keyword
https://read.qxmd.com/read/38536448/arterial-spin-labelling-magnetic-resonance-imaging-and-perfusion-patterns-in-neurocognitive-and-other-mental-disorders-a-systematic-review
#1
REVIEW
Rita Ferreira, António J Bastos-Leite
We reviewed 33 original research studies assessing brain perfusion, using consensus guidelines from a "white paper" issued by the International Society for Magnetic Resonance in Medicine Perfusion Study Group and the European Cooperation in Science and Technology Action BM1103 ("Arterial Spin Labelling Initiative in Dementia"; https://www.cost.eu/actions/BM1103/ ). The studies were published between 2011 and 2023 and included participants with subjective cognitive decline plus; neurocognitive disorders, including mild cognitive impairment (MCI), Alzheimer's disease (AD), frontotemporal lobar degeneration (FTLD), dementia with Lewy bodies (DLB) and vascular cognitive impairment (VCI); as well as schizophrenia spectrum disorders, bipolar and major depressive disorders, autism spectrum disorder, attention-deficit/hyperactivity disorder, panic disorder and alcohol use disorder...
March 27, 2024: Neuroradiology
https://read.qxmd.com/read/38532343/phenome-wide-causal-associations-between-osteoarthritis-and-other-complex-traits-through-the-latent-causal-variable-analysis
#2
JOURNAL ARTICLE
Lin Mei, Zhiming Zhang, Ruiqi Chen, Zhihong Li
BACKGROUND: Individuals with osteoarthritis present with comorbidities, and the potential causal associations remain incompletely elucidated. The present study undertook a large-scale investigation about the causality between osteoarthritis and variable traits, using the summary-level data of genome-wide association studies (GWAS). METHODS: The present study included the summary-level GWS data of knee osteoarthritis, hip osteoarthritis, hip or knee osteoarthritis, hand osteoarthritis, and other 1355 traits...
March 26, 2024: BMC Musculoskeletal Disorders
https://read.qxmd.com/read/38518267/psychedelic-therapy-a-primer-for-primary-care-clinicians-lysergic-acid-diethylamide-lsd
#3
JOURNAL ARTICLE
Bryce D Beutler, Kenneth Shinozuka, Burton J Tabaac, Alejandro Arenas, Kirsten Cherian, Viviana D Evans, Chelsey Fasano, Owen S Muir
BACKGROUND: Lysergic acid diethylamide (LSD) is a hallucinogenic agent. In the mid-20th century, it was used to augment psychoanalysis and to treat alcohol use disorder. However, LSD was banned in 1970 in part because of concerns that it could bring about or exacerbate mental illness. Its therapeutic potential remains incompletely understood. AREAS OF UNCERTAINTY: While uncontrolled recreational use of LSD can, in rare instances, lead to long-term psychosis, adverse events in clinical trials of LSD, such as anxiety, headache, and nausea, have almost always been mild and transient...
March 2024: American Journal of Therapeutics
https://read.qxmd.com/read/38515432/autistic-traits-underlying-social-anxiety-obsessive-compulsive-and-panic-disorders
#4
JOURNAL ARTICLE
Liliana Dell'Osso, Giulia Amatori, Chiara Bonelli, Benedetta Nardi, Enrico Massimetti, Ivan Mirko Cremone, Barbara Carpita
No abstract text is available yet for this article.
March 22, 2024: CNS Spectrums
https://read.qxmd.com/read/38507961/relationship-between-anxiety-sensitivity-and-post-traumatic-stress-symptoms-in-trauma-exposed-adults-a-meta-analysis
#5
REVIEW
Henry Tak Shing Chiu, Debbie Chi Wing Low, Angel Hiu Tung Chan, Richard Meiser-Stedman
Given the high rate of trauma exposure among the general population, it is important to delineate the risk factors for post-traumatic stress disorder (PTSD). While historically implicated in panic disorder, anxiety sensitivity is increasingly found to play a role in PTSD. The present review investigated the size of the relationship between anxiety sensitivity and PTSD symptoms among trauma exposed adults. A systematic search on multiple electronic databases (PTSDpubs, CINAHL, MEDLINE and PsycINFO) generated a total of 1025 records, among which 52 (n = 15173) met study inclusion criteria and were included in our random effects meta-analysis...
March 9, 2024: Journal of Anxiety Disorders
https://read.qxmd.com/read/38504389/current-understanding-of-nociplastic-pain
#6
JOURNAL ARTICLE
Yeong-Min Yoo, Kyung-Hoon Kim
Nociplastic pain by the "International Association for the Study of Pain" is defined as pain that arises from altered nociception despite no clear evidence of nociceptive or neuropathic pain. Augmented central nervous system pain and sensory processing with altered pain modulation are suggested to be the mechanism of nociplastic pain. Clinical criteria for possible nociplastic pain affecting somatic structures include chronic regional pain and evoked pain hypersensitivity including allodynia with after-sensation...
March 20, 2024: Korean Journal of Pain
https://read.qxmd.com/read/38503928/associations-of-altered-leukocyte-ddr1-promoter-methylation-and-childhood-trauma-with-bipolar-disorder-and-suicidal-behavior-in-euthymic-patients
#7
JOURNAL ARTICLE
Beatriz Garcia-Ruiz, Esther Jiménez, Selena Aranda, Norma Verdolini, Alfonso Gutiérrez-Zotes, Cristina Sáez, Elisa Losantos, Silvia Alonso-Lana, Mar Fatjó-Vilas, Salvador Sarró, Llanos Torres, Francesco Panicalli, Caterina Del Mar Bonnin, Edith Pomarol-Clotet, Eduard Vieta, Elisabet Vilella
Altered DNA methylation (DNAm) patterns of discoidin domain receptor 1 (DDR1) have been found in the blood and brain of patients with schizophrenia (SCZ) and the brain of patients with bipolar disorder (BD). Childhood trauma (CT) is associated with changes in DNAm that in turn are related to suicidal behavior (SB) in patients with several psychiatric disorders. Here, using MassARRAY® technology, we studied 128 patients diagnosed with BD in remission and 141 healthy controls (HCs) to compare leukocyte DDR1 promoter DNAm patterns between patients and HCs and between patients with and without SB...
March 19, 2024: Molecular Psychiatry
https://read.qxmd.com/read/38503003/epidemiology-of-dsm-5-psychiatric-disorders-in-kenyan-youth-with-low-and-high-psychosis-risk
#8
JOURNAL ARTICLE
Rebekka H Sæle, David M Ndetei, Victoria N Mutiso, Daniel Mamah
INTRODUCTION: There are few psychiatric epidemiology studies among Kenyan youth and fewer among those at high psychosis risk (HR). METHODS: This study assessed the epidemiology of DSM-5 psychiatric disorders in HR and low-risk (LR) individuals to inform research and mental health services. 567 participants (aged 15-25) in HR (n = 246) and LR (n = 260) groups based on Washington Early Recognition Center Affectivity and Psychosis (WERCAP) Screen scores...
March 11, 2024: Comprehensive Psychiatry
https://read.qxmd.com/read/38502647/adaptation-of-the-client-diagnostic-questionnaire-for-east-africa
#9
JOURNAL ARTICLE
Edith Kamaru Kwobah, Suzanne Goodrich, Jayne Lewis Kulzer, Michael Kanyesigye, Sarah Obatsa, Julius Cheruiyot, Lorna Kiprono, Colma Kibet, Felix Ochieng, Elizabeth A Bukusi, Susan Ofner, Steven A Brown, Constantin T Yiannoutsos, Lukoye Atwoli, Kara Wools-Kaloustian
Research increasingly involves cross-cultural work with non-English-speaking populations, necessitating translation and cultural validation of research tools. This paper describes the process of translating and criterion validation of the Client Diagnostic Questionnaire (CDQ) for use in a multisite study in Kenya and Uganda. The English CDQ was translated into Swahili, Dholuo (Kenya) and Runyankole/Rukiga (Uganda) by expert translators. The translated documents underwent face validation by a bilingual committee, who resolved unclear statements, agreed on final translations and reviewed back translations to English...
2024: PLOS Glob Public Health
https://read.qxmd.com/read/38499084/beyond-confirmed-mast-cell-activation-syndrome-approaching-patients-with-dysautonomia-and-related-conditions
#10
REVIEW
Alexandra E Conway, Marylee Verdi, Marcus S Shaker, Jonathan A Bernstein, Claire C Beamish, Richard Morse, Juliette Madan, Michael W Lee, Gordon Sussman, Amer Al-Nimr, Matthew Hand, Daniel A Albert
Allergist-immunologists face significant challenges as experts in an ever-evolving field of neuroimmunology. Among these challenges is the increasingly frequent need to counsel patients with suspected mast cell-activation disorders about perceived comorbidities, which may include hypermobile Ehlers Danlos syndrome, amplified pain syndrome, fibromyalgia, burning sensation syndromes, migraines, irritable bowel syndrome, and postural orthostatic tachycardia syndrome. Patients may experience comorbid anxiety, panic disorder and depression associated with disturbed sleep, fatigue, and cognitive impairment that often worsen when their physical symptoms increase in severity...
March 16, 2024: Journal of Allergy and Clinical Immunology in Practice
https://read.qxmd.com/read/38481642/peripartum-cardiomyopathy-in-patients-with-psychiatric-disorders-successfully-treated-with-bromocriptine-two-case-reports
#11
Haruka Takanaka, Ryohei Ono, Hirotoshi Kato, Togo Iwahana, Tomoki Miyahara, Hidehisa Takahashi, Yasuhiko Hori, Kenichi Fukushima, Yoshio Kobayashi
UNLABELLED: Peripartum cardiomyopathy (PPCM) is a rare disorder in which left ventricular systolic dysfunction and heart failure symptoms occur during the peripartum period. Inhibition of prolactin secretion by bromocriptine mediates beneficial effects on cardiac function in PPCM. Mental disorders are also associated with the onset of PPCM. Psychiatric medications for mental disorders would affect serotonin production and tryptophan and dopamine metabolism, and they are associated with PPCM...
March 2024: Journal of Cardiology Cases
https://read.qxmd.com/read/38481629/takotsubo-cardiomyopathy-triggered-by-frequent-psychogenic-nonepileptic-seizures-a-case-report
#12
Daichi Yomogida, Hiroyuki Kuwano, Tatsuya Miyakoshi, Shiori Mizuta, Shinjiro Horikawa, Yoshinao Koshida
BACKGROUND: Coexistence of Takotsubo cardiomyopathy and psychogenic nonepileptic seizures has rarely been reported. Herein, we report a case of Takotsubo cardiomyopathy triggered by psychogenic nonepileptic seizures. CASE PRESENTATION: A 50-year-old woman with a 22-year history of dissociative and panic disorders and a 7-year history of seizures increasing in frequency was admitted due to cardiogenic shock. Based on the left ventriculography and electroencephalography findings, she was diagnosed with Takotsubo cardiomyopathy and psychogenic nonepileptic seizures...
2024: Acute Medicine & Surgery
https://read.qxmd.com/read/38479247/fear-of-negative-evaluation-and-intolerance-of-uncertainty-assessing-potential-internalizing-correlates-of-eating-disorder-related-clinical-impairment-and-differences-across-diagnostic-presentations
#13
JOURNAL ARTICLE
Angeline R Bottera, Elizabeth N Dougherty, Sophia Todorov, Jennifer E Wildes
The Hierarchical Taxonomy of Internalizing Dimensions for Eating Disorders model positions eating disorder (ED) symptoms on an internalizing dimension alongside anxiety and mood symptoms. Symptom dimensions falling under the internalizing subfactors of distress (e.g., social anxiety) and fear/avoidance (e.g., panic, compulsions, checking) may differentially guide treatment. We examined relations between fear of negative evaluation and intolerance of uncertainty (core features of social anxiety and obsessive-compulsive disorder, respectively) and ED-related impairment and potential diagnostic differences...
March 5, 2024: Eating Behaviors
https://read.qxmd.com/read/38471801/exploring-brainstem-structural-abnormalities-potential-biomarkers-for-panic-disorder
#14
JOURNAL ARTICLE
Hye-Min Kim, Chanmi Kang, Boram Chae, June Christoph Kang, Ho-Kyoung Yoon
Panic disorder (PD), characterized by recurrent and intense panic attacks, presents a complex interplay between psychological and neurobiological factors. Although the amygdala and hippocampus have been studied extensively in the context of PD, the brainstem's involvement remains relatively underexplored. This study aims to address this gap by examining structural abnormalities within specific brainstem regions, including the medulla, pons, and midbrain. The study sample population comprised twenty-one adult patients diagnosed with PD and an age-gender-education-matched control group...
February 29, 2024: Experimental Neurobiology
https://read.qxmd.com/read/38470630/tokophobia-psychopathology-and-diagnostic-consideration-of-ten-cases
#15
JOURNAL ARTICLE
Toshinori Kitamura, Mizuki Takegata, Yuriko Usui, Yukiko Ohashi, Satoshi Sohda, Jun Takeda, Tomomi Saito, Yasuyo Kasai, Hideki Watanabe, Megumi Haruna, Satoru Takeda
Tokophobia is regarded as the intensive fear of childbirth that some pregnant women have. However, little is known about the psychopathological details of tokophobia (fear of childbirth). Between 2020 and 2021, a total of 10 pregnant women (nine nulliparae and one multipara) with a strong fear of childbirth were referred by obstetricians. Semi-structured psychopathological interviews were conducted, and two cases were judged to have obsession, three an overvalued idea, and one secondary delusion. Three were characterised by both obsession and overvalued idea and one by both obsession and secondary delusion...
February 21, 2024: Healthcare (Basel, Switzerland)
https://read.qxmd.com/read/38468204/the-role-of-subjective-interpersonal-and-structural-social-isolation-in-12-month-and-lifetime-anxiety-disorders
#16
JOURNAL ARTICLE
Ann W Nguyen, Harry Owen Taylor, Robert Joseph Taylor, Alexis Z Ambroise, Tyrone Hamler, Weidi Qin, Linda M Chatters
BACKGROUND: Anxiety disorders are among the most prevalent psychiatric conditions worldwide, and the incidence of anxiety disorders among adults in the U.S. have increased over the last decade. Anxiety disorders can have debilitating effects on multiple areas of functioning and quality of life. Recently, social isolation has emerged as an important public health problem associated with worse health and well-being outcomes. Research on the connection between social isolation and mental health has found that multiple dimensions of social isolation may negatively impact mental health, but few inquiries have focused on the association between social isolation and anxiety...
March 11, 2024: BMC Public Health
https://read.qxmd.com/read/38465410/evaluation-of-effect-of-brief-intensive-cognitive-behavior-therapy-on-symptoms-severity-in-relation-with-catastrophic-cognition-in-patients-with-panic-disorder-a-randomized-controlled-trial
#17
JOURNAL ARTICLE
Rasoul Sabri Piro, Perjan Hashim Taha
Introduction: Due to a dearth of evidence, we examined the effectiveness of brief-intensive CBT on symptom severity and catastrophic cognition in patients with panic disorder (PD). Materials and Methods: In this randomized controlled trial, 155 patients were assigned to either the experimental group (2 successive days of brief-intensive CBT-3 hours per day) or the control group (regular pharmacotherapy only). After excluding ineligible participants, 20 patients in the brief intensive CBT group and 18 patients in the control group completed the study and were included in the final analysis...
March 11, 2024: Current Medical Research and Opinion
https://read.qxmd.com/read/38464769/impaired-implicit-emotion-regulation-in-patients-with-panic-disorder-an-event-related-potential-study-on-affect-labeling
#18
JOURNAL ARTICLE
Hai-Yang Wang, Li-Zhu Li, Yi Chang, Xiao-Mei Pang, Bing-Wei Zhang
BACKGROUND: Panic disorder (PD) involves emotion dysregulation, but its underlying mechanisms remain poorly understood. Previous research suggests that implicit emotion regulation may play a central role in PD-related emotion dysregulation and symptom maintenance. However, there is a lack of studies exploring the neural mechanisms of implicit emotion regulation in PD using neurophysiological indicators. AIM: To study the neural mechanisms of implicit emotion regulation in PD with event-related potentials (ERP)...
February 19, 2024: World Journal of Psychiatry
https://read.qxmd.com/read/38464303/machine-learning-and-bayesian-network-analyses-identifies-psychiatric-disorders-and-symptom-associations-with-insomnia-in-a-national-sample-of-31-285-treatment-seeking-college-students
#19
Adam Calderon, Seung Yeon Baik, Matthew H S Ng, Ellen E Fitzsimmons-Craft, Daniel Eisenberg, Denise E Wilfley, C Barr Taylor, Michelle G Newman
Background: A better understanding of the structure of relations among insomnia and anxiety, mood, eating, and alcohol-use disorders is needed, given its prevalence among young adults. Supervised machine learning provides the ability to evaluate the discriminative accuracy of psychiatric disorders associated with insomnia. Combined with Bayesian network analysis, the directionality between symptoms and their associations may be illuminated. Methods: The current exploratory analyses utilized a national sample of college students across 26 U...
February 21, 2024: Research Square
https://read.qxmd.com/read/38463410/admixture-analysis-of-age-of-onset-in-bipolar-disorder-and-impact-of-anxiety-comorbidity
#20
JOURNAL ARTICLE
Stefano Pini, Barbara Carpita, Benedetta Nardi, Marianna Abelli, Giulia Amatori, Ivan Cremone, Liliana Dell'Osso
BACKGROUND:  The present study aimed to examine clinical differences between subjects with early-onset (<21 years) and adult-onset (>30 years) bipolar I disorder, in particular, in relation to anxiety comorbidity. METHOD: Subjects were selected from a cohort of 161 consecutive patients with bipolar disorder type I as diagnosed by the Structured Clinical Interview for DSM Disorder (SCID-I). Clinical characteristics and axis I comorbidity were compared between those whose illness first emerged before the age of 21 years (n=58) and those whose first episode occurred after the age of 30 years (n=27)...
March 2024: Curēus
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