keyword
https://read.qxmd.com/read/38528786/genistein-enhances-trail-mediated-apoptosis-through-the-inhibition-of-xiap-and-dcr1-in-colon-carcinoma-cells-treated-with-5-fluorouracil
#21
JOURNAL ARTICLE
Tuğbagül Çal Doğan, Sevtap Aydın Dilsiz, Hande Canpınar, Ülkü Ündeğer Bucurgat
OBJECTIVES: Colorectal cancer is one of the most common cancers worldwide. However, surgical intervention and chemotherapy provide only limited benefits for the recovery and survival of patients. The anticarcinogenic effect of genistein has attracted attention because epidemiological studies have shown that soybean consumption is associated with a decrease in the incidence of cancer. There are limited studies on the effects of genistein in colorectal carcinoma cells. We aimed to investigate the cytotoxic, genotoxic, and apoptotic effects of genistein in SW480 and SW620 colon adenocarcinoma cells treated with 5-fluorouracil, the basis of chemotherapy, and the tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) ligand, the mediator of apoptosis, both alone and in combination...
March 25, 2024: Turkish journal of pharmaceutical sciences
https://read.qxmd.com/read/38528569/caffeic-acid-phenethyl-ester-inhibits-neuro-inflammation-and-oxidative-stress-following-spinal-cord-injury-by-mitigating-mitochondrial-dysfunction-via-the-sirt1-pgc1%C3%AE-drp1-signaling-pathway
#22
JOURNAL ARTICLE
Yanan Zhang, Qian Deng, Hongxiang Hong, Zhanyang Qian, Bowen Wan, Mingjie Xia
BACKGROUND: The treatment of spinal cord injury (SCI) has always been a significant research focus of clinical neuroscience, with inhibition of microglia-mediated neuro-inflammation as well as oxidative stress key to successful SCI patient treatment. Caffeic acid phenethyl ester (CAPE), a compound extracted from propolis, has both anti-inflammatory and anti-oxidative effects, but its SCI therapeutic effects have rarely been reported. METHODS: We constructed a mouse spinal cord contusion model and administered CAPE intraperitoneally for 7 consecutive days after injury, and methylprednisolone (MP) was used as a positive control...
March 25, 2024: Journal of Translational Medicine
https://read.qxmd.com/read/38527700/potential-targets-for-the-treatment-of-mi-grp75-mediated-ca-2-transfer-in-mam
#23
JOURNAL ARTICLE
Chenyan Zhang, Bowen Liu, Jiaxing Sheng, Jia Wang, Weijie Zhu, Chen Xie, Xuan Zhou, Yuxin Zhang, Qinghai Meng, Yu Li
After myocardial infarction (MI), there is a notable disruption in cellular calcium ion homeostasis and mitochondrial function, which is believed to be intricately linked to endoplasmic reticulum (ER) stress. This research endeavors to elucidate the involvement of glucose regulated protein 75 (GRP75) in post-MI calcium ion homeostasis and mitochondrial function. In MI rats, symptoms of myocardial injury were accompanied by an increase in the activation of ER stress. Moreover, in oxygen-glucose deprivation (OGD)-induced cardiomyocytes, it was confirmed that inhibiting ER stress exacerbated intracellular Ca2+ disruption and cell apoptosis...
March 23, 2024: European Journal of Pharmacology
https://read.qxmd.com/read/38527284/effect-of-moderate-static-magnetic-fields-on-mice-oocyte-vitrification-calcium-related-genes-expression
#24
JOURNAL ARTICLE
Sara Soleimani Pargoo, Farzaneh Baniasadi, Vida Sadat Kazemein Jasemi, Samira Hajiaghalou, Mohsen Gharanfoli, Rouhollah Fathi
The ability to cryopreserve oocytes without ultrastructural injury has been a concern in the development and use of methods to preserve female reproduction. The stability of the cell membrane must be preserved to reduce the damage caused by ice crystals during vitrification. One approach that has been explored is the use of static magnetic fields (SMFs), which are believed to influence cell membrane stability. In this study, the in vitro effects of SMF that range between 20-80 mT on the vitrification of mice germinal vesicle (GV) oocytes were studied...
March 25, 2024: Biopreservation and Biobanking
https://read.qxmd.com/read/38527038/combination-of-ethyl-acetate-fraction-from-calotropis-gigantea-stem-bark-and-sorafenib-induces-apoptosis-in-hepg2-cells
#25
JOURNAL ARTICLE
Pattaraporn Chaisupasakul, Dumrongsak Pekthong, Apirath Wangteeraprasert, Worasak Kaewkong, Julintorn Somran, Naphat Kaewpaeng, Supawadee Parhira, Piyarat Srisawang
The cytotoxicity of the ethyl acetate fraction of the Calotropis gigantea (L.) Dryand. (C. gigantea) stem bark extract (CGEtOAc) has been demonstrated in many types of cancers. This study examined the improved cancer therapeutic activity of sorafenib when combined with CGEtOAc in HepG2 cells. The cell viability and cell migration assays were applied in HepG2 cells treated with varying concentrations of CGEtOAc, sorafenib, and their combination. Flow cytometry was used to determine apoptosis, which corresponded with a decline in mitochondrial membrane potential and activation of DNA fragmentation...
2024: PloS One
https://read.qxmd.com/read/38526738/curcumin-coating-a-novel-solution-to-mitigate-inherent-carbon-nanotube-toxicity
#26
JOURNAL ARTICLE
Samiksha Rele, Chanchal Kiran Thakur, Fatima Khan, Budhadev Baral, Vaishali Saini, Chandrabose Karthikeyan, N S Hari Narayana Moorthy, Hem Chandra Jha
Multi-walled Carbon Nanotubes (MWCNTs) are inert structures with high aspect ratios that are widely used as vehicles for targeted drug delivery in cancer and many other diseases. They are largely non-toxic in nature however, when cells are exposed to these nanotubes for prolonged durations or at high concentrations, they show certain adverse effects. These include cytotoxicity, inflammation, generation of oxidative stress, and genotoxicity among others. To combat such adverse effects, various moieties can be attached to the surface of these nanotubes...
March 25, 2024: Journal of Materials Science. Materials in Medicine
https://read.qxmd.com/read/38525303/arginine-with-leucine-drives-reactive-oxygen-species-mediated-integrin-%C3%AE-5%C3%AE-1-expression-and-promotes-implantation-in-mouse-blastocysts
#27
JOURNAL ARTICLE
Momoka Nakazato, Mumuka Matsuzaki, Daiki Okai, Eisaku Takeuchi, Misato Seki, Miki Takeuchi, Emiko Fukui, Hiromichi Matsumoto
The implantation rate of in vitro fertilization (IVF)-derived blastocysts after embryo transfer remains low, suggesting that the inadequate expression of specific proteins in culture-induced IVF-derived blastocysts contributes to low implantation rates. Therefore, treatment with appropriate regulation may improve the blastocyst implantation ability. This study demonstrated that the combination of l-arginine (Arg) and l-leucine (Leu) exerts distinct effects on IVF-derived mouse blastocysts. Arg with Leu promotes blastocyst implantation, whereas Arg alone decreases the blastocyst ability...
March 2024: PNAS Nexus
https://read.qxmd.com/read/38523633/arachidonic-acid-metabolism-as-a-therapeutic-target-in-aki-to-ckd-transition
#28
REVIEW
Xiao-Jun Li, Ping Suo, Yan-Ni Wang, Liang Zou, Xiao-Li Nie, Ying-Yong Zhao, Hua Miao
Arachidonic acid (AA) is a main component of cell membrane lipids. AA is mainly metabolized by three enzymes: cyclooxygenase (COX), lipoxygenase (LOX) and cytochrome P450 (CYP450). Esterified AA is hydrolysed by phospholipase A2 into a free form that is further metabolized by COX, LOX and CYP450 to a wide range of bioactive mediators, including prostaglandins, lipoxins, thromboxanes, leukotrienes, hydroxyeicosatetraenoic acids and epoxyeicosatrienoic acids. Increased mitochondrial oxidative stress is considered to be a central mechanism in the pathophysiology of the kidney...
2024: Frontiers in Pharmacology
https://read.qxmd.com/read/38523543/evaluation-of-efficacy-of-curcumin-and-caffeic-acid-phenethyl-ester-in-breast-cancer-by-preclinical-studies
#29
JOURNAL ARTICLE
Sumit Singh Verma, Avadhesh, Ankit Srivastava, Anusmita Shekher, Anupam Dhasmana, Acharan Singh Narula, Subash Chandra Gupta
UNLABELLED: ims: The aim of this study was to evaluate the combined and comparative efficacy of Caffeic acid phenethyl ester (CAPE) and curcumin in breast cancer. BACKGROUND: CAPE and curcumin are a class of phenolics. While curcumin is obtained from turmeric, CAPE is found in Baccharis sarothroides and Populus deltoides. Both agents are reported to produce activities in some cancer types. The combined and comparative effects of the two agents in breast cancer have not yet reported...
March 21, 2024: Current Medicinal Chemistry
https://read.qxmd.com/read/38523265/predicting-the-activity-of-unidentified-chemicals-in-complementary-bioassays-from-the-hrms-data-to-pinpoint-potential-endocrine-disruptors
#30
JOURNAL ARTICLE
Ida Rahu, Meelis Kull, Anneli Kruve
The majority of chemicals detected via nontarget liquid chromatography high-resolution mass spectrometry (HRMS) in environmental samples remain unidentified, challenging the capability of existing machine learning models to pinpoint potential endocrine disruptors (EDs). Here, we predict the activity of unidentified chemicals across 12 bioassays related to EDs within the Tox21 10K dataset. Single- and multi-output models, utilizing various machine learning algorithms and molecular fingerprint features as an input, were trained for this purpose...
March 24, 2024: Journal of Chemical Information and Modeling
https://read.qxmd.com/read/38522585/mitoq-protects-against-carbon-tetrachloride-induced-hepatocyte-ferroptosis-and-acute-liver-injury-by-suppressing-mtros-mediated-acsl4-upregulation
#31
JOURNAL ARTICLE
Li Tao, Yu-Feng Xue, Fei-Fei Sun, Xue He, Hong-Qian Wang, Cheng-Cheng Tong, Cheng Zhang, De-Xiang Xu, Xi Chen
Ferroptosis has been shown to be involved in carbon tetrachloride (CCl4 )-induced acute liver injury (ALI). The mitochondrion-targeted antioxidant MitoQ can eliminate the production of mitochondrial reactive oxygen species (mtROS). This study investigated the role of MitoQ in CCl4 -induced hepatocytic ferroptosis and ALI. MDA and 4HNE were elevated in CCl4 -induced mice. In vitro, CCl4 exposure elevated the levels of oxidized lipids in HepG2 cells. Alterations in the mitochondrial ultrastructure of hepatocytes were observed in the livers of CCl4 -evoked mice...
March 22, 2024: Toxicology and Applied Pharmacology
https://read.qxmd.com/read/38522346/an-insight-into-the-mechanistic-role-of-ampelopsin-f-from-vatica-chinensis-l-in-inducing-insulin-secretion-in-pancreatic-beta-cells
#32
JOURNAL ARTICLE
B Prabha, S Lekshmy Krishnan, Billu Abraham, P Jayamurthy, K V Radhakrishnan
Resveratrol oligomers, ranging from dimers to octamers, are formed through regioselective synthesis involving the phenoxy radical coupling of resveratrol building blocks, exhibiting remarkable therapeutic potential, including antidiabetic properties. In this study, we elucidate the mechanistic insights into the insulin secretion potential of a resveratrol dimer, (-)-Ampelopsin F (AmF), isolated from the acetone extract of Vatica chinensis L. stem bark in Pancreatic Beta-TC-6 cell lines. The AmF (50 µM) treated cells exhibited a 3...
March 21, 2024: Bioorganic & Medicinal Chemistry
https://read.qxmd.com/read/38521474/suppression-of-nsclc-progression-via-the-co-administration-of-danusertib-an-aurk-inhibitor-and-kribb11-an-hsf1-inhibitor
#33
JOURNAL ARTICLE
Xiang Zhang, Ying Lei, Xiang Chen, Jiahuang He, Zitian Liu, Wentao Zhu, Yi Xu, Xuru Jin
Aurora kinase (AURK) and heat shock factor 1 (HSF1) are commonly overexpressed in non-small cell lung cancer (NSCLC), correlating with poor prognosis. This study aims to assess the therapeutic potential of combining the Danusertib (Danu, AURK inhibitor) and KRIBB11 (HSF1 inhibitor) for NSCLC treatment. The effects of this combination were investigated in A549 cells and a tumor xenograft mouse model. The findings demonstrate that concurrent administration of Danu and KRIBB11 effectively impedes cell proliferation, induces apoptosis, and triggers G2/M cell cycle arrest...
March 21, 2024: Biochemical Pharmacology
https://read.qxmd.com/read/38521372/ursolic-acid-alleviates-meiotic-abnormalities-induced-by-3-nitropropionic-acid-in-mouse-oocytes
#34
JOURNAL ARTICLE
Tiancang Han, Zhaoyang Sun, Hongbo Zhang, Yuhan Zhao, Anhui Jiao, Qingshan Gao
3-nitropropionic acid (3-NPA), a toxic metabolite produced by mold, is mainly found in moldy sugarcane. 3-NPA inhibits the activity of succinate dehydrogenase that can induce oxidative stress injury in cells, reduce ATP production and induce oxidative stress in mouse ovaries to cause reproductive disorders. Ursolic acid (UA) has a variety of biological activities and is a pentacyclic triterpene compound found in many plants. This experiment aimed to investigate the cytotoxicity of 3-NPA during mouse oocyte in vitro maturation and the protective effects of UA on oocytes challenged with 3-NPA...
March 21, 2024: Toxicology and Applied Pharmacology
https://read.qxmd.com/read/38521160/mitochondria-targeting-peptide-ss-31-attenuates-ferroptosis-via-inhibition-of-the-p38-mapk-signaling-pathway-in-the-hippocampus-of-epileptic-rats
#35
JOURNAL ARTICLE
Xue Liu, Fei-Yu Wang, Song Chi, Tao Liu, Hai-Lin Yang, Ru-Jie Zhong, Xiao-Yu Li, Jing Gao
Ferroptosis is a newly identified form of non-apoptotic regulated cell death (RCD) andplaysanimportantrole in epileptogenesis. The p38 mitogen-activated protein kinase (p38 MAPK) pathway has been confirmed to be involved in ferroptosis. The mitochondria-targeting antioxidant Elamipretide (SS-31) can reduce the generation of lipid peroxidation and the buildup of reactive oxygen species (ROS). Collectively, our present study was to decipher whether SS-31 inhibits ferroptosis via the p38 MAPK signaling pathway in the rat epilepsy model induced by pilocarpine (PILO)...
March 21, 2024: Brain Research
https://read.qxmd.com/read/38521157/neuropathic-corneal-pain-tear-proteomic-and-neuromediator-profiles-imaging-features-and-clinical-manifestations
#36
JOURNAL ARTICLE
Chang Liu, Molly Tzu-Yu Lin, Isabelle Xin Yu Lee, Jipson Hon Fai Wong, Daqian Lu, Thomas Chuen Lam, Lei Zhou, Jodhbir S Mehta, Hon Shing Ong, Marcus Ang, Louis Tong, Yu-Chi Liu
PURPOSE: To investigate the tear proteomic and neuromediator profiles, in vivo confocal microscopy (IVCM) imaging features, and clinical manifestations in neuropathic corneal pain (NCP) patients. DESIGN: Cross-sectional study. METHODS: Twenty NCP patients and twenty age-matched controls were recruited. All subjects were evaluated by corneal sensitivity, Schirmer's test, tear break-up time, corneal and ocular surface staining, Ocular Surface Disease Index and Ocular Pain Assessment Survey questionnaires, as well as IVCM examinations for corneal nerves, microneruomas, epithelial and dendritic cells...
March 21, 2024: American Journal of Ophthalmology
https://read.qxmd.com/read/38521135/pathogenesis-or-a-response-to-lithium-a-novel-perspective-for-mitochondrial-mass-fluctuation-of-na%C3%A3-ve-t-cells-in-patients-with-bipolar-disorder
#37
JOURNAL ARTICLE
Zhenni Chen, Bingqi Wang, Yiran Huang, Xiaofan Wang, Wanzhen Li, Min Wang
BACKGROUND: Immune imbalances are associated with the pathogenesis and pharmacological efficacy of bipolar disorder (BD). The underlying mechanisms remain largely obscure but may involve immunometabolic dysfunctions of T-lymphocytes. METHODS: We investigated if inflammatory cytokines and the immunometabolic function of T-lymphocytes, including frequencies of subsets, mitochondrial mass (MM), and low mitochondrial membrane potential (MMPLow ) differed between BD patients (n = 47) and healthy controls (HC, n = 43)...
March 21, 2024: Journal of Affective Disorders
https://read.qxmd.com/read/38520870/unveil-the-mechanism-for-ehmt-a-novel-triterpenoid-inhibits-proliferation-and-induces-apoptosis-in-colon-cancer-through-ros-mediated-jnk-signaling-pathway
#38
JOURNAL ARTICLE
Qiushuang Wu, Min Song, Siyuan Luo, Libin Guo, Qingwen Zhang, Hang Fai Kwok
Colon cancer ranks among the most prevalent malignancies worldwide, trailing only lung and breast cancer in incidence. Despite the availability of numerous therapeutic strategies, the burden of new cases and fatalities remains high in countries undergoing socioeconomic transitions. Natural products offer promising avenues for developing more effective and less toxic anticancer agents, expanding the clinical arsenal. In this investigation, we isolated a triterpenoid, (21 S,23 R,24 R)-21,23-epoxy-24-hydroxy-21-methoxytirucalla-7,25-dien-3-one (EHMT), from the fruits of Melia azedarach L...
March 22, 2024: Biomedicine & Pharmacotherapy
https://read.qxmd.com/read/38520035/genomic-characterization-of-equine-influenza-a-subtype-h3n8-viruses-by-long-read-sequencing-and-functional-analyses-of-the-pb1-f2-virulence-factor-of-a-equine-paris-1-2018
#39
JOURNAL ARTICLE
Lena Kleij, Elise Bruder, Dorothée Raoux-Barbot, Nathalie Lejal, Quentin Nevers, Charlotte Deloizy, Bruno Da Costa, Loïc Legrand, Eric Barrey, Alexandre Chenal, Stéphane Pronost, Bernard Delmas, Sophie Dhorne-Pollet
Equine influenza virus (EIV) remains a threat to horses, despite the availability of vaccines. Strategies to monitor the virus and prevent potential vaccine failure revolve around serological assays, RT-qPCR amplification, and sequencing the viral hemagglutinin (HA) and neuraminidase (NA) genes. These approaches overlook the contribution of other viral proteins in driving virulence. This study assesses the potential of long-read nanopore sequencing for fast and precise sequencing of circulating equine influenza viruses...
March 22, 2024: Veterinary Research
https://read.qxmd.com/read/38517750/multi-omics-characterization-of-partial-chemical-reprogramming-reveals-evidence-of-cell-rejuvenation
#40
JOURNAL ARTICLE
Wayne Mitchell, Ludger J E Goeminne, Alexander Tyshkovskiy, Sirui Zhang, Julie Y Chen, Joao A Paulo, Kerry A Pierce, Angelina H Choy, Clary B Clish, Steven P Gygi, Vadim N Gladyshev
Partial reprogramming by cyclic short-term expression of Yamanaka factors holds promise for shifting cells to younger states and consequently delaying the onset of many diseases of aging. However, the delivery of transgenes and potential risk of teratoma formation present challenges for in vivo applications. Recent advances include the use of cocktails of compounds to reprogram somatic cells, but the characteristics and mechanisms of partial cellular reprogramming by chemicals remain unclear. Here, we report a multi-omics characterization of partial chemical reprogramming in fibroblasts from young and aged mice...
March 22, 2024: ELife
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