keyword
https://read.qxmd.com/read/38530364/satellite-glial-gpr37l1-and-its-ligand-maresin-1-regulate-potassium-channel-signaling-and-pain-homeostasis
#1
JOURNAL ARTICLE
Sangsu Bang, Changyu Jiang, Jing Xu, Sharat Chandra, Aidan McGinnis, Xin Luo, Qianru He, Yize Li, Zilong Wang, Xiang Ao, Marc Parisien, Lorenna Oliveira Fernandes de Araujo, Sahel Jahangiri Esfahani, Qin Zhang, Raquel Tonello, Temugin Berta, Luda Diatchenko, Ru-Rong Ji
G protein-coupled receptor 37-like 1 (GPR37L1) is an orphan GPCR with largely unknown functions. Here we report that Gpr37l1/GRP37L1 ranks among the most highly expressed GPCR transcripts in mouse and human dorsal root ganglia (DRGs), selectively expressed in satellite glial cells (SGCs). Peripheral neuropathy induced by streptozotoxin (STZ) and paclitaxel (PTX) led to reduced GPR37L1 expression on the plasma membrane expression in mouse and human DRGs. Transgenic mice with Gpr37l1 deficiency exhibited impaired resolution of neuropathic pain symptoms following PTX and STZ-induced pain, whereas overexpression of Gpr37l1 in mouse DRGs reversed pain...
March 26, 2024: Journal of Clinical Investigation
https://read.qxmd.com/read/38528924/a-new-oxime-synthesized-from-senecio-nutans-sch-bip-chachacoma-reduces-calcium-influx-in-the-vascular-contractile-response-in-rat-aorta
#2
JOURNAL ARTICLE
Javier Palacios, Daniel Asunción-Alvarez, Diego Aravena, Mario Chiong, Marcelo A Catalán, Claudio Parra, Fredi Cifuentes, Adrián Paredes
Senecio nutans Sch. Bip is an endemic plant commonly employed in the Andes culture to counteract the effects of mountain sickness, and its bioactive molecules could provide new drugs for treating hypertension. The purpose was to determine whether the vascular response of the plant bioactive molecules, such as (5-acetyl-6-hydroxy-2-isopropenyl-2,3-dihydrobenzofurane; Sn-I), could be improved by a simple structural modification to synthesize oximes (Ox-Sn-I). We characterized both compounds using IR and NMR spectroscopy and Heteronuclear Multiple Quantum Coherence (HMQC)...
March 20, 2024: RSC Advances
https://read.qxmd.com/read/38528561/transcriptome-and-open-chromatin-analysis-reveals-the-process-of-myocardial-cell-development-and-key-pathogenic-target-proteins-in-long-qt-syndrome-type-7
#3
JOURNAL ARTICLE
Peipei Chen, Junyu Long, Tianrui Hua, Zhifa Zheng, Ying Xiao, Lianfeng Chen, Kang Yu, Wei Wu, Shuyang Zhang
OBJECTIVE: Long QT syndrome type 7 (Andersen-Tawil syndrome, ATS), which is caused by KCNJ2 gene mutation, often leads to ventricular arrhythmia, periodic paralysis and skeletal malformations. The development, differentiation and electrophysiological maturation of cardiomyocytes (CMs) changes promote the pathophysiology of Long QT syndrome type 7(LQT7). We aimed to specifically reproduce the ATS disease phenotype and study the pathogenic mechanism. METHODS AND RESULTS: We established a cardiac cell model derived from human induced pluripotent stem cells (hiPSCs) to the phenotypes and electrophysiological function, and the establishment of a human myocardial cell model that specifically reproduces the symptoms of ATS provides a reliable platform for exploring the mechanism of this disease or potential drugs...
March 25, 2024: Journal of Translational Medicine
https://read.qxmd.com/read/38528167/inferring-parameters-of-pyramidal-neuron-excitability-in-mouse-models-of-alzheimer-s-disease-using-biophysical-modeling-and-deep-learning
#4
JOURNAL ARTICLE
Soheil Saghafi, Timothy Rumbell, Viatcheslav Gurev, James Kozloski, Francesco Tamagnini, Kyle C A Wedgwood, Casey O Diekman
Alzheimer's disease (AD) is believed to occur when abnormal amounts of the proteins amyloid beta and tau aggregate in the brain, resulting in a progressive loss of neuronal function. Hippocampal neurons in transgenic mice with amyloidopathy or tauopathy exhibit altered intrinsic excitability properties. We used deep hybrid modeling (DeepHM), a recently developed parameter inference technique that combines deep learning with biophysical modeling, to map experimental data recorded from hippocampal CA1 neurons in transgenic AD mice and age-matched wildtype littermate controls to the parameter space of a conductance-based CA1 model...
March 25, 2024: Bulletin of Mathematical Biology
https://read.qxmd.com/read/38525817/exploring-the-therapeutic-potential-of-pomegranate-juice-for-uterine-relaxation
#5
JOURNAL ARTICLE
Omar A M Al-Habib, Lina N Adam
BACKGROUND: The effects of pomegranate juice (PJ) and its components on uterine smooth muscle are unknown. Hence, this study unequivocally demonstrates that pomegranate juice (PJ) significantly impacts myometrial function, providing crucial insights into its relaxant properties and their potential therapeutic applications for uterine-related disorders. RESEARCH DESIGN AND METHODS: Rat uterine smooth muscle horn strips were suspended in Krebs solution organ baths...
March 25, 2024: Expert Review of Endocrinology & Metabolism
https://read.qxmd.com/read/38525126/the-sars-coronavirus-accessory-protein-orf3a-rescues-potassium-conductance-in-yeast
#6
JOURNAL ARTICLE
Joel C Rosenbaum, Anne E Carlson
ORF3a is an accessory protein expressed by all human pathogen coronaviruses and is the only accessory protein that strongly affects viral fitness. Its deletion reduces severity in both alpha- and beta-coronaviruses, demonstrating a conserved function across the superfamily. Initially regarded as a non-selective cation channel, ORF3a's function is now disputed. Here, we show that ORF3a from SARS, but not SARS-CoV-2, promotes potassium conductance in a yeast model system commonly used to study potassium channels...
2024: microPublication. Biology
https://read.qxmd.com/read/38523672/the-key-mediator-of-diabetic-kidney-disease-potassium-channel-dysfunction
#7
REVIEW
Jia Guo, Chaojie Zhang, Hui Zhao, Yufan Yan, Zhangsuo Liu
Diabetic kidney disease is a leading cause of end-stage renal disease, making it a global public health concern. The molecular mechanisms underlying diabetic kidney disease have not been elucidated due to its complex pathogenesis. Thus, exploring these mechanisms from new perspectives is the current focus of research concerning diabetic kidney disease. Ion channels are important proteins that maintain the physiological functions of cells and organs. Among ion channels, potassium channels stand out, because they are the most common and important channels on eukaryotic cell surfaces and function as the basis for cell excitability...
July 2024: Genes & Diseases
https://read.qxmd.com/read/38518392/tinnitus-related-increases-in-single-unit-activity-in-awake-rat-auditory-cortex-correlate-with-tinnitus-behavior
#8
JOURNAL ARTICLE
Rui Cai, Lynne Ling, Madan Ghimire, Kevin A Brownell, Donald M Caspary
Tinnitus is known to affect 10-15 % of the population, severely impacting 1-2 % of those afflicted. Canonically, tinnitus is generally a consequence of peripheral auditory damage resulting in maladaptive plastic changes in excitatory/inhibitory homeostasis at multiple levels of the central auditory pathway as well as changes in diverse nonauditory structures. Animal studies of primary auditory cortex (A1) generally find tinnitus-related changes in excitability across A1 layers and differences between inhibitory neuronal subtypes...
March 16, 2024: Hearing Research
https://read.qxmd.com/read/38517941/modelling-and-analysis-of-camp-induced-mixed-mode-oscillations-in-cortical-neurons-critical-roles-of-hcn-and-m-type-potassium-channels
#9
JOURNAL ARTICLE
Matteo Martin, Morten Gram Pedersen
Cyclic AMP controls neuronal ion channel activity. For example hyperpolarization-activated cyclic nucleotide-gated (HCN) and M-type K+ channels are activated by cAMP. These effects have been suggested to be involved in astrocyte control of neuronal activity, for example, by controlling the action potential firing frequency. In cortical neurons, cAMP can induce mixed-mode oscillations (MMOs) consisting of small-amplitude, subthreshold oscillations separating complete action potentials, which lowers the firing frequency greatly...
March 22, 2024: PLoS Computational Biology
https://read.qxmd.com/read/38517617/roles-of-kcna2-in-neurological-diseases-from-physiology-to-pathology
#10
REVIEW
Changning Xie, Miriam Kessi, Fei Yin, Jing Peng
Potassium voltage-gated channel subfamily a member 2 (Kv1.2, encoded by KCNA2) is highly expressed in the central and peripheral nervous systems. Based on the patch clamp studies, gain-of function (GOF), loss-of-function (LOF), and a mixed type (GOF/LOF) variants can cause different conditions/disorders. KCNA2-related neurological diseases include epilepsy, intellectual disability (ID), attention deficit/hyperactive disorder (ADHD), autism spectrum disorder (ASD), pain as well as autoimmune and movement disorders...
March 22, 2024: Molecular Neurobiology
https://read.qxmd.com/read/38515135/recent-research-advances-in-pain-mechanisms-in-mccune-albright-syndrome-thinking-about-the-pain-mechanism-of-fd-mas
#11
REVIEW
Yong Wang, Tao Jiang
BACKGROUND: The lack of effective understanding of the pain mechanism of McCune-Albright syndrome (MAS) has made the treatment of pain in this disease a difficult clinical challenge, and new therapeutic targets are urgently needed to address this dilemma. OBJECTIVE: This paper summarizes the novel mechanisms, targets, and treatments that may produce pain in MAS and fibrous dysplasia (polyfibrous dysplasia, or FD). METHODS: We conducted a systematic search in the PubMed database, Web of Science, China Knowledge Network (CNKI) with the following keywords: "McCune-Albright syndrome (MAS); polyfibrous dysplasia (FD); bone pain; bone remodeling; G protein coupled receptors; GDNF family receptors; purinergic receptors and glycogen synthase kinase", as well as other keywords were systematically searched...
March 21, 2024: Journal of Orthopaedic Surgery and Research
https://read.qxmd.com/read/38512829/in-situ-potassium-and-hydrogen-ion-exchange-into-a-cubic-zirconium-silicate-microporous-material
#12
JOURNAL ARTICLE
Jason Lively, Aaron J Celestian
The selective separation of ions from aqueous systems, and even in the human body, is a crucial to overall environmental management and health. Nanoporous materials are widely known for their selective removal of cations from aqueous media, and therefore have been targeted for use as a pharmaceutical to treat hyperkalemia. This study investigated the detailed crystallographic molecular mechanisms that control the potassium ion selectivity in the nanoporous cubic zirconium silicate (CZS) related materials. Using time-resolved in situ Raman spectroscopy and time-resolved in situ X-ray diffraction, the selectivity mechanisms were determined to involve a synchronous cation-cation repulsion process that serves to open a favorable coordination bonding environment for potassium, not unlike the ion selectivity filter process found in potassium ion channels in proteins...
2024: PloS One
https://read.qxmd.com/read/38512428/quantitative-proteomic-analysis-identifying-and-evaluating-traf6-and-il-8-as-potential-diagnostic-biomarkers-in-neonatal-patients-with-necrotizing-enterocolitis
#13
JOURNAL ARTICLE
Jing Wang, Minhan Qu, Aijuan Qiu, Lili Yang, Hui Xu, Shenglin Yu, Zhaojun Pan
Necrotizing enterocolitis (NEC) is a common gastrointestinal complication in premature infants, resulting in high morbidity and mortality, and its early detection is crucial for accurate treatment and outcome prediction. Extensive research has demonstrated a clear correlation between NEC and extremely low birth weight, degree of preterm, formula feeding, infection, hypoxic/ischemic damage, and intestinal dysbiosis. The development of noninvasive biomarkers of NEC from stool, urine, and serum has attracted a great deal of interest because to these clinical connections and the quest for a deeper knowledge of disease pathophysiology...
March 21, 2024: Molecular Biotechnology
https://read.qxmd.com/read/38511871/a-simple-cost-effective-method-to-fabricate-single-nanochannels-by-embedding-electrospun-polyethylene-oxide-nanofibers
#14
JOURNAL ARTICLE
Lei Zhou, Zhuonan Chen, Jian Ma
Solid state nanochannels provide significant practical advantages in many fields due to their interesting properties, such as controllable shape and size, robustness, ion selectivity. But their complex preparation processes severely limit their application. In this study, a simple cost-effective method to fabricate single nanochannel by embedding a single polyethylene oxide (PEO) nanofiber is presented. Firstly, PEO nanofibers are prepared by electrospinning, and then a single PEO nanofiber are precisely transferred to the target sample using a micromanipulation platform...
March 21, 2024: ChemistryOpen
https://read.qxmd.com/read/38511575/cardiotoxicity-assessment-through-a-polymer-based-cantilever-platform-an-integrated-electro-mechanical-screening-approach
#15
JOURNAL ARTICLE
Pooja P Kanade, Nomin-Erdene Oyunbaatar, Jongyun Kim, Bong-Kee Lee, Eung-Sam Kim, Dong-Weon Lee
Preclinical drug screening for cardiac toxicity has traditionally relied on observing changes in cardiomyocytes' electrical activity, primarily through invasive patch clamp techniques or non-invasive microelectrode arrays (MEA). However, relying solely on field potential duration (FPD) measurements for electrophysiological assessment can miss the full spectrum of drug-induced toxicity, as different drugs affect cardiomyocytes through various mechanisms. A more comprehensive approach, combining field potential and contractility measurements, is essential for accurate toxicity profiling, particularly for drugs targeting contractile proteins without affecting electrophysiology...
March 21, 2024: Small
https://read.qxmd.com/read/38511536/in-situ-defect-engineering-in-carbon-by-atomic-self-activation-to-boost-the-accessible-low-voltage-insertion-for-advanced-potassium-ion-full-cells
#16
JOURNAL ARTICLE
Jianzhen Xiong, Zecheng Yang, Rui Zhou, Anyong Xiao, Xiangkai Kong, Jiangmin Jiang, Liang Dong, Quanchao Zhuang, Zhicheng Ju, Yaxin Chen
Enhancing the low-potential capacity of anode materials is significant in boosting the operating voltage of full-cells and constructing high energy-density energy storage devices. Graphitic carbons exhibit outstanding low-potential potassium storage performance, but show a low K+ diffusion kinetics. Herein, in situ defect engineering in graphitic nanocarbon is achieved by an atomic self-activation strategy to boost the accessible low-voltage insertion. Graphitic carbon layers grow on nanoscale-nickel to form the graphitic nanosphere with short-range ordered microcrystalline due to nickel graphitization catalyst...
March 21, 2024: Small
https://read.qxmd.com/read/38511069/comparison-of-different-medical-treatments-for-primary-hyperaldosteronism-a-systematic-review-and-network-meta-analysis
#17
JOURNAL ARTICLE
Wen-Yu Ho, Ching-Chung Hsiao, Ping-Hsun Wu, Jui-Yi Chen, Yu-Kang Tu, Vin-Cent Wu, Jia-Jin Chen
BACKGROUND: The effectiveness and side effects between different medical treatments in patients with primary hyperaldosteronism have not been systematically studied. OBJECTIVE: To analyze the efficacy between different mineralocorticoid receptor antagonists (MRAs) and epithelial sodium channel (ENaC) inhibitors in a network meta-analysis (NMA) framework, while also evaluating adverse events. DESIGN: Systematic review and NMA. DATA SOURCES AND METHODS: The systematic review and NMA was reported according to Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines...
2024: Therapeutic Advances in Chronic Disease
https://read.qxmd.com/read/38509679/targeting-hypertension-a-review-on-pathophysiological-factors-and-treatment-strategies
#18
JOURNAL ARTICLE
Ruhani Raj, Minakshi Garg, Anupreet Kaur
Hypertension is one of the primary causes of cardiovascular diseases and death, with a higher prevalence in low- and middle-income countries. The pathophysiology of hypertension remains complex, with 2% to 5% of patients having underlying renal or adrenal disorders. The rest are referred to as essential hypertension, with derangements in various physiological mechanisms potentially contributing to the development of essential hypertension. Hypertension elevates the risk of cardiovascular disease (CVD) events (coronary heart disease, heart failure, and stroke) and mortality...
March 20, 2024: Current Hypertension Reviews
https://read.qxmd.com/read/38509283/akap150-anchored-pka-regulates-synaptic-transmission-and-plasticity-neuronal-excitability-and-crf-neuromodulation-in-the-mouse-lateral-habenula
#19
JOURNAL ARTICLE
Sarah C Simmons, William J Flerlage, Ludovic D Langlois, Ryan D Shepard, Christopher Bouslog, Emily H Thomas, Kaitlyn M Gouty, Jennifer L Sanderson, Shawn Gouty, Brian M Cox, Mark L Dell'Acqua, Fereshteh S Nugent
The scaffolding A-kinase anchoring protein 150 (AKAP150) is critically involved in kinase and phosphatase regulation of synaptic transmission/plasticity, and neuronal excitability. Emerging evidence also suggests that AKAP150 signaling may play a key role in brain's processing of rewarding/aversive experiences, however its role in the lateral habenula (LHb, as an important brain reward circuitry) is completely unknown. Using whole cell patch clamp recordings in LHb of male wildtype and ΔPKA knockin mice (with deficiency in AKAP-anchoring of PKA), here we show that the genetic disruption of PKA anchoring to AKAP150 significantly reduces AMPA receptor-mediated glutamatergic transmission and prevents the induction of presynaptic endocannabinoid-mediated long-term depression in LHb neurons...
March 20, 2024: Communications Biology
https://read.qxmd.com/read/38509107/structure-of-an-open-k-atp-channel-reveals-tandem-pip-2-binding-sites-mediating-the-kir6-2-and-sur1-regulatory-interface
#20
JOURNAL ARTICLE
Camden M Driggers, Yi-Ying Kuo, Phillip Zhu, Assmaa ElSheikh, Show-Ling Shyng
ATP-sensitive potassium (KATP ) channels, composed of four pore-lining Kir6.2 subunits and four regulatory sulfonylurea receptor 1 (SUR1) subunits, control insulin secretion in pancreatic β-cells. KATP channel opening is stimulated by PIP2 and inhibited by ATP. Mutations that increase channel opening by PIP2 reduce ATP inhibition and cause neonatal diabetes. Although considerable evidence has implicated a role for PIP2 in KATP channel function, previously solved open-channel structures have lacked bound PIP2 , and mechanisms by which PIP2 regulates KATP channels remain unresolved...
March 20, 2024: Nature Communications
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