas C Pinheiro, José Eduardo Tanus-Santos, Hélio Zangrossi Jr
Exposure of rats to an environment with low O2 levels evokes a panic-like escape behavior and recruits the dorsal periaqueductal gray (dPAG), which is considered to be a key region in the pathophysiology of panic disorder. The neurochemical basis of this response is, however, currently unknown. We here investigated the role played by nitric oxide (NO) within the dPAG in mediation of the escape reaction induced by hypoxia exposure. The results showed that exposure of male Wistar rats to 7% O2 increased nitrite levels, a NO metabolite, in the dPAG but not in the amygdala or hypothalamus...
February 8, 2019: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://read.qxmd.com/read/30742590/effects-of-cytochrome-p450-2c19-genetic-polymorphisms-on-responses-to-escitalopram-and-levels-of-brain-derived-neurotrophic-factor-in-patients-with-panic-disorder
#2
Qianqian He, Yan Mei, Yuanyuan Liu, Zhuo Yuan, Jian Zhang, Hong Yan, Li Shen, Yong Zhang
PURPOSE/BACKGROUND: The purpose of this study was to examine the relationships between ytochrome P450 family 2 subfamily C member 19 (CYP2C19) polymorphisms, brain-derived neurotrophic factor (BDNF) plasma levels, and treatment responses to escitalopram in Chinese patients with panic disorder (PD). METHODS/PROCEDURES: Ninety patients with PD were administered the Panic Disorder Severity Scale-Chinese Version (PDSS-CV) and Hamilton Anxiety Scale (HAMA-14) from baseline to 8 weeks...
February 7, 2019: Journal of Clinical Psychopharmacology
https://read.qxmd.com/read/30738930/cannabis-use-behaviors-and-prevalence-of-anxiety-and-depressive-symptoms-in-a-cohort-of-canadian-medicinal-cannabis-users
#3
Jasmine Turna, William Simpson, Beth Patterson, Philippe Lucas, Michael Van Ameringen
Cannabis is commonly used recreationally for its euphoric and relaxing effects, while its medical use is permitted in several jurisdictions. With only low-quality evidence suggesting anxiolytic effects of cannabis and strong public sentiment surrounding such purported effects, the purpose of this study was to examine the prevalence of cannabis for medicinal purposes (CMP) use for anxiety symptoms. An online survey was disseminated to CMP users registered with a Canadian licensed producer. Respondents completed demographic and validated self-report questionnaires (GAD-7, PHQ-9, MINI-SPIN, and panic disorder/agoraphobia DSM-5 criteria)...
January 31, 2019: Journal of Psychiatric Research
https://read.qxmd.com/read/30733913/reciprocal-associations-between-screen-time-and-emotional-disorder-symptoms-during-adolescence
#4
Jennifer Zink, Britni R Belcher, Afton Kechter, Matthew D Stone, Adam M Leventhal
Screen-based sedentary behaviors and emotional disorders are associated with one another in youth. Yet, the direction of the association is unclear, as is whether specific types of screen-based sedentary behaviors and emotional disorder symptoms are more closely linked. This study estimated the bi-directional associations between two types of screen-based sedentary behaviors and four types of self-reported emotional disorder symptoms, and tested whether physical activity buffered these associations in a Los Angeles high school student cohort ( N  = 2525, baseline M age = 14...
March 2019: Preventive Medicine Reports
https://read.qxmd.com/read/30724830/high-intensity-interval-training-in-panic-disorder-patients-a-pilot-study
#5
Jens Plag, Deniz-Levent Ergec, Thomas Fydrich, Andreas Ströhle
High-intensity interval training (HIIT) may produce strong physiological but also psychological effects within a short period. However, it is questionable if this type of training is applicable and effective in patients with panic disorder (PD) because they are more vulnerable to the adverse effects of exercise. Twelve PD patients performed a 12-day HIIT trial. Every second day, patients performed 10 high-intensive 1-minute intervals at 77% to 95% of their maximum heart rate separated by 1-minute intervals with moderate to low intensity...
February 4, 2019: Journal of Nervous and Mental Disease
https://read.qxmd.com/read/30719316/minocycline-induced-transient-depersonalization-a-case-report
#6
Yassein Shamout, Alissa Sigal, Ivan V Litvinov
Minocycline is a medication commonly used for the treatment of acne vulgaris. The central nervous system-induced side effects of minocycline include headaches, pseudotumor cerebri, ataxia, and vestibular dysfunction. Many minocycline-related side effects have been presented in the literature, however, reports of depersonalization symptoms induced by the medication are rare. We present the case of a 37-year-old female diagnosed with perioral dermatitis treated with minocycline, who within 1 week suffered from severe depersonalization symptoms...
2019: SAGE open medical case reports
https://read.qxmd.com/read/30718541/orexin-in-the-anxiety-spectrum-association-of-a-hcrtr1-polymorphism-with-panic-disorder-agoraphobia-cbt-treatment-response-and-fear-related-intermediate-phenotypes
#7
Michael G Gottschalk, Jan Richter, Christiane Ziegler, Miriam A Schiele, Julia Mann, Maximilian J Geiger, Christoph Schartner, György A Homola, Georg W Alpers, Christian Büchel, Lydia Fehm, Thomas Fydrich, Alexander L Gerlach, Andrew T Gloster, Sylvia Helbig-Lang, Raffael Kalisch, Tilo Kircher, Thomas Lang, Tina B Lonsdorf, Christiane A Pané-Farré, Andreas Ströhle, Heike Weber, Peter Zwanzger, Volker Arolt, Marcel Romanos, Hans-Ulrich Wittchen, Alfons Hamm, Paul Pauli, Andreas Reif, Jürgen Deckert, Susanne Neufang, Michael Höfler, Katharina Domschke
Preclinical studies point to a pivotal role of the orexin 1 (OX1 ) receptor in arousal and fear learning and therefore suggest the HCRTR1 gene as a prime candidate in panic disorder (PD) with/without agoraphobia (AG), PD/AG treatment response, and PD/AG-related intermediate phenotypes. Here, a multilevel approach was applied to test the non-synonymous HCRTR1 C/T Ile408Val gene variant (rs2271933) for association with PD/AG in two independent case-control samples (total n = 613 cases, 1839 healthy subjects), as an outcome predictor of a six-weeks exposure-based cognitive behavioral therapy (CBT) in PD/AG patients (n = 189), as well as with respect to agoraphobic cognitions (ACQ) (n = 483 patients, n = 2382 healthy subjects), fMRI alerting network activation in healthy subjects (n = 94), and a behavioral avoidance task in PD/AG pre- and post-CBT (n = 271)...
February 4, 2019: Translational Psychiatry
https://read.qxmd.com/read/30715554/-development-of-virtual-reality-as-an-exposure-technique
#8
REVIEW
Julia Diemer, Peter Zwanzger
BACKGROUND: Virtual reality (VR) has been investigated as a medium for exposure therapy of anxiety disorders for 20 years. Various meta-analyses have provided convincing evidence of the therapeutic efficacy of exposure therapy in VR. OBJECTIVE: In recent years VR technology and its applications have considerably improved. Therefore, the current state of the art of VR exposure therapy is presented. MATERIAL AND METHODS: This article provides a narrative review of current research on VR exposure therapy for anxiety disorders and major directions of development in this area...
February 4, 2019: Der Nervenarzt
https://read.qxmd.com/read/30714607/the-prevalence-of-patients-with-panic-attacks-pas-and-panic-disorder-pd-visiting-emergency-departments-of-the-verona-hospital
#9
S Majori, D Gazzani, J Paiano, B Carobolante, A Sannino, S Ferrari, L Antolini, I Aprili, M Zanon
BACKGROUND: Panic Attacks (PAs) and Panic Disorder (PD) represent a heavy burden not only because of the difficulty in distinguishing them from other pathologies and in treating them appropriately but also because of their impact on public health worldwide. In Europe, PD constitutes one of the five most common mental disorders adversely affecting quality of life. STUDY DESIGN: The aim of this study is to evaluate the period prevalence of visits to the Emergency Departments of the University Hospital of Verona (North East of Italy) over the period between 2012-2016 because of symptoms of PAs or PD in order to quantify the burden of the disorder...
March 2019: Annali di Igiene: Medicina Preventiva e di Comunità
https://read.qxmd.com/read/30712520/lifetime-experience-of-multiple-common-mental-disorders-and-19-year-mortality-results-from-a-canadian-population-based-cohort
#10
M Kingsbury, E Sucha, N J Horton, H Sampasa-Kanyinga, J M Murphy, S E Gilman, I Colman
AimsTo examine the impact of multiple psychiatric disorders over the lifetime on risk of mortality in the general population. METHODS: Data came from a random community-based sample of 1397 adults in Atlantic Canada, recruited in 1992. Major depression, dysthymia, panic disorder, generalised anxiety disorder and alcohol use disorders were assessed using the Diagnostic Interview Schedule (DIS). Vital status of participants through 2011 was determined using probabilistic linkages to the Canadian Mortality Database...
February 4, 2019: Epidemiology and Psychiatric Sciences
https://read.qxmd.com/read/30708402/the-genetic-and-environmental-structure-of-fear-and-anxiety-in-juvenile-twins
#11
Chelsea Sawyers, Thomas Ollendick, Melissa A Brotman, Daniel S Pine, Ellen Leibenluft, Dever M Carney, Roxann Roberson-Nay, John M Hettema
Fear and anxiety are conceptualized as responses to acute or potential threat, respectively. Adult twin studies found substantial interplay between genetic and environmental factors influencing fear disorders (phobias) and anxiety disorders. Research in children, however, has largely examined these factors independently. Thus, there exists a substantial knowledge gap regarding the underlying etiologic structure of these closely-related constructs during development. Symptom counts for five fear (criticism, the unknown, death, animal, medical) and four anxiety (generalized, panic, separation, social) dimensions were obtained for 373 twin pairs ages 9-14...
February 1, 2019: American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics
https://read.qxmd.com/read/30707725/non-cardiac-chest-pain-patients-in-the-emergency-department-do-physicians-have-a-plan-how-to-diagnose-and-treat-them-a-retrospective-study
#12
Maria M Wertli, Tenzin D Dangma, Sarah E Müller, Laura M Gort, Benjamin S Klauser, Lina Melzer, Ulrike Held, Johann Steurer, Susann Hasler, Jakob M Burgstaller
BACKGROUND: Non-cardiac chest pain is common and there is no formal recommendation on what diagnostic tests to use to identify underlying diseases after an acute coronary syndrome has been ruled out. OBJECTIVE: To evaluate the diagnostic tests, treatment recommendations and initiated treatments in patients presenting with non-cardiac chest pain to the emergency department (ED). METHODS: Single-center, retrospective medical chart review of patients presenting to the ED...
2019: PloS One
https://read.qxmd.com/read/30701861/chronic-obstructive-pulmonary-disease-and-cerebrovascular-diseases-functional-and-clinical-aspect-of-comorbidity
#13
REVIEW
B I Geltser, I G Kurpatov, V N Kotelnikov, Yu V Zayats
Literature data of chronic obstructive pulmonary disease (COPD) and cerebrovascular diseases (CVD) comorbidity are represented in this review. Key aspects of this interaction and its importance for clinical medicine have been considered. CVD and COPD are the main mortality factors in adults, which contribute to great economic wastes. The incidence of chronic cerebral ischemia for COPD patients is almost three times as high as for general population. The incidence of ischemic stroke for COPD patients is 1,2 times higher than in general population...
April 19, 2018: Terapevticheskiĭ Arkhiv
https://read.qxmd.com/read/30698127/the-genetic-and-environmental-relationship-between-childhood-behavioral-inhibition-and-preadolescent-anxiety
#14
Jessica L Bourdon, Jeanne E Savage, Brad Verhulst, Dever M Carney, Melissa A Brotman, Daniel S Pine, Ellen Leibenluft, Roxann Roberson-Nay, John M Hettema
This study uses novel approaches to examine genetic and environmental influences shared between childhood behavioral inhibition (BI) and symptoms of preadolescent anxiety disorders. Three hundred and fifty-two twin pairs aged 9-13 and their mothers completed questionnaires about BI and anxiety symptoms. Biometrical twin modeling, including a direction-of-causation design, investigated genetic and environmental risk factors shared between BI and social, generalized, panic and separation anxiety. Social anxiety shared the greatest proportion of genetic (20%) and environmental (16%) variance with BI with tentative evidence for causality...
January 30, 2019: Twin Research and Human Genetics: the Official Journal of the International Society for Twin Studies
https://read.qxmd.com/read/30696485/neuromyelitis-optica-spectrum-disorder-with-increased-aquaporin-4-microparticles-prior-to-autoantibodies-in-cerebrospinal-fluid-a-case-report
#15
Susanne Bejerot, Eva Hesselmark, Fariborz Mobarrez, Håkan Wallén, Max Albert Hietala, Rolf Nybom, Lennart Wetterberg
BACKGROUND: Neuromyelitis optica spectrum disorders are severe autoimmune inflammatory diseases of the central nervous system associated with the presence of immunoglobulin G antibodies against the water channel protein aquaporin-4. During exacerbation, specific aquaporin-4 immunoglobulin G may be produced intrathecally. We measured extracellular aquaporin-4 microparticles in the cerebrospinal fluid of a patient who later developed the typical symptoms and signs of a neuromyelitis optica spectrum disorder...
January 30, 2019: Journal of Medical Case Reports
https://read.qxmd.com/read/30696238/pharmacological-and-neuromodulatory-treatments-for-panic-disorder-clinical-trials-from-2010-to-2018
#16
Morena M Zugliani, Mariana C Cabo, Antonio E Nardi, Giampaolo Perna, Rafael C Freire
OBJECTIVE: Treatment for panic disorder (PD) have evolved, although there is still a strong unmet need for more effective and tolerable options. The present study summarizes and discusses recent evidence regarding the pharmacological and neuromodulatory treatment of PD. METHODS: MEDLINE, Cochrane Library, PsycINFO and Thomson Reuters's Web of Science were searched for clinical trials published between 2010 and 2018. We included all prospective experimental studies including randomized controlled trials (RCT) and other clinical trials with more than 10 patients...
January 2019: Psychiatry Investigation
https://read.qxmd.com/read/30696237/panic-disorder-current-research-and-management-approaches
#17
Yong-Ku Kim
No abstract text is available yet for this article.
January 2019: Psychiatry Investigation
https://read.qxmd.com/read/30677422/hypothalamic-endocannabinoid-signalling-modulates-aversive-responses-related-to-panic-attacks
#18
Thércia G Viana, Juliana R Bastos, Rayssa B Costa, Sara C Hott, Frederico S Mansur, Cândido C Coimbra, Leonardo B Resstel, Daniele C Aguiar, Fabrício A Moreira
Recurrent panic attacks, comprising emotional and cardiovascular aversive responses, are common features in panic disorder, a subtype of anxiety disorder. The underlying brain circuitry includes nuclei of the hypothalamus, such as the dorsomedial hypothalamus (DMH). The endocannabinoid system has been proposed to modulate several biological processes in the hypothalamus. Thus, we tested the hypothesis that hypothalamic endocannabinoid signalling controls aversive responses in an animal model of panic attacks...
January 21, 2019: Neuropharmacology
https://read.qxmd.com/read/30670681/assessment-of-fear-and-anxiety-associated-behaviors-physiology-and-neural-circuits-in-rats-with-reduced-serotonin-transporter-sert-levels
#19
Philip L Johnson, Andrei I Molosh, Lauren M Federici, Cristian Bernabe, David Haggerty, Stephanie D Fitz, Eugene Nalivaiko, William Truitt, Anantha Shekhar
Genetic variation in serotonin transporter (SERT) that reduces transcriptional efficiency is associated with higher anxiety and fear traits and a greater incidence of post traumatic stress disorder (PTSD). Although previous studies have shown that rats with no expression of SERT (SERT-/- ) have increased baseline anxiety behaviors, SERT+/- rats with low SERT expression (and more relevant to the clinical condition with low SERT expression) do not. Yet, no systematic studies of fear acquisition/extinction or their underlying neural mechanisms have been conducted in this preclinical genetic SERT+/- model...
January 22, 2019: Translational Psychiatry
https://read.qxmd.com/read/30662265/prevalence-and-associated-factors-of-comorbid-anxiety-disorders-in-late-life-depression-findings-from-geriatric-tertiary-outpatient-settings
#20
Chawisa Suradom, Nahathai Wongpakaran, Tinakon Wongpakaran, Peerasak Lerttrakarnnon, Surin Jiraniramai, Unchulee Taemeeyapradit, Surang Lertkachatarn, Suwanna Arunpongpaisal
Purpose: The study evaluated the prevalence of comorbid anxiety disorders in late-life depression (LLD) and identified their associated factors. Patients and methods: This study involved 190 elderly Thais with depressive disorders diagnosed according to the Mini-International Neuropsychiatric Interview (MINI). Anxiety disorders were also diagnosed by the MINI. The 7-item Hamilton Depression Rating Scale (HAMD-7), Montreal Cognitive Assessment, Geriatric Depression Scale (GDS), Core Symptoms Index, Neuroticism Inventory, Perceived Stress Scale and Multidimensional Scale for Perceived Social Support were completed...
2019: Neuropsychiatric Disease and Treatment
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